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Regular treatment with formoterol and inhaled steroids for chronic asthma: serious adverse events

  1. Christopher J Cates1,*,
  2. Roman Jaeschke2,
  3. Stefanie Schmidt3,
  4. Montse Ferrer3

Editorial Group: Cochrane Airways Group

Published Online: 7 JUN 2013

DOI: 10.1002/14651858.CD006924.pub3


How to Cite

Cates CJ, Jaeschke R, Schmidt S, Ferrer M. Regular treatment with formoterol and inhaled steroids for chronic asthma: serious adverse events. Cochrane Database of Systematic Reviews 2013, Issue 6. Art. No.: CD006924. DOI: 10.1002/14651858.CD006924.pub3.

Author Information

  1. 1

    St George's University of London, Population Health Sciences and Education, London, UK

  2. 2

    McMaster University, Department of Medicine and Department of Clinical Epidemiology and Biostatistics, Hamilton, Ontario, Canada

  3. 3

    IMIM (Hospital del Mar Medical Research Institute), Health Services Research Unit, Barcelona, Spain

*Christopher J Cates, Population Health Sciences and Education, St George's University of London, Cranmer Terrace, London, SW17 0RE, UK. ccates@sgul.ac.uk.

Publication History

  1. Publication Status: New search for studies and content updated (conclusions changed)
  2. Published Online: 7 JUN 2013

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[Figure 1]
Figure 1. Methodological quality summary: review authors' judgements about each methodological quality item for each included study.
[Figure 2]
Figure 2. Forest plot of comparison: 1 Formoterol and ICS versus same dose ICS, outcome: 1.1 All-cause mortality.
[Figure 3]
Figure 3. Forest plot of comparison: 1 Formoterol and ICS versus same dose ICS, outcome: 1.2 All-cause non-fatal serious adverse events.
[Figure 4]
Figure 4. Forest plot of comparison: 1 Formoterol and ICS versus same dose ICS, outcome: 1.3 Asthma mortality.
[Figure 5]
Figure 5. Forest plot of comparison: 1 Formoterol and ICS versus same dose ICS, outcome: 1.4 Asthma-related non-fatal serious adverse events.
[Figure 6]
Figure 6. Funnel plot of comparison: 1 Formoterol and ICS versus same dose ICS, outcome: 1.2 All-cause non-fatal serious adverse events.
[Figure 7]
Figure 7. All-cause serious adverse events in children given regular formoterol (with or without ICS).
[Analysis 1.1]
Analysis 1.1. Comparison 1 Formoterol and ICS versus same dose ICS, Outcome 1 All-cause mortality.
[Analysis 1.2]
Analysis 1.2. Comparison 1 Formoterol and ICS versus same dose ICS, Outcome 2 All-cause non-fatal serious adverse events.
[Analysis 1.3]
Analysis 1.3. Comparison 1 Formoterol and ICS versus same dose ICS, Outcome 3 Asthma mortality.
[Analysis 1.4]
Analysis 1.4. Comparison 1 Formoterol and ICS versus same dose ICS, Outcome 4 Asthma-related non-fatal serious adverse events.