Intervention Review

You have free access to this content

Pharmacological treatment of depression in patients with a primary brain tumour

  1. Alasdair G Rooney*,
  2. Robin Grant

Editorial Group: Cochrane Gynaecological, Neuro-oncology and Orphan Cancer Group

Published Online: 31 MAY 2013

Assessed as up-to-date: 29 APR 2013

DOI: 10.1002/14651858.CD006932.pub3

How to Cite

Rooney AG, Grant R. Pharmacological treatment of depression in patients with a primary brain tumour. Cochrane Database of Systematic Reviews 2013, Issue 5. Art. No.: CD006932. DOI: 10.1002/14651858.CD006932.pub3.

Author Information

  1. Western General Hospital, Edinburgh Centre for Neuro-Oncology (ECNO), Edinburgh, Scotland, UK

*Alasdair G Rooney, Edinburgh Centre for Neuro-Oncology (ECNO), Western General Hospital, Crewe Road South, Edinburgh, Scotland, EH4 2XU, UK.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 31 MAY 2013



References to studies excluded from this review

  1. References to studies excluded from this review
  2. Additional references
  3. References to other published versions of this review
Caudill 2011 {published data only}
  • Caudill JS, Brown PD, Cerhan JH, Rummans TA. Selective serotonin reuptake inhibitors, glioblastoma multiforme, and impact on toxicities and overall survival. The Mayo Clinic experience. American Journal of Clinical Oncology 2011;34:385-7.
Koval'chuk 2007 {published data only}
  • Koval'chuk VV. Pharmacologic correction of psycho-emotive disorders in the rehabilitation of patients after removal of brain tumors [Original title unavailable (Russian)]. Voprosy Onkologii 2007;53(6):704-10.
Litofsky 2004 {published data only}
Meyers 1998 {published data only}
  • Meyers CA, Weitzner MA, Valentine AD, Levin VA. Methylphenidate therapy improves cognition, mood, and function of brain tumor patients. Journal of Clinical Oncology 1998;16(7):2522-7.
Morrow 2003 {published data only}
  • Morrow GR, Hickok JT, Roscoe JA, Raubertas RF, Andrews PLR, Flynn PJ. Differential effects of paroxetine on fatigue and depression: a randomized, double-blind trial from the University of Rochester Cancer Centre Community Clinical Oncology Programme. Journal of Clinical Oncology 2003;21(24):4635-41.
Moss 2006 {published data only}
Oyewumi 1981 {published data only}
Rabey 1985 {published data only}
Shaw 2006 {published data only}
  • Shaw EG, Rosdhal R, D'Agostino Jr RB, Lovato J, Naughton MJ, Robbins ME, et al. Phase II study of donepezil in irradiated brain tumor patients: Effect on cognitive function, mood, and quality of life. Journal of Clinical Oncology 2006;24(9):1415-20.
Wellisch 2006 {published data only}
  • Wellisch DK, Steh B, Kaleita TA, Graham CA, Cloughes TF. A modafinil therapeutic trial for adult brain tumor patients: III. Depression outcomes. Psycho-oncology 2006;15 Suppl:455.

Additional references

  1. References to studies excluded from this review
  2. Additional references
  3. References to other published versions of this review
APA 2000
  • American Psychiatric Association. Practice guideline for the treatment of patients with major depressive disorder (revision). American Journal of Psychiatry 2000;157 Suppl 4:1-45.
APA 2000b
  • American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (4th edition, text rev.). Diagnostic and Statistical Manual of Mental Disorders (4th edition, text revision). Washington DC: American Psychiatric Association, 2000.
Armstrong 2002
  • Armstrong CL, Goldstein B, Cohen B, et al. Clinical predictors of depression in patients with low-grade brain tumors: consideration of a neurologic versus a psychogenic model. Journal of Clinical Psychology in Medical Settings 2002;9(2):97-107.
Barnholtz-Sloan 2003
  • Barnholtz-Sloan JS, Sloan AE, Schwartz AG. Relative survival rates and patterns of diagnosis analyzed by time period for individuals with primary malignant brain tumour, 1973-1997. Journal of Neurosurgery 2003;99(3):458-66.
Cassano 2004
  • Cassano P, Fava M. Tolerability issues during long-term treatment with antidepressants. Annals of Clinical Psychiatry 2004;16(1):15-25.
Dalton 2009
  • Dalton SO, Laursen TM, Ross L, Mortensen PB, Johansen C. Risk for hospitalisation with depression after a cancer diagnosis: a nationwide, population-based study of cancer patients in Denmark from 1973 to 2003. Journal of Clinical Oncology 2009;27:1440-5.
Feuerstein 2007
First 2002
  • First MB, Spitzer RL, Gibbon M. Structured Clinical Interview for DSM-IV-TR Axis I disorders. Patient Edition (SCID-I/P, 11/2002 revision) 2002.
Gathinji 2009
  • Gathinji M, McGirt M, Attenello F, Chaichana K, Than K, Olivi A, et al. Association of preoperative depression and survival after resection of malignant brain astrocytoma. Surgical Neurology 2009;71(3):299-303.
Gelder 2000
  • Gelder M (editor). Oxford Textbook of Psychiatry. Oxford University Press, 2000.
Greenberg 2004
  • Greenberg DB. Barriers to the treatment of depression in cancer patients. Journal of the National Cancer Institute. Monographs 2004;32:127-35.
Hachad 2002
Hackett 2008
  • Hackett ML, Anderson CS, House AO, Xia J. Interventions for treating depression after stroke. Cochrane Database of Systematic Reviews 2008, Issue 4. [DOI: 10.1002/14651858.CD003437.pub3]
Hesdorffer 2000
Iosifescu 2004
  • Iosifescu DV, Bankier B, Fava M. Impact of medical co-morbid disease on antidepressant treatment of major depressive disorder. Current Psychiatry Reports 2004;6(3):193-201.
Lima 2005
  • Lima MS, Moncrieff J, Soares BGO. Drugs versus placebo for dysthymia. Cochrane Database of Systematic Reviews 2005, Issue 2. [DOI: 10.1002/14651858.CD001130]
Litofsky 2009
  • Litofsky NS, Resnick AG. The relationship between depression and brain tumours. Journal of Neuro-oncology 2009 Mar 5 [Epub ahead of print].
Louis 2007
Mainio 2005
  • Mainio A, Hakko H, Timonen M, Niemelä A,  Koivukangas J,  Räsänen P. Depression in relation to survival among neurosurgical patients with a primary brain tumor: a 5-year follow-up study. Neurosurgery 2005;56:1234-42.
Mainio 2006
  • Mainio A, Hakko H, Niemela A. Gender difference in relation to depression and quality of life among patients with a primary brain tumour. European Psychiatry: the journal of the Association of European Psychiatrists 2006;21(3):194-9.
Mainio 2006b
  • Mainio A, Tuunanen S, Hakko H. Decreased quality of life and depression as predictors for shorter survival among patients with low-grade gliomas: a follow-up from 1990 to 2003. European Archives of Psychiatry and Clinical Neuroscience 2006;256(8):516-21.
Moncrieff 2004
Montgomery 2005
Mottram 2006
NICE 2004
  • Management of depression in primary and secondary care. National Clinical Practice Guideline No. 23. London: National Institute for Health and Care Excellence 2004.
Pace 1998
  • Pace A, Bove L, Innocenti P. Epilepsy and gliomas: incidence and treatment in 119 patients. Journal of Experimental and Clinical Cancer Research 1998;17(4):479-82.
Pangilinan 2007
  • Pangilinan PH Jr, Kelly BM, Pangilinan JM. Depression in the patient with brain cancer. Community Oncology 2007;4:533-7.
Parkin 2005
  • Parkin DM, Whelan SL, Ferlay J. Cancer incidence in five continents, vol. I to VIII. IARC Cancerbase No 7, Lyon 2005.
Peretti 2000
Pignatti 2002
Price 2008
  • Price TRP, Goetz KL, Lovell MR. Neuropsychiatric aspects of brain tumors. In: Yudofsky SC, Hales RE editor(s). The American Psychiatric Publishing Textbook of Neuropsychiatry and Behavioural Neurosciences. 5th Edition. Arlington: American Psychiatric Publishing Inc., 2008.
RevMan 2012 [Computer program]
  • The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). Version 5.2. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2012.
Rihmer 2007
Rooney 2011
  • Rooney AG, McNamara S, MacKinnon M, Fraser M, Rampling R, Carson A, et al. Frequency, clinical associations, and longitudinal course of major depressive disorder in adults with cerebral glioma. Journal of Clinical Oncology 2011;29:4307-12.
Sharpe 2004
Stefanova 2006
Strong 2007
  • Strong V, Waters R, Hibberd C, Rush R,  Cargill A,  Storey D, et al. Emotional distress in cancer patients: the Edinburgh Cancer Centre symptoms study. British Journal of Cancer 2007;96(6):868-74.
Stupp 2005
  • Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJB, et al. Radiotherapy plus concomitant and adjuvant chemotherapy for glioblastoma. New England Journal of Medicine 2005;352:987-96.
Van den Bent 2005
  • Van Den Bent MJ, Afra D, de Witte O. Long-term efficacy of early versus delayed radiotherapy for low-grade astrocytoma and oligodendroglioma in adults: the EORTC 22845 randomised trial. Lancet 2005;366:985-90.
Weitzner 1999
Wellisch 2002
Wen 2008
Wijkstra 2005
Wrensch 2002
Zigmond 1968

References to other published versions of this review

  1. References to studies excluded from this review
  2. Additional references
  3. References to other published versions of this review
Rooney 2010