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Surgical resection versus liver transplant for patients with hepatocellular carcinoma

  1. Amir Taefi1,*,
  2. Amir Abrishami2,
  3. Siavosh Nasseri-Moghaddam3,
  4. Bijan Eghtesad4,
  5. Morris Sherman5

Editorial Group: Cochrane Hepato-Biliary Group

Published Online: 29 JUN 2013

Assessed as up-to-date: 18 FEB 2013

DOI: 10.1002/14651858.CD006935.pub2


How to Cite

Taefi A, Abrishami A, Nasseri-Moghaddam S, Eghtesad B, Sherman M. Surgical resection versus liver transplant for patients with hepatocellular carcinoma. Cochrane Database of Systematic Reviews 2013, Issue 6. Art. No.: CD006935. DOI: 10.1002/14651858.CD006935.pub2.

Author Information

  1. 1

    Medstar Washington Hospital Center, Department of Internal Medicine, Washington, DC, USA

  2. 2

    Toronto Western Hospital, University Health Network, University of Toronto, Department of Anesthesia, Toronto, Ontario, Canada

  3. 3

    Shariati Hospital, Tehran University of Medical Sciences, Digestive Diseases Research Centre, Tehran, Tehran, Iran

  4. 4

    Cleveland Clinic Main Campus, Transplant Surgery Desk A-100, Cleveland, USA

  5. 5

    Toronto General Hospital, Toronto, Canada

*Amir Taefi, Department of Internal Medicine, Medstar Washington Hospital Center, 110 Irving Street, Washington, DC, 20010, USA. amirtaefi@yahoo.com.

Publication History

  1. Publication Status: New
  2. Published Online: 29 JUN 2013

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References

References to studies excluded from this review

  1. References to studies excluded from this review
  2. Additional references
Bartlett 2007 {published data only}
  • Bartlett AJR, McCall JL, Koea JB, Holden A, Yeong ML, Gurusinghe N, et al. Liver resection for hepatocellular carcinoma in a hepatitis B endemic area. World Journal of Surgery 2007;31:1775-81.
Bartlett 2008 {published data only}
Belghiti 2003 {published data only}
  • Belghiti J, Cortes A, Abdalla EK, Regimbeau JM, Prakash K, Durand F, et al. Resection prior to liver transplantation for hepatocellular carcinoma. Annals of Surgery 2003;238:885-92.
Bismuth 1993 {published data only}
Chen 2006 {published data only}
  • Chen MS, Li JQ, Zheng Y, Guo RP, Liang HH, Zhang YQ, et al. A prospective randomised trial comparing percutaneous local ablative therapy and partial hepatectomy for small hepatocellular carcinoma. Annals of Surgery 2006;243(3):321-8.
Choti 2002 {published data only}
Chung 1994 {published data only}
Colleoni 1998 {published data only}
Decaens 2006 {published data only}
Ercolani 2003 {published data only}
Fan 1999 {published data only}
Figueras 2001 {published data only}
Fong 1999 {published data only}
Huang 2011 {published data only}
  • Huang ZY, Chen G, Hao XY, Cai RY, Zhao YF, Chen XP. Outcomes of non-anatomic liver resection for hepatocellular carcinoma in the patients with liver cirrhosis and analysis of prognostic factors. Langenbeck's Archives of Surgery 2011;396(2):193-9.
Hwang 2005 {published data only}
Jonas 2001 {published data only}
Jonas 2007 {published data only}
Lise 1998 {published data only}
Llovet 1999 {published data only}
Mazzaferro 1996 {published data only}
  • Mazzaferro V, Regalia E, Doci R, Andreola S, Pulvirenti A, Bozzetti F, et al. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. New England Journal of Medicine 1996;334(11):693-9.
Nagasue 1993 {published data only}
Nuzzo 2007 {published data only}
  • Nuzzo G, Giuliante F, Gauzolino R, Vellone M, Giovannini I. Liver resections for hepatocellular carcinoma in chronic liver disease: experience in an Italian centre. European Journal of Surgical Oncology 2007;33:1014-8.
Sim 2003 {published data only}
Todo 2004 {published data only}
Yao 2001 {published data only}

Additional references

  1. References to studies excluded from this review
  2. Additional references
Adam 2003
  • Adam R, Azoulay D, Castaing D, Eshkenazy R, Pascal G, Hashizume K, et al. Liver resection as a bridge to transplantation for hepatocellular carcinoma on cirrhosis: a reasonable strategy. Annual of Surgery 2003;238(4):518-9.
Badvie 2000
Bain 1997
  • Bain I, McMaster P. Benign and malignant liver tumours. Surgery 1997;15:169-74.
Bangalore 2008
  • Bangalore S, Wetterslev J, Pranesh S, Sawhney S, Gluud C, Messerli FH. Peri-operative beta-blockers in patients undergoing non-cardiac surgery. A meta-analysis and trial sequential analysis of 12,306 patients from randomised trials. Lancet 2008;372:1962-76.
Begg 1994
Belghiti 1991
Bhoori 2007
Blum 2005
Bosch 2004
Botha 2007
  • Botha JF, Grant WJ, Shaw BW. Surgical options for the treatment of hepatocellular carcinoma. In: Schiff ER, Sorrell MF, Maddrey WC editor(s). Schiff's Diseases of the Liver. 10th Edition. Vol. 2, Philadelphia: Lippincott Williams & Wilkins, 2007:1266-71.
Brok 2008
  • Brok J, Thorlund K, Gluud C, Wetterslev J. Trial sequential analysis reveals insufficient information size and potentially false positive results in many meta-analyses. Journal of Clinical Epidemiology 2008;61:763-9.
Brok 2009
  • Brok J, Thorlund K, Wetterslev J, Gluud C. Apparently conclusive meta-analyses may be inconclusive - Trial sequential analysis adjustment of random error risk due to repetitive testing of accumulating data in apparently conclusive neonatal meta-analyses. International Journal of Epidemiology 2009;38(1):287-98.
Bruix 1996
Bruix 2005
Bruix 2006
Buyse 1987
Capussotti 2006
  • Capussotti L, Muratore A, Amisano M, Massucco P, Polastri R, Bouzari H. Liver resection for large-size hepatocellular carcinomas in 47 non-cirrhotic patients - no mortality and long-term survival. Hepato-Gastroenterology 2006;53(71):768-72.
Carr 2012
  • Carr BI. Tumors of the liver and biliary tree. In: Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson JL, Loscalzo J editor(s). Harrison's Principle of Internal Medicine (http://www.accessmedicine.com/content.aspx?aID=9116154). 18th Edition. New York: McGraw-Hill, 2012 (accessed January 17, 2013):Chapter 92.
Clark 2005
Collier 1998
CTU 2011
  • Copenhagen Trial Unit. TSA - Trial Sequential Analysis. http://ctu.dk/tsa/ 2011 (accessed 26 June 2013).
DeMets 1987
DerSimonian 1986
Deuffic 1998
Egger 1997
El-Serag 2007
Farmer 1994
Galandi 2004
  • Galandi D, Antes G. Radiofrequency thermal ablation versus other interventions for hepatocellular carcinoma. Cochrane Database of Systematic Reviews 2004, Issue 2. [DOI: 10.1002/14651858.CD003046.pub2]
Gluud 2013
  • Gluud C, Nikolova D, Klingenberg SL, Alexakis N, Als-Nielsen B, Colli A, et al. Cochrane Hepato-Biliary Group. About The Cochrane Collaboration (Cochrane Review Groups (CRGs)). 2013, Issue 5. Art. No.: LIVER.
Grazi 2001
Higgins 2011
  • Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
Hwang 2007
ICH-GCP 1997
  • International Conference on Harmonisation Expert Working Group. International conference on harmonisation of technical requirements for registration of pharmaceuticals for human use. ICH harmonised tripartite guideline. Guideline for good clinical practice1997 CFR & ICH Guidelines. Vol. 1, PA 19063-2043, USA: Barnett International/PAREXEL, 1997.
Kim 2006
Kjaergard 2001
Kwon 2007
Lencioni 1997
  • Lencioni R, Pinto F, Bassi AM, Moretti M, Di Giulio M, Marchi S, et al. Long-term results of percutaneous ethanol injection therapy for hepatocellular carcinoma in cirrhosis: an European experience. European Radiology 1997;7:514-9.
Lencioni 2003
  • Lencioni RA, Allgaier HP, Cioni D, Olschewski M, Deibert P, Crocetti L, et al. Small hepatocellular carcinoma in cirrhosis: randomised comparison of radio-frequency thermal ablation versus percutaneous ethanol injection. Radiology 2003;228(1):235-40.
Lencioni 2005
  • Lencioni R, Cioni D. Early-stage hepatocellular carcinoma in patients with cirrhosis: long-term results of percutaneous image-guided radiofrequency ablation. Radiology 2005;234(3):961-7.
Li 2012
  • Li HY, Wei YG, Yan LN, Li B. Salvage liver transplantation in the treatment of hepatocellular carcinoma: a meta-analysis. World Journal of Gastroenterology 2012;18(19):2415-22.
Liu 2004
Livraghi 1995
  • Livraghi T, Giorgio A, Marin G, Salmi A, de Sio I, Bolodi L, et al. Hepatocellular carcinoma and cirrhosis in 746 patients: long-term results of percutaneous ethanol injection. Radiology 1995;197(1):101-8.
Llovet 2003
Llovet 2005
Lundh 2012
Marin 2003
Mazariegos 2007
McCormack 2005
Moher 1998
  • Moher D, Pham B, Jones A, Cook DJ, Jadad AR, Moher M, et al. Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses?. Lancet 1998;352:609-13.
Nagasue 1986
Nagorney 1989
Ohnishi 1996
Ohnishi 1998
Okuda 2002
  • Okuda K. Where we go with hepatocellular carcinoma: past, present, and future perspectives. Journal of Hepato-Biliary-Pancreatic Surgery 2002;9(6):683-5.
Onaca 2007
Paquet 1991
Paraskevopoulos 1994
Parmar 1998
Poon 2004
  • Poon RT, Fan ST. Hepatectomy for hepatocellular carcinoma: patient selection and postoperative outcome. Liver Transplantation 2004;10(2 Suppl 1):S39-S45.
Popescu 2005
  • Popescu I, Ionescu M, Ciurea S, Brasoveanu V, Sarbu-Boeti P, Hrehoret D, et al. Current treatment of hepatocellular carcinoma. Analysis of a series of 123 cases over a 5-year period. Chirurgia 2005;100(4):321-31.
RevMan 2012 [Computer program]
  • The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). Version 5.2. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2012.
Ribero 2006
Royle 2003
  • Royle P, Milne R. Literature searching for randomised controlled trials used in Cochrane reviews: rapid versus exhaustive searches. International Journal of Technology Assessment in Health Care 2003;19(4):591-603.
Savović 2012
  • Savović J, Jones HE, Altman DG, Harris RJ, Jüni P, Pildal J, et al. Influence of reported study design characteristics on intervention effect estimates from randomised, controlled trials. Health Technology Assessment 2012;16(35):1-82.
Savović 2012a
  • Savović J, Jones HE, Altman DG, Harris RJ, Jüni P, Pildal J, et al. Influence of reported study design characteristics on intervention effect estimates from randomised, controlled trials. Annals of Internal Medicine 2012;157(6):429-38.
Schoppmeyer 2007
  • Schoppmeyer K, Wagner AD, Mossner J, Fleig W. Percutanous ethanol injection or percutaneous acetic acid injection for early hepatocellular carcinoma. Cochrane Database of Systematic Reviews 2007, Issue 3. [DOI: 10.1002/14651858.CD006745]
Schulz 1995
Sherman 2005
Soejima 2007
  • Soejima Y, Taketomi A, Yoshizumi T, Uchiyama H, Aishima A, Terashi T. Extended indication for living donor liver transplantation in patients with hepatocellular carcinoma. Transplantation 2007;83:893-9.
Song 2004
Sotiropoulos 2006
  • Sotiropoulos GC, Lang H, Frilling A. Resectability of hepatocellular carcinoma: evaluation of 333 consecutive cases at a single hepatobiliary specialty center and systematic review of the literature. Hepato-Gastroenterology 2006;53(69):322-9.
Sugawara 2007
Takayama 1998
Takayama 2000
Taylor-Robinson 1997
Thorlund 2009
  • Thorlund K, Devereaux PJ, Wetterslev J, Guyatt G, Ioannidis JP, Thabane L, et al. Can trial sequential monitoring boundaries reduce spurious inferences from meta-analyses. International Journal of Epidemiology 2009;38(1):276-86.
Thorlund 2010
  • Thorlund K, Anema A, Mills E. Interpreting meta-analysis according to the adequacy of sample size. An example using isoniazid chemoprophylaxis for tuberculosis in purified protein derivative negative HIV-infected individuals. Clinical Epidemiology 2010;2:57-66.
Thorlund 2011
  • Thorlund K, Engstrøm J, Wetterslev J, Brok J, Imberger G, Gluud C. User manual for Trial Sequential Analysis (TSA). http://ctu.dk/tsa/files/tsa_manual.pdf 2011 (accessed 23 April 2013).
Verhoef 2004
  • Verhoef C, de Man RA, Zondervan PE, Eijkemans MJ, Tilanus HW, Ijzermans JN. Good outcomes after resection of large hepatocellular carcinoma in the non-cirrhotic liver. Digestive Surgery 2004;21(5-6):380-6.
Wallner 1994
Wetterslev 2008
  • Wetterslev J, Thorlund K, Brok J, Gluud C. Trial sequential analysis may establish when firm evidence is reached in cumulative meta-analysis. Journal of Clinical Epidemiology 2008;61(1):64-75.
Wetterslev 2009
  • Wetterslev J, Thorlund K, Brok J, Gluud C. Estimating required information size by quantifying diversity in a random-effects meta-analysis. BMC Medical Research Methodology 2009;9:86.
Wood 2008
  • Wood L, Egger M, Gluud LL, Schulz KF, Jüni P, Altman GD, et al. Empirical evidence of bias in treatment effect estimates in controlled trials with different interventions and outcomes: meta-epidemiological study. BMJ (Clinical Resarch Ed.) 2008;336:601-5.
Wu 2012
  • Wu L, Hu A, Tam N, Zhang J, Lin M, Guo Z, He X. Salvage liver transplantation for patients with recurrent hepatocellular carcinoma after curative resection. PLoS ONE 2012;7(7):e41820.
Yeh 2002