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Surgical resection versus liver transplant for patients with hepatocellular carcinoma

  1. Amir Taefi1,*,
  2. Amir Abrishami2,
  3. Siavosh Nasseri-Moghaddam3,
  4. Bijan Eghtesad4,
  5. Morris Sherman5

Editorial Group: Cochrane Hepato-Biliary Group

Published Online: 29 JUN 2013

Assessed as up-to-date: 18 FEB 2013

DOI: 10.1002/14651858.CD006935.pub2


How to Cite

Taefi A, Abrishami A, Nasseri-Moghaddam S, Eghtesad B, Sherman M. Surgical resection versus liver transplant for patients with hepatocellular carcinoma. Cochrane Database of Systematic Reviews 2013, Issue 6. Art. No.: CD006935. DOI: 10.1002/14651858.CD006935.pub2.

Author Information

  1. 1

    Medstar Washington Hospital Center, Department of Internal Medicine, Washington, DC, USA

  2. 2

    Toronto Western Hospital, University Health Network, University of Toronto, Department of Anesthesia, Toronto, Ontario, Canada

  3. 3

    Shariati Hospital, Tehran University of Medical Sciences, Digestive Diseases Research Centre, Tehran, Tehran, Iran

  4. 4

    Cleveland Clinic Main Campus, Transplant Surgery Desk A-100, Cleveland, USA

  5. 5

    Toronto General Hospital, Toronto, Canada

*Amir Taefi, Department of Internal Medicine, Medstar Washington Hospital Center, 110 Irving Street, Washington, DC, 20010, USA. amirtaefi@yahoo.com.

Publication History

  1. Publication Status: New
  2. Published Online: 29 JUN 2013

SEARCH

 
Characteristics of excluded studies [ordered by study ID]

StudyReason for exclusion

Bartlett 2007Patient series.

Bartlett 2008Narrative review.

Belghiti 2003Patient series.

Bismuth 1993Patient series.

Chen 2006Comparing PLAT and resection.

Choti 2002Narrative review.

Chung 1994Patient series.

Colleoni 1998Narrative review.

Decaens 2006Patient series.

Ercolani 2003Patient series.

Fan 1999Patient series.

Figueras 2001Patient series.

Fong 1999Patient series.

Huang 2011Patient series.

Hwang 2005Patient series.

Jonas 2001Patient series.

Jonas 2007Patient series.

Lise 1998Patient series.

Llovet 1999Patient series.

Mazzaferro 1996Patient series.

Nagasue 1993Patient series.

Nuzzo 2007Patient series.

Sim 2003Patient series.

Todo 2004Patient series.

Yao 2001Patient series.

 
Table 1. Liver resection

AuthorNumber of participantsCirrhosis

 
Mean tumour sizeRecurrence proportion

(%)
Mean time to recurrence (months)3-year survival

(%)
Mean age (Years)Mean follow-up time

Bartlett 20075343%N/A4713.849.455.734 m

Sim 20038153.2%N/AN/A9.6595621 m

Ercolani 2003224100%N/A41.5N/A62.862.535.6 m

Nuzzo 200797N/AN/A46N/AN/A65.5N/A

Chen 200690N/AN/AN/AN/A73.449.4N/A

Bismuth 199360100%N/AN/AN/A52N/AN/A

Fan 199921146%N/A5810.650N/A21 m

Lise 199810078%N/A5012.648N/AN/A

Fong 199915465%N/AN/AN/A5459.5N/A

Llovet 199977100%N/A57N/A626132 m

Belghiti 199147100%N/A60N/A35N/AN/A

Nagasue 199322977.3%N/AN/AN/AN/A60.8N/A

Huang 201177100%7.4 ± 4.3N/AN/A5646.7N/A

 N/A = not available
 
Table 2. Liver transplantation

AuthorType of transplantCriteriaNumber of participantsCirrhosisRecurrence proportion (%)Mean time to recurrence (Months)3-year survival (%)5-year survival (%)Mean age (Years)Mean follow-up time

Mazzaferro 1996Deceased donorMilan48100%8N/AN/A75.4N/A26 m

Jonas 2001Deceased donorMilan120100%16N/AN/A71N/A49 m

Figueras 2001Deceased donor5cm, localised307100%21N/A6763N/A24 m

Yao 2001Deceased donorUCSF70100%11.48.1N/A75.2N/A24 m

Decaens 2006Deceased donorMilan27996%922N/A60.15352.4 m

Deceased donorBeyond Milan, within UCSF4495%137.6N/A45.654.248.8

m

Deceased donorBeyond Milan & UCSF14586%4510N/A34.752.126.7

Todo 2004Living donorMilan137100%1.4N/A79.4N/AN/A16 m

Living donorExtended172100%22.2N/A60N/AN/A

Hwang 2005Living donorMilan173100%15.5N/A73.2N/A5026 m

Living donorBeyond Milan64100%N/AN/A

Deceased donorMilan53100%18N/A61.1N/A4916 m

Deceased donorBeyond Milan22100%N/AN/A

Jonas 2007Living donorMilan8100%N/AN/A75N/AN/A26 m

Beyond Milan13100%N/AN/A62N/AN/A

Kwon 2007Living donorMilan85N/A1410.382.679.95128 m

Beyond Milan139N/A20

Sugawara 2007Living donorMilan68N/A4.6N/A94755524 m

Beyond Milan32N/A30N/A70

Soejima 2007Living donorMilan16N/A0N/A100100N/A437 d

Living donorBeyond Milan44N/A18.2N/A7474N/A

Hwang 2007SalvageN/A17N/AN/AN/AN/AN/A49.330.7 m

Chung 1994Deceased DonorN/A2986%N/AN/A46N/A5333 m

 N/A = not available