Intervention Review

You have free access to this content

Neonatal vitamin A supplementation for the prevention of mortality and morbidity in term neonates in developing countries

  1. Batool A Haider1,
  2. Zulfiqar A Bhutta2,*

Editorial Group: Cochrane Neonatal Group

Published Online: 5 OCT 2011

Assessed as up-to-date: 30 NOV 2010

DOI: 10.1002/14651858.CD006980.pub2


How to Cite

Haider BA, Bhutta ZA. Neonatal vitamin A supplementation for the prevention of mortality and morbidity in term neonates in developing countries. Cochrane Database of Systematic Reviews 2011, Issue 10. Art. No.: CD006980. DOI: 10.1002/14651858.CD006980.pub2.

Author Information

  1. 1

    Harvard School of Public Health, Departments of Epidemiology and Nutrition, Boston, MA, USA

  2. 2

    Aga Khan University Hospital, Division of Women and Child Health, Karachi, Sindh, Pakistan

*Zulfiqar A Bhutta, Division of Women and Child Health, Aga Khan University Hospital, Stadium Road, PO Box 3500, Karachi, Sindh, 74800, Pakistan. zulfiqar.bhutta@aku.edu.

Publication History

  1. Publication Status: New
  2. Published Online: 5 OCT 2011

SEARCH

References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
Benn 2008 {published data only}
  • Benn CS, Diness BR, Roth A, Nante E, Fisker AB, Lisse IM, et al. Effect of 50,000 IU vitamin A given with BCG vaccine on mortality in infants in Guinea-Bissau: randomised placebo controlled trial. BMJ 2008;336(7658):1416-20.
  • Diness BR, Fisker AB, Roth A, Yazdanbakhsh M, Sartono E, Whittle H, et al. Effect of high-dose vitamin A supplementation on the immune response to Bacille Calmette-Guerin vaccine. The American Journal of Clinical Nutrition 2007;86(4):1152-9.
  • Fisker AB, Lisse IM, Aaby P, Erhardt JG, Rodrigues A, Bibby BM, et al. Effect of vitamin A supplementation with BCG vaccine at birth on vitamin A status at 6 wk and 4 mo of age. The American Journal of Clinical Nutrition 2007;86(4):1032-9.
  • Nante JE, Diness BR, Ravn H, Roth A, Aaby P, Benn CS. No adverse events after simultaneous administration of 50 000 IU vitamin A and Bacille Calmette-Guerin vaccination to normal-birth-weight newborns in Guinea-Bissau. European Journal of Clinical Nutrition July 2008;62(7):842-8.
Benn 2010 {published data only}
  • Benn CS, Fisker AB, Napirna BM, Roth A, Diness BR, Lausch KR, et al. Vitamin A supplementation and BCG vaccination at birth in low birthweight neonates: two by two factorial randomised controlled trial. BMJ 2010;340:c1101.
Humphrey 1996 {published data only}
  • Agoestina T, Humphrey JH, Taylor GA, Usman A, Subardja D, Hidayat S, et al. Safety of one 52-mumol (50,000 IU) oral dose of vitamin A administered to neonates. Bulletin of the World Health Organization 1994;72(6):859-68.
  • Humphrey JH, Agoestina T, Juliana A, Septiana S, Widjaja H, Cerreto MC, et al. Neonatal vitamin A supplementation: effect on development and growth at 3 y of age. The American Journal of Clinical Nutrition 1998;68(1):109-17.
  • Humphrey JH, Agoestina T, Wu L, Usman A, Nurachim M, Subardja D, et al. Impact of neonatal vitamin A supplementation on infant morbidity and mortality. The Journal of Pediatrics 1996;128(4):489-96.
Klemm 2008 {published data only}
  • Klemm RD, Labrique AB, Christian P, Rashid M, Shamim AA, Katz J, et al. Newborn vitamin A supplementation reduced infant mortality in rural Bangladesh. Pediatrics 2008;122(1):e242-50.
Malaba 2005 {published and unpublished data}
  • Humphrey JH, Iliff PJ, Marinda ET, Mutasa K, Moulton LH, Chidawanyika H, et al. Effects of a single large dose of vitamin A, given during the postpartum period to HIV-positive women and their infants, on child HIV infection, HIV-free survival, and mortality. The Journal of Infectious Diseases 2006;193(6):860-71.
  • Malaba LC, Iliff PJ, Nathoo KJ, Marinda E, Moulton LH, Zijenah LS, et al. Effect of postpartum maternal or neonatal vitamin A supplementation on infant mortality among infants born to HIV-negative mothers in Zimbabwe. The American Journal of Clinical Nutrition 2005;81(2):454-60.
  • Miller MF, Stoltzfus RJ, Iliff PJ, Malaba LC, Mbuya NV, Zimbabwe Vitamin A for Mothers and Babies Project (ZVITAMBO) Study Group, Humphrey JH. Effect of maternal and neonatal vitamin A supplementation and other postnatal factors on anemia in Zimbabwean infants: a prospective, randomized study. The American Journal of Clinical Nutrition 2006;84(1):212-22.
Rahmathullah 2003 {published data only}
  • Coles CL, Rahmathullah L, Kanungo R, Thulasiraj RD, Katz J, Santhosham M, et al. Vitamin A supplementation at birth delays pneumococcal colonization in South Indian infants. Journal of Nutrition 2001;131(2):255-61.
  • Rahmathullah L, Tielsch JM, Thulasiraj RD, Katz J, Coles C, Devi S, et al. Impact of supplementing newborn infants with vitamin A on early infant mortality: community based randomised trial in southern India. BMJ 2003;327(7409):254.
  • Tielsch JM, Rahmathullah L, Thulasiraj RD, Katz J, Coles C, Sheeladevi S, et al. Newborn vitamin A dosing reduces the case fatality but not incidence of common childhood morbidities in South India. Journal of Nutrition 2007;137(11):2470-4.
West 1995 {published data only}
  • Katz J, West KP, Khatry SK, Thapa MD, LeClerq SC, Pradhan EK, et al. Impact of vitamin A supplementation on prevalence and incidence of xerophthalmia in Nepal. Investigative Ophthalmology and Visual Science 1995;36(13):2577-83.
  • West KP Jr, Katz J, Shrestha SR, LeClerq SC, KhatrY SK, Pradhan EK, et al. Mortality of infants <6 mo of age supplemented with vitamin A: a randomized, double-masked trial in Nepal. The American Journal of Clinical Nutrition 1995;62(1):143-8.
  • West KP, Khatry SK, LeClerq SC, Adhikari R, See L, Katz J, et al. Tolerance of young infants to a single, large dose of vitamin A: a randomized community trial in Nepal. Bulletin of the World Health Organization 1992;70(6):733-9.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
Bezzera 2009 {published data only}
  • Bezerra DS, Araújo KF, Azevêdo GM, Dimenstein R. Maternal supplementation with retinyl palmitate during immediate postpartum period: potential consumption by infants. Revista de Saúde Pública 2009;43(4):572-9.
Bhaskaram 1998 {published data only}
  • Bhaskaram P, Balakrishna N. Effect of administration of 200,000 IU of vitamin A to women within 24 hrs after delivery on response to PPV administered to the newborn. Indian Pediatrics 1998;35(3):217-22.

References to ongoing studies

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
Ghana 2010 {published data only}
  • Efficacy of newborn vitamin A supplementation in improving child survival in rural Ghana: generation of evidence necessary for informing global policy (Neovita). Ongoing study Anticipated date of first participant enrolment: Aug 16, 2010.
India 2010 {published data only}
  • Efficacy of Neonatal Vitamin A Supplementation in Improving Child Survival in Haryana, India: Generation of Evidence Necessary for Informing Global Policy (NeoVitA Trial). Ongoing study June 2010.
Pakistan 2008 {published data only}
  • Feasibility study of delivering a neonatal dose of vitamin A through the Lady Health Workers (LHWs) program in Pakistan. Ongoing study January 2007.
Tanzania 2010 {published data only}
  • Efficacy of newborn vitamin A supplementation in improving child survival in Tanzania: generation of evidence necessary for informing global policy. Ongoing study Anticipated date of first participant enrolment: July 1, 2010.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
Abrams 2008
Beaton 1993
  • Beaton GH, Martorell R, Aronson KJ, Edmonston B, McCabe G, Ross AC, et al. Effectiveness of vitamin A supplementation in the control of young child morbidity and mortality in developing countries. ACC/SCN State-of-the-Art Series policy discussion paper no. 13. World Health Organization, Geneva, Switzerland 1993.
Bhutta 2008
Daulaire 1992
DRI 2001
  • Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. The National Academies 2001.
Gogia 2009
  • Gogia S, Sachdev HS. Neonatal vitamin A supplementation for prevention of mortality and morbidity in infancy: systematic review of randomised controlled trials. BMJ 2009;338:b919.
Haskell 1999
Hathcock 1997
Hopkins 1912
  • Hopkins FG. Feeding experiments illustrating the importance of accessory factors in normal dietaries. The Journal of Physiology 1912;44(5-6):425-60.
Huiming 2005
Imdad 2010
  • Imdad A, Herzer K, Mayo-Wilson E, Yakoob MY, Bhutta ZA. Vitamin A supplementation for preventing morbidity and mortality in children from 6 months to 5 years of age. Cochrane Database of Systematic Reviews 2010, Issue 12. Art. No.: CD008524.. [DOI: 10.1002/14651858.CD008524.pub2]
Kirkwood 2010
  • Kirkwood BR, Hurt L, Amenga-Etego S, Tawiah C, Zandoh C, Danso S, et al. Effect of vitamin A supplementation in women of reproductive age on maternal survival in Ghana (ObaapaVitA): a cluster-randomised, placebo-controlled trial. Lancet 2010;375(9726):1640-9.
McCollum 1915
  • McCollum EV, Davis M. The influence of certain vegetable fats on growth. Journal of Biochemistry 1915;21:179-82.
Rahman 1995
  • Rahman MM, Mahalanabis D, Wahed MA, Islam MA, Habte D. Administration of 25,000 IU vitamin A doses at routine immunisation in young infants. European Journal of Clinical Nutrition 1995;49(6):439-45.
Rice 2004
  • Rice AL, West KP Jr, Black RE. Vitamin A deficiency. Global and regional burden of disease attributable to selected major risk factors. Vol. 1, Geneva: World Health Organization, 2004.
Sachdev 2008
Shenai 1993
  • Shenai JP. Vitamin A. In: Tsang RC, Lucas A, Uauy R editor(s). Nutritional needs of the preterm infant: scientific basis and practical guidelines. Baltimore: Williams and Williams, 1993:87-100.
Smith 1976
Sommer 1995
  • Sommer A. Vitamin A deficiency and its consequences: a field guide to their detection and control. 3rd ed Geneva: World Health Organization 1995.
Sommer 1996
  • Sommer A, West KP Jr. Vitamin A deficiency: health, survival, and vision. New York: Oxford University Press, 1996.
Sommer 2002
  • Sommer A, Davidson FR. Assessment and control of vitamin A deficiency: the Annecy Accords. Journal of Nutrition 2002;132 Suppl(9):2845-50.
SOWC 1998
Sugana 1978
Tielsch 2007
  • Tielsch JM, Rahmathullah L, Thulasiraj RD, Katz J, Coles C, Sheeladevi S, et al. Newborn vitamin A dosing reduces the case fatality but not incidence of common childhood morbidities in South India. Journal of Nutrition 2007;137(11):2470-4.
Tielsch 2008a
Underwood 1994
  • Underwood BA. Maternal vitamin A status and its importance in infancy and early childhood. The American Journal of Clinical Nutrition 1994;59 Suppl(2):517-24.
Wallingford 1986
  • Wallingford JC, Underwood BA. Vitamin A deficiency in pregnancy, lactation, and the nursing child. Vitamin A deficiency and its control. Bauernfeind IC, ed.. New York: Academic Press, 1986:101-52.
West 1999
  • West KP Jr, Katz J, Khatry SK, LeClerq SC, Pradhan EK, Shrestha SR, et al. Double blind, cluster randomised trial of low dose supplementation with vitamin A or beta carotene on mortality related to pregnancy in Nepal. The NNIPS-2 Study Group. BMJ 1999;318(7183):570-5.
WHO 1998
  • Global Programme for Vaccines and Immunizations. Integration of vitamin A supplementation with immunization: policy and programme implications. Geneva: World Health Organization (WHO/EPI/GEN/98.07) 1998.
WHO 2000
  • World Health Organization. Nutrition for health and development. WHO/NHD/00 6: WHO, Geneva, Switzerland 2000.
WHO 2009
  • World Health Organization. Global Prevalence of Vitamin A Deficiency in Populations at Risk 1995-2005. WHO Global Database on Vitamin A Deficiency. Geneva, Switzerland 2009.
WHO/CHD 1998
  • WHO/CHD Immunization-Linked Vitamin A Supplementation Study Group. Randomized trial to assess benefits and safety of vitamin A supplementation linked to immunization in early infancy. Lancet 1998;352(9136):1257-63.
WHO/NUT 1998
  • Safe vitamin A dosage during pregnancy and lactation. Geneva, World Health Organization, 1998 (WHO/NUT/98.4).
WHO/NUT/98.1 1998
  • Complementary feeding of young children in developing countries: a review of current scientific knowledge. Geneva, World Health Organization, 1998 (WHO/NUT/98.1).
Wolbach 1925
  • Wolbach SB, Howe PR. Tissue changes following deprivation of fat-soluble vitamin A. Journal of Experimental Medicine 1925;42(6):753-77.