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Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes

  1. Pranom Buppasiri1,*,
  2. Pisake Lumbiganon1,
  3. Jadsada Thinkhamrop1,
  4. Chetta Ngamjarus2,
  5. Malinee Laopaiboon3

Editorial Group: Cochrane Pregnancy and Childbirth Group

Published Online: 5 OCT 2011

Assessed as up-to-date: 22 JUN 2011

DOI: 10.1002/14651858.CD007079.pub2


How to Cite

Buppasiri P, Lumbiganon P, Thinkhamrop J, Ngamjarus C, Laopaiboon M. Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes. Cochrane Database of Systematic Reviews 2011, Issue 10. Art. No.: CD007079. DOI: 10.1002/14651858.CD007079.pub2.

Author Information

  1. 1

    Khon Kaen University, Department of Obstetrics and Gynaecology, Faculty of Medicine, Khon Kaen, Khon Kaen, Thailand

  2. 2

    Faculty of Public Health, Khon Kaen University, Department of Biostatistics and Demography, Khon Kaen, Thailand

  3. 3

    Khon Kaen University, Department of Biostatistics and Demography, Faculty of Public Health, Khon Kaen, Thailand

*Pranom Buppasiri, Department of Obstetrics and Gynaecology, Faculty of Medicine, Khon Kaen University, Faculty of Medicine, Khon Kaen, Khon Kaen, 40002, Thailand. bprano@kku.ac.th.

Publication History

  1. Publication Status: New
  2. Published Online: 5 OCT 2011

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[Figure 1]
Figure 1. Methodological quality graph: review authors' judgements about each methodological quality item presented as percentages across all included studies.
[Figure 2]
Figure 2. Methodological quality summary: review authors' judgements about each methodological quality item for each included study.
[Figure 3]
Figure 3. Funnel plot of comparison: 1 Calcium supplementation versus placebo or no treatment (maternal outcomes), outcome: 1.1 Preterm birth (a) Birth prior to 37 weeks.
[Figure 4]
Figure 4. Egger's plot for preterm birth (a) Birth prior to 37 weeks.
[Analysis 1.1]
Analysis 1.1. Comparison 1 Calcium supplementation versus placebo or no treatment (maternal outcomes), Outcome 1 Preterm birth (a) Birth prior to 37 weeks.
[Analysis 1.2]
Analysis 1.2. Comparison 1 Calcium supplementation versus placebo or no treatment (maternal outcomes), Outcome 2 Preterm birth (a) Birth prior to 37 weeks by dose of calcium.
[Analysis 1.3]
Analysis 1.3. Comparison 1 Calcium supplementation versus placebo or no treatment (maternal outcomes), Outcome 3 Preterm birth (a) Birth prior to 37 weeks by started to take calcium.
[Analysis 1.4]
Analysis 1.4. Comparison 1 Calcium supplementation versus placebo or no treatment (maternal outcomes), Outcome 4 Preterm birth (a) Birth prior to 37 weeks by type of calcium.
[Analysis 1.5]
Analysis 1.5. Comparison 1 Calcium supplementation versus placebo or no treatment (maternal outcomes), Outcome 5 Preterm birth (b) Birth prior to 34 weeks.
[Analysis 1.6]
Analysis 1.6. Comparison 1 Calcium supplementation versus placebo or no treatment (maternal outcomes), Outcome 6 Preterm birth (b) Birth prior to 34 weeks - Sensitivity analysis by concealment allocation.
[Analysis 1.7]
Analysis 1.7. Comparison 1 Calcium supplementation versus placebo or no treatment (maternal outcomes), Outcome 7 Maternal weight gain (g/w).
[Analysis 1.8]
Analysis 1.8. Comparison 1 Calcium supplementation versus placebo or no treatment (maternal outcomes), Outcome 8 Maternal bone mineral density (g/cm2) - First phalanx (calcium 300 mg).
[Analysis 1.9]
Analysis 1.9. Comparison 1 Calcium supplementation versus placebo or no treatment (maternal outcomes), Outcome 9 Maternal bone mineral density (g/cm2) - Second metacarpal (calcium 300 mg).
[Analysis 1.10]
Analysis 1.10. Comparison 1 Calcium supplementation versus placebo or no treatment (maternal outcomes), Outcome 10 Maternal bone mineral density (g/cm2) - Fourth metacarpal (calcium 300 mg).
[Analysis 1.11]
Analysis 1.11. Comparison 1 Calcium supplementation versus placebo or no treatment (maternal outcomes), Outcome 11 Maternal bone mineral density (g/cm2) - First phalanx (calcium 600 mg).
[Analysis 1.12]
Analysis 1.12. Comparison 1 Calcium supplementation versus placebo or no treatment (maternal outcomes), Outcome 12 Maternal bone mineral density (g/cm2) - Second metacarpal (calcium 600 mg).
[Analysis 1.13]
Analysis 1.13. Comparison 1 Calcium supplementation versus placebo or no treatment (maternal outcomes), Outcome 13 Maternal bone mineral density (g/cm2) - Fourth metacarpal (calcium 600 mg).
[Analysis 1.14]
Analysis 1.14. Comparison 1 Calcium supplementation versus placebo or no treatment (maternal outcomes), Outcome 14 Maternal death.
[Analysis 1.15]
Analysis 1.15. Comparison 1 Calcium supplementation versus placebo or no treatment (maternal outcomes), Outcome 15 Maternal admission to intensive care unit.
[Analysis 1.16]
Analysis 1.16. Comparison 1 Calcium supplementation versus placebo or no treatment (maternal outcomes), Outcome 16 Vaginal birth.
[Analysis 1.17]
Analysis 1.17. Comparison 1 Calcium supplementation versus placebo or no treatment (maternal outcomes), Outcome 17 Instrumental vaginal birth.
[Analysis 1.18]
Analysis 1.18. Comparison 1 Calcium supplementation versus placebo or no treatment (maternal outcomes), Outcome 18 Cesarean section.
[Analysis 2.1]
Analysis 2.1. Comparison 2 Calcium supplementation versus placebo or no treatment (infant outcomes), Outcome 1 Low birth weight (< 2500 g).
[Analysis 2.2]
Analysis 2.2. Comparison 2 Calcium supplementation versus placebo or no treatment (infant outcomes), Outcome 2 Low birth weight (< 2500 g) by started to take calcium.
[Analysis 2.3]
Analysis 2.3. Comparison 2 Calcium supplementation versus placebo or no treatment (infant outcomes), Outcome 3 Low birth weight (< 2500 g) by type of calcium.
[Analysis 2.4]
Analysis 2.4. Comparison 2 Calcium supplementation versus placebo or no treatment (infant outcomes), Outcome 4 Birth weight (g).
[Analysis 2.5]
Analysis 2.5. Comparison 2 Calcium supplementation versus placebo or no treatment (infant outcomes), Outcome 5 Perinatal mortality.
[Analysis 2.6]
Analysis 2.6. Comparison 2 Calcium supplementation versus placebo or no treatment (infant outcomes), Outcome 6 Stillbirth or fetal death.
[Analysis 2.7]
Analysis 2.7. Comparison 2 Calcium supplementation versus placebo or no treatment (infant outcomes), Outcome 7 Admission to neonatal intensive care unit.
[Analysis 2.8]
Analysis 2.8. Comparison 2 Calcium supplementation versus placebo or no treatment (infant outcomes), Outcome 8 Birth length (cm).
[Analysis 2.9]
Analysis 2.9. Comparison 2 Calcium supplementation versus placebo or no treatment (infant outcomes), Outcome 9 Head circumference (cm).
[Analysis 2.10]
Analysis 2.10. Comparison 2 Calcium supplementation versus placebo or no treatment (infant outcomes), Outcome 10 Intrauterine growth restriction.
[Analysis 2.11]
Analysis 2.11. Comparison 2 Calcium supplementation versus placebo or no treatment (infant outcomes), Outcome 11 Neonatal bone mineral density (g/cm2).
[Analysis 3.1]
Analysis 3.1. Comparison 3 Calcium supplementation versus placebo or no treatment (adverse outcomes), Outcome 1 Side effects of calcium supplementation - Maternal cholestatic jaundice.
[Analysis 3.2]
Analysis 3.2. Comparison 3 Calcium supplementation versus placebo or no treatment (adverse outcomes), Outcome 2 Urinary stones.
[Analysis 3.3]
Analysis 3.3. Comparison 3 Calcium supplementation versus placebo or no treatment (adverse outcomes), Outcome 3 Urinary tract infection.
[Analysis 3.4]
Analysis 3.4. Comparison 3 Calcium supplementation versus placebo or no treatment (adverse outcomes), Outcome 4 Renal colic.
[Analysis 3.5]
Analysis 3.5. Comparison 3 Calcium supplementation versus placebo or no treatment (adverse outcomes), Outcome 5 Impaired renal function.
[Analysis 3.6]
Analysis 3.6. Comparison 3 Calcium supplementation versus placebo or no treatment (adverse outcomes), Outcome 6 Maternal anemia.