This is the protocol for a review and there is no abstract. The objectives are as follows:
The primary objective of this review is to determine the effects of high protein content (=> 1 g per 100 ml of human milk) vs. standard protein content (< 1 g per 100 ml of human milk) of human milk fortifier on growth and neurological development in preterm infants.
A series of subgroup analyses will be undertaken to assess the effect of protein dose on primary outcomes as follows:
1. in more vulnerable, less mature infants (defined as < 1250 g or < 28 weeks gestation)
2. by compliance (when intake of fortified human milk is > 80% of intake).
3. by use of hydrolysed protein.