Intervention Protocol

High versus standard protein content of human milk fortifier for promoting growth and neurological development in preterm infants

  1. Jacqueline Miller2,
  2. Maria Makrides3,
  3. Carmel T Collins1,*

Editorial Group: Cochrane Neonatal Group

Published Online: 23 APR 2008

Assessed as up-to-date: 31 JAN 2008

DOI: 10.1002/14651858.CD007090


How to Cite

Miller J, Makrides M, Collins CT. High versus standard protein content of human milk fortifier for promoting growth and neurological development in preterm infants (Protocol). Cochrane Database of Systematic Reviews 2008, Issue 2. Art. No.: CD007090. DOI: 10.1002/14651858.CD007090.

Author Information

  1. 1

    Women's and Children' Health Research Institute, Flinders Medical Centre and Women's and Children's Hospital; Discipline of Paediatrics, The University of Adelaide; School of Nursing and Midwifery, The University of South Australia., Child Nutrition Research Centre, Bedford Park, South Australia, Australia

  2. 2

    Discipline of Paediatrics, Women's & Children's Health Research Institute, Flinders Med Ctr and Women's and Children's Hospital, South Australia, South Australia, Australia

  3. 3

    Women's and Children's Health Research Institute, Child Health Research Institute, North Adelaide, SA, Australia

*Carmel T Collins, Child Nutrition Research Centre, Women's and Children' Health Research Institute, Flinders Medical Centre and Women's and Children's Hospital; Discipline of Paediatrics, The University of Adelaide; School of Nursing and Midwifery, The University of South Australia., Flinders Medical Centre, Bedford Park, South Australia, 5042, Australia. carmel.collins@fmc.sa.gov.au.

Publication History

  1. Publication Status: New
  2. Published Online: 23 APR 2008

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Abstract

  1. Top of page
  2. Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

The primary objective of this review is to determine the effects of high protein content (=> 1 g per 100 ml of human milk) vs. standard protein content (< 1 g per 100 ml of human milk) of human milk fortifier on growth and neurological development in preterm infants.

A series of subgroup analyses will be undertaken to assess the effect of protein dose on primary outcomes as follows:
1. in more vulnerable, less mature infants (defined as < 1250 g or < 28 weeks gestation)
2. by compliance (when intake of fortified human milk is > 80% of intake).
3. by use of hydrolysed protein.