High versus standard protein content of human milk fortifier for promoting growth and neurological development in preterm infants

  • Protocol
  • Intervention

Authors

  • Jacqueline Miller,

    1. Discipline of Paediatrics, Women's & Children's Health Research Institute, Flinders Med Ctr and Women's and Children's Hospital, South Australia, South Australia, Australia
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  • Maria Makrides,

    1. Women's and Children's Health Research Institute, Child Health Research Institute, North Adelaide, SA, Australia
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  • Carmel T Collins

    Corresponding author
    1. Women's and Children' Health Research Institute, Flinders Medical Centre and Women's and Children's Hospital; Discipline of Paediatrics, The University of Adelaide; School of Nursing and Midwifery, The University of South Australia., Child Nutrition Research Centre, Bedford Park, South Australia, Australia
    • Carmel T Collins, Child Nutrition Research Centre, Women's and Children' Health Research Institute, Flinders Medical Centre and Women's and Children's Hospital; Discipline of Paediatrics, The University of Adelaide; School of Nursing and Midwifery, The University of South Australia., Flinders Medical Centre, Bedford Park, South Australia, 5042, Australia. carmel.collins@fmc.sa.gov.au.

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Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

The primary objective of this review is to determine the effects of high protein content (=> 1 g per 100 ml of human milk) vs. standard protein content (< 1 g per 100 ml of human milk) of human milk fortifier on growth and neurological development in preterm infants.

A series of subgroup analyses will be undertaken to assess the effect of protein dose on primary outcomes as follows:
1. in more vulnerable, less mature infants (defined as < 1250 g or < 28 weeks gestation)
2. by compliance (when intake of fortified human milk is > 80% of intake).
3. by use of hydrolysed protein.

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