Intervention Review

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Interventions for the restorative care of amelogenesis imperfecta in children and adolescents

  1. Mayssoon Dashash1,*,
  2. C Albert Yeung2,
  3. Issam Jamous3,
  4. Anthony Blinkhorn4

Editorial Group: Cochrane Oral Health Group

Published Online: 6 JUN 2013

Assessed as up-to-date: 30 APR 2013

DOI: 10.1002/14651858.CD007157.pub2

How to Cite

Dashash M, Yeung CA, Jamous I, Blinkhorn A. Interventions for the restorative care of amelogenesis imperfecta in children and adolescents. Cochrane Database of Systematic Reviews 2013, Issue 6. Art. No.: CD007157. DOI: 10.1002/14651858.CD007157.pub2.

Author Information

  1. 1

    Faculty of Dentistry, University of Damascus, Department of Paediatric Dentistry, Damascus, Syrian Arab Republic

  2. 2

    NHS Lanarkshire, Department of Public Health, Bothwell, UK

  3. 3

    Dental School, University of Damascus, Department of Fixed Prosthodontics, Mazzeh Jabal, Damascus, Syrian Arab Republic

  4. 4

    Faculty of Dentistry, The University of Sydney, Population Oral Health, Westmead, Australia

*Mayssoon Dashash, Department of Paediatric Dentistry, Faculty of Dentistry, University of Damascus, Mezza Autustrad, Behind Razzi Hospital, Doctors' Building, Damascus, Syrian Arab Republic.

Publication History

  1. Publication Status: New
  2. Published Online: 6 JUN 2013



References to studies excluded from this review

  1. References to studies excluded from this review
  2. References to ongoing studies
  3. Additional references
Baratieri 2003 {published data only}
  • Baratieri LN, Canabarro S, Lopes GC, Ritter AV. Effect of resin viscosity and enamel beveling on the clinical performance of Class V composite restorations: three-year results. Operative Dentistry 2003;28(5):482-7.
Cheng 2004 {published data only}
  • Cheng PH, He GR. Observation of the clinical effects of two kinds of resin materials for restoring the defects of maxillary incisor. Shanghai Journal of Stomatology 2004;13(4):353-4.
Coll 1991 {published data only}
  • Coll JA, Jackson P, Strassler HE. Comparison of enamel microabrasion techniques: Prema Compound versus a 12-fluted finishing bur. Journal of Esthetic Dentistry 1991;3(5):180-6.
Deliperi 2006 {published data only}
  • Deliperi S, Bardwell DN. Clinical evaluation of direct cuspal coverage with posterior composite resin restorations. Journal of Esthetic and Restorative Dentistry 2006;18(5):256-65; discussion 266-7.
Folwaczny 2001 {published and unpublished data}
  • Folwaczny M, Loher C, Mehl A, Kunzelmann KH, Hickel R. Class V lesions restored with four different tooth-colored materials – 3-year results. Clinical Oral Investigations 2001;5(1):31-9.
Fron 2011 {published data only}
  • Fron H, Vergnes JN, Moussally C, Cazier S, Simon AL, Chieze JB, et al. Effectiveness of a new one-step self-etch adhesive in the restoration of non-carious cervical lesions: 2-year results of a randomized controlled practice-based study. Dental Materials 2011;27(3):304-12.
Gladys 1998 {published data only}
  • Gladys S, Van Meerbeek B, Lambrechts P, Vanherle G. Marginal adaptation and retention of a glass-ionomer, resin-modified glass-ionomers and a polyacid-modified resin composite in cervical Class-V lesions. Dental Materials 1998;14(4):294-306.
Kim 2011 {published and unpublished data}
Kramer 2005 {published data only}
Lygidakis 2009 {published data only}
  • Lygidakis NA, Dimou G, Stamataki E. Retention of fissure sealants using two different methods of application in teeth with hypomineralised molars (MIH): a 4 year clinical study. European Archives of Paediatric Dentistry 2009;10(4):223-6.
Markovic 2010 {published data only}
  • Markovic D, Petrovic B, Peric T. Case series: clinical findings and oral rehabilitation of patients with amelogenesis imperfecta. European Archives of Paediatric Dentistry 2010;11(4):201-8.
Marta 2000 {published data only}
  • Marta SN, Oliveira FS, Silva SMB, Lanza CRM, Machado MAAM. Microbrasion clinical comparison: PREMA compound X phosphoric acid. Journal of Dental Research 2000;79(5):1040 (Abs No 284).
Peumans 2005 {published and unpublished data}
Peumans 2010 {published and unpublished data}
  • Peumans M, De Munck J, Van Landuyt KL, Poitevin A, Lambrechts P, Van Meerbeek B. Eight-year clinical evaluation of a 2-step self-etch adhesive with and without selective enamel etching. Dental Materials 2010;26(12):1176-84.
Sönmez 2009 {published data only}
  • Sِönmez IS, Aras S, Tunç ES, Küçükeşmen C. Clinical success of deproteinization in hypocalcified amelogenesis imperfecta. Quintessence International 2009;40(2):113-8.
Van Landuyt 2008 {published data only}
  • Van Landuyt KL, Peumans M, Fieuws S, De Munck J, Cardoso MV, Ermis RB, et al. A randomized controlled clinical trial of a HEMA-free all-in-one adhesive in non-carious cervical lesions at 1 year. Journal of Dentistry 2008;36(10):847-55.
Van Meerbeek 2005 {published data only}
  • Van Meerbeek B, Kanumilli P, De Munck J, Van Landuyt K, Lambrechts P, Peumans M. A randomized controlled study evaluating the effectiveness of a two-step self-etch adhesive with and without selective phosphoric-acid etching of enamel. Dental Materials 2005;21(4):375-83.
Walls 1988 {published data only}
Zagdwon 2003 {published data only}
  • Zagdwon AM, Fayle SA, Pollard MA. A prospective clinical trial comparing preformed metal crowns and cast restorations for defective first permanent molars. European Journal of Paediatric Dentistry 2003;4(3):138-42.

References to ongoing studies

  1. References to studies excluded from this review
  2. References to ongoing studies
  3. Additional references
ISRCTN70438627 {published and unpublished data}
  • ISRCTN70438627. Early restorative crown therapy in children and adolescents with Amelogenesis Imperfecta: a prospective double-blind randomised controlled trial. (accessed 30 April 2013). [DOI: 10.1186/ISRCTN70438627]
  • Pousette Lundgren G, Trulsson M, Dahllöf G. One year results of a RCT of prosthetic therapy in patients with amelogenesis imperfecta. In: Abstract Book of the 11th Congress of the European Academy of Paediatric Dentistry; 24–27 May 2012; Strasbourg; page 26 (Abs No O55). Available from
  • Pousette Lundgren G, Trulsson M, Dahllöf G. RCT of prosthetic therapy in young patients with amelogenesis imperfecta - one year results. Swedish Dental Journal 2012;36(4):219 (Abs No 21).

Additional references

  1. References to studies excluded from this review
  2. References to ongoing studies
  3. Additional references
Aldred 2008
  • Aldred M, Crawford PJM, Cameron A, King NM, Widmer R. Dental anomalies. In: Cameron AC, Widmer RP editor(s). Handbook of Pediatric Dentistry. 3rd Edition. Edinburgh: Mosby Elsevier, 2008:217-77.
Ashkenazi 2000
  • Ashkenazi M, Sarnat H. Microabrasion of teeth with discoloration resembling hypomaturation enamel defects: four-year follow up. Journal of Clinical Pediatric Dentistry 2000;25(1):29-34.
Ayers 2004
  • Ayers KM, Drummond BK, Harding WJ, Salis SG, Liston PN. Amelogenesis imperfecta – multidisciplinary management from eruption to adulthood. Review and case report. The New Zealand Dental Journal 2004;100(4):101-4.
Bäckman 1988
Coffield 2005
  • Coffield KD, Phillips C, Brady M, Roberts MW, Strauss RP, Wright JT. The psychosocial impact of developmental dental defects in people with hereditary amelogenesis imperfecta. Journal of the American Dental Association 2005;136(5):620-30.
Fonseca 2006
  • Fonseca RB, Correr Sobrinho L, Fernandes Neto AJ, da Mota AS, Soares CJ. Enamel hypoplasia or amelogenesis imperfecta – a restorative approach. Brazilian Journal of Oral Sciences 2006;5(16):941-3.
Hart 2003
Higgins 2011
  • Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011. Available from
Hoppenreijs 1998
  • Hoppenreijs TJ, Voorsmit RA, Freihofer HP. Open bite deformity in amelogenesis imperfecta. Part 1: An analysis of contributory factors and implications for treatment. Journal of Cranio-Maxillo-Facial Surgery 1998;26(4):260-6.
Kida 2002
  • Kida M, Ariga T, Shirakawa T, Oguchi H, Sakiyama Y. Autosomal-dominant hypoplastic form of amelogenesis imperfecta caused by an enamelin gene mutation at the exon-intron boundary. Journal of Dental Research 2002;81(11):738-42.
Kim 2006
  • Kim JW, Simmer JP, Lin BP, Seymen F, Bartlett JD, Hu JC. Mutational analysis of candidate genes in 24 amelogenesis imperfecta families. European Journal of Oral Sciences 2006;114 Suppl 1:3-12; discussion 39-41, 379.
Lygidakis 2010
  • Lygidakis NA. Treatment modalities in children with teeth affected by molar-incisor enamel hypomineralisation (MIH): A systematic review. European Archives of Paediatric Dentistry 2010;11(2):65-74.
Mackie 1991
  • Mackie IC, Blinkhorn AS. Amelogenesis imperfecta: early interception to prevent attrition. Dental Update 1991;18(2):79-80.
Sari 2003
Simmer 2001
  • Simmer JP, Hu JC. Dental enamel formation and its impact on clinical dentistry. Journal of Dental Education 2001;65(9):896-905.
Venezie 1994
  • Venezie RD, Vadiakas G, Christensen JR, Wright JT. Enamel pretreatment with sodium hypochlorite to enhance bonding in hypocalcified amelogenesis imperfecta: case report and SEM analysis. Pediatric Dentistry 1994;16(6):433-6.
Vitkov 2006
  • Vitkov L, Hannig M, Krautgartner WD. Restorative therapy of primary teeth severely affected by amelogenesis imperfecta. Quintessence International 2006;37(3):219-24.
William 2006
  • William V,  Messer LB,  Burrow MF. Molar incisor hypomineralization: review and recommendations for clinical management. Pediatric Dentistry 2006;28(3):224-32.
Witkop 1988
Yamaguti 2006
  • Yamaguti PM, Acevedo AC, de Paula LM. Rehabilitation of an adolescent with autosomal dominant amelogenesis imperfecta: case report. Operative Dentistry 2006;31(2):266-72.