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Blood pressure lowering efficacy of calcium-channel blockers as second-line therapy for primary hypertension

  • Protocol
  • Intervention

Authors

  • Jenny MH Chen,

    Corresponding author
    1. University of British Columbia, Department of Anesthesiology, Pharmacology and Therapeutics, Vancouver, BC, Canada
    • Jenny MH Chen, Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, 2176 Health Sciences Mall, Vancouver, BC, V6T 1Z3, Canada. koko_jesse@hotmail.com.

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  • Balraj S Heran,

    1. University of British Columbia, Department of Anesthesiology, Pharmacology and Therapeutics, Vancouver, BC, Canada
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  • Marco I Perez,

    1. University of British Columbia, Department of Anesthesiology, Pharmacology and Therapeutics, Vancouver, BC, Canada
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  • James M Wright

    1. University of British Columbia, Department of Anesthesiology, Pharmacology and Therapeutics, Vancouver, BC, Canada
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Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

Primary objective: To quantify the additional reduction in systolic blood pressure (SBP) and diastolic blood pressure (DBP) of calcium-channel blocker (CCB) therapy as a second-line drug in hypertensive patients.

Secondary objectives:
1. To determine the effects of second-line CCB on variability of blood pressure.
2. To determine the effects of second-line CCB on pulse pressure.
3. To quantify the effect of second-line CCB on heart rate.
4. To quantify the effect of second-line CCB on withdrawals due to adverse effects.