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Intervention Review

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Medical treatments for incomplete miscarriage

  1. James P Neilson1,*,
  2. Gillian ML Gyte2,
  3. Martha Hickey3,
  4. Juan C Vazquez4,
  5. Lixia Dou2

Editorial Group: Cochrane Pregnancy and Childbirth Group

Published Online: 28 MAR 2013

Assessed as up-to-date: 7 JAN 2013

DOI: 10.1002/14651858.CD007223.pub3


How to Cite

Neilson JP, Gyte GML, Hickey M, Vazquez JC, Dou L. Medical treatments for incomplete miscarriage. Cochrane Database of Systematic Reviews 2013, Issue 3. Art. No.: CD007223. DOI: 10.1002/14651858.CD007223.pub3.

Author Information

  1. 1

    The University of Liverpool, Department of Women's and Children's Health, Liverpool, UK

  2. 2

    The University of Liverpool, Cochrane Pregnancy and Childbirth Group, Department of Women's and Children's Health, Liverpool, UK

  3. 3

    The Royal Women's Hospital, The University of Melbourne, Melbourne, Victoria, Australia

  4. 4

    Instituto Nacional de Endocrinologia (INEN), Departamento de Salud Reproductiva, Habana, Cuba

*James P Neilson, Department of Women's and Children's Health, The University of Liverpool, First Floor, Liverpool Women's NHS Foundation Trust, Crown Street, Liverpool, L8 7SS, UK. jneilson@liverpool.ac.uk.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 28 MAR 2013

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This is not the most recent version of the article. View current version (31 JAN 2017)

[Figure 1]
Figure 1. Methodological quality summary: review authors' judgements about each methodological quality item for each included study.
[Figure 2]
Figure 2. Funnel plot of comparison: 2 Misoprostol versus surgery, outcome: 2.1 Complete miscarriage.
[Figure 3]
Figure 3. Funnel plot of comparison: 2 Misoprostol versus surgery, outcome: 2.2 Surgical evacuation.
[Analysis 1.1]
Analysis 1.1. Comparison 1 Misoprostol versus expectant care, Outcome 1 Complete miscarriage.
[Analysis 1.2]
Analysis 1.2. Comparison 1 Misoprostol versus expectant care, Outcome 2 Surgical evacuation.
[Analysis 1.3]
Analysis 1.3. Comparison 1 Misoprostol versus expectant care, Outcome 3 Death or serious complication.
[Analysis 1.4]
Analysis 1.4. Comparison 1 Misoprostol versus expectant care, Outcome 4 Unplanned surgical intervention.
[Analysis 1.5]
Analysis 1.5. Comparison 1 Misoprostol versus expectant care, Outcome 5 Blood transfusion.
[Analysis 1.10]
Analysis 1.10. Comparison 1 Misoprostol versus expectant care, Outcome 10 Pain relief.
[Analysis 1.11]
Analysis 1.11. Comparison 1 Misoprostol versus expectant care, Outcome 11 Pelvic infection < 14 days.
[Analysis 1.21]
Analysis 1.21. Comparison 1 Misoprostol versus expectant care, Outcome 21 Serious morbidity.
[Analysis 2.1]
Analysis 2.1. Comparison 2 Misoprostol versus surgery, Outcome 1 Complete miscarriage.
[Analysis 2.2]
Analysis 2.2. Comparison 2 Misoprostol versus surgery, Outcome 2 Surgical evacuation.
[Analysis 2.3]
Analysis 2.3. Comparison 2 Misoprostol versus surgery, Outcome 3 Death or serious complication.
[Analysis 2.4]
Analysis 2.4. Comparison 2 Misoprostol versus surgery, Outcome 4 Unplanned surgical intervention.
[Analysis 2.5]
Analysis 2.5. Comparison 2 Misoprostol versus surgery, Outcome 5 Blood transfusion.
[Analysis 2.8]
Analysis 2.8. Comparison 2 Misoprostol versus surgery, Outcome 8 Anaemia.
[Analysis 2.9]
Analysis 2.9. Comparison 2 Misoprostol versus surgery, Outcome 9 Days of bleeding.
[Analysis 2.10]
Analysis 2.10. Comparison 2 Misoprostol versus surgery, Outcome 10 Pain relief.
[Analysis 2.11]
Analysis 2.11. Comparison 2 Misoprostol versus surgery, Outcome 11 Pelvic infection < 14 days.
[Analysis 2.12]
Analysis 2.12. Comparison 2 Misoprostol versus surgery, Outcome 12 Cervical damage.
[Analysis 2.18]
Analysis 2.18. Comparison 2 Misoprostol versus surgery, Outcome 18 Women's views/satisfaction.
[Analysis 2.19]
Analysis 2.19. Comparison 2 Misoprostol versus surgery, Outcome 19 Women's views/satisfaction - continuous data.
[Analysis 2.20]
Analysis 2.20. Comparison 2 Misoprostol versus surgery, Outcome 20 Death.
[Analysis 2.21]
Analysis 2.21. Comparison 2 Misoprostol versus surgery, Outcome 21 Serious morbidity.
[Analysis 2.24]
Analysis 2.24. Comparison 2 Misoprostol versus surgery, Outcome 24 Nausea.
[Analysis 2.25]
Analysis 2.25. Comparison 2 Misoprostol versus surgery, Outcome 25 Vomiting.
[Analysis 2.26]
Analysis 2.26. Comparison 2 Misoprostol versus surgery, Outcome 26 Diarrhoea.
[Analysis 3.1]
Analysis 3.1. Comparison 3 Vaginal misoprostol versus expectant care, Outcome 1 Complete miscarriage.
[Analysis 3.2]
Analysis 3.2. Comparison 3 Vaginal misoprostol versus expectant care, Outcome 2 Surgical evacuation.
[Analysis 3.3]
Analysis 3.3. Comparison 3 Vaginal misoprostol versus expectant care, Outcome 3 Death or serious complication.
[Analysis 3.4]
Analysis 3.4. Comparison 3 Vaginal misoprostol versus expectant care, Outcome 4 Unplanned surgical intervention.
[Analysis 3.5]
Analysis 3.5. Comparison 3 Vaginal misoprostol versus expectant care, Outcome 5 Blood transfusion.
[Analysis 3.10]
Analysis 3.10. Comparison 3 Vaginal misoprostol versus expectant care, Outcome 10 Pain relief.
[Analysis 3.11]
Analysis 3.11. Comparison 3 Vaginal misoprostol versus expectant care, Outcome 11 Pelvic infection < 14 days.
[Analysis 7.1]
Analysis 7.1. Comparison 7 Vaginal misoprostol versus surgery, Outcome 1 Complete miscarriage.
[Analysis 7.2]
Analysis 7.2. Comparison 7 Vaginal misoprostol versus surgery, Outcome 2 Surgical evacuation.
[Analysis 7.3]
Analysis 7.3. Comparison 7 Vaginal misoprostol versus surgery, Outcome 3 Death or serious complication.
[Analysis 7.4]
Analysis 7.4. Comparison 7 Vaginal misoprostol versus surgery, Outcome 4 Unplanned surgical intervention.
[Analysis 7.5]
Analysis 7.5. Comparison 7 Vaginal misoprostol versus surgery, Outcome 5 Blood transfusion.
[Analysis 7.8]
Analysis 7.8. Comparison 7 Vaginal misoprostol versus surgery, Outcome 8 Anaemia.
[Analysis 7.9]
Analysis 7.9. Comparison 7 Vaginal misoprostol versus surgery, Outcome 9 Days of bleeding.
[Analysis 7.10]
Analysis 7.10. Comparison 7 Vaginal misoprostol versus surgery, Outcome 10 Pain relief.
[Analysis 7.11]
Analysis 7.11. Comparison 7 Vaginal misoprostol versus surgery, Outcome 11 Pelvic infection < 14 days.
[Analysis 7.19]
Analysis 7.19. Comparison 7 Vaginal misoprostol versus surgery, Outcome 19 Women's views/satisfaction - continuous data.
[Analysis 7.20]
Analysis 7.20. Comparison 7 Vaginal misoprostol versus surgery, Outcome 20 Death.
[Analysis 7.21]
Analysis 7.21. Comparison 7 Vaginal misoprostol versus surgery, Outcome 21 Serious morbidity.
[Analysis 7.24]
Analysis 7.24. Comparison 7 Vaginal misoprostol versus surgery, Outcome 24 Nausea.
[Analysis 7.25]
Analysis 7.25. Comparison 7 Vaginal misoprostol versus surgery, Outcome 25 Vomiting.
[Analysis 7.26]
Analysis 7.26. Comparison 7 Vaginal misoprostol versus surgery, Outcome 26 Diarrhoea.
[Analysis 8.1]
Analysis 8.1. Comparison 8 Oral misoprostol versus surgery, Outcome 1 Complete miscarriage.
[Analysis 8.2]
Analysis 8.2. Comparison 8 Oral misoprostol versus surgery, Outcome 2 Surgical evacuation.
[Analysis 8.4]
Analysis 8.4. Comparison 8 Oral misoprostol versus surgery, Outcome 4 Unplanned surgical intervention.
[Analysis 8.5]
Analysis 8.5. Comparison 8 Oral misoprostol versus surgery, Outcome 5 Blood transfusion.
[Analysis 8.10]
Analysis 8.10. Comparison 8 Oral misoprostol versus surgery, Outcome 10 Pain relief.
[Analysis 8.11]
Analysis 8.11. Comparison 8 Oral misoprostol versus surgery, Outcome 11 Pelvic infection.
[Analysis 8.12]
Analysis 8.12. Comparison 8 Oral misoprostol versus surgery, Outcome 12 Cervical damage.
[Analysis 8.18]
Analysis 8.18. Comparison 8 Oral misoprostol versus surgery, Outcome 18 Women's views/satisfaction.
[Analysis 8.24]
Analysis 8.24. Comparison 8 Oral misoprostol versus surgery, Outcome 24 Nausea.
[Analysis 8.25]
Analysis 8.25. Comparison 8 Oral misoprostol versus surgery, Outcome 25 Vomiting.
[Analysis 8.26]
Analysis 8.26. Comparison 8 Oral misoprostol versus surgery, Outcome 26 Diarrhoea.
[Analysis 9.1]
Analysis 9.1. Comparison 9 Vaginal + oral misoprostol versus surgery, Outcome 1 Complete miscarriage.
[Analysis 9.2]
Analysis 9.2. Comparison 9 Vaginal + oral misoprostol versus surgery, Outcome 2 Surgical evacuation.
[Analysis 9.9]
Analysis 9.9. Comparison 9 Vaginal + oral misoprostol versus surgery, Outcome 9 Days of bleeding.
[Analysis 9.11]
Analysis 9.11. Comparison 9 Vaginal + oral misoprostol versus surgery, Outcome 11 Pelvic infection.
[Analysis 12.1]
Analysis 12.1. Comparison 12 Vaginal misoprostol versus oral misoprostol, Outcome 1 Complete miscarriage.
[Analysis 12.2]
Analysis 12.2. Comparison 12 Vaginal misoprostol versus oral misoprostol, Outcome 2 Surgical evacuation.
[Analysis 12.4]
Analysis 12.4. Comparison 12 Vaginal misoprostol versus oral misoprostol, Outcome 4 Unplanned surgical intervention.
[Analysis 12.10]
Analysis 12.10. Comparison 12 Vaginal misoprostol versus oral misoprostol, Outcome 10 Pain relief.
[Analysis 12.24]
Analysis 12.24. Comparison 12 Vaginal misoprostol versus oral misoprostol, Outcome 24 Nausea.
[Analysis 12.25]
Analysis 12.25. Comparison 12 Vaginal misoprostol versus oral misoprostol, Outcome 25 Vomiting.
[Analysis 12.26]
Analysis 12.26. Comparison 12 Vaginal misoprostol versus oral misoprostol, Outcome 26 Diarrhoea.
[Analysis 14.1]
Analysis 14.1. Comparison 14 Oral misoprostol: 600 ug versus 1200 ug, Outcome 1 Complete miscarriage.
[Analysis 14.2]
Analysis 14.2. Comparison 14 Oral misoprostol: 600 ug versus 1200 ug, Outcome 2 Surgical evacuation.
[Analysis 14.3]
Analysis 14.3. Comparison 14 Oral misoprostol: 600 ug versus 1200 ug, Outcome 3 Death or serious complication.
[Analysis 14.4]
Analysis 14.4. Comparison 14 Oral misoprostol: 600 ug versus 1200 ug, Outcome 4 Unplanned surgical intervention.
[Analysis 14.18]
Analysis 14.18. Comparison 14 Oral misoprostol: 600 ug versus 1200 ug, Outcome 18 Women's views/satisfaction.
[Analysis 14.20]
Analysis 14.20. Comparison 14 Oral misoprostol: 600 ug versus 1200 ug, Outcome 20 Death.
[Analysis 14.21]
Analysis 14.21. Comparison 14 Oral misoprostol: 600 ug versus 1200 ug, Outcome 21 Serious morbidity.
[Analysis 14.24]
Analysis 14.24. Comparison 14 Oral misoprostol: 600 ug versus 1200 ug, Outcome 24 Nausea.
[Analysis 14.25]
Analysis 14.25. Comparison 14 Oral misoprostol: 600 ug versus 1200 ug, Outcome 25 Vomiting.
[Analysis 14.26]
Analysis 14.26. Comparison 14 Oral misoprostol: 600 ug versus 1200 ug, Outcome 26 Diarrhoea.
[Analysis 15.1]
Analysis 15.1. Comparison 15 Oral mifepristone + vaginal misoprostol versus surgery, Outcome 1 Complete miscarriage.
[Analysis 15.2]
Analysis 15.2. Comparison 15 Oral mifepristone + vaginal misoprostol versus surgery, Outcome 2 Surgical evacuation.
[Analysis 15.11]
Analysis 15.11. Comparison 15 Oral mifepristone + vaginal misoprostol versus surgery, Outcome 11 Pelvic infection < 14 days.
[Analysis 16.4]
Analysis 16.4. Comparison 16 Vaginal prostaglandin E1 (gemeprost) versus surgery, Outcome 4 Unplanned surgical intervention.
[Analysis 17.1]
Analysis 17.1. Comparison 17 Sublingual misoprostol versus oral misoprostol, Outcome 1 Complete miscarriage.
[Analysis 17.2]
Analysis 17.2. Comparison 17 Sublingual misoprostol versus oral misoprostol, Outcome 2 Surgical evacuation.
[Analysis 17.3]
Analysis 17.3. Comparison 17 Sublingual misoprostol versus oral misoprostol, Outcome 3 Death or serious complication.
[Analysis 17.4]
Analysis 17.4. Comparison 17 Sublingual misoprostol versus oral misoprostol, Outcome 4 Women's views/satisfaction.
[Analysis 17.5]
Analysis 17.5. Comparison 17 Sublingual misoprostol versus oral misoprostol, Outcome 5 Nausea.
[Analysis 17.6]
Analysis 17.6. Comparison 17 Sublingual misoprostol versus oral misoprostol, Outcome 6 Vomiting.
[Analysis 17.7]
Analysis 17.7. Comparison 17 Sublingual misoprostol versus oral misoprostol, Outcome 7 Diarrhoea.