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Antiepileptic drugs as prophylaxis for post-craniotomy seizures

  1. Jennifer Pulman1,*,
  2. Janette Greenhalgh2,
  3. Anthony G Marson1

Editorial Group: Cochrane Epilepsy Group

Published Online: 28 FEB 2013

Assessed as up-to-date: 17 DEC 2012

DOI: 10.1002/14651858.CD007286.pub2


How to Cite

Pulman J, Greenhalgh J, Marson AG. Antiepileptic drugs as prophylaxis for post-craniotomy seizures. Cochrane Database of Systematic Reviews 2013, Issue 2. Art. No.: CD007286. DOI: 10.1002/14651858.CD007286.pub2.

Author Information

  1. 1

    Institute of Translational Medicine, University of Liverpool, Department of Molecular and Clinical Pharmacology, Liverpool, Merseyside, UK

  2. 2

    University of Liverpool, Liverpool Reviews and Implementation Group, Liverpool, UK

*Jennifer Pulman, Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Clinical Sciences Centre for Research and Education, Lower Lane, Fazakerley, Liverpool, Merseyside, L9 7LJ, UK. jennifer.pulman@liv.ac.uk.

Publication History

  1. Publication Status: New
  2. Published Online: 28 FEB 2013

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
Beenen 1999 {published data only}
  • Beenen LF, Lindeboom J, Kasteleijn Nolst Trenite DG, Heimans JJ, Snoek FJ, Touw DJ, et al. Comparative double blind clinical trial of phenytoin and sodium valproate as anticonvulsant prophylaxis after craniotomy: efficacy, tolerability, and cognitive effects. Journal of Neurology, Neurosurgery, and Psychiatry 1999; Vol. 67, issue 4:474-80.
Foy 1992 {published data only}
  • Foy P, Chadwick D, Rajgopalan N, Johnson A, Shaw M. Do prophylactic anticonvulsant drugs alter the pattern of seizures after craniotomy?. Journal of Neurology, Neurosurgery, and Psychiatry 1992; Vol. 55, issue 9:753-7.
  • Shaw MDM, Foy P, Chadwick D. The effectiveness of prophylactic anticonvulsants following neurosurgery. Acta Neurochirurgica 1983;69(3-4):253-8.
Franceschetti 1990 {published data only}
  • Franceschetti S, Binelli S, Casazza M, Lodrini S, Panzica F, Pluchino F, et al. Influence of surgery and antiepileptic drugs on seizures symptomatic of cerebral tumours. Acta Neurochirurgica 1990;103(1-2):47-51.
Lee 1989 {published data only}
  • Lee S, Lui T, Chang C, Cheng W, Wang D, Heimburger R, et al. Prophylactic anticonvulsants for prevention of immediate and early postcraniotomy seizures. Surgical Neurology 1989; Vol. 31, issue 5:361-4.
Nakamura 1999 {published data only}
  • Nakamura N, Ishijima B, Mayanagi Y, Manaka S. A randomized controlled trial of zonisamide in postoperative epilepsy: a report of the Cooperative Group Study. Japanese Journal of Neurosurgery 1999;8(10):647-56.
North 1983 {published data only}
  • North J, Penhall R, Hanieh A, Frewin D, Taylor W. Phenytoin and postoperative epilepsy. A double blind study. Journal of Neurosurgery 1983; Vol. 58, issue 5:672-7.
  • North JB, Penhall RK, Hanieh A, Hann CS, Challen RG, Frewin DB. Postoperative epilepsy: a double-blind trial of phenytoin after craniotomy. Lancet 1980;23(1)(8165):384-6.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
Baker 1995 {published data only}
  • Baker CJ, Prestigiacomo CJ, Solomon RA. Short-term perioperative anticonvulsant prophylaxis for the surgical treatment of low-risk patients with intracranial aneurysms. Neurosurgery 1995;37(5):863-70.
Boarini 1985 {published data only}
  • Boarini DJ, Beck DW, VanGilder JC. Postoperative prophylactic anticonvulsant therapy in cerebral gliomas. Neurosurgery 1985;16(3):290-2.
De Santis 1996 {published data only}
  • De Santis A, Baratta P, Bello L, Spagnoli D, Ceccarelli G, Songa V, et al. Early postoperative seizures and endovenous phenytoin. Preliminary clinical data. Journal of Neurosurgical Sciences 1996;40(3-4):207-12.
De Santis 2002 {published data only}
  • De Santis A, Villani R, Sinisi M, Stocchetti N, Perucca E. Add-on phenytoin fails to prevent early seizures after surgery for supratentorial brain tumors: a randomized controlled study. Epilepsia 2002; Vol. 43, issue 2:175-82.
Grobelny 2009 {published data only}
  • Grobelny BT, Ducruet AF, Zacharia BE, Hickman ZL, Andersen KN, Sussman E, et al. Preoperative antiepileptic drug administration and the incidence of postoperative seizures following bur hole-treated chronic subdural hematoma. Journal of Neurosurgery 2009;111(6):1257-62.
Hayashi 1999 {published data only}
  • Hayashi T, Hadeishi H, Kawamura S, Nonoyama Y, Suzuki A, Yasui N. Postoperative anticonvulsant prophylaxis for patients treated for cerebral aneurysms. Neurologia Medico-Chirurgica 1999;39(12):828-33.
Levati 1996 {published data only}
  • Levati A, Savoia G, Zoppi F, Boselli L, Tommasino C. Peri-operative prophylaxis with phenytoin: dosage and therapeutic plasma levels. Acta Neurochirurgica 1996; Vol. 138, issue 3:274-9.
Lim 2009 {published data only}
  • Lim DA, Tarapore P, Chang E, Burt M, Chakalian L, Barbaro N, et al. Safety and feasibility of switching from phenytoin to levetiracetam monotherapy for glioma-related seizure control following craniotomy: a randomized phase II pilot study. Journal of Neuro-Oncology 2009;93(3):349-54.
Manaka 2003 {published data only}
Murri 1992 {published data only}
Notani 1984 {published data only}
  • Notani M, Kawamura H, Amano K, Tanikawa T, Kawabatake H, Iseki H, et al. The incidence of postoperative epilepsy and prophylactic anticonvulsants in patients with intracranial aneurysm. No Shinkei Geka 1984;12(3 Suppl):269-74.
Shaw 1991 {published data only}
  • Shaw MD, Foy PM. Epilepsy after craniotomy and the place of prophylactic anticonvulsant drugs: discussion paper. Journal of the Royal Society of Medicine 1991;84(4):221-3.
Temkin 1990 {published data only}
  • Temkin NR, Dikmen SS, Wilensky AJ, Keihm J, Chabal S, Winn HR. A randomized, double-blind study of phenytoin for the prevention of post-traumatic seizures. New England Journal of Medicine 1990;323(8):497-502.
Temkin 1999 {published data only}
  • Temkin NR, Dikmen SS, Anderson GD, Wilensky AJ, Holmes MD, Cohen W, et al. Valproate therapy for prevention of posttraumatic seizures: a randomized trial. Journal of Neurosurgery 1999;91(4):593-600.
Tsolaki 1997 {published data only}
  • Tsolaki M, Yannacou-Peftoulidou M, Grammaticos P, Sofianos E, Foroglou G. Phenytoin plasma levels after intraoperative administration, for the prevention of post-craniotomy seizures. Acta Neurochirurgica 1987;84(1-2):36-8.

References to studies awaiting assessment

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
Zhang 2000 {published data only}
  • Zhang Y, Zhou LF, Du GL, Gao L, Xu B, XU J, et al. Phenytoin or sodium valproate for prophylaxis of postoperative epilepsy: a randomised comparison. Chinese Journal of Nervous and Mental Diseases 2000;26(4):231-3.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
Calabresi 2003
Foy 1981
Higgins 2002
Lefebvre 2011
  • Lefebvre C, Manheimer E, Glanville J. Chapter 6: Searching for studies. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
Matthew 1980
  • Matthew E, Sherwin AL, Welner SA, Odusote K, Stratford JG. Seizures following intracranial surgery: incidence in the first post-operative week. The Canadian Journal of Neurological Sciences 1980;7(4):285-90.
North 1983a
Temkin 2002