Intervention Review

You have free access to this content

Vitamin D supplementation for cystic fibrosis

  1. Janet H Ferguson1,*,
  2. Anne B Chang2

Editorial Group: Cochrane Cystic Fibrosis and Genetic Disorders Group

Published Online: 14 MAY 2014

Assessed as up-to-date: 7 MAY 2014

DOI: 10.1002/14651858.CD007298.pub4


How to Cite

Ferguson JH, Chang AB. Vitamin D supplementation for cystic fibrosis. Cochrane Database of Systematic Reviews 2014, Issue 5. Art. No.: CD007298. DOI: 10.1002/14651858.CD007298.pub4.

Author Information

  1. 1

    Canterbury District Health Board, Christchurch Hospital, Christchurch, New Zealand

  2. 2

    Menzies School of Health Research, Charles Darwin University, Child Health Division, Darwin, Northern Territories, Australia

*Janet H Ferguson, Christchurch Hospital, Canterbury District Health Board, Private Bag 4710, Christchurch, 8140, New Zealand. janet.ferguson@actrix.co.nz. janet.ferguson@cdhb.health.nz.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 14 MAY 2014

SEARCH

References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Brown 2005 {published data only (unpublished sought but not used)}
  • Brown SA, Aris RM, Leigh MW, Retsch-Bogart GZ, Caminiti MJ, Jennings-Grant T, et al. Baseline BMD status in children and young adults with CF: calcitriol intervention study [abstract]. Pediatric Pulmonology 2005;40 Suppl 28:354. [CFGD Register: CO20]
Deghan Manshadi 2012 {published data only}
  • Deghan Manshadi S, Robert R, Brotherwood M, Tullis E, Stephenson A. A randomized placebo-controlled trial of cholecalciferol for vitamin D deficiency in adults with cystic fibrosis [abstract]. Pediatric Pulmonology 2012;47 Suppl 35:412, Abstract no:515. [CFGD Register: GN228]
Grossmann 2012 {published data only}
  • Grossmann RE, Zughaier S, Kumari M, Seydafkan S, Liu S, Lyles R, et al. Clinical responses to a novel vitamin D supplementation strategy in adult CF patients hospitalized for pulmonary exacerbations [abstract]. Pediatric Pulmonology 2011;46 Suppl 34:404, Abstract 526. [CFGD Register: GN217b]
  • Grossmann RE, Zughaier SM, Kumari M, Seydafkan S, Lyles RH, Liu S, et al. Pilot study of vitamin D supplementation in adults with cystic fibrosis pulmonary exacerbation: A randomized, controlled trial. Dermato-endocrinology 2012;4(2):191-7. [CFGD Register: GN217d; ]
  • Grossmann RE, Zughaier SM, Liu S, Lyles RH, Tangpricha V. Impact of vitamin D supplementation on markers of inflammation in adults with cystic fibrosis hospitalized for a pulmonary exacerbation. European Journal of Clinical Nutrition 2012;66(9):1072-4. [CFGD Register: GN217c]
  • Kumara M, Colman L, Grossmann R, Wolfenden LL, Tangpricha V. High dose vitamin D supplementation in cystic fibrosis patients hospitalised for respiratory exacerbation [abstract]. Pediatric Pulmonology 2009;44 Suppl 32:Abstract 549. [CFGD Register: GN217a]
Haworth 2004 {published data only}
  • Haworth CS, Jones A, Selby PL, Adams JE, Mawer EB, Webb AK. Randomised, double blind, placebo controlled trial investigating the effect of calcium and vitamin D supplementation on bone mineral density and bone metabolism in adults with cystic fibrosis [abstract]. Pediatric Pulmonology 2001;32 Suppl 22:330-1. [CFGD Register: CO18a]
  • Haworth CS, Jones AM, Adams JE, Selby PL, Webb AK. Randomised double blind placebo controlled trial investigating the effect of calcium and vitamin D supplementation on bone mineral density and bone metabolism in adult patients with cystic fibrosis. Journal of  Cystic Fibrosis 2004;3(4):233-6. [CFGD Register: CO18b]
Hillman 2008 {published data only}
  • Hillman LS, Cassidy JT, Popescu MF, Hewett JE, Kyger J, Robertson JD. Percent true calcium absorption, mineral metabolism, and bone mineralization in children with cystic fibrosis: effect of supplementation with vitamin D and calcium. Pediatric Pulmonology 2008;43(8):772-80. [CFGD Register: CO21]
  • Popescu M, Morris J, Hillman L. Calcium and vitamin D supplementation in CF children [abstract]. Pediatric Pulmonology 1998;26 Suppl 17:359, Abstract no: 539.
Sciuca 2011 {published data only}
  • Sciuca S, Turcu O. Correction of low bone mass density in patients with cystic fibrosis [abstract]. Journal of Cystic Fibrosis 2011;10 Suppl 1:S78, Abstract no: 308. [MEDLINE: 97400975; CO46]

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Aris 2000 {published data only}
  • Aris RM, Lester GE, Neuringer IP, Winders AW, Gott KK, Rea J, et al. Efficacy of pamidronate for osteoporosis in cystic fibrosis patients following lung transplantation [abstract]. Pediatric Pulmonology 1998;26(Suppl 17):365.
  • Aris RM, Lester GE, Renner JB, Winders A, Denene Blackwood A, Lark RK, et al. Efficacy of pamidronate for osteoporosis in patients with cystic fibrosis following lung transplantation. American Journal of Respiratory and Critical Care Medicine 2000;162(3 part 1):941-6.
  • Aris RM, Ontjes DA, Winders AW, Blackwood D, Lester GE. Effect of pamidronate on bone biomarkers in post-transplant osteoporotic cystic fibrosis patients [abstract]. Pediatric Pulmonology 1998;26(Suppl 17):364-5.
Gronowitz 2003 {published data only}
  • Gronowitz E, Gilljam M, Hollsing A, Lindblad A, Larko O, Strandvik B. Ultraviolet B radiation improves serum levels of vitamin D in patients with cystic fibrosis (abstract). Pediatric Pulmonology 2003;36(Suppl 25):345.
Homola 2010 {published data only}
  • Homola L, Holcikova A, Mikolasek P, Pavelka J. Vitamin D supplementation in children with cystic fibrosis:sunshine, cholecalciferol and ergocalciferol [abstract]. Journal of Cystic Fibrosis 2011;10 Suppl 1:S76, Abstract no: 302. [CFGD Register: GN220; MEDLINE: 97400975]
Khazai 2009 {published data only}
  • Judd SE, Khazai N, Jeng L, Stecenko A, Wolfenden L, Tangpricha V. Evaluation of ergocalciferol, cholecalciferol or UVB light therapy to improve vitamin D status in cystic fibrosis: a prospective randomized study [abstract]. Pediatric Pulmonology 2008;43(Suppl 31):420.
  • Khazai NB, Judd SE, Jeng L, Wolfenden LL, Stecenko A, Ziegler TR, Tangpricha V. Treatment and prevention of vitamin D insufficiency in cystic fibrosis patients: comparative efficacy of ergocalciferol, cholecalciferol, and UV light. Journal of Clinical Endocrinology and Metabolism 2009;94(6):2037-43. [MEDLINE: 97400975]

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Aris 2005
  • Aris RM, Merkel PA, Bachrach LK, Borowitz DS, Boyle MP, Elkin SL, et al. Consensus statement: Guide to bone health and disease in cystic fibrosis. Journal of Clinical Endocrinology and Metabolism 2005;90(3):1888-96.
Black 2005
Bonifant 2012
Borowitz 2002
Brenckmann 2001
  • Brenckmann C, Papaioannou A. Bisphosphonates for osteoporosis in people with cystic fibrosis. Cochrane Database of Systematic Reviews 2001, Issue 4. [DOI: 10.1002/14651858.CD002010]
Cates 2003 [Computer program]
  • Cates C. Visual Rx. Online NNT Calculator. http://www.nntonline.net/: Cates C, 2003.
Chesney 1989
Deeks 2011
  • Deeks J, Higgins J, Altman D. Chapter 9 Analysing data and undertaking meta-analysis. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
Dimitri 2007
  • Dimitri P, Bishop N. Rickets. Paediatrics and Child Health 2007;17(7):279-87.
Dodge 2006
Higgins 2003
Higgins 2011
  • Julian PT Higgins, Douglas G Altman and Jonathan AC Sterne on behalf of the Cochrane Statistical Methods Group and the Cochrane Bias Methods Group. Chapter 8: Assessing risk of bias in included studies. In: Higgins JPT, Green S (editors). Cochrane Handbook of Systematic Reviews of Interventions. Version 5.1.0 [updated March 2011]. Available from www.cochrane-handbook.org. The Cochrane Collaboration, 2011.
Holick 2007
Holick 2008
  • Holick MF, Biancuzzo RM, Chen TC, Klein EK, Young A, Bibuld D, et al. Vitamin D2 is as effective as vitamin D3 in maintaining circulating concentrations of 25-hydroxyvitamin D. Journal of Clinical Endocrinology and Metabolism 2007;Dec 18:[Epub ahead of print]. [DOI: 10.1210/jc.2007-2308]
Jagannath 2013
Joiner 2000
  • Joiner TA, Foster C, Shape T. The many faces of vitamin D deficient rickets. Pediatrics in review 2000;21(9):296-302.
NIH 2007
  • NIH. Office of Dietary Supplements. Dietary Supplement Fact Sheet: Vitamin D. http://ods.od.nih.gov/factsheets/vitamind.asp (accessed 31st October 2007).
Okebukola 2011
  • Okebukola PO, Kansra S, McCabe H. Vitamin E supplementation in people with cystic fibrosis (Protocol). Cochrane Database of Systematic Reviews 2011, Issue 11. [DOI: 10.1002/14651858.CD009422]
Popescu 1998
  • Popescu M, Morris J, Hillman L. Calcium and vitamin D supplementation in CF children [abstract]. Pediatric Pulmonology 1998;26 Suppl 17:359.
RevMan 2012 [Computer program]
  • The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). Version 5.2. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2012.
Sethuraman 2006
Sinaasappel 2002
  • Sinaasappel M, Stern M, Littlewood J, Wolfe S, Steinkamp G, Heijerman HG, et al. Nutrition in patients with cystic fibrosis: a European Consensus. Journal of Cystic Fibrosis 2002;1:51-75.
Theodoratou 2014
  • T heodoratou E, Tzoulaki I, Zgaga L, Ioannidis JP. Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational studies and randomised trials . BMJ 2014 ; 348 :g2035.
UK CF Trust 2007
  • The UK Cystic Fibrosis Trust Bone Mineralisation Working Group. Bone mineralisation in cystic fibrosis. Report of the UK Cystic Fibrosis Trust Bone Mineralisation Working Group. Cystic Fibrosis Trust, February 2007.
Wagener 2003
  • Wagener JS, Headley AA. Cystic fibrosis: current trends in respiratory care. Respiratory Care 2003;48(3):234-45.
Wharton 2003
World Health Organization 1994
  • World Health Organization. Definition of osteoporosis. Assessment of Fracture Risk and Its Application to Screening for Postmenopausal Osteoporosis 1994:1-129.
Wright 2005

References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Ferguson 2010
  • Ferguson JH, Chang AB. Vitamin D supplementation for cystic fibrosis. Cochrane Database of Systematic Reviews 2010, Issue 6. [DOI: 10.1002/14651858.CD007298.pub2]
Ferguson 2012