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Antibiotic prophylaxis for leptospirosis

  1. David M Brett-Major1,*,
  2. Robert J Lipnick2

Editorial Group: Cochrane Hepato-Biliary Group

Published Online: 8 JUL 2009

Assessed as up-to-date: 17 FEB 2009

DOI: 10.1002/14651858.CD007342.pub2

How to Cite

Brett-Major DM, Lipnick RJ. Antibiotic prophylaxis for leptospirosis. Cochrane Database of Systematic Reviews 2009, Issue 3. Art. No.: CD007342. DOI: 10.1002/14651858.CD007342.pub2.

Author Information

  1. 1

    NAVMED MPT&E, Military Tropical Medicine Course, Bethesda, MD, USA

  2. 2

    Armed Forces Health Surveillance Center, Communications, Standards, & Training Division, Silver Spring, MD, USA

*David M Brett-Major, Military Tropical Medicine Course, NAVMED MPT&E, 8901 Wisconsin Avenue, Bethesda, MD, 20889-5611, USA. dmbrettmajor@gmail.com. David.Brett-Major@med.navy.mil.

Publication History

  1. Publication Status: New
  2. Published Online: 8 JUL 2009

SEARCH

[Figure 1]
Figure 1. Search results by database. CHBG- Cochrane Hepato-Biliary Group.
[Figure 2]
Figure 2. Methodological quality graph: review authors' judgements about each methodological quality item presented as percentages across all included studies.
[Figure 3]
Figure 3. Methodological quality summary: review authors' judgements about each methodological quality item for each included study.
[Figure 4]
Figure 4. Forest plot of comparison: 1 Pre-Exposure Prophylaxis with Doxycycline, outcome: 1.1 Laboratory Identified Infection.
[Figure 5]
Figure 5. Forest plot of comparison: 1 Pre-Exposure Prophylaxis with Doxycycline, outcome: 1.2 Adverse Events, Minor.
[Analysis 1.1]
Analysis 1.1. Comparison 1 Pre-exposure prophylaxis with doxycycline, Outcome 1 Laboratory identified infection.
[Analysis 1.2]
Analysis 1.2. Comparison 1 Pre-exposure prophylaxis with doxycycline, Outcome 2 Adverse events, minor.
[Analysis 1.3]
Analysis 1.3. Comparison 1 Pre-exposure prophylaxis with doxycycline, Outcome 3 Clinical infection, laboratory confirmed.
[Analysis 1.4]
Analysis 1.4. Comparison 1 Pre-exposure prophylaxis with doxycycline, Outcome 4 Death.
[Analysis 1.5]
Analysis 1.5. Comparison 1 Pre-exposure prophylaxis with doxycycline, Outcome 5 Laboratory identified infection, baseline IgM titer zero.
[Analysis 1.6]
Analysis 1.6. Comparison 1 Pre-exposure prophylaxis with doxycycline, Outcome 6 Laboratory identified infection, baseline IgM titer non-zero.
[Analysis 2.1]
Analysis 2.1. Comparison 2 Post-exposure prophylaxis with doxycycline, Outcome 1 Laboratory identified infection.
[Analysis 2.2]
Analysis 2.2. Comparison 2 Post-exposure prophylaxis with doxycycline, Outcome 2 Clinical infection, laboratory confirmed.
[Analysis 2.3]
Analysis 2.3. Comparison 2 Post-exposure prophylaxis with doxycycline, Outcome 3 Clinical infection, laboratory confirmed when IgM+ at baseline removed.