Intervention Review

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Antibiotic prophylaxis for leptospirosis

  1. David M Brett-Major1,*,
  2. Robert J Lipnick2

Editorial Group: Cochrane Hepato-Biliary Group

Published Online: 8 JUL 2009

Assessed as up-to-date: 17 FEB 2009

DOI: 10.1002/14651858.CD007342.pub2

How to Cite

Brett-Major DM, Lipnick RJ. Antibiotic prophylaxis for leptospirosis. Cochrane Database of Systematic Reviews 2009, Issue 3. Art. No.: CD007342. DOI: 10.1002/14651858.CD007342.pub2.

Author Information

  1. 1

    NAVMED MPT&E, Military Tropical Medicine Course, Bethesda, MD, USA

  2. 2

    Armed Forces Health Surveillance Center, Communications, Standards, & Training Division, Silver Spring, MD, USA

*David M Brett-Major, Military Tropical Medicine Course, NAVMED MPT&E, 8901 Wisconsin Avenue, Bethesda, MD, 20889-5611, USA.

Publication History

  1. Publication Status: New
  2. Published Online: 8 JUL 2009



References to studies included in this review

  1. References to studies included in this review
  2. Additional references
Gonsalez 1998 {published data only (unpublished sought but not used)}
  • Gonsalez CR, Casseb J, Monteiro FG, Paula-Neto JB, Fernandez RB, Silva MV, et al. Use of doxycycline for leptospirosis after high-risk exposure in São Paulo, Brazil. Revista do Instituto de Medicina Tropical de São Paulo 1988;40(1):59-61.
Sehgal 2000 {published data only (unpublished sought but not used)}
  • Sehgal SC, Sugunan AP, Murhekar MV, Sharma S, Vijayachari P. Randomized controlled trial of doxycycline prophylaxis against leptospirosis in an endemic area. International Journal of Antimicrobial Agents 2000;13(4):249-55.
Takafuji 1984 {published data only (unpublished sought but not used)}
  • Takafuji ET, Kirkpatrick JW, Miller RN, Karwacki JJ, Kelley PW, Gray MR, et al. An efficacy trial of doxycycline chemoprophylaxis against leptospirosis. New England Journal of Medicine 1984;310(8):497-500.

Additional references

  1. References to studies included in this review
  2. Additional references
Bharti 2003
Dziuban 2006
  • Dziuban EJ, Liang JL, Craun GF, Hill V, Yu PA, Painter J, et al. Surveillance for waterborne disease and outbreaks associated with recreational water - United States, 2003-2004. Morbidity Mortality Weekly Report Surveillance Summaries 2006;55(12):1-30.
Egger 1997
Gaynor 2007
  • Gaynor K, Katz AR, Park SY, Nakata M, Clark TA, Effler PV. Leptospirosis on Oahu: an outbreak associated with flooding of a university campus. The American Journal of Tropical Medicine and Hygiene 2007;76(5):882-5.
Gluud 2008
  • Gluud C, Nikolova D, Klingenberg SL, Whitfield K, Alexakis N, Als-Nielsen B, et al. Cochrane Hepato-Biliary Group. About The Cochrane Collaboration (Cochrane Review Groups (CRGs)). 2008, Issue 4. Art. No.: LIVER.
Guidugli 2000
Hadad 2006
  • Hadad E, Pirogovsky A, Bartal C, Gilad J, Barnea A, Yitzhaki S, et al. An outbreak of leptospirosis among Israeli troops near the Jordan River. The American Journal of Tropical Medicine and Hygiene 2006;74(1):127-31.
Higgins 2008
  • Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.0 [updated February 2008]. The Cochrane Colloboration, 2008. Available from
Hollis 1999
ICH-E3 1995
  • ICH harmonized tripartite guideline. Guideline on structure and content of clinical study reports (E3). Geneva: International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use. (accessed 19 May 2008) 1995.
ICH-GCP 1996
  • ICH harmonised tripartite guideline. Guideline for good clinical practice E6 (R1). Geneva: International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use. (accessed 15 May 2008) 1996.
Kjaergard 2001
Moher 1998
  • Moher D, Pham B, Jones A, Cook DJ, Jadad AR, Moher M, et al. Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses?. Lancet 1998;352:609-13.
Narita 2005
  • Narita M, Fujitani S, Haake DA, Paterson DL. Leptospirosis after recreational exposure to water in the Yaeyama islands, Japan. The American Journal of Tropical Medicine and Hygiene 2005;73(4):652-6.
Niwetpathomwat 2005
  • Niwetpathomwat A, Niwatayakul K, Doungchawee G. Surveillance of leptospirosis after flooding at Loei Province, Thailand by year 2002. The Southeast Asian Journal of Tropical Medicine and Public Health 2005;36 (Suppl 4):202-5.
Pappachan 2004
  • Pappachan MJ, Sheela M, Aravindan KP. Relation of rainfall pattern and epidemic leptospirosis in the Indian state of Kerala. Journal of Epidemiology and Community Health 2004;58(12):1054.
Pappas 2007
Ramakrishnan 2003
  • Ramakrishnan R, Patel MS, Gupte MD, Manickam P, Venkataraghavan S. An institutional outbreak of leptospirosis in Chennai, South India. The Journal of Communicable Diseases 2003;35(1):1-8.
RevMan 2008 [Computer program]
  • The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). Version 5.0. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2008.
Royle 2003
  • Royle P, Milne R. Literature searching for randomized controlled trials used in Cochrane reviews: rapid versus exhaustive searches. International Journal of Technology Assessment in Health Care 2003;19(4):591-603.
Russell 2003
  • Russell KL, Montiel Gonzalez MA, Watts DM, Lagos-Figueroa RC, Chauca G, Ore M, et al. An outbreak of leptospirosis among Peruvian military recruits. The American Journal of Tropical Medicine and Hygiene 2003;69(1):53-7.
Schulz 1995
  • Schulz KF, Chalmers I, Hayes RJ, Altman DG. Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. JAMA 1995;273:408-12.
Sejvar 2003
  • Sejvar J, Bancroft E, Winthrop K, Bettinger J, Bajani M, Bragg S, et al. Leptospirosis in "Eco-Challenge" athletes, Malaysian Borneo, 2000. Emerging Infectious Diseases 2003;9(6):702-7.
Thai 2008
  • Thai KT, Nga TT, Phuong HL, Giao PT, Hung le Q, Binh TQ, et al. Seroepidemiology and serological follow-up of anti-leptospiral IgG in children in Southern Vietnam. Acta Tropica 2008;106(2):128-31.
Wood 2008
  • Wood L, Egger M, Gluud LL, Schulz KF, Jüni P, Altman DG, et al. Empirical evidence of bias in treatment effect estimates in controlled trials with different interventions and outcomes: meta-epidemiological study. BMJ (Clinical Research Ed.) 2008;336(7644):601-5.