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Posatirelin (l-pyro-2-aminoadipyl-l-leucyl-l-prolinamide) treatment for persons with dementia

  • Protocol
  • Intervention

Authors

  • Ivan Culum,

    Corresponding author
    1. University of Western Ontario, Health and Rehabilitation Sciences, Elborn College, London, Ontario, Canada
    • Ivan Culum, Health and Rehabilitation Sciences, Elborn College, University of Western Ontario, London, Ontario, N6G 1H1, Canada. iculum@uwo.ca.

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  • Dorothy Forbes

    1. University of Western Ontario, H33 Health Sciences Addition, School of Nursing, London, Ontario, Canada
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Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

Primary:

  • To assess the efficacy of posatirelin treatment in improving function, cognition, mood, behaviour, quality of life, and mortality in older persons with dementia.

Secondary:

  • To assess the efficacy of posatirelin treatment in decreasing medication use for the purpose of minimizing negative drug interactions (for example, ChEIs, whose effectiveness can decrease when paired with incontinence medication) and number of adverse drug reactions.

  • To make recommendations for consumers, healthcare professionals, decision-makers, and researchers regarding the efficacy of posatirelin treatment for dementia.

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