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Zinc supplementation as an adjunct to antibiotics in the treatment of pneumonia in children 2 to 59 months of age

  1. Batool A Haider1,
  2. Zohra S Lassi2,
  3. Amina Ahmed3,
  4. Zulfiqar A Bhutta2,*

Editorial Group: Cochrane Acute Respiratory Infections Group

Published Online: 5 OCT 2011

Assessed as up-to-date: 24 MAR 2011

DOI: 10.1002/14651858.CD007368.pub2


How to Cite

Haider BA, Lassi ZS, Ahmed A, Bhutta ZA. Zinc supplementation as an adjunct to antibiotics in the treatment of pneumonia in children 2 to 59 months of age. Cochrane Database of Systematic Reviews 2011, Issue 10. Art. No.: CD007368. DOI: 10.1002/14651858.CD007368.pub2.

Author Information

  1. 1

    Harvard School of Public Health, Departments of Epidemiology and Nutrition, Boston, MA, USA

  2. 2

    Aga Khan University Hospital, Division of Women and Child Health, Karachi, Pakistan

  3. 3

    Aga Khan University Hospital, Department of Paediatrics and Child Health, Karachi, Pakistan

*Zulfiqar A Bhutta, Division of Women and Child Health, Aga Khan University Hospital, Stadium Road, PO Box 3500, Karachi, 74800, Pakistan. zulfiqar.bhutta@aku.edu.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 5 OCT 2011

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
Bansal 2011 {published data only}
  • Bansal A, Parmar VR, Basu S, Kaur J, Jain S, Saha A, et al. Zinc supplementation in severe acute lower respiratory tract infection in children: a triple-blind randomized placebo controlled trial. Indian Journal of Pediatrics 2011;78(1):33–7.
Bose 2006 {published data only}
  • Bose A, Coles CL, Gunavathi JH, Moses P, Raghupathy P, Kirubakaran C, et al. Efficacy of zinc in the treatment of severe pneumonia in hospitalised children < 2 y old. American Journal of Clinical Nutrition 2006;83(5):1089-96.
Brooks 2004 {published data only}
Valentiner-Branth 2010 {published data only}
  • Valentiner-Branth P, Shrestha PS, Chandyo RK, Mathisen M, Basnet S, Bhandari N, et al. A randomised controlled trial of the effect of zinc as adjuvant therapy in children 2-35 months of age with severe or non severe pneumonia in Bhaktapur, Nepal. American Journal of Clinical Nutrition 2010;91(6):1667-74.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
Chang 2006 {published data only}
  • Chang AB, Torzillo PJ, Boyce NC, White AV, Stewart PM, Wheaton GR, et al. Zinc and vitamin A supplementation in indigenous Australian children hospitalised with lower respiratory tract infection: a randomised controlled trial. Medical Journal of Australia 2006;184(3):107-12.
Khaled 2001 {published data only}
  • Khaled MA, Mahalanabis D, Jana S, Chowdhury MK, Bhattacharya M, Chakrabarty MK, et al. Zinc supplementation and lipid peroxidation in children with measles and pneumonia. Faseb Journal 2001;15:4.
Mahalanabis 2002 {published data only}
  • Mahalanabis D, Chowdhury A, Jana S, Bhattacharya MK, Chakraborti MK, Wahed MA. Zinc supplementation as adjunct therapy in children with measles accompanied by pneumonia: a double-blind, randomised controlled trial. American Journal of Clinical Nutrition 2002;76(3):604-7.
Mahalanabis 2004 {published data only}
  • Mahalanabis D, Lahiri M, Paul D, Gupta S, Gupta A, Wahed MA, et al. Ransomized, double-blind, placebo-controlled clinical trial of the efficacy of treatment with zinc or vitamin A in infants and young children with severe acute lower respiratory infection. American Journal of Clinical Nutrition 2004;79(3):430-6.
Shah 2011 {unpublished data only}
  • Shah UH, Malik MA,  Alam S, Abu-Shaheen AK, Riaz M, AL-Tannir MA. The efficacy of zinc supplementation in young children with recurrent acute lower respiratory infections: a randomised double-blind controlled trial. [Personal communication] 2011.

References to ongoing studies

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
NCT00142285 {published data only}
  • NCT00142285. Zinc pneumonia outpatient trial in children < 2 years. http://clinicaltrials.gov/ct2/show/NCT00142285 Accessed on 11 May 2011.
NCT00347386 {published data only}
  • NCT00347386. Therapeutic zinc in infant bacterial illness. http://clinicaltrials.gov/ct2/show/NCT00347386 Accessed on 11 May 2011.
NCT00373100 {published data only}
  • NCT00373100. Efficacy of zinc as an adjunct therapy in the management of severe pneumonia among Gambian children. http://clinicaltrials.gov/ct2/show/NCT00373100 Accessed on 11 May 2011.
NCT00513929 {published data only}
  • NCT00513929. Zinc as adjunct to treatment of pneumonia (EcuaPAZ). http://clinicaltrials.gov/ct2/show/NCT00513929 Accessed on 11 May 2011.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
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Bhatangar 2004
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Bhutta 1999
  • Bhutta ZA, Black RE, Brown KH, Gardner JM, Gore S, Hidayat A, et al. Prevention of diarrhoea and pneumonia by zinc supplementation in children in developing countries: pooled analysis of randomised controlled trials. Journal of Pediatrics 1999;135(6):689-97.
Bhutta 2008
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Fraker 1993
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