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Diagnostic Test Accuracy Protocol

Antenatal screening for Down's syndrome

  1. S Kate Alldred1,*,
  2. Zarko Alfirevic1,
  3. Jonathan J Deeks2,
  4. James P Neilson1

Editorial Group: Cochrane Pregnancy and Childbirth Group

Published Online: 8 OCT 2008

DOI: 10.1002/14651858.CD007384

Database Title

Additional Information

How to Cite

Alldred SK, Alfirevic Z, Deeks JJ, Neilson JP. Antenatal screening for Down's syndrome (Protocol). Cochrane Database of Systematic Reviews 2008, Issue 4. Art. No.: CD007384. DOI: 10.1002/14651858.CD007384.

Author Information

  1. 1

    The University of Liverpool, School of Reproductive and Developmental Medicine, Division of Perinatal and Reproductive Medicine, Liverpool, UK

  2. 2

    University of Birmingham, Department of Public Health and Epidemiology, Birmingham, UK

*S Kate Alldred, School of Reproductive and Developmental Medicine, Division of Perinatal and Reproductive Medicine, The University of Liverpool, First Floor, Liverpool Women's NHS Foundation Trust, Crown Street, Liverpool, L8 7SS, UK. k.alldred@liv.ac.uk.

Publication History

  1. Publication Status: New
  2. Published Online: 8 OCT 2008

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Abstract

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  2. Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

To compare different screening methods in isolation, and in various combinations to identify the most sensitive and specific test or tests for Down’s syndrome in the antenatal period.

Screening tests will be compared with respect to the following:

  • proportion of screened fetuses with Down’s syndrome detected by screening before birth;
  • the number of women with a high risk screening test result who subsequently have an unaffected pregnancy;
  • the number of invasive diagnostic procedures in women with fetuses subsequently found to have a normal karyotype;
  • the number of iatrogenic miscarriages in women with fetuses subsequently found to have a normal karyotype; and
  • the number of other adverse effects of screening and diagnosis.

To consider whether there is a uniform test suitable for all women, or whether different screening methods are more applicable to different groups (i.e. higher risk groups or different ethnic groups).

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