This is the protocol for a review and there is no abstract. The objectives are as follows:
To compare the diagnostic accuracy (sensitivity and specificity) of the Chlamydia antibody titer test and of hysterosalpingography in diagnosing tubal pathology verified by laparoscopy in subfertile women, by using studies with a paired design (i.e. CAT and HSG testing in the same patient population, the results of which have been verified in all women with laparoscopy).
As we do not expect to find a paired design in many studies, the review will be extended with two separate reviews comparing the accuracy of CAT versus laparoscopy on the one hand, and HSG versus laparoscopy on the other hand.
Should direct comparison of CAT and HSG versus laparoscopy be possible, we will explore the impact of different types of CAT assays on diagnostic accuracy. Furthermore, the impact of evaluation of HSG with oil- or water-soluble contrast medium will be explored. Should an indirect comparison have to be performed, study type (cohort versus case-control), type of assay; type of HSG contrast medium, and definition of tubal pathology (any tubal pathology versus two-sided tubal pathology) will be considered as potential sources of heterogeneity.