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Blood pressure lowering efficacy of dual alpha and beta blockers for primary hypertension

  • Protocol
  • Intervention

Authors

  • Gavin WK Wong,

    Corresponding author
    1. University of British Columbia, Department of Anesthesiology, Pharmacology and Therapeutics, Vancouver, BC, Canada
    • Gavin WK Wong, Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, 2176 Health Sciences Mall, Vancouver, BC, V6T 1Z3, Canada. gavin.wong@ti.ubc.ca.

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  • Alexandra Laugerotte,

    1. University of British Coulumbia, Anesthesiology, Pharmacology & Therapeutics, Vancouver, BC, Canada
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  • James M Wright

    1. University of British Columbia, Department of Anesthesiology, Pharmacology and Therapeutics, Vancouver, BC, Canada
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Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

Primary objective

To quantify the dose-related effects of various doses and types of dual alpha and beta adrenergic receptor blockers on systolic and diastolic blood pressure versus placebo in patients with primary hypertension.

Secondary objectives

  1. To determine the effects of dual alpha and beta adrenergic receptor blockers on variability of blood pressure.

  2. To determine the effects of dual alpha and beta adrenergic receptor blockers on pulse pressure.

  3. To quantify the dose-related effects of dual alpha and beta adrenergic receptor blockers on heart rate.

  4. To quantify the effects of dual alpha and beta adrenergic receptor blockers in different doses on withdrawals due to adverse events.

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