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Blood pressure lowering efficacy of beta-1 selective beta blockers for primary hypertension

  • Protocol
  • Intervention

Authors

  • Gavin WK Wong,

    Corresponding author
    1. University of British Columbia, Department of Anesthesiology, Pharmacology and Therapeutics, Vancouver, BC, Canada
    • Gavin WK Wong, Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, 2176 Health Sciences Mall, Vancouver, BC, V6T 1Z3, Canada. gavin.wong@ti.ubc.ca.

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  • Alexandra Laugerotte,

    1. University of British Coulumbia, Anesthesiology, Pharmacology & Therapeutics, Vancouver, BC, Canada
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  • James M Wright

    1. University of British Columbia, Department of Anesthesiology, Pharmacology and Therapeutics, Vancouver, BC, Canada
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Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

Primary objective

To quantify the dose-related effects of various doses and types of beta-1 selective beta adrenergic receptor blockers on systolic and diastolic blood pressure versus placebo in patients with primary hypertension.

Secondary objectives

  1. To determine the effects of beta-1 selective beta adrenergic receptor blockers on variability of blood pressure.

  2. To determine the effects of beta-1 selective beta adrenergic receptor blockers on pulse pressure.

  3. To quantify the dose-related effects of beta-1 selective beta adrenergic receptor blockers on heart rate.

  4. To quantify the effects of beta-1 selective beta adrenergic receptor blockers in different doses on withdrawals due to adverse events.

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