Intervention Review

You have free access to this content

Blood pressure lowering efficacy of nonselective beta-blockers for primary hypertension

  1. Gavin WK Wong*,
  2. James M Wright

Editorial Group: Cochrane Hypertension Group

Published Online: 28 FEB 2014

Assessed as up-to-date: 11 OCT 2013

DOI: 10.1002/14651858.CD007452.pub2

How to Cite

Wong GWK, Wright JM. Blood pressure lowering efficacy of nonselective beta-blockers for primary hypertension. Cochrane Database of Systematic Reviews 2014, Issue 2. Art. No.: CD007452. DOI: 10.1002/14651858.CD007452.pub2.

Author Information

  1. University of British Columbia, Department of Anesthesiology, Pharmacology and Therapeutics, Vancouver, BC, Canada

*Gavin WK Wong, Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, 2176 Health Sciences Mall, Vancouver, BC, V6T 1Z3, Canada.

Publication History

  1. Publication Status: New
  2. Published Online: 28 FEB 2014



References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Chalmers 1976 {published data only}
  • Chalmers J, Horvath J, Tiller D, Bune A. Effect of timolol and hydrochlorothiazide on blood pressure and plasma renin activity. Double blind factorial trial. Lancet 1976;2(7981):328-31. [: NSC016-TIMOLOL315]
Dargie 1986 {published data only}
  • Dargie H, Cleland J, Findlay I, Murray G, McInnes G. Combination of verapamil and beta blockers in systematic hypertension. American Journal of Cardiology 1986;57:80D-2D. [: NSC-Propranolol-546]
De Plean 1981 {published data only}
  • De Plean JF, Vander Elst E, Van Ypersele de Strihou C. Penbutolol or hydrochlorothiazide once a day in hypertension. A controlled study with home measurements. British Journal of Clinical Pharmacology 1981;12:215-21. [: NSC-Penbutolol-380]
Dupont 1984 {published data only}
  • Dupont AG, Bossuyt AM, Jonckheer MH, Six RO. Effect of nadolol on ambulatory blood pressure, renal haemodynamics and cardiac function in hypertension. Proceedings of BPS. 1984:129P. [: NSC-Nadolol-527]
Fasano 1991 {published data only}
  • Fasano ML, Gaeta I, De Simone G, Iannuzzi R, Ferrara LA. Cardiovascular response to adrenergic simulation during treatment with tertatolol. A new non cardioselective beta blocking agent in primary hypertensive patients. Japanese Heart Journal 1991;32(4):435-44. [: NSP005-TERTATOLOL161]
Ferrara 1987 {published data only}
  • Ferrara LA, Capaldo B, Rivellese A, Genovese S, Iovine C, Mastranzo P, et al. Adrenergic system and carbohydrate metabolism. Effect of beta receptor blockade on insulin secretion and peripheral insulin sensitivity in normoglycemic patients . European Journal of Clinical Pharmacology 1987;33:273-7. [: NSC-Propranolol-459]
Galloway 1976 {published data only}
  • Galloway DB, Glover SC, Hendry WG, Logie AW, Petrie JC, Smith MC, et al. Propranolol in hypertension: a dose response study. BMJ 1976;2:140-2. [: NSC015-PROPRANOLOL-318]
Kelemen 1990 {published data only}
  • Kelemen MH, Effron MB, Valenti SA, Stewart KJ. Exercise training combined with antihypertensive drug therapy. JAMA 1990;263(20):2766-71. [: NSP-propranolol-469]
Lepantalo 1985 {published data only}
Malacco 1985 {published data only}
  • Malacco E, Mailland F, Bevilacqua M, Bosisio E, Meroni R. Long term hemodynamic effects of indenolol in hypertension at rest and during isometric exercise. Current Therapeutic Research 1985;37(3):537-44. [: NSC-Propranolol/indenolol-439]
McCorvey 1993 {published data only}
  • McCorvey E, Wright JT, Culbert JP, McKenney JM, Proctor JD, Annett MP. Effect of hydrochlorothiazide, enalapril and propranolol on quality of life and cognitive and motor function in hypertensive patients. Clinical Pharmacy 1993;12:300-5. [: NSC014-PROPRANOLOL-363]
McInnes 1985 {published data only}
  • McInnes GT, Findlay IN, Murray G, Cleland JGF, Dargie HJ. Cardiovascular responses to verapamil and propranolol in hypertensive patients. Journal of Hypertension 1985;3(Suppl 3):S219-21. [: NSC-Propranolol-236]
Nicaise 1981 {published data only}
  • Nicaise J, Desmedt J, Kunstler M, Vryens R, Wuestenberghs A. (-)Moprolol as antihypertensive therapy in the elderly. Current Therapeutic Research 1981;30(1):93-7. [: NSC-Moprolol-379]
Oh 1985 {published data only}
  • Oh VMS, Chia BL, Taylor EA. Effect of long acting propranolol on blood pressure and heart rate in hypertensive Chinese. British Journal Clinical Pharmacology 1985;20:144-7. [: NSC-Propranolol-243]
Pearson 1979 {published data only}
  • Pearson RM, Bulpitt CJ, Havard CWH. Propranolol and tienilic acid in essential hypertension. Postgraduate Medical Journal 1979;55(Suppl 3):115-9. [: NSC-Propranolol-447]
Petrie 1976 {published data only}
  • Petrie JC, Galloway DB, Jeffers TA, Millar HR, Smith MC, Wood RA, Lewis JA, Simpson WT. Methyldopa and propranolol or practolol in moderate hypertension. BMJ 1976;2:137-139. [: NSC-Propranolol/practolol-443]
Petrie 1980 {published data only}
  • Petrie JC, Jeffers TA, Robb OJ, Scott AK, Webster J. Atenolol, sustained release oxprenolol and long acting propranolol in hypertension. BMJ 1980;280(6231):1573-4. [: NSC017-PROPRANOLOL-278]
Ravid 1985 {published data only}
  • Ravid M, Lang R, Jutrin I. The relative antihypertensive potency of propranolol, oxpranolol, atenolol and metoprolol given once daily. Archive Internal Medicine 1985;145:1321-3. [: NSC021-PROPRANOLOL248]
Richardson 1968 {published data only}
  • Richardson DW, Freund J, Gear AS, Mauck HP, Preston LW. Effect of propranolol on elevated arterial blood pressure. Circulation 1968;37:534-42. [: NSC020-PROPRANOLOL354]
Rosen 1994 {published data only}
  • Rosen RC, Kostis JB, Jekelis A, Taska LS. Sexual sequelae of antihypertensive drugs: treatment effects on self report and physiological measures in middle aged male hypertensive. Archives of Sexual Behavior 1994;23(2):135-51. [: NSC-Propranolol-115]
Schoenberger 1989 {published data only}
Shukla 1979 {published data only}
  • Shukla SK, Bhatnagar MK, Agarwal RK, Dwivedi RN, Gupta R. Beta blocker (propranolol) in mild hypertension. A dose response study. Indian Heart Journal 1979;31(6):330-2. [: NSC012-PROPRANOLOL419]
Sica 2004 {published data only}
  • Sica DA, Neutel JM, Weber MA, Manwitz N. The antihypertensive efficacy and safety of a chronotherapeutic formulation of propranolol in patients with hypertension. Journal of Clinical Hypertension 2004;6:231-41. [: NSP003-PROPRANOLOL042]
van Herwaarden 1977 {published data only}
  • van Herwaarden CLA, Fennis JFM, Binkhorst RA, Van t'Laar A. Haemodynamic effects of adrenaline during treatment of hypertensive patients with propranolol and metoprolol. European Journal of Clinical Pharmacology 1977;12:397-402. [: NSC-Propranolol-446]
West 1980 {published data only}
  • West MJ. Comparison of labetalol, hydrallazine, and propranolol in the therapy of moderate hypertension. Medical Journal of Australia 1980;1:224-5. [: NSC-Propranolol-451]

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Ades 1988 {published data only}
  • Ades PA, Gunther PGS, Meacham CP, Handy MA. Hypertension, exercise and beta adrenergic blockade. Annals of Internal Medicine 1988;109:629-34. [: NSP-PROPRANOLOL-209]
Ades 1990 {published data only}
  • Ades PA, Gunther PGS, Meyer WL, Gibson TC, Maddalena J, Orfeo T. Cardiac and skeletal muscle adaptation to training in systemic hypertension and effect of beta blockade (metoprolol or propranolol). American Journal of Cardiology 1990;66:591-6.
Agnes 1989 {published data only}
Beilin 1972 {published data only}
  • Beilin LJ, Juel-Jensen BE. Alpha and beta adrenergic blockade in hypertension. Lancet 1972;1:979-82.
Cherchi 1985 {published data only}
  • Cherchi A. Controlled study of the antihypertensive efficacy of the combination of nadolol and bendroflumethiazide with respect to nadolol alone and placebo. Clinica Terapeutica 1985;113:301-6.
Costa 1984 {published data only}
  • Costa FV, Caldari R, Borghi C, Bassein L, Ambrosioni E. Acebutalol, atenolol and nadolol: comparison of their antihypertensive efficacy at rest and during exercise. Current Therapeutics Research 1984;35(6):961-73.
Davidson 1976 {published data only}
  • Davidson C, Thadani U, Singleton W, Taylor SH. Comparison of antihypertensive active of beta blocking drugs during chronic treatment. BMJ 1976;2:7-9.
Kubik 1984 {published data only}
Smith 1988 {published data only}
  • Smith SA, Littler WA. The effect of epanolol on intra-arterial ambulatory blood pressure and baroreceptor heart rate reflex in essential hypertension. Clinical and Experimental Pharmacology and Physiology 1988;15:327-31.
Weigmann 1998 {published data only}
  • Weigmann I, Terhaag B, Wierich W, Herrmann WM. Antihypertensive effects of different talinolol dosages after four weeks of treatment in comparison with placebo. Drug Research 1998;48(3):240-4.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Brophy 2001
  • Brophy JM, Joseph L, Rouleau JL. Beta blockers in congestive heart failure. A Bayesian meta-analysis. Annals of Internal Medicine 2001;134:550-60.
Chen 2010
  • Canadian Pharmacist Association. e-CPS drug monograph. (assessed 21 February 2014).
  • FDA Online Label Repository. (accessed 21 February 2014).
Heran 2008 (ACEI)
  • Heran BS, Wong MMY, Heran IK, Wright JM. Blood pressure lowering efficacy of angiotensin converting enzyme (ACE) inhibitors for primary hypertension. Cochrane Database of Systematic Reviews 2008, Issue 4. [DOI: 10.1002/14651858.CD003823.pub2]
Heran 2008 (ARB)
  • Heran BS, Wong MMY, Heran IK, Wright JM. Blood pressure lowering efficacy of angiotensin receptor blockers for primary hypertension. Cochrane Database of Systematic Reviews 2008, Issue 4. [DOI: 10.1002/14651858.CD003822.pub2]
Higgins 2011
  • Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from
Jadad 1996
  • Jadad AR, Moore RA, Carrol D, Jenkinson C, Reynolds DJ, Gavaghan DJ, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary?. Controlled Clinical Trials 1996;17:1-12.
Ko 2004
  • Ko DT, Hebert PR, Coffey CS, Curtis JP, Foody JM, Sedrakyan A, et al. Adverse effects of beta-blocker therapy for patients with heart failure. Archives of Internal Medicine 2004;164:1389-94.
Law 2005
  • Law M, Morris JK, Jordan R, Wald N. Headaches and the treatment of blood pressure results from a meta-analysis of 94 randomized placebo-controlled trials with 24 000 participants. Circulation 2005;112:2301-6.
Magee 2003
  • Magee LA, Duley L. Oral beta-blockers for mild to moderate hypertension during pregnancy. Cochrane Database of Systematic Reviews 2003, Issue 1. [DOI: 10.1002/14651858.CD002863]
Musini 2009
Prichard 1966
Prichard 1969
  • Prichard BNC, Gillam PMS. Treatment of hypertension with propranolol. BMJ 1969;1:7-16.
RevMan 2012
  • The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). 5.2. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2012.
Teo 1993
  • Teo KK, Yusuf S, Furberg CD. Effects of prophylactic antiarrhythmic drug therapy in acute myocardial infarction. JAMA 1993;270:1589-95.
Webb 2011
  • Webb AJS, Fischer U, Rothwell PM. Effect of beta-blocker selectivity on blood pressure variability and stroke. Neurology 2011;77:731-7.
Wiysonge 2007
Wong 2008
  • Wong GWK, Laugerotte A, Wright JM. Blood pressure lowering efficacy of non-selective beta blockers for primary hypertension. Cochrane Database of Systematic Reviews 2008, Issue 4. [DOI: 10.1002/14651858.CD007452]
Wright 2000
Wright 2009