Intrapartum antibiotics for known maternal Group B streptococcal colonisation

  • Protocol
  • Intervention

Authors

  • Arne Ohlsson,

    Corresponding author
    1. University of Toronto, Departments of Paediatrics, Obstetrics and Gynaecology and Health Policy, Management and Evaluation, Warkworh, Ontario, Canada
    • Arne Ohlsson, Departments of Paediatrics, Obstetrics and Gynaecology and Health Policy, Management and Evaluation, University of Toronto, # 14324 County Rd 29, Warkworh, Ontario, K0K 3K0, Canada. aohlsson@mtsinai.on.ca.

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  • Vibhuti S Shah

    1. Mount Sinai Hospital, Department of Paediatrics, Toronto, Ontario, Canada
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Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

Primary objective

To assess the effect of intrapartum antibiotics for maternal GBS colonization on mortality from any cause, from GBS infection and from organisms other than GBS.

Secondary objectives

To assess the effect of intrapartum antibiotics for maternal GBS colonization on neonatal morbidity from early onset neonatal GBS infection (as defined under outcomes below).

To assess the effect of intrapartum antibiotics for maternal GBS colonization on probable early (postnatal age less than seven days) neonatal GBS infection.

To assess the effect of intrapartum antibiotics for maternal GBS colonization on late onset GBS sepsis (sepsis due to GBS in an infant at least seven days old).

To assess the effect of intrapartum antibiotics for maternal GBS colonization on long-term child development (motor and cognitive).

To assess the effect of intrapartum antibiotics for maternal GBS colonization on maternal outcomes including; chorioamnionitis, sepsis, urinary tract infection, hospital stay and allergic reactions to antibiotics.