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Vitamin A supplementation for the prevention of morbidity and mortality in infants six months of age or less

  1. Siddhartha Gogia*,
  2. Harshpal S Sachdev

Editorial Group: Cochrane Neonatal Group

Published Online: 8 OCT 2008

Assessed as up-to-date: 22 JUL 2008

DOI: 10.1002/14651858.CD007480


How to Cite

Gogia S, Sachdev HS. Vitamin A supplementation for the prevention of morbidity and mortality in infants six months of age or less (Protocol). Cochrane Database of Systematic Reviews 2008, Issue 4. Art. No.: CD007480. DOI: 10.1002/14651858.CD007480.

Author Information

  1. Sitaram Bhartia Institute of Science and Research, Pediatrics and Clinical Epidemiology, Delhi, India

*Siddhartha Gogia, Pediatrics and Clinical Epidemiology, Sitaram Bhartia Institute of Science and Research, Delhi, 110016, India. gogiasiddhartha@gmail.com.

Publication History

  1. Publication Status: New
  2. Published Online: 8 OCT 2008

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Abstract

  1. Top of page
  2. Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

Primary:

  1. To evaluate the effect of synthetic vitamin A supplementation in postpartum mothers in developing countries irrespective of antenatal vitamin A supplementation status, on mortality, morbidity, and adverse effects in their infants until the age of one year.
  2. To evaluate the effect of synthetic vitamin A supplementation initiated in the first half of infancy (< 6 months of age) in developing countries irrespective of maternal antenatal or postnatal vitamin A supplementation status on mortality, morbidity, and reactions until the age of one year.

Subgroup analyses:

The proposed subgroup analyses for the infant mortality component in the maternal postpartum supplementation review are:

  • Cumulative vitamin A dose received by the mother; low dose (< 200,000 IU) vs. high dose (> 200,000 IU)
  • Baseline maternal vitamin A status; maternal night blindness prevalences of < 5% (low) vs . > 5% (high), and mean maternal antenatal or postpartum serum retinol levels of > 1.1 micromoles/L (low) vs . <1.1 micromoles/L (high)
  • Birth weight; <2500 grams (low birth weight) vs. > 2500 grams (normal birth weight)

The proposed subgroup analyses for the infant mortality component in the infant supplementation review are:

  • Age at initiation of prophylactic vitamin A supplementation; neonatal period (0 - 1 month) vs. post-neonatal period (1 - 6 months)
  • Cumulative vitamin A dose received by the infant until the age of six months; low dose (< 50,000 IU) vs. high dose (> 50,000)
  • Maternal postpartum vitamin A supplementation; received vs. not received
  • Baseline maternal vitamin A status; maternal night blindness prevalences of < 5% (low) vs. > 5% (high), and mean maternal antenatal or postpartum serum retinol levels of > 1.1 micromoles/L (low) vs . < 1.1 micromoles/L (high)
  • Birth weight; < 2500 grams (low birth weight) vs. > 2500 grams (normal birth weight)