This is the protocol for a review and there is no abstract. The objectives are as follows:
1. To assess the effectiveness of adding one camptothecin compounds to other chemotherapy agents in the first line and second line treatment of metastatic colorectal cancer.
2. To assess the effectiveness of individual camptothecin compounds compared with each other (e.g. irinotecan, topotecan and homocamptothecin).
3. To assess the effectiveness of different formulations, dose, route of administration and schedule of the same type of camptothecin compounds.