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Fetal and umbilical Doppler ultrasound in high-risk pregnancies

  1. Zarko Alfirevic1,*,
  2. Tamara Stampalija2,
  3. Gillian ML Gyte3

Editorial Group: Cochrane Pregnancy and Childbirth Group

Published Online: 12 NOV 2013

Assessed as up-to-date: 30 SEP 2013

DOI: 10.1002/14651858.CD007529.pub3


How to Cite

Alfirevic Z, Stampalija T, Gyte GML. Fetal and umbilical Doppler ultrasound in high-risk pregnancies. Cochrane Database of Systematic Reviews 2013, Issue 11. Art. No.: CD007529. DOI: 10.1002/14651858.CD007529.pub3.

Author Information

  1. 1

    The University of Liverpool, Department of Women's and Children's Health, Liverpool, UK

  2. 2

    Insitute for Maternal and Child Health, IRCCS Burlo Garofalo, Unit of Prenatal Diagnosis, Trieste, Italy

  3. 3

    The University of Liverpool, Cochrane Pregnancy and Childbirth Group, Department of Women's and Children's Health, Liverpool, UK

*Zarko Alfirevic, Department of Women's and Children's Health, The University of Liverpool, First Floor, Liverpool Women's NHS Foundation Trust, Crown Street, Liverpool, L8 7SS, UK. zarko@liverpool.ac.uk.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 12 NOV 2013

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[Figure 1]
Figure 1. Methodological quality summary: review authors' judgements about each methodological quality item for each included study.
[Figure 2]
Figure 2. Funnel plot of comparison: 1 Doppler ultrasound versus no Doppler ultrasound, outcome: 1.1 Any perinatal death after randomisation.
[Figure 3]
Figure 3. Funnel plot of comparison: 1 Doppler ultrasound versus no Doppler ultrasound, outcome: 1.8 Cesarean section (elective and emergency).
[Figure 4]
Figure 4. Funnel plot of comparison: 1 Doppler ultrasound versus no Doppler ultrasound, outcome: 1.9 Cesarean section - elective.
[Figure 5]
Figure 5. Funnel plot of comparison: 1 Doppler ultrasound versus no Doppler ultrasound, outcome: 1.10 Cesarean section - emergency.
[Analysis 1.1]
Analysis 1.1. Comparison 1 Doppler ultrasound versus no Doppler ultrasound, Outcome 1 Any perinatal death after randomisation.
[Analysis 1.2]
Analysis 1.2. Comparison 1 Doppler ultrasound versus no Doppler ultrasound, Outcome 2 Serious neonatal morbidity.
[Analysis 1.3]
Analysis 1.3. Comparison 1 Doppler ultrasound versus no Doppler ultrasound, Outcome 3 Stillbirth.
[Analysis 1.4]
Analysis 1.4. Comparison 1 Doppler ultrasound versus no Doppler ultrasound, Outcome 4 Neonatal death.
[Analysis 1.5]
Analysis 1.5. Comparison 1 Doppler ultrasound versus no Doppler ultrasound, Outcome 5 Any potentially preventable perinatal death*.
[Analysis 1.7]
Analysis 1.7. Comparison 1 Doppler ultrasound versus no Doppler ultrasound, Outcome 7 Apgar < 7 at 5 minutes.
[Analysis 1.8]
Analysis 1.8. Comparison 1 Doppler ultrasound versus no Doppler ultrasound, Outcome 8 Caesarean section (elective and emergency).
[Analysis 1.9]
Analysis 1.9. Comparison 1 Doppler ultrasound versus no Doppler ultrasound, Outcome 9 Caesarean section - elective.
[Analysis 1.10]
Analysis 1.10. Comparison 1 Doppler ultrasound versus no Doppler ultrasound, Outcome 10 Caesarean section - emergency.
[Analysis 1.11]
Analysis 1.11. Comparison 1 Doppler ultrasound versus no Doppler ultrasound, Outcome 11 Spontaneous vaginal birth.
[Analysis 1.12]
Analysis 1.12. Comparison 1 Doppler ultrasound versus no Doppler ultrasound, Outcome 12 Operative vaginal birth.
[Analysis 1.13]
Analysis 1.13. Comparison 1 Doppler ultrasound versus no Doppler ultrasound, Outcome 13 Induction of labour.
[Analysis 1.16]
Analysis 1.16. Comparison 1 Doppler ultrasound versus no Doppler ultrasound, Outcome 16 Infant requiring intubation/ventilation.
[Analysis 1.17]
Analysis 1.17. Comparison 1 Doppler ultrasound versus no Doppler ultrasound, Outcome 17 Neonatal fitting/seizures.
[Analysis 1.18]
Analysis 1.18. Comparison 1 Doppler ultrasound versus no Doppler ultrasound, Outcome 18 Preterm labour.
[Analysis 1.19]
Analysis 1.19. Comparison 1 Doppler ultrasound versus no Doppler ultrasound, Outcome 19 Infant respiratory distress syndrome (RDS).
[Analysis 1.21]
Analysis 1.21. Comparison 1 Doppler ultrasound versus no Doppler ultrasound, Outcome 21 Neonatal admission to SCBU and/or NICU.
[Analysis 1.22]
Analysis 1.22. Comparison 1 Doppler ultrasound versus no Doppler ultrasound, Outcome 22 Hypoxic ischaemic encephalopathy.
[Analysis 1.23]
Analysis 1.23. Comparison 1 Doppler ultrasound versus no Doppler ultrasound, Outcome 23 Intraventricular haemorrhage.
[Analysis 1.28]
Analysis 1.28. Comparison 1 Doppler ultrasound versus no Doppler ultrasound, Outcome 28 Gestational age at birth.
[Analysis 1.29]
Analysis 1.29. Comparison 1 Doppler ultrasound versus no Doppler ultrasound, Outcome 29 Birth weight.
[Analysis 1.30]
Analysis 1.30. Comparison 1 Doppler ultrasound versus no Doppler ultrasound, Outcome 30 Length of infant hospital stay.
[Analysis 1.31]
Analysis 1.31. Comparison 1 Doppler ultrasound versus no Doppler ultrasound, Outcome 31 Birth < 34 weeks (not prespecified).
[Analysis 1.32]
Analysis 1.32. Comparison 1 Doppler ultrasound versus no Doppler ultrasound, Outcome 32 Antenatal admissions (not prespecified).
[Analysis 1.33]
Analysis 1.33. Comparison 1 Doppler ultrasound versus no Doppler ultrasound, Outcome 33 Phototherapy for neonatal jaundice (not prespecified).
[Analysis 1.34]
Analysis 1.34. Comparison 1 Doppler ultrasound versus no Doppler ultrasound, Outcome 34 Abnormal neurological development at 9months (not pre-specified).
[Analysis 1.35]
Analysis 1.35. Comparison 1 Doppler ultrasound versus no Doppler ultrasound, Outcome 35 Hospitalisation for IUGR neonatal (not prespecified).
[Analysis 1.36]
Analysis 1.36. Comparison 1 Doppler ultrasound versus no Doppler ultrasound, Outcome 36 Fetal distress in labour (not prespecified).
[Analysis 1.37]
Analysis 1.37. Comparison 1 Doppler ultrasound versus no Doppler ultrasound, Outcome 37 Birth weight < 5 percentile (not prespecified).
[Analysis 1.38]
Analysis 1.38. Comparison 1 Doppler ultrasound versus no Doppler ultrasound, Outcome 38 Periventricular leucomalacia (not prespecified).
[Analysis 1.39]
Analysis 1.39. Comparison 1 Doppler ultrasound versus no Doppler ultrasound, Outcome 39 Antenatal hospital stay.
[Analysis 2.1]
Analysis 2.1. Comparison 2 Doppler ultrasound versus no Doppler ultrasound (all subgroups), Outcome 1 Any perinatal death after randomisation.
[Analysis 2.2]
Analysis 2.2. Comparison 2 Doppler ultrasound versus no Doppler ultrasound (all subgroups), Outcome 2 Serious neonatal morbidity.
[Analysis 3.1]
Analysis 3.1. Comparison 3 Doppler ultrasound alone versus CTG alone, Outcome 1 Any perinatal death after randomisation.
[Analysis 3.3]
Analysis 3.3. Comparison 3 Doppler ultrasound alone versus CTG alone, Outcome 3 Stillbirth.
[Analysis 3.4]
Analysis 3.4. Comparison 3 Doppler ultrasound alone versus CTG alone, Outcome 4 Neonatal death.
[Analysis 3.5]
Analysis 3.5. Comparison 3 Doppler ultrasound alone versus CTG alone, Outcome 5 Any potentially preventable perinatal death*.
[Analysis 3.7]
Analysis 3.7. Comparison 3 Doppler ultrasound alone versus CTG alone, Outcome 7 Apgar < 7 at 5 minutes.
[Analysis 3.8]
Analysis 3.8. Comparison 3 Doppler ultrasound alone versus CTG alone, Outcome 8 Caesarean section (elective and emergency).
[Analysis 3.9]
Analysis 3.9. Comparison 3 Doppler ultrasound alone versus CTG alone, Outcome 9 Caesarean section - elective.
[Analysis 3.10]
Analysis 3.10. Comparison 3 Doppler ultrasound alone versus CTG alone, Outcome 10 Caesarean section - emergency.
[Analysis 3.11]
Analysis 3.11. Comparison 3 Doppler ultrasound alone versus CTG alone, Outcome 11 Spontaneous vaginal birth.
[Analysis 3.12]
Analysis 3.12. Comparison 3 Doppler ultrasound alone versus CTG alone, Outcome 12 Operative vaginal birth.
[Analysis 3.13]
Analysis 3.13. Comparison 3 Doppler ultrasound alone versus CTG alone, Outcome 13 Induction of labour.
[Analysis 3.16]
Analysis 3.16. Comparison 3 Doppler ultrasound alone versus CTG alone, Outcome 16 Infant requiring intubation/ventilation.
[Analysis 3.17]
Analysis 3.17. Comparison 3 Doppler ultrasound alone versus CTG alone, Outcome 17 Neonatal fitting/seizures.
[Analysis 3.21]
Analysis 3.21. Comparison 3 Doppler ultrasound alone versus CTG alone, Outcome 21 Neonatal admission to SCBU and/or NICU.
[Analysis 3.28]
Analysis 3.28. Comparison 3 Doppler ultrasound alone versus CTG alone, Outcome 28 Gestational age at birth.
[Analysis 3.29]
Analysis 3.29. Comparison 3 Doppler ultrasound alone versus CTG alone, Outcome 29 Birth weight.
[Analysis 3.30]
Analysis 3.30. Comparison 3 Doppler ultrasound alone versus CTG alone, Outcome 30 Length of infant hospital stay.
[Analysis 3.32]
Analysis 3.32. Comparison 3 Doppler ultrasound alone versus CTG alone, Outcome 32 Antenatal admissions (not pre-specified).
[Analysis 3.33]
Analysis 3.33. Comparison 3 Doppler ultrasound alone versus CTG alone, Outcome 33 Phototherapy for neonatal jaundice (not pre-specified).
[Analysis 3.39]
Analysis 3.39. Comparison 3 Doppler ultrasound alone versus CTG alone, Outcome 39 Antenatal hospital stay.
[Analysis 4.1]
Analysis 4.1. Comparison 4 Doppler ultrasound alone versus CTG alone (all subgroups), Outcome 1 Any perinatal death after randomisation.
[Analysis 5.1]
Analysis 5.1. Comparison 5 Doppler ultrasound versus no Doppler ultrasound - SGA/IUGR, Outcome 1 Any perinatal death after randomisation (SGA/IUGR).
[Analysis 6.1]
Analysis 6.1. Comparison 6 Doppler ultrasound alone versus CTG - SGA/IUGR, Outcome 1 Any perinatal death after randomisation (SGA/IUGR).
[Analysis 7.1]
Analysis 7.1. Comparison 7 Doppler ultrasound versus no Doppler ultrasound - in hypertension/pre-eclampsia, Outcome 1 Any perinatal death after randomisation (hypertension/pre-eclampsia).
[Analysis 8.1]
Analysis 8.1. Comparison 8 Doppler ultrasound versus CTG - in hypertension/pre-eclampsia, Outcome 1 Any perinatal death after randomisation (hypertension/pre-eclampsia).
[Analysis 13.1]
Analysis 13.1. Comparison 13 Doppler ultrasound versus no Doppler ultrasound - previous pregnancy loss, Outcome 1 Any perinatal death after randomisation (previous pregnancy loss).
[Analysis 13.2]
Analysis 13.2. Comparison 13 Doppler ultrasound versus no Doppler ultrasound - previous pregnancy loss, Outcome 2 Serious neonatal morbidity (previous pregnancy loss).