Intervention Review

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Progestin-only pills for contraception

  1. David A Grimes1,*,
  2. Laureen M Lopez2,
  3. Paul A O'Brien3,
  4. Elizabeth G. Raymond4

Editorial Group: Cochrane Fertility Regulation Group

Published Online: 13 NOV 2013

Assessed as up-to-date: 29 OCT 2013

DOI: 10.1002/14651858.CD007541.pub3


How to Cite

Grimes DA, Lopez LM, O'Brien PA, Raymond EG. Progestin-only pills for contraception. Cochrane Database of Systematic Reviews 2013, Issue 11. Art. No.: CD007541. DOI: 10.1002/14651858.CD007541.pub3.

Author Information

  1. 1

    University of North Carolina, School of Medicine, Obstetrics and Gynecology, Chapel Hill, North Carolina, USA

  2. 2

    FHI 360, Clinical Sciences, Research Triangle Park, North Carolina, USA

  3. 3

    London Community Healthcare, Westside Contraceptive Services, London, UK

  4. 4

    Gynuity Health projects, New York, New York, USA

*David A Grimes, Obstetrics and Gynecology, University of North Carolina, School of Medicine, CB#7570, Chapel Hill, North Carolina, 27599-7570, USA. david_grimes@med.unc.edu.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 13 NOV 2013

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Collaborative 1998 {published and unpublished data}
  • Collaborative Study Group on the Desogestrel-containing Progestogen-only Pill. A double-blind study comparing the contraceptive efficacy, acceptability and safety of two progestogen-only pills containing desogestrel 75 μg/day or levonorgestrel 30 μg/day. European Journal of Contraception and Reproductive Health Care 1998;3:169-78.
Lakha 2007 {published and unpublished data}
  • Lakha F, Ho PC, Van der Spuy ZM, Dada K, Elton R, Glasier AF, et al. A novel estrogen-free oral contraceptive pill for women: multicentre, double-blind, randomized controlled trial of mifepristone and progestogen-only pill (levonorgestrel). Human Reproduction 2007;22:2428-36.
Paulsen 1974 {published data only}
Sheth 1982 {published data only}
  • Sheth A, Jain U, Sharma S, Adatia A, Patankar S, Andolsek L, et al. A randomized, double-blind study of two combined and two progestogen-only oral contraceptives. Contraception 1982;25:243-52.
Vessey 1972 {published data only}
Were 1997 {published data only}
  • Were EO, Kendall JZ, Nyongesa P. Randomised clinical trial to determine optimum initiation time of norgestrel-progestin only contraception in Eldoret Teaching Hospital, Kenya. East African Medical Journal 1997;74:103-7.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Bhattacharya 2012 {published data only}
  • Bhattacharya SM, Jha A. Comparative study of the therapeutic effects of oral contraceptive pills containing desogestrel, cyproterone acetate, and drospirenone in patients with polycystic ovary syndrome. Fertility and Sterility 2012;98(4):1053-9.
Korver 2005 {published data only}
  • Korver T, Klipping C, Heger-Mahn D, Duijkers I, van Osta G, Dieben T. Maintenance of ovulation inhibition with the 75-μg desogestrel-only contraceptive pill (Cerazette®) after scheduled 12-h delays in tablet intake. Contraception 2005;71:8-13.
Rice 1999 {published data only}
  • Rice CF, Killick SR, Dieben R, Coelingh Bennink H. A comparison of the inhibition of ovulation achieved by desogestrel 75μg and levonorgestrel 30 μg daily. Human Reproduction 1999;14:982-5.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
ACOG 2006
  • American College of Obstetricians and Gynecologists. ACOG technical bulletin. Use of hormonal contraception in women with coexisting medical conditions. Washington, D.C.: American College of Obstetricians and Gynecologists, 2006.
Bjarnadóttir 2001
  • Bjarnadóttir RI, Gottfredsdóttir H, Sigurdardóttir K, Geirsson RT, Dieben TOM. Comparative study of the effects of a progestogen-only pill containing desogestrel and an intrauterine contraceptive device in lactating women. British Journal of Obstetrics and Gynaecology 2001;108:1174-80.
CONSORT 2010
  • CONSORT group. CONSORT: Transparent reporting of trials. http://www.consort-statement.org/ (accessed 04 May 2011).
Dunson 1993
Edelman 2005
Family Health International 1991
  • Family Health International. Time of progestin-only oral contraceptive initiation among lactating women (protocol #874). Internal document 1991.
FFPRHC 2003
  • Faculty of Family Planning and Reproductive Health Care Clinical Effectiveness Unit. New product review (April 2003) desogestrel-only pill (Cerazette). Journal of Family Planning and Reproductive Health Care 2003;29:162-4.
FFPRHC 2004
  • Faculty of Family Planning and Reproductive Health Care. FFPRHC guidance (July 2004) Contraceptive choices for breastfeeding women. Journal of Family Planning and Reproductive Health Care 2004;30:181-9.
FSRH 2008
  • Faculty of Sexual and Reproductive Healthcare Clinical Effectiveness Unit. Progestogen-only pills. http://www.ffprhc.org.uk/ (accessed 2 April 2009).
Goldzieher 1994
  • Goldzieher JW, Fotherby K. Pharmacology of the contraceptive steroids. New York: Raven Press, 1994.
Grimes 2010
Higgins 2008
  • Higgins JPT, Green S. Cochrane handbook for systematic reviews of interventions 5.0.0 [updated February 2008]. http://www.cochrane-handbook.org/ (accessed 9 July 2008).
Lidegaard 2009
Lopez 2012
Manchikanti 2007
McCann 1994
  • McCann MF, Potter LS. Progestin-only oral contraception: a comprehensive review. Contraception 1994;50:S1-S198.
Moggia 1991
  • Mogggia AV, Harris GS, Dunson TR, Dias R, Moffia MS, Ferrer MA, et al. A comparative study of a progestin-only oral contraceptive versus non-hormonal methods in lactating women in Buenos Aires, Argentina. Contraception 1991;44:31-43.
Moher 2001
Raymond 2011
  • Raymond EG. Progestin-only pills. In: Hatcher RA, Trussell J, Nelson AL, Cates W Jr, Kowal D, Policar MS editor(s). Contraceptive Technology. 20th Edition. New York: Ardent Media, Inc., 2011:237-47.
Schulz 2002a
Schulz 2002b
Trussell 2011
van Vliet 2011
  • van Vliet HA, Grimes DA, Lopez LM, Schulz KF, Helmerhorst FM. Triphasic versus monophasic oral contraceptives for contraception. Cochrane Database of Systematic Reviews 2011, Issue 11. [DOI: 10.1002/14651858.CD003553.pub3]
Wallach 2000
  • Wallach M, Grimes DA, Chaney EJ, Connell EB, Creinin MD, Emans SJ, et al. Modern oral contraception. Totowa, NJ: Enron, 2000.
WHO 1998
  • World Health Organization collaborative study of cardiovascular disease and steroid contraception. Cardiovascular disease and use of oral and injectable progestogen-only contraceptives and combined injectable contraceptives: results of an international, multicenter, case-control study. Contraception 1998;57:315-24.