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Long-term effects of weight-reducing drugs in hypertensive patients

  1. Andrea Siebenhofer1,*,
  2. Klaus Jeitler2,
  3. Karl Horvath3,
  4. Andrea Berghold4,
  5. Ulrich Siering5,
  6. Thomas Semlitsch6

Editorial Group: Cochrane Hypertension Group

Published Online: 28 MAR 2013

Assessed as up-to-date: 15 JAN 2013

DOI: 10.1002/14651858.CD007654.pub3


How to Cite

Siebenhofer A, Jeitler K, Horvath K, Berghold A, Siering U, Semlitsch T. Long-term effects of weight-reducing drugs in hypertensive patients. Cochrane Database of Systematic Reviews 2013, Issue 3. Art. No.: CD007654. DOI: 10.1002/14651858.CD007654.pub3.

Author Information

  1. 1

    Goethe University, Institute for General Practice, Frankfurt am Main, Germany

  2. 2

    Medical University of Graz, EBM Review Center, Department of Internal Medicine and Institute for Medical Informatics, Statistics and Documentation, Graz, Austria

  3. 3

    Medical University of Graz, Department of Internal Medicine, Division of Endocrinology and Metabolism, Graz, Austria

  4. 4

    Medical University of Graz, Institute for Medical Informatics, Statistics and Documentation, Graz, Austria

  5. 5

    Institute for Quality and Efficiency in Health Care, Quality of Health Care, Köln, Germany

  6. 6

    and HEALTH - Institute of Medical Technologies and Health Management, Joanneum Research, EBM Review Center, Department of Internal Medicine, Medical University of Graz, Graz, Austria

*Andrea Siebenhofer, Institute for General Practice, Goethe University, Theodor-Stern-Kai 7, Frankfurt am Main, 60590, Germany. andrea.siebenhofer@medunigraz.at.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 28 MAR 2013

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[Figure 1]
Figure 1. Study flow diagram

* IQWiG 2006
[Figure 2]
Figure 2. Forest plot of comparison: 1 Orlistat versus Placebo, outcome: 1.1 Change in systolic blood pressure from baseline to endpoint [mm Hg].
[Figure 3]
Figure 3. Forest plot of comparison: 1 Orlistat versus Placebo, outcome: 1.2 Change in diastolic blood pressure from baseline to endpoint [mm Hg].
[Figure 4]
Figure 4. Forest plot of comparison: 1 Orlistat versus Placebo, outcome: 1.3 Change in body weight from baseline to endpoint [kg].
[Figure 5]
Figure 5. Forest plot of comparison: 2 Sibutramine versus Placebo, outcome: 2.1 Change in diastolic blood pressure from baseline to endpoint [mm Hg].
[Figure 6]
Figure 6. Forest plot of comparison: 2 Sibutramine versus Placebo, outcome: 2.2 Change in body weight from baseline to endpoint [kg].
[Analysis 1.1]
Analysis 1.1. Comparison 1 Orlistat versus Placebo, Outcome 1 Change in systolic blood pressure from baseline to endpoint.
[Analysis 1.2]
Analysis 1.2. Comparison 1 Orlistat versus Placebo, Outcome 2 Change in diastolic blood pressure from baseline to endpoint.
[Analysis 1.3]
Analysis 1.3. Comparison 1 Orlistat versus Placebo, Outcome 3 Change in body weight from baseline to endpoint.
[Analysis 2.1]
Analysis 2.1. Comparison 2 Sibutramine versus Placebo, Outcome 1 Change in diastolic blood pressure from baseline to endpoint.
[Analysis 2.2]
Analysis 2.2. Comparison 2 Sibutramine versus Placebo, Outcome 2 Change in body weight from baseline to endpoint.