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Intravenous fluids for reducing the duration of labour in low risk nulliparous women

  1. Feroza Dawood1,*,
  2. Therese Dowswell2,
  3. Siobhan Quenby3

Editorial Group: Cochrane Pregnancy and Childbirth Group

Published Online: 18 JUN 2013

Assessed as up-to-date: 17 JUN 2013

DOI: 10.1002/14651858.CD007715.pub2

How to Cite

Dawood F, Dowswell T, Quenby S. Intravenous fluids for reducing the duration of labour in low risk nulliparous women. Cochrane Database of Systematic Reviews 2013, Issue 6. Art. No.: CD007715. DOI: 10.1002/14651858.CD007715.pub2.

Author Information

  1. 1

    Liverpool Women's NHS Foundation Trust, Liverpool, UK

  2. 2

    The University of Liverpool, Cochrane Pregnancy and Childbirth Group, Department of Women's and Children's Health, Liverpool, UK

  3. 3

    University of Warwick, Clinical Sciences Research Institute, Coventry, UK

*Feroza Dawood, Liverpool Women's NHS Foundation Trust, Crown Street, Liverpool, L8 7SS, UK. feroza.dawood@lwh.nhs.uk. fdawood@liv.ac.uk.

Publication History

  1. Publication Status: New
  2. Published Online: 18 JUN 2013

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Alavi 2005 {published data only}
  • Alavi MH, Talaei Rad Z, Dadgar SR. Assessment of the effects of increased intravenous hydration on the course of labor in nulliparous term pregnancies. Medical Journal of the Islamic Republic of Iran 2005;18(4):289-92.
Coco 2010 {published data only}
  • Coco A, Derksen-Schrock A, Coco K, Raff T, Horst M, Hussar E. A randomized trial of increased intravenous hydration in labor when oral fluid is unrestricted. Family Medicine 2010;42(1):52-6.
Direkvand-Moghadam 2012 {published data only}
  • Direkvand-Moghadam A, Rezaeian M. Increased intravenous hydration of nulliparas in labor. International Journal of Gynecology and Obstetrics 2012;118(3):213-5.
Eslamian 2006 {published data only}
Garite 2000 {published data only}
  • Garite TJ, Weeks J, Peters-Phair K. A randomized trial on the influence of increased intravenous hydration on the course of nulliparous labor. American Journal of Obstetrics and Gynecology 2000;182(1 Pt 2):S37.
  • Garite TJ, Weeks J, Peters-Phair K, Pattilo C, Brewster WR. A randomized controlled trial of the effect of increased intravenous hydration on the course of labor in nulliparous women. American Journal of Obstetrics and Gynecology 2000;183:1544-8.
  • Hausman N, Garite T, Rumney P. The influence of increased intravenous hydration on the incidence of nonreassuring fetal heart rate patterns in nulliparous labor [abstract]. American Journal of Obstetrics and Gynecology 2001;184(1):S6.
Kavitha 2012 {published data only}
  • Kavitha A, Chacko KP, Thomas E, Rathore S, Christoper S, Biswas B, et al. A randomized controlled trial to study the effect of IV hydration on the duration of labor in nulliparous women. Archives of Gynecology and Obstetrics 2012;285(2):343-6.
Maderia 2007 {published data only}
  • Maderia LM, Hoffman MK, Wilson S, Chichester ML. Effect of intravenous hydration on labor length and delivery mode [abstract]. Obstetrics & Gynecology 2007;109(4 Suppl):90S.
Shrivastava 2009 {published data only}
  • Shrivastava V, Garite T, Jenkins S, Saul L, Rumney P, Preslicka C, et al. A double-blinded randomized controlled trial comparing normal saline with and without dextrose on the course of labor in nulliparas. American Journal of Obstetrics and Gynecology 2007;197(6 Suppl 1):S18, Abstract no: 36.
  • Shrivastava VK, Garite TJ, Jenkins SM, Saul L, Rumney P, Preslicka C, et al. A randomized, double-blinded, controlled trial comparing parenteral normal saline with and without dextrose on the course of labor in nulliparas. American Journal of Obstetrics and Gynecology 2009;200(4):379.e1-6.
Stratton 1995 {published data only}
  • Stratton JF, Stronge J, Boylan P. Non-electrolyte solutions in labouring primigravida. 27th British Congress of Obstetrics and Gynaecology; 1995 July 4-7; Dublin, Ireland. 1995:Abstract no: 490.
  • Stratton JF, Stronge J, Boylan PC. Hyponatraemia and non-electrolyte solutions in labouring primigravida. European Journal of Obstetrics & Gynecology and Reproductive Biology 1995;59:149-51.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Boylan 1980 {published data only}
Caspi 1979 {published data only}
  • Caspi E, Ron-El R, Modai D. Controlled intravenous bicarbonate and fetal-maternal acid-base balance. I. The primipara. Obstetrics & Gynecology 1979;54:615-23.
Cerri 2000 {published data only}
  • Cerri V, Tarantini M, Zuliani G, Schena V, Redaelli C, Nicolini U. Intravenous glucose infusion in labor does not affect maternal and fetal acid-base balance. Journal of Maternal-Fetal Medicine 2000;9:204-8.
Cheek 1996 {published data only}
  • Cheek TG, Samuels P, Miller F, Tobin M, Gutsche BB. Normal saline i.v. fluid load decreases uterine activity in active labour. British Journal of Anaesthesia 1996;77:632-5.
  • Cheek TG, Samuels P, Tobin M, Gutsche BB. Rapid intravenous saline infusion decreases uterine activity in labor, epidural analgesia does not. Anesthesiology 1989;71:A884.
Fisher 1997 {published data only}
  • Fisher AJ, Huddleston JF. Intrapartum maternal d-glucose infusion reduces the risk of umbilical cord acidemia. American Journal of Obstetrics and Gynecology 1997;176(1 Pt 2):S20.
Haesslein 1975 {published data only}
Higgins 1996 {published data only}
  • Higgins J, Gleeson R, Holohan M, Cooney C, Darling M. Maternal and neonatal hyponatraemia: a comparison of Hartmanns solution with 5% dextrose for the delivery of oxytocin in labour. European Journal of Obstetrics & Gynecology and Reproductive Biology 1996;68:47-8.
Hofmann 2001 {published data only}
  • Hofmann J, Schrod L, Schleelein O, Springer S, Steck T. Effects of prepartum infusion solutions on glucose and bilirubin metabolism of mother and child in the prepartum and postpartum period [Auswirkungen von prapartal verabreichten Infusionslosungen auf den Zucker- und Bilirubinstoffwechsel von Mutter und Kind peri- und postpartal]. Zeitschrift fur Geburtshilfe und Neonatologie 2001;205(2):60-4.
Jamal 2007 {published data only}
Kenepp 1985 {published data only}
  • Kenepp NB, Cheek TC, Gabbe SG, Gutsche BB. Intrapartum maternal intravenous dextrose administration. Anesthesiology 1985;63:436.
Loong 1987 {published data only}
Menigaux 1993 {published data only}
  • Menigaux C, Hamza J, Bougnieres P, Saint-Maurice C. Neonatal glycemia: does the maternal iv fluid regimen during labor make a difference?. Regional Anesthesia 1993;18:91.
Navarette,1982 {published data only}
  • Navarrete L, Ratinoff I, Clavero P, Sabatel R, Herrera R. Maternal metabolic control in the intrapartum management [Control metabólico materno intraparto]. Acta Obstétrica y Ginecológica Hispano-Lusitana 1982;30(2):121-30.
Nordstrom 1995 {published data only}
  • Nordstrom L, Arulkumaran S, Chua S, Ratnam S, Ingemarsson I, Kublickas M, et al. Continuous maternal glucose infusion during labor: effects on maternal and fetal glucose and lactate levels. American Journal of Perinatology 1995;12:357-62.
Omigbodun 1989 {published data only}
Omigbodun 1991 {published data only}
  • Omigbodun AO, Fajimi JL, Adeleye JA. Effects of using either saline or glucose as a vehicle for infusion in labour. East African Medical Journal 1991;68:88-92.
Omigbodun 1993 {published data only}
  • Omigbodun AO, Akindele JA, Osotimehin BO, Fatinikun T, Fajimi JL, Adeleye JA. Effect of saline and glucose infusions of oxytocin on neonatal bilirubin levels. International Journal of Gynecology & Obstetrics 1993;40:235-9.
Oral 2003 {published data only}
  • Oral E, Gezer A, Cagdas A, Pakkal N. Oxytocin infusion in labor: the effect different indications and the use of different diluents on neonatal bilirubin levels. Archives of Gynecology & Obstetrics 2003;267:117-20.
Rooth 1967 {published data only}
  • Rooth G, Jacobson L. Interrelationship between maternal and foetal acid-base and electrolyte balance during labour. 5th World Congress of Gynecology and Obstetrics; 1967; Sydney, Australia. 1967:187.
Rosenberg 2006 {published data only}
  • Rosenberg V, Rauch E, Eglinton G, Skupski D. Intrapartum maternal glycemic control in women with insulin requiring diabetes: a randomized clinical trial of rotating fluids vs. insulin drip [abstract]. American Journal of Obstetrics and Gynecology 2005;193(6 Suppl):S93.
  • Rosenberg VA, Eglinton GS, Rauch ER, Skupski DW. Intrapartum maternal glycemic control in women with insulin requiring diabetes: a randomized clinical trial of rotating fluids versus insulin drip. American Journal of Obstetrics and Gynecology 2006;195(4):1095-9.
Simpson 2005 {published data only}
Singhi 1982 {published data only}
  • Singhi S, Choo Kang E, Hall JS. Hazards of maternal hydration with 5% dextrose. Lancet 1982;2:335-6.
Thaler 2007 {published data only}
  • Thaler I. Maternal glucose infusion during labor increases fetal lactate production and modifies fetal acid-base balance. American Journal of Obstetrics and Gynecology 2007;197(6 Suppl 1):S182, Abstract no: 629.
Watson 2012 {published data only}
  • Watson J. The effect of intrapartum intravenous fluid management on breastfed newborn weight loss. JOGNN: Journal of Obstetric, Gynecologic & Neonatal Nursing 2011;40:S97.
  • Watson J, Hodnett E, Armson BA, Davies B, Watt-Watson J. A randomized controlled trial of the effect of intrapartum intravenous fluid management on breastfed newborn weight loss. Journal of Obstetric, Gynecologic, & Neonatal Nursing 2012;41(1):24-32.
Wells-Brooks 2001 {published data only}
  • Wells-Brooks NY. Uterine contraction frequency changes following crystalloid infusion [thesis]. Tennessee: University of Tennessee, 2001.
Wright 2000 {published data only}
  • Wright TE, Martin D, Qualls C, Curet LB. Effects of intrapartum administration of invert sugar and D5LR on neonatal blood glucose levels. Journal of Perinatology 2000;20:217-8.

References to studies awaiting assessment

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Amir 2004 {published data only}
  • Amir AliAkbari S, Dabiri F, Bakhshori Z, Alavii Majd H. Effects of increased intravenous hydration on the outcome of labor in nulliparous women at Shariati hospital in Bandar Abbas, 2003. Journal of Faculty of Nursing & Midwifery of Shaheed Beheshti University of Medical Sciences And Health Services 2004;14(46):49.
Rad 2012 {published data only}
  • Rad RH, Najar S, Hekmat K. Effects of intravenous normal saline with and without dextrose on labour duration and delivery outcomes in nulliparous women. Koomesh 2012;13(4):434-9.

References to ongoing studies

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Salim 2011 {unpublished data only}
  • Salim R. Intrapartum hydration. http://www.controlled-trials.com/mrct/trial/1276843/nct01242293 (accessed 2011).

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
ASA 2007
  • American Society of Anesthesiologists Task Force on Obstetric Anesthesia. Practice guidelines for obstetric anesthesia: An updated report by the American Society of Anesthesiologists. Anesthesiology 2007;106(4):843-63.
Barr 1991
  • Barr SI, Costill DL, Fink WJ. Fluid replacement during prolonged exercise: effects of water, saline, or no fluid. Medicine and Science in Sports and Exercise 1991;23(7):811-7.
Carvalho 1994
  • Carvalho JC, Mathias RS. Intravenous hydration in obstetrics. International Anesthesiology Clinics 1994;32(2):10-15.
Chantry 2011
  • Chantry CJ, Nommsen-Rivers LA. Excess weight loss in first-born breastfed newborns relates to maternal intrapartum fluid balance. Pediatrics 2011;127(1):171-9.
Egger 1997
  • Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997;315(7109):629-34.
Harbord 2006
Higgins 2011
  • Higgins JPT, Green S, editors. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
Keppler 1988
Maughan 1996
  • Maughan RJ, Bethell LR, Leiper JB. Effects of ingested fluids on exercise capacity and on cardiovascular and metabolic responses to prolonged exercise in man. Experimental Physiology 1996;81(5):847-59.
Michael 1991
Montain 1992
Montain 2008
Morton 1985
Noakes 1993
  • Noakes TD. Fluid replacement during exercise. Exercise and Sport Sciences Reviews 1993;21:297-330.
Noel-Weiss 2011
  • Noel-Weiss J, Woodend AK, Peterson WE, Gibb W, Groll D. An observational study of associations among maternal fluids during parturition,neonatal output,and breastfed newborn weight loss. International Breatsfeeding Journal 2011;6(9):1-10.
O'Sullivan 2003
  • O’Sullivan G, Scrutton M. NPO during labor. Is there any scientific validation?. Anesthesiology Clinics of North America 2003;21(1):87-98.
Pierce 2003
  • Pierce SJ, Kupittayanant S, Shmigol A, Wray S. The effects of pH change on calcium signalling and force in pregnant human myometrium. American Journal of Obstetrics and Gynecology 2003;188:1031-8.
RevMan 2011
  • The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). 5.1. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2011.
Romano 2009
  • Romano AM. First, do no harm: How routine interventions, common restrictions, and the organisation of our health-care system affect the health of mothers and newborns. J perinatal Educ 2009;18(3):58-62.
Saltin 1998
  • Saltin S, Costill DL. Fluid and electrolyte balance during prolonged exercise. In: Horton ES, Terjung RL editor(s). Exercise, Nutrition and Metabolism. New York: MacMillan, 1988:150-8.
Scheepers 1998
  • Scheepers H, Essed G, Brouns F. Aspects of fodd and fluid intake during labour. Policies of midwives and obstetricians in the Netherlands. European Journal of Obstetrics & Gynecology and Reproductive Biology 1998;78(1):37-40.
Schuitemaker 1997
  • Schuitemaker N, van Roosmalen J, Dekker G, van Dongen P, van Geijn H, Gravenhorst JB. Maternal mortality after cesarean scetion in the Netherlands. Acta Obstetricia et Gynecologica Scandinavia 1997;76(4):332-4.
Singata 2010
Tarnow-Mordi 1981
  • Tarnow-Mordi WO, Shaw JC, Liu D, Gardner DA, Flynn FV. Iatrogenic hyponatraemia of the newborn due to maternal fluid overload: a prospective study. British Medical Journal 1981;283(6292):639-42.