Intervention Review

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Withdrawal versus continuation of chronic antipsychotic drugs for behavioural and psychological symptoms in older people with dementia

  1. Tom Declercq1,*,
  2. Mirko Petrovic2,
  3. Majda Azermai3,
  4. Robert Vander Stichele4,
  5. An IM De Sutter1,
  6. Mieke L van Driel5,
  7. Thierry Christiaens1

Editorial Group: Cochrane Dementia and Cognitive Improvement Group

Published Online: 28 MAR 2013

Assessed as up-to-date: 6 DEC 2012

DOI: 10.1002/14651858.CD007726.pub2


How to Cite

Declercq T, Petrovic M, Azermai M, Vander Stichele R, De Sutter AIM, van Driel ML, Christiaens T. Withdrawal versus continuation of chronic antipsychotic drugs for behavioural and psychological symptoms in older people with dementia. Cochrane Database of Systematic Reviews 2013, Issue 3. Art. No.: CD007726. DOI: 10.1002/14651858.CD007726.pub2.

Author Information

  1. 1

    Ghent University, Department of General Practice and Primary Health Care, Ghent, Belgium

  2. 2

    Ghent University Hospital, Department of Geriatrics, Ghent, Belgium

  3. 3

    Ghent University, Heymans Institute of Pharmacology, Ghent, Belgium

  4. 4

    Heymans Institute of Pharmacology, Ghent, Belgium

  5. 5

    The University of Queensland, Discipline of General Practice, School of Medicine, Brisbane, Queensland, Australia

*Tom Declercq, Department of General Practice and Primary Health Care, Ghent University, De Pintelaan 185, UZ-6K3, Ghent, B-9000, Belgium. tomrw.declercq@ugent.be.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 28 MAR 2013

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[Figure 1]
Figure 1. Risk of bias graph for the 9 included studies.
[Figure 2]
Figure 2. Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
[Figure 3]
Figure 3. Forest plot of comparison: 1 Discontinuation versus continuation of antipsychotic medication: continuous data, analysis method mean difference, outcome: 1.1. Behavioural assessment by using Neuropsychiatric Inventory (NPI) measuring neuropsychiatric symptoms (NPS) at 3 months (Ballard 2004 and Ballard DART-AD) (forest plot 1).
[Analysis 1.1]
Analysis 1.1. Comparison 1 Discontinuation versus continuation of antipsychotic medication: continuous data, analysis method mean difference, Outcome 1 Behavioural assessment by using NPI measuring NPS at 3 months (Ballard 2004 and Ballard DART-AD) (forest plot 1).