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Aerosolized prostacyclin for acute lung injury (ALI) and acute respiratory distress syndrome (ARDS)

  1. Arash Afshari1,*,
  2. Jesper Brok2,
  3. Ann Merete Møller3,
  4. Jørn Wetterslev4

Editorial Group: Cochrane Anaesthesia, Critical and Emergency Care Group

Published Online: 4 AUG 2010

Assessed as up-to-date: 23 JUN 2010

DOI: 10.1002/14651858.CD007733.pub2


How to Cite

Afshari A, Brok J, Møller AM, Wetterslev J. Aerosolized prostacyclin for acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Cochrane Database of Systematic Reviews 2010, Issue 8. Art. No.: CD007733. DOI: 10.1002/14651858.CD007733.pub2.

Author Information

  1. 1

    Rigshospitalet, The Cochrane Anaesthesia Review Group & Copenhagen Trial Unit and Department of Paediatric and Obstetric Anaesthesia, Copenhagen, Denmark

  2. 2

    Rigshospitalet, Paediatric Department 4072, Copenhagen, Denmark

  3. 3

    Herlev University Hospital, The Cochrane Anaesthesia Review Group, Rigshospitalet & Department of Anaesthesiology, Herlev, Denmark

  4. 4

    Rigshospitalet, Copenhagen University Hospital, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 7812, Copenhagen, Denmark

*Arash Afshari, The Cochrane Anaesthesia Review Group & Copenhagen Trial Unit and Department of Paediatric and Obstetric Anaesthesia, Rigshospitalet, Blegdamsvej 9, Afsnit 3342, rum 52, Copenhagen, 2100, Denmark. arriba.a@gmail.com. afshari@rocketmail.com.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 4 AUG 2010

SEARCH

References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
Dahlem 2004 {published and unpublished data}
  • Dahlem P, van Aalderen WM, de Neef M, Dijkgraaf MG, Bos AP. Randomized controlled trial of aerosolized prostacyclin therapy in children with acute lung injury. Critical Care Medicine 2004;32(4):1055-60. [PUBMED: 15071401]

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
Abraham 1996 {published data only}
  • Abraham E, Park YC, Covington P, Conrad SA, Schwartz M. Liposomal prostaglandin E1 in acute respiratory distress syndrome: a placebo-controlled, randomized, double-blind, multicenter clinical trial. Critical Care Medicine 1996;24(1):10-5. [PUBMED: 8565513]
Abraham 1999 {published data only}
  • Abraham E, Baughman R, Fletcher E, Heard S, Lamberti J, Levy H, N, et al. Liposomal prostaglandin E1 (TLC C-53) in acute respiratory distress syndrome: a controlled, randomized, double-blind, multicenter clinical trial. TLC C-53 ARDS Study Group. Critical Care Medicine 1999;27(8):1478-85. [PUBMED: 10470753 ]
Archer 1996 {published data only}
Bein 1994 {published data only}
  • Bein T, Pfeifer M, Riegger GA, Taeger K. Continuous intraarterial measurement of oxygenation during aerosolized prostacyclin administration in severe respiratory failure. New England Journal of Medicine 1994;331(5):335-6. [PUBMED: 8022461]
Bone 1989 {published data only}
  • Bone RC, Slotman G, Maunder R, Silverman H, Hyers TM, Kerstein MD, Ursprung JJ. Randomized double-blind, multicenter study of prostaglandin E1 in patients with the adult respiratory distress syndrome. Prostaglandin E1 Study Group. Chest 1989;96(1):114-9. [PUBMED: PMID: 2661155]
  • Silverman HJ, Slotman G, Bone RC, Maunder R, Hyers TM, Kerstein MD, et al. Effects of prostaglandin E1 on oxygen delivery and consumption in patients with the adult respiratory distress syndrome. Results from the prostaglandin E1 multicenter trial. The Prostaglandin E1 Study Group. Chest 1990;98(2):405-10. [PUBMED: 2198140]
  • Slotman GJ, Kerstein MD, Bone RC, Silverman H, Maunder R, Hyers TM, et al. The effects of prostaglandin E1 on non-pulmonary organ function during clinical acute respiratory failure. The Prostaglandin E1 Study Group. The Journal of Trauma 1992;32(4):480-8. [PUBMED: 1569622]
Domenighetti 2001 {published data only}
  • Domenighetti G, Stricker H, Waldispuehl B. Nebulized prostacyclin (PGI2) in acute respiratory distress syndrome: impact of primary (pulmonary injury) and secondary (extrapulmonary injury) disease on gas exchange response. Critical Care Medicine 2001;29(1):57-62. [PUBMED: 11176161]
Eichelbrönner 1996 {published data only}
  • Eichelbrönner O, Reinelt H, Wiedeck H, Mezödy M, Rossaint R, Georgieff M, et al. Aerosolized prostacyclin and inhaled nitric oxide in septic shock--different effects on splanchnic oxygenation?. Intensive Care Medicine 1996;22(9):880-7. [PUBMED: 8905421]
Holcroft 1986 {published data only}
  • Holcroft JW, Vassar MJ, Weber CJ. Prostaglandin E(1) and survival in patients with the adult respiratory distress syndrome: A prospective trial. Seminars in Respiratory Medicine 1986;8 Suppl:40-7.
  • Holcroft JW, Vassar MJ, Weber CJ. Prostaglandin E1 and survival in patients with the adult respiratory distress syndrome. A prospective trial. Annals of Surgery 1986;203(4):371-8. [PUBMED: 3516085]
Meyer 1998 {published data only}
  • Meyer J, Theilmeier G, Van Aken H, Bone HG, Busse H, Waurick R, et al. Inhaled prostaglandin E1 for treatment of acute lung injury in severe multiple organ failure. Anesthesia and Analgesia 1998;86(4):753-8. [PUBMED: 9539597]
Pappert 1995 {published data only}
  • Pappert D, Busch T, Gerlach H, Lewandowski K, Radermacher P, Rossaint R. Aerosolized prostacyclin versus inhaled nitric oxide in children with severe acute respiratory distress syndrome. Anesthesiology 1995;82(6):1507-11. [PUBMED: 7793662]
Putensen 1998 {published data only}
  • Putensen C, Hörmann C, Kleinsasser A, Putensen-Himmer G. Cardiopulmonary effects of aerosolized prostaglandin E1 and nitric oxide inhalation in patients with acute respiratory distress syndrome. American Journal of Respiratory and Critical Care Medicine 1998;157(6 Pt 1):1743-7. [PUBMED: 9620900]
Rossignon 1990 {published data only}
  • Rossignon MD, Khayat D, Royer C, Rouby JJ, Jacquillat C, Viars P. Functional and metabolic activity of polymorphonuclear leukocytes from patients with adult respiratory distress syndrome: results of a randomized double-blind placebo-controlled study on the activity of prostaglandin E1. Anesthesiology 1990;72(2):276-81. [PUBMED: 2405741]
Shoemaker 1986 {published data only}
Van Heerden 1996 {published data only}
  • Van Heerden PV, Blythe D, Webb SA. Inhaled aerosolized prostacyclin and nitric oxide as selective pulmonary vasodilators in ARDS--a pilot study. Anaesthesia and Intensive Care 1996;24(5):564-8. [PUBMED: 8909667]
Van Heerden 2000 {published data only}
  • Van Heerden PV, Barden A, Michalopoulos N, Bulsara MK, Roberts BL. Dose-response to inhaled aerosolized prostacyclin for hypoxemia due to ARDS. Chest 2000;117(3):819-27. [PUBMED: 10713012]
Vassar 1991 {published data only}
  • Vassar MJ, Fletcher MP, Perry CA, Holcroft JW. Evaluation of prostaglandin E1 for prevention of respiratory failure in high risk trauma patients: a prospective clinical trial and correlation with plasma suppressive factors for neutrophil activation. Prostaglandins, leukotrienes and essential fatty acids 1991;44(4):223-31. [PUBMED: 1667693]
Vincent 2001 {published data only}
  • Vincent JL, Brase R, Santman F, Suter PM, McLuckie A, Dhainaut JF, et al. A multi-centre, double-blind, placebo-controlled study of liposomal prostaglandin E1 (TLC C-53) in patients with acute respiratory distress syndrome. Intensive Care Medicine 2001;27(10):1578-83. [PUBMED: 11685297]
Walmrath 1995 {published data only}
  • Walmrath D, Schneider T, Pilch J, Schermuly R, Grimminger F, Seeger W. Effects of aerosolized prostacyclin in severe pneumonia. Impact of fibrosis. American Journal of Respiratory and Critical Care Medicine 1995;151(3 Pt 1):724-30. [PUBMED: 7881662]
Walmrath 1996 {published data only}
  • Walmrath D, Schneider T, Schermuly R, Olschewski H, Grimminger F, Seeger W. Direct comparison of inhaled nitric oxide and aerosolized prostacyclin in acute respiratory distress syndrome. American Journal of Respiratory and Critical Care Medicine 1996;153(3):991-6. [PUBMED: 8630585]
Zwissler 1996 {published data only}
  • Zwissler B, Kemming G, Habler O, Kleen M, Merkel M, Haller M, et al. Inhaled prostacyclin (PGI2) versus inhaled nitric oxide in adult respiratory distress syndrome. American Journal of Respiratory and Critical Care Medicine 1996;154(6 Pt 1):1671-7. [PUBMED: 8970353]

References to ongoing studies

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
Siddiqui 2009 {unpublished data only}
  • Inhaled Prostacyclin for Adult Respiratory Distress Syndrome (ARDS) and pulmonary hypertension. Ongoing study May 2006.
Yung 2010 {unpublished data only}
  • A randomized, double blind, placebo-controlled pilot study of the safety and effective dosing of inhaled Iloprost in Pediatric Critical Care Patients with pulmonary hypertension treated with inhaled nitric oxide. Ongoing study September 2009.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
Adhikari 2004
  • Adhikari N, Burns KE, Meade MO. Pharmacologic therapies for adults with acute lung injury and acute respiratory distress syndrome. Cochrane Database of Systematic Reviews 2004, Issue 4. [DOI: 10.1002/14651858.CD004477.pub2]
Adhikari 2007
Afshari 2010
  • Afshari A, Brok J, Møller AM, Wetterslev J. Inhaled nitric oxide for acute respiratory distress syndrome (ARDS) and acute lung injury in children and adults. Cochrane Database of Systematic Reviews 2010, Issue Issue 7.
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Anderson 2003
  • Anderson MR. Update on pediatric acute respiratory distress syndrome. Respiratory Care 2003;48(3):261-76. [MEDLINE: 12667276]
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Barrington 2007
  • Barrington KJ, Finer NN. Inhaled nitric oxide for respiratory failure in preterm infants. Cochrane Database of Systematic Reviews 2007, Issue 3. [CD000509. DOI: 10.1002/14651858.CD000509.pub3]
Bekelman 2003
Bernard 1994
  • Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, Hudson L, et al. The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. American Journal of Respiratory and Critical Care Medicine 1994;149(3):818-24. [MEDLINE: 7509706]
Brok 2008
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  • Dahlem P, van Aalderen WM, Hamaker ME, Dijkgraaf MG, Bos AP. Incidence and short-term outcome of acute lung injury in mechanically ventilated children. European Respiratory Journal 2003;22(6):980-5. [PUBMED: 14680089]
Dahlem 2007
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Eichelbrönner 1996
  • Eichelbrönner O, Reinelt H, Wiedeck H, Mezödy M, Rossaint R, Georgieff M, et al. Aerosolized prostacyclin and inhaled nitric oxide in septic shock--different effects on splanchnic oxygenation?. Intensive Care Medicine 1996;22(9):880-7. [MEDLINE: 8905421]
Flori 2005
  • Flori HR, Glidden DV, Rutherford GW, Matthay MA. Pediatric acute lung injury: prospective evaluation of risk factors associated with mortality. American Journal of Respiratory and Critical Care Medicine 2005;171(9):995-1001. [PUBMED: 15618461]
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  • Hoeper MM, Olschewski H, Ghofrani HA, Wilkens H, Winkler J, Borst MM, et al. A comparison of the acute hemodynamic effects of inhaled nitric oxide and aerosolized iloprost in primary pulmonary hypertension. German PPH study group. Journal of the American College of Cardiology 2000;35(1):176-82. [MEDLINE: 10636277]
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