Intervention Review

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Interventions for clinical and subclinical hypothyroidism pre-pregnancy and during pregnancy

  1. Sally M Reid1,*,
  2. Philippa Middleton1,
  3. Mary C Cossich2,
  4. Caroline A Crowther1,3,
  5. Emily Bain1

Editorial Group: Cochrane Pregnancy and Childbirth Group

Published Online: 31 MAY 2013

Assessed as up-to-date: 8 APR 2013

DOI: 10.1002/14651858.CD007752.pub3


How to Cite

Reid SM, Middleton P, Cossich MC, Crowther CA, Bain E. Interventions for clinical and subclinical hypothyroidism pre-pregnancy and during pregnancy. Cochrane Database of Systematic Reviews 2013, Issue 5. Art. No.: CD007752. DOI: 10.1002/14651858.CD007752.pub3.

Author Information

  1. 1

    The University of Adelaide, ARCH: Australian Research Centre for Health of Women and Babies, The Robinson Institute, Discipline of Obstetrics and Gynaecology, Adelaide, South Australia, Australia

  2. 2

    Women's and Children's Hospital, Department of Paediatrics, Adelaide, South Australia, Australia

  3. 3

    The University of Auckland, Liggins Institute, Auckland, New Zealand

*Sally M Reid, ARCH: Australian Research Centre for Health of Women and Babies, The Robinson Institute, Discipline of Obstetrics and Gynaecology, The University of Adelaide, Women's and Children's Hospital, 72 King William Road, Adelaide, South Australia, 5006, Australia. sally.reid@adelaide.edu.au.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 31 MAY 2013

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[Figure 1]
Figure 1. Methodological quality graph: review authors' judgements about each methodological quality item presented as percentages across all included studies.
[Figure 2]
Figure 2. Methodological quality summary: review authors' judgements about each methodological quality item for each included study.
[Analysis 1.1]
Analysis 1.1. Comparison 1 Levothyroxine versus no treatment, Outcome 1 Pre-eclampsia.
[Analysis 1.2]
Analysis 1.2. Comparison 1 Levothyroxine versus no treatment, Outcome 2 Preterm birth.
[Analysis 1.3]
Analysis 1.3. Comparison 1 Levothyroxine versus no treatment, Outcome 3 Miscarriage (first trimester).
[Analysis 1.4]
Analysis 1.4. Comparison 1 Levothyroxine versus no treatment, Outcome 4 Gestational hypertension.
[Analysis 1.5]
Analysis 1.5. Comparison 1 Levothyroxine versus no treatment, Outcome 5 Placental abruption.
[Analysis 2.1]
Analysis 2.1. Comparison 2 Selenomethionine versus placebo, Outcome 1 Pre-eclampsia.
[Analysis 2.2]
Analysis 2.2. Comparison 2 Selenomethionine versus placebo, Outcome 2 Preterm birth.
[Analysis 2.3]
Analysis 2.3. Comparison 2 Selenomethionine versus placebo, Outcome 3 Miscarriage.
[Analysis 2.4]
Analysis 2.4. Comparison 2 Selenomethionine versus placebo, Outcome 4 Hypothyroidism (2 months after birth and after stopping levothyroxine).
[Analysis 2.5]
Analysis 2.5. Comparison 2 Selenomethionine versus placebo, Outcome 5 Postpartum thyroid dysfunction (within 12 months post delivery).
[Analysis 2.6]
Analysis 2.6. Comparison 2 Selenomethionine versus placebo, Outcome 6 Hypothyroidism (12 months post delivery).
[Analysis 2.7]
Analysis 2.7. Comparison 2 Selenomethionine versus placebo, Outcome 7 Thyroiditis (moderate or advanced at end of postpartum period).
[Analysis 2.8]
Analysis 2.8. Comparison 2 Selenomethionine versus placebo, Outcome 8 Thyroiditis (mild, moderate or advanced at end of postpartum period).