Intervention Review

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Interventions for clinical and subclinical hypothyroidism pre-pregnancy and during pregnancy

  1. Sally M Reid1,*,
  2. Philippa Middleton1,
  3. Mary C Cossich2,
  4. Caroline A Crowther1,3,
  5. Emily Bain1

Editorial Group: Cochrane Pregnancy and Childbirth Group

Published Online: 31 MAY 2013

Assessed as up-to-date: 8 APR 2013

DOI: 10.1002/14651858.CD007752.pub3


How to Cite

Reid SM, Middleton P, Cossich MC, Crowther CA, Bain E. Interventions for clinical and subclinical hypothyroidism pre-pregnancy and during pregnancy. Cochrane Database of Systematic Reviews 2013, Issue 5. Art. No.: CD007752. DOI: 10.1002/14651858.CD007752.pub3.

Author Information

  1. 1

    The University of Adelaide, ARCH: Australian Research Centre for Health of Women and Babies, The Robinson Institute, Discipline of Obstetrics and Gynaecology, Adelaide, South Australia, Australia

  2. 2

    Women's and Children's Hospital, Department of Paediatrics, Adelaide, South Australia, Australia

  3. 3

    The University of Auckland, Liggins Institute, Auckland, New Zealand

*Sally M Reid, ARCH: Australian Research Centre for Health of Women and Babies, The Robinson Institute, Discipline of Obstetrics and Gynaecology, The University of Adelaide, Women's and Children's Hospital, 72 King William Road, Adelaide, South Australia, 5006, Australia. sally.reid@adelaide.edu.au.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 31 MAY 2013

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Negro 2006 {published and unpublished data}
  • Negro R, Formoso G, Mangieri T, Pezzarossa A, Dazzi D, Hassan H. Levothyroxine treatment in euthyroid pregnant women with autoimmune thyroid disease: effects on obstetrical complications. Journal of Clinical Endocrinology and Metabolism 2006;91(7):2587-91.
Negro 2007 {published and unpublished data}
  • Negro R, Greco G, Mangieri T, Pezzarossa P, Dazzi D, Hassan H. The influence of selenium supplementation on postpartum thyroid status in pregnant women with thyroid peroxidase autoantibodies. Journal of Clinical Endocrinology and Metabolism 2007;92(4):1263-8.
Rotondi 2004 {published and unpublished data}
  • Rotondi M, Mazziotti G, Sorvillo F, Piscopo M, Cioffi M, Amato G, et al. Effects of increased thyroxine dosage pre-conception on thyroid function during early pregnancy. European Journal of Endocrinology 2004;151:695-700.
Yassa 2010 {published data only}
  • Yassa L, Marqusee E, Fawcett R, Alexander EK. Thyroid hormone early adjustment in pregnancy (the THERAPY) trial. Journal of Clinical Endocrinology and Metabolism 2010;95(7):3234-41.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Harris 2002 {published and unpublished data}
  • Harris B, Oretti R, Lazarus J, Parkes A, John R, Richards C, et al. Randomised trial of thyroxine to prevent postnatal depression in thyroid-antibody-positive women. British Journal of Psychiatry 2002;180:327-30.
Lazarus 2012 {published and unpublished data}
  • Lazarus JH. Randomised controlled trial of the effect of gestational thyroid hormone intervention therapy on childhood development. http://www.controlled-trials.com/ISRCTN46178175/ (accessed 21 June 2007).
  • Lazarus JH, Bestwick JP, Channon S, Paradice R, Maina A, Rees R, et al. Antenatal thyroid screening and childhood cognitive function. New England Journal of Medicine 2012;366(6):493-501.
Negro 2010 {published data only}
  • Negro R, Schwartz A, Gismondi R, Tinelli A, Mangieri T, Stagnaro-Green A. Universal screening versus case finding for detection and treatment of thyroid hormonal dysfunction during pregnancy. Journal of Clinical Endocrinology and Metabolism 2010;95(4):1699-707.
Petri 2011 {unpublished data only}
  • Petri M. Levothyroxine in pregnant SLE patients. ClinicalTrials.gov (http://clinicaltrials.gov/) (accessed 15 February 2011).

References to ongoing studies

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Spong 2008 {unpublished data only}
  • Spong CY. Thyroid therapy for mild thyroid deficiency in pregnancy. ClinicalTrials.gov (http://clinicaltrials.gov/) (accessed 20 February 2008).

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Abalovich 2002
Abalovich 2007
  • Abalovich M, Amino N, Barbour L, Cobin RH, De Groot LJ, Glinoer D, et al. Management of thyroid dysfunction during pregnancy and postpartum: an Endocrine Society Clinical Practice Guideline. Journal of Clinical Endocrinology and Metabolism 2007;92(8 Suppl):S1-S47.
Angermayr 2004
  • Angermayr L, Clar C. Iodine supplementation for preventing iodine deficiency disorders in children. Cochrane Database of Systematic Reviews 2004, Issue 2. [DOI: 10.1002/14651858.CD003819.pub2]
Cao 1994
  • Cao XY, Jiang XM, Dou ZH, Rakeman MA, Zhang ML, O'Donnell K, et al. Timing of vulnerability of the brain to iodine deficiency in endemic cretinism. New England Journal of Medicine 1994;331(26):1739-44.
Casey 2006
Casey 2007
  • Casey BM, Dashe JS, Spong CY, McIntire DD, Leveno KJ, Cunningham GF. Perinatal significance of isolated maternal hypothyroxinemia identified in the first half of pregnancy. Obstetrics and Gynecology 2007;109(5):1129-35.
Cleary-Goldman 2006
  • Cleary-Goldman J, Malone FD, Messerlian G, Sullivan L, Canick J. Subclinical hypothyroidism and pregnancy outcomes. American Journal of Obstetrics and Gynecology 2006;193:S3.
Contempre 1993
Davis 1988
Gharib 2005
  • Gharib H, Tuttle RM, Baskin HJ, Fish LH, Singer PA, McDermott MT, et al. Consensus Statement #1: Subclinical thyroid dysfunction: a joint statement on management from the American Association of Clinical Endocrinologists, the American Thyroid Association, and The Endocrine Society. Thyroid 2005;15(1):24-8.
Haddow 1999
  • Haddow JE, Palomaki GE, Allan WC, Williams JR, Knight GJ, Gagnon J, et al. Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child. New England Journal of Medicine 1999;341(8):549-56.
Harborne 2004
Higgins 2011
  • Higgins JPT, Green S, editors. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
Jameson 2008
  • Jameson JL, Weetman AP. Disorders of the thyroid gland. Harrison’s Principles of Internal Medicine. 17th Edition. USA: Blackwell Publishing, 2008:2224-47.
Lazarus 2005
  • Lazarus JH. Thyroid disorders associated with pregnancy: etiology, diagnosis and management. Treatments in Endocrinology 2005;4(1):31-41.
Leung 1993
Man 1969
  • Man EB, Jones WS. Thyroid function in human pregnancy: incidence of maternal serum low butanol extractable iodines and of normal gestational TBG and TBPA capacities: retardation of 8-month-old infants. American Journal of Obstetrics and Gynecology 1969;104:898-908.
McElduff 2008
Pop 1999
  • Pop VJ, Kuijpens JL, Van Baar AL, Verkerk G, Van Son MM, de Vijlder JJ, et al. Low maternal free thyroxine concentrations during early pregnancy are associated with impaired psychomotor development in infancy. Clinical Endocrinology 1999;50(2):149-55.
Premawardhana 2000
  • Premawardhana LD, Parkes LD, Ammari F, John R, Darke C, Adams H, et al. Postpartum thyroiditis and long-term thyroid status: prognostic influence of thyroid peroxidase antibodies and ultrasound echogenicity. Journal of Clinical Endocrinology and Metabolism 2000;85:71-5.
RevMan 2011
  • The Nordic Cochrane Center, The Cochrane Collaboration. Review Manager (RevMan). 5.1. Copenhagen: The Nordic Cochrane Center, The Cochrane Collaboration, 2011.
Wu 2002

References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Reid 2010