This is the protocol for a review and there is no abstract. The objectives are as follows:
To assess the efficacy of adjuvant or neo-adjuvant chemotherapy (whatever its type and mode of administration) in addition to curative surgery for initially resectable liver metastases from CRCs. The primary objective of the study is Progression Free Survival improvement with chemotherapy. The secondary objectives are the Overall survival improvement and the evaluation of liver toxicity after chemotherapy.