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Chinese herbal medicine for diabetic peripheral neuropathy

  1. Wei Chen1,*,
  2. Yin Zhang2,
  3. Xinxue Li1,
  4. Guoyan Yang1,
  5. Jian Ping Liu1

Editorial Group: Cochrane Neuromuscular Group

Published Online: 6 OCT 2013

Assessed as up-to-date: 14 MAY 2012

DOI: 10.1002/14651858.CD007796.pub3


How to Cite

Chen W, Zhang Y, Li X, Yang G, Liu JP. Chinese herbal medicine for diabetic peripheral neuropathy. Cochrane Database of Systematic Reviews 2013, Issue 10. Art. No.: CD007796. DOI: 10.1002/14651858.CD007796.pub3.

Author Information

  1. 1

    Beijing University of Chinese Medicine, Centre for Evidence-Based Chinese Medicine, Beijing, China

  2. 2

    Guang'anmen Hospital, China Academy of Chinese Medicine, Center of Clinical Evaluation, Beijing, China

*Wei Chen, Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, 11 Bei San Huan Dong Lu, Chaoyang District, Beijing, 100029, China. chen7916@hotmail.com.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 6 OCT 2013

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Cao 2010 {published data only}
  • Cao W, Wang XC, Liu KM. Clinical observation of Xiaoke Tongluo Tang on 30 diabetic peripheral neuropathy cases. Practical Clinical Journal of Integrated Traditional Chinese and Western Medicine 2010;10(2):24-5.
Cao 2011 {published data only}
  • Cao W, Luo JH. Zhuyu Huatan Tang for treating diabetic peripheral neuropathy in 40 cases. Traditional Chinese Medicine Research 2011;24(1):43-4.
Chen 2006 {published data only}
  • Chen LP, Liu M. Observation on the effect of modified Huangqi Guizhi Wuwu Tang combined with mecobalamin in treating 34 patients with diabetic peripheral neuropathy. New Journal of Traditional Chinese Medicine 2006;38(6):56-7.
Chen 2009 {published data only}
  • Chen YC. Clinical observation of Tongbi Tang in the treatment of 43 diabetic peripheral neuropathy patients. Guiding Journal of Traditional Chinese Medicine and Pharmacy 2009;15(1):25-6.
Cheng 2005 {published data only}
  • Cheng QC, Lv QM. Modified Sishen decoction on 35 diabetic peripheral neuropathy cases. Journal of Medical Theory & Practice 2005;18(5):555-6.
Ding 2010 {published data only}
  • Ding BM. Qiqi Yangxue Huoxue formula for the treatment of diabetic peripheral neuropathy on 32 cases. Shaanxi Journal of Traditional Chinese Medicine 2010;31(4):417-9.
Gao 2008 {published data only}
  • Gao H, Lu XL. Clinical observation on effectiveness and influence of Compound Qiying Granule on homocysteine in DPN patients. Nei Mongol Journal of Traditional Chinese Medicine 2008;18(4):2-5.
Hao 2010 {published data only}
  • Hao LP, Wu MY. Observation on the treatment of diabetes peripheral neuropathy with Xuesaitong tablet and mecobalamine. Internal Journal of Traditional Chinese Medicine 2010;32(6):511-2.
He 2005 {published data only}
  • He T, Hao YL. Xuesaitong capsule on 33 diabetic peripheral neuropathy cases. Chinese Journal of Integrated Traditional and Western Medicine 2005;25(2):166.
Hu 2005 {published data only}
  • Hu L, Wang X. Clinical observation on the method of invigorating the spleen, benefiting vital energy and freeing the network vessels in treating 24 cases of diabetic peripheral neuropathy. Chinese Journal of Current Traditional and Western Medicine 2005;3(15):1394-6.
Jiao 2007 {published data only}
  • Jiao XK, Yang LB. Clinical study of the combination of Tongxinluo capsule and mecobalamin on the treatment effect in diabetic peripheral neuropathy. Pharmacology and Clinics of Chinese Materia Medica 2007;23(1):71-2.
Li 2001 {published data only}
  • Li J. Observation on the effect of Tongxinluo capsule in treating diabetic peripheral neuropathy. Journal of Guangxi Medical University 2001;18(5):681-2.
Li 2005 {published data only}
  • Li ZL. Clinical observation on the treatment of diabetic peripheral neuropathy with combination of Modified Huangqi Guizhi Wuwu Tang and Western Medicine. Guiding Journal of Traditional Chinese Medicine 2005;11(1):36-8.
Li 2008b {published data only}
  • Li YB. Combination of Tongxinluo capsule and mecobalamin on 24 diabetic peripheral neuropathy cases. Beijing Journal of Traditional Chinese Medicine 2008;27(8):596-8.
Li 2009 {published data only}
  • Li Y. Clinical observation on Chinese and Western Medicine treatment on 18 diabetic peripheral neuropathy patients. Guiding Journal of Traditional Chinese Medicine and Pharmacy 2009;15(4):27-9.
Li 2010 {published data only}
  • Li H, Zhang XH, Shan SQ. Effect of prescription with dispelling dampness and dredging collaterals on diabetic peripheral neuropathy. Hebei Chinese Medicine 2010;32(9):1293-5.
Lin 2008 {published data only}
  • Lin ZH, Du ZH. Effectiveness observation on Chinese compound prescription for diabetic peripheral neuropathy. Modern Traditional Chinese Medicine 2008;28(4):6-7.
Lin 2008a {published data only}
  • Lin ZY. Combination of Xuefu Zhuyu capsule and methycobal on 30 diabetic peripheral neuropathy cases. Jiangxi Journal of Traditional Chinese Medicine 2008;39(303):31-2.
Liu 2001 {published data only}
  • Liu HQ, Li P, Liu CS. The influence of aloe on the nerve conduction velocity of diabetic peripheral neuropathy patients. Clinical Focus 2001;16(15):682-4.
Liu 2004 {published data only}
  • Liu LF. Clinical observation of Tongxinluo capsule in treating diabetic peripheral neuropathy. Chinese Journal of Integrated Traditional and Western Medicine 2004;24(4):36768.
Liu 2006 {published data only}
  • Liu C. Observation on 58 cases of diabetic peripheral neuritis with He Gong collateral - Dredging therapy. Modern Traditional Chinese Medicine 2006;26(3):3-5.
Liu 2008 {published data only}
  • Liu DX. Clinical observation on the treatment of 58 cases of diabetic peripheral neuropathy by modified Buyang Huanwu Tang. Guiding Journal of Traditional Chinese Medicine and Pharmacy 2008;14(6):43-5.
Liu 2011 {published data only}
  • Liu ZC. Integrative medicine for treating diabetic peripheral neuropathy in 40 cases. Chinese Medicine Modern Distance Education of China 2011;9(2):77-8.
Luo 2008 {published data only}
  • Luo ML, Li QX. Clinical observation on warming-meridian-and-nourishing-qi-blood method for diabetic peripheral neuropathy. Journal of Sichuan of Traditional Chinese Medicine 2008;26(5):41-3.
Luo 2009 {published data only}
  • Luo ML, Cai SB, Liang RQ. Clinical Observation of Yiyiren Tang in the treatment of painful diabetic neuropathy. Liaoning Journal of Traditional Chinese Medicine 2009;36(8):1359-61.
Ma 2008 {published data only}
  • Ma XY, Lu HX, Li Y. Clinical observation of Fufang Danshen injection and methycobal in treating diabetic peripheral neuropathy. Medical Journal of National Defending Forces in Southwest China 2008;18(3):391-2.
Niu 2008 {published data only}
  • Niu YY, Zhao GH. Clinical experiences in Chinese and Western integrative medicine for diabetic peripheral neuropathy. China Medical Herald 2008;5(20):87-8.
Peng 2009 {published data only}
  • Peng ZC, Huang PM. Clinical Observation on Yiqitongluo Tang treatment of 45 diabetic peripheral neuropathy patients. Guiding Journal of Traditional Chinese Medicine and Pharmacy 2009;15(3):43-4.
Shen 2009 {published data only}
  • Shen J, Shu XC. Clinical study of Tangmaining capsule in the treatment of diabetic peripheral neuropathy. Chinese Journal of Experimental Traditional Medical Formulae 2009;15(1):74-6.
Shu 2007 {published data only}
  • Shu CX, Yu LH. Clinical observation of modified Huangqi Guizhi Wuwu Tang in treating diabetic peripheral neuropathy. Guangxi Journal of Traditional Chinese Medicine 2007;30(4):12-3.
Sun 2008 {published data only}
  • Sun SZ, Wang YZ. Therapeutic effect of Buyang Huanwu Tang combined with methylcobalamin on 42 diabetic peripheral neuropathy. Jiangsu Journal of Traditional Chinese Medicine 2008;40(3):48-9.
Sun 2009 {published data only}
  • Sun HK, Tian Y. Clinical observation on modified Wuyang Huanwu Tang treatment on diabetic peripheral neuropathy patients. Beijing Journal of Traditional Chinese Medicine 2009;28(7):541-2.
Sun 2010 {published data only}
  • Sun WL, Guo HY, Chen JL, Yu WX, Li BF, Su XH. Clinical observation of Furongtong capsule in treating diabetic peripheral neuropathy. Chinese Journal of Information on TCM 2010;17(3):80-1.
Sun 2010b {published data only}
  • Sun YF. Clinical observation modified Duhuo Jisheng decoction in treatment of DPN. Beijing Journal of Traditional Chinese Medicine 2010 July;29(07):555-6.
Wang 2008 {published data only}
  • Wang WJ. Clinical observation on the treatment of diabetic peripheral neuropathy with Guizhi Gegen Tang. Chinese Journal of Information on Traditional Chinese Medicine 2008;15(2):77-8.
Wu 2003 {published data only}
  • Wu QH. Clinical observation of Erigeron in treating diabetic peripheral neuropathy. Zhejiang Clinical Medical Journal 2003;5(12):922-3.
Wu 2006 {published data only}
  • Wu DH. Therapeutic effect of Ciwujia injection on diabetic peripheral neuropathy. Medical Forums in Basic 2006;10(6):520.
Wu 2010 {published data only}
  • Wu MY, Hao LP. Observation on the treatment diabetic peripheral neuropathy with methylcobalamln and Chinese medicines of nourishing Yin and promoting blood circulation. International Journal of Traditional Chinese Medicine 2010;32(2):144-5.
Xie 2008 {published data only}
  • Xie WT, Pei CC, Yuan JF, Zhu CY. Combination of modified Taoren Honghua Jian and Methycobal on 40 diabetic peripheral neuropathy cases. Guangxi Journal of Traditional Chinese Medicine 2008;31(3):9-10.
Xin 2003 {published data only}
  • Xin L, Tong WX, Zhang RJ, Chen YH. Xuesaitong injection on 31 diabetic peripheral neuropathy cases. Chinese Journal of Integrated Traditional and Western Medicine 2003;23(3):230.
Yan 2006 {published data only}
  • Yan GH, Hou QZ, Guo WB. Observation on the effect of modified Danggui Sini Tang in treating 35 patients with diabetic peripheral neuropathy. New Journal of Traditional Chinese Medicine 2006;38(7):53-4.
Yan 2008 {published data only}
  • Yan QZ, Feng D. Combination of Chinese and western therapies on diabetic peripheral neuropathy. Shanxi Journal of Traditional Chinese Medicine 2008;24(6):30-1.
Yang 2011 {unpublished data only}
  • Yang YL. Dredging method in the treatment of diabetes fundamental peripheral neuropathy clinical research [Dissertation for a Master's Degree]. Nanjing University of Chinese Medicine, Nanjing, China 2010.
Yao 2010 {published data only}
  • Yao GM, Hu SY. Therapeutic observation of tonifying kidney and activating blood therapy for treatment of DPN. Chinese Journal of Primary Medicine Pharmacy 2010;17(13):1800-1.
Yin 2011 {published data only}
  • Yin LP, Du L, Zhou XH, Xie CG. The effect of Tongluo Tangtai Decoction on the conduction velocity of sensory nerve of patients with diabetic peripheral neuropathy. Conference Proceeding of the 5th International TCM Diabetes Conference and the Establishing Meeting of TCM Diabetic Clinical Trials Federation. Cheng Du: China Association of Chinese Medicine, 2011:186-90.
Zhang 2007 {published data only}
  • Zhang MG. Observation of formulas of nourish qi, promote blood circulation and warm yang on diabetic peripheral neuropathy cases. Clinical Journal of Traditional Chinese Medicine 2007;19(5):430-1.
Zhao 2008 {published data only}
  • Zhao W, Li XQ, Yang J, Xu HS, Zhao S. Clinical study of Tangluoan capsule in treating diabetic peripheral neuropathy. Shanghai Journal of Traditional Chinese Medicine 2008;42(10):33-5.
Zhou 2006 {published data only}
  • Zhou XH, Li L, Mou DY, Xia JL, Zheng JM. Treating diabetic peripheral neuropathy with methycobal and Huangqi Guizhi Wuwu Tang. Journal of Integrated Traditional Chinese and Western Medicine 2006;16(8):469-70.
Zhou 2010a {published data only}
  • Zhou XL. Clinical observation on Yiqi Huayu Tongbi Decoction for treating diabetic peripheral neuropathy (syndrome of the deficiency of qi and yin combined with blood stasis). Liaoning Journal of Traditional Chinese Medicine 2010;37(7):1297-8.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Chrubasik 2002 {published data only}
  • Chrubasik S. Jinmaitong composita for diabetic peripheral neuropathy. Focus on Alternative and Complementary Therapies 2002;7(1):16.
He 2005a {published data only}
  • He TH. Effects of Zhenyuan capsule in ameliorating the symptoms of aching and numbness of limbs in diabetic patients evaluated by nerve conduction velocity. Chinese Journal of Clinical Rehabilitation 2005;9(33):16-7.
Incandela 2001 {published data only}
  • Incandela L, Belcaro G, Cesarone MR, De Sanctis MT, Nargi E, Patricelli P, et al. Treatment of diabetic microangiopathy and edema with total triterpenic fraction of Centella asiatica: a prospective, placebo-controlled randomized study. Angiology 2001;52 Suppl 2:27-31.
Jamal 1990 {published data only}
Lane 2006 {published data only}
  • Lane N. FACT focuses on diabetic neuropathy, ginseng in colds, and homoeopathy. Pharmaceutical Journal 2006;276(7390):275.
Leonard 2004 {published data only}
  • Leonard DR, Farooqi MH, Myers S. Restoration of sensation, reduced pain, and improved balance in subjects with diabetic peripheral neuropathy: a double-blind, randomized, placebo-controlled study with monochromatic near-infrared treatment. Diabetes Care 2004;27(1):168-72.
Li 1999 {published data only}
  • Li M, Wang X. Clinical observation on treatment of diabetic peripheral neuropathy with reinforced tianma duzhong capsule. Journal of Traditional Chinese Medicine 1999;19(3):182-4.
Li 2009a {published data only}
  • Li YW, Yang Y, Chen FJ, Chen HL. Qiqi Huoxue Decoction plus. Chinese Journal of Modern Drug Application 2009;3(1):120-1.
Ren 2000 {published data only}
  • Ren H. A clinical study on treatment of diabetic peripheral neuropathy with tang zhi min capsules. Journal of Traditional Chinese Medicine 2000;20(4):258-61.
Sakamoto 1987 {published data only}
  • Sakamoto M, Sato Y, Goto Y. Treatment of diabetic neuropathy with traditional oriental medicine. Journal of the Japan Diabetes Society 1987;30(8):729-37.
Shu 2011 {published data only}
  • Shu C. Clinical observation of modified Huangqi Guizhi Wuwu decoction in treating DPN . 9th promoting blood circulation and removing blood stasis. Academic seminar thesis book. 2011.
Tawata 1994 {published data only}
  • Tawata M, Kurihara A, Nitta K, Iwase E, Gan N, Onaya T. The effects of goshajinkigan, a herbal medicine, on subjective symptoms and vibratory threshold in patients with diabetic neuropathy. Diabetes Research & Clinical Practice 1994;26(2):121-8.
Tong 2006 {published data only}
Wang 2012 {published data only}
  • Wang N. Yiqi Huoxue Tongluo Tang combined with Western medicine for treating diabetic peripheral neuropathy in 40 cases. Traditional Chinese Medicine Research 2012;25(1):24-5.
Yang 2011a {published data only}
  • Yang JC. Clinical research on effectiveness of self-prescribed decoction for treating diabetic peripheral neuropathy. Information on Traditional Chinese Medicine 2011;28(4):110-1.
Zhang 2011 {published data only}
  • Zhang GH. The effect of Jiangtang Tongluo decoction for treating diabetic peripheral neuropathy in 36 cases. China Foreign Medical Treatment 2011;7(11):81.
Zhou 2007 {published data only}
  • Zhou WQ, Lu XW, Zhu LH. Internal and external treatment of integrated Chinese and western medicine on type 2 diabetic peripheral neuropathy. Journal of Traditional Chinese Medicine 2007;48(1):41-3.
Zhou 2010 {published data only}
  • Zhou YH. Clinical analysis of modified Buyang Huanwu Tang on diabetic peripheral neuropathy. Medical Information 2010;6(2):417-8.
Zhou 2010b {published data only}
  • Zhou ZR, Kang J, Zhang NN, Hou PH. Clinical study on Shu Xue Tong for treatment of DPN. Chinese Archives of Traditional Chinese Medicine 2010;28(3):663-5.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Adler 1997
  • Adler AI, Boyko EJ, Ahroni JH, Stensel V, Forsberg RC, Smith DG. Risk factors for diabetic peripheral sensory neuropathy: results of the Seattle Prospective Diabetic Foot Study. Diabetes Care 1997;20(Jul):1162-7.
Ametov 2003
  • Ametov AS, Barinov A, Dyck PJ, Hermann R, Kozlova N, Litchy WJ, et al. The sensory symptoms of diabetic polyneuropathy are improved with alpha-lipoic: the SYDNEY trial. Diabetes Care 2003;26(3):770-6.
Callaghan 2012
DCCT 1988
  • The Diabetes Control and Complications Trial Research Group. Factors in development of diabetic neuropathy. Baseline analysis of neuropathy in feasibility phase of Diabetes Control and Complications Trial (DCCT). Diabetes 1988;37(4):476-81.
DCCT 1993
  • The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. New England Journal of Medicine 1993;329(14):977-86.
Duby 2004
Egger 1997
Fan 1999
  • Fan DF, Weng XG, Dou JF. The clinical observation of Tetramethylpyrazine for diabetic peripheral neuropathy. Chinese Journal of Integrated Traditional and Western Medicine 1999;19:550-1.
Fedele 1997
Gagnier 2006
  • Gagnier JJ, Boon H, Rochon P, Moher D, Barnes J, Bombardier C. Reporting randomized, controlled trials of herbal interventions: an elaborated CONSORT statement. Annals of Internal Medicine 2006;144(5):364-7.
Girach 2006
Gottieb 2000
Halat 2003
  • Halat KM, Dennehy CE. Botanicals and dietary supplements in diabetic peripheral neuropathy. The Journal of the American Board of Family Practice 2003;16(1):47-57.
Higgins 2008
  • Higgins JPT, Green S, editors. Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.0. The Cochrane Collaboration 2008.
Higgins 2011
  • Higgins JPT, Altman DG, Sterne JAC (editors). Chapter 8: Assessing risk of bias in included studies. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
Ishizaki 1996
  • Ishizaki T, Sasaki F, Ameshima S, Shiozaki K, Takahashi H, Abe Y, et al. Pneumonitis during interferon and/or herbal drug therapy in patients with chronic active hepatitis. European Respiratory Journal 1996;9(12):2691-6.
Kjaergard 2001
Li 2008
  • Li J, Wan Z. Prostaglandin E1 in conjunction with high doses of vitamin B12 improves nerve conduction velocity of patients with diabetic peripheral neuropathy. Neural Regeneration Research 2008;3:529-32.
Maser 1989
  • Maser RE, Steenkiste AR, Dorman JS, Nielsen VK, Bass EB, Manjoo Q, et al. Epidemiological correlates of diabetic neuropathy. Report from the Pittsburgh Epidemiology of Diabetes Complications Study. Diabetes 1989;38(11):1456-61.
Melchart 1999
Moher 1998
  • Moher D, Pham B, Jones A, Cook DJ, Jadad AR, Moher M, et al. Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses?. Lancet 1998;352:609-13.
Moher 2010
  • Moher D, Hopewell S, Schulz KF, Montori V, Gotzsche PC, Devereaux PJ, Elbourne D, Egger M, Altman DG, for the CONSORT Group. CONSORT 2010 Explanation and Elaboration: updated guidelines for reporting parallel group randomised trial. BMJ 2010;340:c869.
O'Hare 1994
Oates 2001
  • Oates PJ. The polyol pathway and diabetic peripheral neuropathy. In: Tomlinson DR editor(s). The neurobiology of diabetic neuropathy. New York, NY: Academic Press, 2001.
Perkins 2001
Perkins 2003
Pocock 1990
  • Pocock SJ. Clinical Trials: A Practical Approach. UK: John Wiley & Sons, 1990.
Revill 1976
Schulz 1995
Schulz 2010
Shichiri 2000
  • Shichiri M, Kishikawa H, Ohkubo Y, Wake N. Long-term results of the Kumamoto study on optimal diabetes control in type 2 diabetic patients. Diabetes Care 2000;23 Suppl 2:B21-9.
Siemionow 2004
Sun 2005
  • Sun Y, Lai MS, Lu CJ. Effectiveness of vitamin B12 on diabetic neuropathy: systematic review of clinical controlled trials. Acta Neurologica Taiwanica 2005;14(2):48-52.
Tang 1999
Tesfaye 1996
  • Tesfaye S, Stevens LK, Stephenson JM, Fuller JH, Plater M, Ionescu-Tirgoviste C et al. and the EURODIAB IDDM Study Group. Prevalence of diabetic peripheral neuropathy and its relation to glycaemic control and potential risk factors: the EURODIAB IDDM Complications Study. Diabetologia 1996;39(11):1377-84.
Tong 2003
  • Tong Y, Hou H. Effects of Huangqi Guizhi Wuwu Tang on diabetic peripheral neuropathy. Zhongguo Zhong Xi Yi Jie He Za Zhi 2003;23:826-8.
Tu 2006
  • Tu Y, Fei YT. Practice and Exploration of Chinese Model "Integration of Chinese/Western Medicine". Towards Integrative Medicine: Japan, Korea and China. 2006.
UKPDS 1998
  • UKPDS. Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38. BMJ 1998;317(7160):703-13.
Vickers 1998
Vincent 2002
  • Vincent AM, Brownlee M, Russell JW. Oxidative stress and programmed cell death in diabetic neuropathy. Annals of the New York Academy of Sciences 2002;Apr;959:368-83.
Vinik 1999
  • Vinik AI. Diabetic neuropathy: pathogenesis and therapy. American Journal of Medicine 1999;20:198-204.
Vinik 2000
Ware 1992
WHO 1999
  • WHO Diagnosis and Classification of Diabetes Mellitus. WHO Department of Noncommunicable Disease Surveillance 1999.
Zhang 2006
  • Zhang DG, Zhao Y, Xia PJ, Huang XQ, Liu ZM, Zhou H, et al. Effects of Tongluo recipe on experimental diabetic peripheral neuropathy in rats. Zhong Xi Yi Jie He Xue Bao 2006;4(6):601-5.

References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Chen 2011