This is the protocol for a review and there is no abstract. The objectives are as follows:
To assess the effectiveness of antiseptic or antibiotic impregnation, coating or bonding on CVC in reducing catheter related infections in adult patients who require central venous catheterization, along with their safety and cost-effectiveness where data are available. Specifically, we plan to undertake the following comparisons:
Catheters with antimicrobial modifications in the form of antiseptic or antibiotic impregnation, coating or bonding against catheters without antimicrobial modifications.
Catheters with one type of antimicrobial impregnation against catheters with another type of antimicrobial impregnation.
Catheters with any type of antimicrobial impregnation against catheters with other antimicrobial modifications, for example, anti-septic dressings, hubs, tunnelling, needleless connectors or anti-septic lock solutions.
Additionally, we will examine as subgroup analyses the effectiveness, safety and cost-effectiveness of these catheters in patients for whom they are intended for use over short term (< 10 days) versus long term, in studies using different types of catheter impregnation (e.g. C-SS or MR) in the experimental arm, in studies performed in settings with different levels of care (e.g. intensive care unit, standard ward and oncology unit), in studies with consensus definitions of clinical sepsis versus other definitions, in studies that examine these modified catheters with and without co-interventions, and in studies that assess cost-effectiveness in different units of measurement (e.g. different currencies).