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De-escalation of antimicrobial treatment for adults with sepsis, severe sepsis or septic shock

  1. Brenda NG Silva1,*,
  2. Régis B Andriolo2,
  3. Álvaro N Atallah3,
  4. Reinaldo Salomão4

Editorial Group: Cochrane Anaesthesia, Critical and Emergency Care Group

Published Online: 28 MAR 2013

Assessed as up-to-date: 31 OCT 2012

DOI: 10.1002/14651858.CD007934.pub3

How to Cite

Silva BNG, Andriolo RB, Atallah ÁN, Salomão R. De-escalation of antimicrobial treatment for adults with sepsis, severe sepsis or septic shock. Cochrane Database of Systematic Reviews 2013, Issue 3. Art. No.: CD007934. DOI: 10.1002/14651858.CD007934.pub3.

Author Information

  1. 1

    Centro de Estudos de Medicina Baseada em Evidências e Avaliação Tecnológica de Saúde, Brazilian Cochrane Centre, São Paulo, São Paulo, Brazil

  2. 2

    Universidade do Estado do Pará, Department of Public Health, Belém, Pará, Brazil

  3. 3

    Centro de Estudos de Medicina Baseada em Evidências e Avaliação Tecnológica em Saúde, Brazilian Cochrane Centre, São Paulo, São Paulo, Brazil

  4. 4

    Universidade Federal de São Paulo, Department of Medicine, São Paulo, São Paulo, Brazil

*Brenda NG Silva, Brazilian Cochrane Centre, Centro de Estudos de Medicina Baseada em Evidências e Avaliação Tecnológica de Saúde, Rua Borges Lagoa, 564 cj 63, Vl. Clementino, São Paulo, São Paulo, 04038-000, Brazil.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 28 MAR 2013



References to studies excluded from this review

  1. References to studies excluded from this review
  2. References to ongoing studies
  3. Additional references
  4. References to other published versions of this review
Bailey 1996 {published data only}
  • Bailey RR, Begg EJ, Smith AH, Robson RA, Lynn KL, Chambers ST, et al. Prospective, randomized, controlled study comparing two dosing regimens of gentamicin/oral ciprofloxacin switch therapy for acute pyelonephritis. Clinical Nephrology 1996;46(3):183-6. [PUBMED: 8879853]
Bouadma 2010 {published data only}
  • Bouadma L, Luyt CE, Tubach F, Cracco C, Alvarez A, Schwebel C, et al. Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomised controlled trial. Lancet 2010;375(9713):463-74. [NCT00472667; PUBMED: 20097417]
Christ-Crain 2004 {published data only}
  • Bergmans DC, Bonten MJ, Gaillard CA, van Tiel FH, van der Geest S, de Leeuw PW, et al. Indications for antibiotic use in ICU patients: a one-year prospective surveillance. Journal of Antimicrobial Chemotherapy 1997;39(4):527-35. [PUBMED: 9145828]
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References to ongoing studies

  1. References to studies excluded from this review
  2. References to ongoing studies
  3. Additional references
  4. References to other published versions of this review
Leone 2012 {published data only}
  • De-escalation of Empirical Antimicrobial Therapy Study in Severe Sepsis. Ongoing study October 2011.

Additional references

  1. References to studies excluded from this review
  2. References to ongoing studies
  3. Additional references
  4. References to other published versions of this review
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References to other published versions of this review

  1. References to studies excluded from this review
  2. References to ongoing studies
  3. Additional references
  4. References to other published versions of this review
Silva 2010
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