Characteristics of excluded studies [ordered by study ID]
|Study||Reason for exclusion|
|Bailey 1996||Intervention not of interest: single large iv dose (10 mg/kg) of gentamicin with a standard multiple dose regimen of gentamicin.|
|Bouadma 2010||Intervention not of interest, patients were randomized to:|
The patients were not randomized to have an initial empirical and broad-spectrum antimicrobial therapy, adjusted according to the culture results or clinical condition.
|Christ-Crain 2004||Intervention not of interest: patients randomized to be monitored by inflammatory marker (procalcitonin) or control group. The patients were not randomized to have their antimicrobial therapy adjusted according to the culture results or clinical condition.|
Clinical condition out of area of interest: ICU patients with no obvious site of Infection.
|Horisberger 2004||Interventions not of interest: routine sepsis work up versus intervention strategy with additional cytokine measurements.|
Clinical condition not of interest: paediatric patients.
|Jensen 2008||Interventions not of interest: procalcitonin measurements.|
Clinical condition out of area of interest: ICU patients.
|Mabasa 2009||Intervention out of area of interest: participants with septic shock were randomized to have renally adjusted dosage of antibiotics.|
|Masaoka 2000||Interventions out of area of interest: intravenous immunoglobulin in combination therapy with antibiotics versus antibiotics monotherapy.|
|Roberts 2009||Intervention out of area of interest: different daily doses of piperacillin-tazobactam by bolus dosing or continuous infusion.|
|Schroeder 2009||Intervention out of area of interest, patients were randomized to:|
be monitored by inflammatory marker (procalcitonin),
control group (absence of monitoring by inflammatory markers).
|van den Anker 1995||Intervention not of interest (once-daily versus twice-daily administration of ceftazidime), clinical condition not of interest|
|Vuori-Holopainen 2000||Interventions out of area of interest: procaine penicillin intramuscularly (narrow-spectrum antimicrobial) versus cefuroxime intravenously (broad-spectrum antimicrobial) for 4 to 7 days.|
Clinical condition out of area of interest: common infections of childhood.
Characteristics of ongoing studies [ordered by study ID]
|Trial name or title||De-escalation of Empirical Antimicrobial Therapy Study in Severe Sepsis|
|Methods||Open label randomized controlled trial|
Subject having a sepsis engraves (burns) defined according to the following criteria during the initiation of the probability antibiotic treatment:
criteria of SIRS [14 ], and
a suspected infection, and
a failure of organ: low blood pressure, respiratory failure, coma, hepatic insufficiency, renal insufficiency, thrombopenia, spontaneous extension of the TCA.
Subject for which an antibiotic treatment was begun within 6 hours following the diagnosis of sepsis engraves (burns).
Subject for which taking the microbiological aim was made within 48 hours following the diagnosis of sepsis.
|Interventions||1. Experimental: a strategy based on de-escalation intervention. Procedure: streamlining of the empirical antimicrobial therapy|
2. Active comparator: a conservative strategy intervention. Procedure: continuation of the empirical antimicrobial therapy
|Starting date||October 2011|
|Contact information||Marc Leone email@example.com|