This is the protocol for a review and there is no abstract. The objectives are as follows:
To determine the effects of psychological and pharmacological interventions for depression in CAD patients with comorbid depressive disorder. Effectiveness will be evaluated regarding different types of outcomes. Primary outcomes are remission of depression or reduction of depressive symptoms following the intervention, all-cause and CAD-related mortality as well as non-fatal cardiac events or surgery (coronary artery bypass graft (CABG), percutaneous transluminal coronary angioplasty (PTCA)). Secondary outcomes are health care costs or resource utilisation and health-related quality of life.