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Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults

  1. Sheena Derry*,
  2. R Andrew Moore

Editorial Group: Cochrane Pain, Palliative and Supportive Care Group

Published Online: 30 APR 2013

Assessed as up-to-date: 5 MAR 2013

DOI: 10.1002/14651858.CD008040.pub3


How to Cite

Derry S, Moore RA. Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults. Cochrane Database of Systematic Reviews 2013, Issue 4. Art. No.: CD008040. DOI: 10.1002/14651858.CD008040.pub3.

Author Information

  1. University of Oxford, Pain Research and Nuffield Department of Clinical Neurosciences, Oxford, Oxfordshire, UK

*Sheena Derry, Pain Research and Nuffield Department of Clinical Neurosciences, University of Oxford, Pain Research Unit, Churchill Hospital, Oxford, Oxfordshire, OX3 7LE, UK. sheena.derry@ndcn.ox.ac.uk.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 30 APR 2013

SEARCH

[Figure 1]
Figure 1. Methodological quality graph: review authors' judgements about each methodological quality item presented as percentages across all included studies.
[Figure 2]
Figure 2. Forest plot of comparison: 1 Paracetamol 1000 mg versus placebo, outcome: 1.1 Pain-free at 2 hours.
[Figure 3]
Figure 3. Forest plot of comparison: 1 Paracetamol 1000 mg versus placebo, outcome: 1.3 Headache relief at 2 hours.
[Analysis 1.1]
Analysis 1.1. Comparison 1 Paracetamol 1000 mg versus placebo, Outcome 1 Pain-free at 2 hours.
[Analysis 1.2]
Analysis 1.2. Comparison 1 Paracetamol 1000 mg versus placebo, Outcome 2 Headache relief at 1 hour.
[Analysis 1.3]
Analysis 1.3. Comparison 1 Paracetamol 1000 mg versus placebo, Outcome 3 Headache relief at 2 hours.
[Analysis 1.4]
Analysis 1.4. Comparison 1 Paracetamol 1000 mg versus placebo, Outcome 4 Any adverse event.
[Analysis 1.5]
Analysis 1.5. Comparison 1 Paracetamol 1000 mg versus placebo, Outcome 5 Use of rescue medication at 6 h.
[Analysis 1.6]
Analysis 1.6. Comparison 1 Paracetamol 1000 mg versus placebo, Outcome 6 Relief of associated symptoms at 2 hours.
[Analysis 1.7]
Analysis 1.7. Comparison 1 Paracetamol 1000 mg versus placebo, Outcome 7 Relief of functional disability at 2 hours.
[Analysis 2.1]
Analysis 2.1. Comparison 2 Paracetamol 1000 mg plus metoclopramide 10 mg versus sumatriptan 100 mg, Outcome 1 Headache relief at 2 hours.
[Analysis 2.2]
Analysis 2.2. Comparison 2 Paracetamol 1000 mg plus metoclopramide 10 mg versus sumatriptan 100 mg, Outcome 2 Any adverse event.
[Analysis 2.3]
Analysis 2.3. Comparison 2 Paracetamol 1000 mg plus metoclopramide 10 mg versus sumatriptan 100 mg, Outcome 3 Major adverse event.
[Analysis 2.4]
Analysis 2.4. Comparison 2 Paracetamol 1000 mg plus metoclopramide 10 mg versus sumatriptan 100 mg, Outcome 4 Use of rescue medication at 24 h.
[Analysis 2.5]
Analysis 2.5. Comparison 2 Paracetamol 1000 mg plus metoclopramide 10 mg versus sumatriptan 100 mg, Outcome 5 Relief of light/noise sensitivity at 2 hours.