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Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults

  1. Sheena Derry*,
  2. R Andrew Moore

Editorial Group: Cochrane Pain, Palliative and Supportive Care Group

Published Online: 30 APR 2013

Assessed as up-to-date: 5 MAR 2013

DOI: 10.1002/14651858.CD008040.pub3


How to Cite

Derry S, Moore RA. Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults. Cochrane Database of Systematic Reviews 2013, Issue 4. Art. No.: CD008040. DOI: 10.1002/14651858.CD008040.pub3.

Author Information

  1. University of Oxford, Pain Research and Nuffield Department of Clinical Neurosciences, Oxford, Oxfordshire, UK

*Sheena Derry, Pain Research and Nuffield Department of Clinical Neurosciences, University of Oxford, Pain Research Unit, Churchill Hospital, Oxford, Oxfordshire, OX3 7LE, UK. sheena.derry@ndcn.ox.ac.uk.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 30 APR 2013

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Dexter 1985 {published data only}
  • Dexter SL, Graham AN, Johnston ES, Ratcliffe DM, Wilkinson MI, Rose AJ. Double-blind controlled study of paramax in the acute treatment of common and classical migraine. British Journal of Clinical Practice 1985;39(10):388-92.
Dowson 2000 {published data only}
  • Dowson A, Ball K, Haworth D. Comparison of a fixed combination of domperidone and paracetamol (Domperamol) with sumatriptan 50 mg in moderate to severe migraine: a randomised UK primary care study. Current Medical Research and Opinion 2000;16(3):190-7.
Freitag 2008 {published data only}
GL/MIG/001/92 {unpublished data only}
  • A double-blind, general practice study to compare GR43175 with paracetamol and metoclopramide in the acute treatment of migraine (Original protocol). 1992. Available at: www.gsk-clinicalstudyregister.com/.
GL/MIG/001A/92 {unpublished data only}
  • A double-blind, general practice study to compare GR43175 with paracetamol and metoclopramide in the acute treatment of migraine (Amended protocol). 1992. Available at: www.gsk-clinicalstudyregister.com/.
Hoernecke 1993 {published data only}
  • Hoernecke R, Doenicke A. Treatment of migraine attacks: combination of dihydroergotamine tartrate and paracetamol in comparison with individual drugs and placebo [Behandlung des Migraneanfalls: die Kombination Dihydroergotamintartrat und Paracetamol im Vergleich zu den Einzelsubstanzen und Placebo]. Medizinische Klinik (Munich) 1993;88(11):642-8.
Lipton 2000 {published data only}
  • Lipton RB, Baggish JS, Stewart WF, Codispoti JR, Fu M. Efficacy and safety of acetaminophenin the treatment of migraine. Results of a randomized, double-blind, placebo-controlled, population-based study. Archives of Internal Medicine 2000;160(22):3486-92.
MacGregor 1993 {published data only}
Norrelund 1989 {published data only}
  • Nørrelund N, Christiansen LV, Plantener S. Tolfenamic acid versus paracetamol in migraine attacks. A double-blind study in general practice [Tolfenamsyre versus paracetamol ved migraeneanfald. En dobbeltblind undersogelse i almen praksis]. Ugeskrift for Laeger 1989;151(38):2436-8.
Oztürk 2012 {published data only}
  • Oztürk V, Ertaş M, Baykan B, Sirin H, Ozge A, The Mig-Etol Study Group. Efficacy and safety of 400 and 800 mg etodolac vs. 1,000 mg paracetamol in acute treatment of migraine: a randomized, double-blind, crossover, multicenter, phase III clinical trial. Pain Practice 2012:Epub ahead of print. [DOI: 10.1111/j.1533-2500.2012.00572.x]
Prior 2010 {published data only}

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Diamond 1976 {published data only}
Diener 2005 {published data only}
Larsen 1990 {published data only}

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Ad Hoc 1962
  • Ad Hoc Committee on the Classification of Headache, National Institute of Neurological Diseases and Blindness. Classification of headache. JAMA 1962;179(9):717-8.
Ayzenberg 2012
Bigal 2008
Bloudek 2012
Botting 2000
  • Botting RM. Mechanism of action of acetaminophen: is there a cyclooxygenase 3?. Clinical Infectious Diseases 2000;31(5):S203-S210.
Buse 2011
Chandrasekharan 2002
  • Chandrasekharan NV. COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure and expression. Proceedings of the National Academy of Sciences of the United States of America 2002;99(21):13926-31.
Collins 1997
Cook 1995
CSM 1997
  • Committee on Safety of Medicines. Medicines Control Agency. Paracetamol and aspirin. Current Problems in Pharmacovigilance 1997;23:9.
Dart 2000
  • Dart RC, Kuffner EK, Rumack BH. Treatment of pain or fever with paracetamol (acetaminophen) in the alcoholic patient: a systematic review. American Journal of Medicine 2000;7(2):123-34.
Derry 2012b
  • Derry CJ, Derry S, Moore RA. Sumatriptan (oral route of administration) for acute migraine attacks in adults. Cochrane Database of Systematic Reviews 2012, Issue 2. [DOI: 10.1002/14651858.CD008615.pub2]
Derry 2013
  • Derry S, Rabbie R, Moore RA. Diclofenac with or without an antiemetic for acute migraine headaches in adults. Cochrane Database of Systematic Reviews 2013, Issue 4. [DOI: 10.1002/14651858.CD008783.pub3]
Diamond 2007
Diener 1998
Elbourne 2002
Evers 2009
Flower 1972
Friedman 2005
Graham 2005
Gunnell 1997
  • Gunnell D, Hawton K, Garnier V, Bismuth C, Fagg J. Use of paracetamol for suicide and non-fatal poisoning in the UK and France: are restrictions on availability justified?. Journal of Epidemiology and Community Health 1997;51(2):175-9.
Hawkins 2007
Hawton 2001
  • Hawton K, Townsend E, Deeks J, Appleby L, Gunnell D, Bennewith O, et al. Effects of legislation restricting pack sizes of paracetamol and salicylate on self poisoning in the United Kingdom: before and after study. BMJ 2001;322(7296):1203-7.
Hazard 2009
Higgins 2011
  • Higgins JPT, Green S (editors). Chapter 8: Assessing risk of bias in included studies. In: Higgins JPT, Altman DG, Sterne JAC editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
Hinz 2008
IHS 1988
  • Headache Classification Committee of the International Headache Society. Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. Cephalalgia 1988;8 Suppl 7:1-96.
IHS 2000
IHS 2004
  • Headache Classification Subcommittee of the International Headache Society. The International Classification of Headache Disorders: 2nd edition. Cephalalgia 2004;24 Suppl 1:1-160.
Jadad 1996a
Jadad 1996b
  • Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJM, Gavaghan DJ, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary?. Controlled Clinical Trials 1996;17(1):1-12.
Kirthi 2013
L'Abbé 1987
Leonardi 2005
  • Leonardi M, Steiner TJ, Scher AT, Lipton RB. The global burden of migraine: measuring disability in headache disorders with WHO's Classification of Functioning, Disability and Health (ICF). Journal of Headache and Pain 2005;6(6):429-40. [DOI: 10.1007/s10194-005-0252-4]
Linde 2012
Lipton 1999
  • Lipton RB, Stewart WF. Acute migraine therapy: do doctors understand what patients with migraine want from therapy?. Headache 1999;39 Suppl 2:S20-S26.
Lipton 2007
Lucas 2006
Moore 1998
Moore 2008
  • Moore RA, Barden J, Derry S, McQuay HJ. Managing potential publication bias. In: McQuay HJ, Kalso E, Moore RA editor(s). Systematic Reviews in Pain Research: Methodology Refined. Seattle: IASP Press, 2008:15-24. [ISBN: 978-0-931092-69-5]
Morris 1995
  • Morris JA, Gardner MJ. Calculating confidence intervals for relative risk, odds ratios and standardised ratios and rates. In: Gardner MJ, Altman DG editor(s). Statistics with confidence - confidence intervals and statistical guidelines. London: British Medical Journal, 1995:50-63.
Munakata 2009
Norris 2008
Oldman 2002
PIC 2009
  • PharmWeb. Paracetamol Information Centre. www.pharmweb.net/pwmirror/pwy/paracetamol/pharmwebpic.html (accessed 30 July 2009).
Prescott 2000
  • Prescott LF. Therapeutic misadventure with paracetamol: fact or fiction?. American Journal of Therapeutics 2000;7(2):99-114.
Rabbie 2013
Radtke 2009
RevMan 2012 [Computer program]
  • The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). Version 5.2. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2012.
Ross-Lee 1983
Salazar-Tortolero 2008
  • Salazar-Tortolero G, Huertas-Campistol A, Vergez-Pinto L, Ramos-Brunet A, Lluch-López J. Metoclopramide as a painkiller for intense migraine headache in emergency departments [Metoclopramida como analgésicoen la cefalea migrañosa intensa en urgencias]. Revista de Neurologia 2008;47(10):506-8.
Schwab 2003
Soyka 1988
Steiner 2013
Stovner 2010
Tramer 1997
Victor 2010
Volans 1974
Volans 1975
Vos 2012
  • Vos T, Flaxman AD, Naghavi M, Lozano R, Michaud C, Ezzati M, et al. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012;380(9859):2163-96. [DOI: 1016/S0140-6736(12)61729-2]
Wenzel 2003
Yu 2012

References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Derry 2010
  • Derry S, Moore RA, McQuay HJ. Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults. Cochrane Database of Systematic Reviews 2010, Issue 11. [DOI: 10.1002/14651858.CD008040.pub2]