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Aspirin with or without an antiemetic for acute migraine headaches in adults

  1. Varo Kirthi1,
  2. Sheena Derry2,*,
  3. R Andrew Moore2

Editorial Group: Cochrane Pain, Palliative and Supportive Care Group

Published Online: 30 APR 2013

Assessed as up-to-date: 5 MAR 2013

DOI: 10.1002/14651858.CD008041.pub3


How to Cite

Kirthi V, Derry S, Moore RA. Aspirin with or without an antiemetic for acute migraine headaches in adults. Cochrane Database of Systematic Reviews 2013, Issue 4. Art. No.: CD008041. DOI: 10.1002/14651858.CD008041.pub3.

Author Information

  1. 1

    University of Oxford, Pain Research and Nuffield Department of Clinical Neurosciences, Oxford, UK

  2. 2

    University of Oxford, Pain Research and Nuffield Department of Clinical Neurosciences (Nuffield Division of Anaesthetics), Oxford, Oxfordshire, UK

*Sheena Derry, Pain Research and Nuffield Department of Clinical Neurosciences (Nuffield Division of Anaesthetics), University of Oxford, Pain Research Unit, Churchill Hospital, Oxford, Oxfordshire, OX3 7LE, UK. sheena.derry@ndcn.ox.ac.uk.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 30 APR 2013

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[Figure 1]
Figure 1. Methodological quality graph: review authors' judgements about each methodological quality item presented as percentages across all included studies.
[Figure 2]
Figure 2. Forest plot of comparison: 1 Aspirin 900 mg or 1000 mg versus placebo, outcome: 1.1 Pain free at 2 hours.
[Figure 3]
Figure 3. L'Abbé plot showing pain-free at 2 h response in individual studies. Each circle represents one study, with size on the inset scale.
[Figure 4]
Figure 4. Forest plot of comparison: 1 Aspirin 900 mg or 1000 mg versus placebo, outcome: 1.2 Headache relief at 2 hours.
[Figure 5]
Figure 5. L'Abbé plot showing headache response at 2 h in individual studies. Each circle represents one study, with size on the inset scale.
[Figure 6]
Figure 6. Response rates for aspirin 900 mg plus metoclopramide 10 mg in consecutive attacks, reported in five studies (from left:Tfelt-Hansen 1995; Chabriat 1994; Thomson 1992; Le Jeunne 1998; Geraud 2002)
[Figure 7]
Figure 7. Forest plot of comparison: 5 Aspirin ± metoclopramide versus placebo, outcome: 5.2 Use of rescue medication.
[Analysis 1.1]
Analysis 1.1. Comparison 1 Aspirin 900 mg or 1000 mg versus placebo, Outcome 1 Pain free at 2 hours.
[Analysis 1.2]
Analysis 1.2. Comparison 1 Aspirin 900 mg or 1000 mg versus placebo, Outcome 2 Headache relief at 2 hours.
[Analysis 1.3]
Analysis 1.3. Comparison 1 Aspirin 900 mg or 1000 mg versus placebo, Outcome 3 Headache relief at 1 hour.
[Analysis 1.4]
Analysis 1.4. Comparison 1 Aspirin 900 mg or 1000 mg versus placebo, Outcome 4 24-hour sustained headache relief.
[Analysis 1.5]
Analysis 1.5. Comparison 1 Aspirin 900 mg or 1000 mg versus placebo, Outcome 5 Pain free at 2 hours - effect of formulation.
[Analysis 1.6]
Analysis 1.6. Comparison 1 Aspirin 900 mg or 1000 mg versus placebo, Outcome 6 Headache relief at 2 hours - effect of formulation.
[Analysis 1.7]
Analysis 1.7. Comparison 1 Aspirin 900 mg or 1000 mg versus placebo, Outcome 7 Relief of associated symptoms at 2 hours.
[Analysis 2.1]
Analysis 2.1. Comparison 2 Aspirin 900 mg plus metoclopramide 10 mg versus placebo, Outcome 1 Pain free at 2 hours.
[Analysis 2.2]
Analysis 2.2. Comparison 2 Aspirin 900 mg plus metoclopramide 10 mg versus placebo, Outcome 2 Headache relief at 2 hours.
[Analysis 2.3]
Analysis 2.3. Comparison 2 Aspirin 900 mg plus metoclopramide 10 mg versus placebo, Outcome 3 24-hour sustained headache relief.
[Analysis 2.4]
Analysis 2.4. Comparison 2 Aspirin 900 mg plus metoclopramide 10 mg versus placebo, Outcome 4 Relief of associated symptoms at 2 hours.
[Analysis 3.1]
Analysis 3.1. Comparison 3 Aspirin 900 mg or 1000 mg versus active comparator, Outcome 1 Pain free at 2 hours.
[Analysis 3.2]
Analysis 3.2. Comparison 3 Aspirin 900 mg or 1000 mg versus active comparator, Outcome 2 Headache relief at 2 hours.
[Analysis 3.3]
Analysis 3.3. Comparison 3 Aspirin 900 mg or 1000 mg versus active comparator, Outcome 3 Headache relief at 1 hour.
[Analysis 3.4]
Analysis 3.4. Comparison 3 Aspirin 900 mg or 1000 mg versus active comparator, Outcome 4 Relief of associated symptoms at 2 hours.
[Analysis 4.1]
Analysis 4.1. Comparison 4 Aspirin 900 mg plus metoclopramide 10 mg versus active comparator, Outcome 1 Pain free at 2 hours.
[Analysis 4.2]
Analysis 4.2. Comparison 4 Aspirin 900 mg plus metoclopramide 10 mg versus active comparator, Outcome 2 Headache relief at 2 hours.
[Analysis 4.3]
Analysis 4.3. Comparison 4 Aspirin 900 mg plus metoclopramide 10 mg versus active comparator, Outcome 3 Relief of associated symptoms at 2 hours.
[Analysis 5.1]
Analysis 5.1. Comparison 5 Aspirin ± metoclopramide versus placebo, Outcome 1 Any adverse event within 24 hours.
[Analysis 5.2]
Analysis 5.2. Comparison 5 Aspirin ± metoclopramide versus placebo, Outcome 2 Use of rescue medication.
[Analysis 6.1]
Analysis 6.1. Comparison 6 Aspirin ± metoclopramide versus active comparator, Outcome 1 Any adverse event within 24 hours.
[Analysis 6.2]
Analysis 6.2. Comparison 6 Aspirin ± metoclopramide versus active comparator, Outcome 2 Use of rescue medication.