Diagnostic Test Accuracy Review

You have full text access to this OnlineOpen article

Human papillomavirus testing versus repeat cytology for triage of minor cytological cervical lesions

  1. Marc Arbyn1,*,
  2. Jolien Roelens1,
  3. Cindy Simoens1,
  4. Frank Buntinx2,
  5. Evangelos Paraskevaidis3,
  6. Pierre PL Martin-Hirsch4,
  7. Walter J Prendiville5

Editorial Group: Cochrane Gynaecological Cancer Group

Published Online: 28 MAR 2013

Assessed as up-to-date: 20 DEC 2012

DOI: 10.1002/14651858.CD008054.pub2

How to Cite

Arbyn M, Roelens J, Simoens C, Buntinx F, Paraskevaidis E, Martin-Hirsch PPL, Prendiville WJ. Human papillomavirus testing versus repeat cytology for triage of minor cytological cervical lesions. Cochrane Database of Systematic Reviews 2013, Issue 3. Art. No.: CD008054. DOI: 10.1002/14651858.CD008054.pub2.

Author Information

  1. 1

    Scientific Institute of Public Health, Unit of Cancer Epidemiology, Brussels, Belgium

  2. 2

    Academisch Centrum voor Huisartsgeneeskunde, General Practice, KU Leuven, Belgium

  3. 3

    Ioannina University Hospital, Department of Obstetrics and Gynaecology, Ioannina, Greece

  4. 4

    Royal Preston Hospital, Lancashire Teaching Hospital NHS Trust, Gynaecological Oncology Unit, Preston, Lancashire, UK

  5. 5

    Coombe Lying-In Hospital, Department of Obstetrics and Gynaecology, Dublin 8, Ireland

*Marc Arbyn, Unit of Cancer Epidemiology, Scientific Institute of Public Health, Juliette Wytsmanstreet 14, Brussels, B-1050, Belgium. Marc.Arbyn@wiv-isp.be.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 28 MAR 2013

SEARCH

[Figure 1]
Figure 1. Flowchart of retrieval, selection and exclusion of studies.
[Figure 2]
Figure 2. Methodological quality graph: review authors' judgements about each methodological quality item presented as percentages across all included studies.
[Figure 3]
Figure 3. Methodological quality summary: review authors' judgements about each QUADAS item for each included study.
[Figure 4]
Figure 4. Analysis 1: Summary ROC-plot (Bivariate model with test as covariate): Sensitivity and specificity of triage of ASCUS with HC2 (black) (at RLU>1) versus repeat cytology (red) at cut-off ASCUS+ for an outcome of underlying CIN2+ based on within study comparisons.
[Figure 5]
Figure 5. Analysis 2: Summary ROC-plot (Bivariate model with test as covariate): Sensitivity and specificity of triage of LSIL with HC2 (black) (at RLU>1) versus repeat cytology (red) at cut-off ASCUS+ for an outcome of underlying CIN2+ based on within study comparisons.
[Figure 6]
Figure 6. Analysis 7: Summary ROC-plot (Bivariate model with test as covariate): Sensitivity and specificity of triage of ASCUS with HC2 (black) (at RLU>1) versus repeat cytology (red) at cut-off LSIL+ for an outcome of underlying CIN2+ based on within study comparisons.
[Figure 7]
Figure 7. Assymmetry regression plot showing the relation between the effective sample size and the logarithm of the diagnostic odds ratio of HC2 triage of ASCUS for the detection of CIN2+
[Test 1]
Test 1. Triage ASCUS with HC2, CIN2+ (all studies).
[Test 2]
Test 2. Triage of ASCUS with HC2, CIN2+ (studies with both tests).
[Test 3]
Test 3. Triage of ASCUS with HC2, CIN3+ (all studies).
[Test 4]
Test 4. Triage of ASCUS with HC2, CIN3+ (studies with both tests).
[Test 5]
Test 5. Triage of ASCUS with repeat cytology (cut-off ASCUS+), CIN2+.
[Test 6]
Test 6. Triage of ASCUS with repeat cytology (cut-off LSIL+), CIN2+.
[Test 7]
Test 7. Triage of ASCUS with repeat cytology (cut-off HSIL+), CIN2+.
[Test 8]
Test 8. Triage of ASCUS with repeat cytology (cut-off ASCUS+), CIN3+.
[Test 9]
Test 9. Triage of ASCUS with repeat cytology (cut-off LSIL+), CIN3+.
[Test 10]
Test 10. Triage of ASCUS with repeat cytology (cut-off HSIL+), CIN3+.
[Test 11]
Test 11. Triage LSIL with HC2, CIN2+ (all studies).
[Test 12]
Test 12. Triage of LSIL with HC2, CIN2+ (studies with both tests).
[Test 13]
Test 13. Triage of LSIL with HC2, CIN3+ (all studies).
[Test 14]
Test 14. Triage of LSIL with HC2, CIN3+ (studies with both tests).
[Test 15]
Test 15. Triage of LISL with repeat cytology (cut-off ASCUS+), CIN2+.
[Test 16]
Test 16. Triage of LSIL with repeat cytology (cut-off LSIL+), CIN2+.
[Test 17]
Test 17. Triage of LSIL with repeat cytology (cut-off HSIL+), CIN2+.
[Test 18]
Test 18. Triage of LSIL with repeat cytology (cut-off ASCUS+), CIN3+.
[Test 19]
Test 19. Triage of LSIL with repeat cytology (cut-off LSIL+), CIN3+.
[Test 20]
Test 20. Triage of LSIL with repeat cytology (cut-off HSIL+), CIN3+.
[Test 25]
Test 25. Triage of ASCUS with HC2, CIN2+ (according to collection device).
[Test 26]
Test 26. Triage of ASCUS with HC2, CIN2+ (according to transport medium).
[Test 27]
Test 27. Triage of ASCUS with HC2, CIN2+ (<30y).
[Test 28]
Test 28. Triage of ASCUS with HC2, CIN2+ (30-39y).
[Test 29]
Test 29. Triage of ASCUS with HC2, CIN2+ (40-49y).
[Test 30]
Test 30. Triage of ASCUS with HC2, CIN2+ (50y or older).
[Test 31]
Test 31. Triage of ASCUS with HC2, CIN3+ (<30y).
[Test 32]
Test 32. Triage of ASCUS with HC2, CIN3+ (30-39y).
[Test 33]
Test 33. Triage of ASCUS with HC2, CIN3+ (40-49y).
[Test 34]
Test 34. Triage of ASCUS with HC2, CIN3+ (50y or older).
[Test 35]
Test 35. Triage of LSIL with HC2, CIN2+ (<30y).
[Test 36]
Test 36. Triage of LSIL with HC2, CIN2+ (30-39y).
[Test 37]
Test 37. Triage of LSIL with HC2, CIN2+ (40-49y).
[Test 38]
Test 38. Triage of LSIL with HC2, CIN2+ (50y or older).
[Test 39]
Test 39. Triage of LSIL with HC2, CIN3+ (<30y).
[Test 40]
Test 40. Triage of LSIL with HC2, CIN3+ (30-39y).
[Test 41]
Test 41. Triage of LSIL with HC2, CIN3+ (30-49y).
[Test 42]
Test 42. Triage of LSIL with HC2, CIN3+ (50y or older).