Diagnostic Test Accuracy Review

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Human papillomavirus testing versus repeat cytology for triage of minor cytological cervical lesions

  1. Marc Arbyn1,*,
  2. Jolien Roelens1,
  3. Cindy Simoens1,
  4. Frank Buntinx2,
  5. Evangelos Paraskevaidis3,
  6. Pierre PL Martin-Hirsch4,
  7. Walter J Prendiville5

Editorial Group: Cochrane Gynaecological Cancer Group

Published Online: 28 MAR 2013

Assessed as up-to-date: 20 DEC 2012

DOI: 10.1002/14651858.CD008054.pub2


How to Cite

Arbyn M, Roelens J, Simoens C, Buntinx F, Paraskevaidis E, Martin-Hirsch PPL, Prendiville WJ. Human papillomavirus testing versus repeat cytology for triage of minor cytological cervical lesions. Cochrane Database of Systematic Reviews 2013, Issue 3. Art. No.: CD008054. DOI: 10.1002/14651858.CD008054.pub2.

Author Information

  1. 1

    Scientific Institute of Public Health, Unit of Cancer Epidemiology, Brussels, Belgium

  2. 2

    Academisch Centrum voor Huisartsgeneeskunde, General Practice, KU Leuven, Belgium

  3. 3

    Ioannina University Hospital, Department of Obstetrics and Gynaecology, Ioannina, Greece

  4. 4

    Royal Preston Hospital, Lancashire Teaching Hospital NHS Trust, Gynaecological Oncology Unit, Preston, Lancashire, UK

  5. 5

    Coombe Lying-In Hospital, Department of Obstetrics and Gynaecology, Dublin 8, Ireland

*Marc Arbyn, Unit of Cancer Epidemiology, Scientific Institute of Public Health, Juliette Wytsmanstreet 14, Brussels, B-1050, Belgium. Marc.Arbyn@wiv-isp.be.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 28 MAR 2013

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
Andersson 2005 {published and unpublished data}
  • Andersson S, Dillner L, Elfgren K, Mints M, Persson M, Rylander E. A comparison of the human papillomavirus test and Papanicolaou smear as a second screening method for women with minor cytological abnormalities. Acta Obstetricia et Gynecologica Scandinavica 2005;84(10):996-1000. [MEDLINE: 24912]
Bergeron 2000 {published data only}
Bergeron 2006 {published data only}
  • Bergeron C, Cas F, Fagnani F, Contrepas A, Wadler R, Poveda JD. Assessment of human papillomavirus testing on liquid-based CYTO-screen system for women with atypical squamous cells of undetermined significance. Effect of age. Gynécologie, Obstétrique and Fertilité 2006;34:312-6. [MEDLINE: 25244]
Castle 2010a {published and unpublished data}
  • Castle PE, Fetterman B, Thomas CJ, Shaber R, Poitras N, Lorey T, et al. The age-specific relationships of abnormal cytology and human papillomavirus DNA results to the risk of cervical precancer and cancer. Obstetrics and Gynecology 2010;116:76-84.
Cattani 2009 {published data only}
  • Cattani P, Zannoni GF, Ricci C, D'Onghia S, Trivellizzi IN, Di Franco A, et al. Clinical performance of human papillomavirus E6 and E7 mRNA testing for high-grade lesions of the cervix. Journal of Clinical Microbiology 2009;47:3895-3901. [MEDLINE: 30311]
Chen 2005b {published data only}
  • Chen HS, Yang YC, Su TH, Wang TY, Huang YW. Human papillomavirus testing (Hybrid Capture II) to detect high-grade cervical intraepithelial neoplasia in women with mildly abnormal Papanicolaou results. Taiwanese Journal of Obstetrics and Gynecology 2005;44:252-7. [MEDLINE: 28826]
Cuschieri 2007 {published data only}
  • Cuschieri KS, Grahamb C, Moorea C, Cubie HA. Human Papillomavirus testing for the management of low-grade cervical abnormalities in the UK—Influence of age and testing strategy. Journal of Clinical Virology 2007;38(1):14-8. [MEDLINE: 26476]
Cuzick 2003 {published data only}
Dalla Palma 2005 {published data only}
Davis-Devine 2005 {published data only}
  • Davis-Devine S, Day SJ, Freund GG. Test performance comparison of inform HPV and hybrid capture 2 high-risk HPV DNA tests using the SurePath liquid-based Pap test as the collection method. American Journal of Clinical Pathology 2005;124:24-30. [MEDLINE: 24691]
De Francesco 2008 {published data only}
  • De Francesco MA, Gargiulo F, Schreiber C, Ciravolo G, Salinaro F, Manca N. Comparison of the AMPLICOR human papillomavirus test and the hybrid capture 2 assay for detection of high-risk human papillomavirus in women with abnormal PAP smear. Journal of Virological Methods 2008;147:10-7. [MEDLINE: 27690]
Del Mistro 2010 {published data only}
  • Del Mistro A, Frayle-Salamanca H, Trevisan R, Matteucci M, Pinarello A, Zambenedetti P, et al. Triage of women with atypical squamous cells of undetermined significance (ASC-US): Results of an Italian multicentric study. Gynecologic Oncology 2010;117:77-88. [MEDLINE: 30230]
Denton 2010 {published data only}
  • Denton KJ, Bergeron C, Klement P Trunk MJ, Keller T, Ridder R. The sensitivity and specificity of p16(INK4a) cytology vs HPV testing for detecting high-grade cervical disease in the triage of ASC-US and LSIL pap cytology results. American Journal of Clinical Pathology 2010;134:12-21. [MEDLINE: 30471]
Giovannelli 2005 {published data only}
  • Giovannelli L, Capra G, Lama A, Bustinto T, Genco A, Valenti FM. Atypical squamous cells of undetermined significance-favour reactive compared to atypical squamous cells of undetermined significance-favour dysplasia: association with cervical intraepithelial lesions and human papillomavirus infection. Journal of Clinical Virology 2005;33(4):281-6. [MEDLINE: 24769]
Guyot 2003 {published and unpublished data}
  • Guyot A, Karim S, Kyi MS, Fox J. Evaluation of adjunctive HPV testing by hybrid capture II(R) in women with minor cytological abnormalities for the diagnosis of CIN2/3 and cost comparison with colposcopy. BMC Infectious Diseases [electronic resource] 2003;3(23):1-7. [MEDLINE: 19106]
Holladay 2006 {published data only}
Huang 2009 {published data only}
  • Huang S, Erickson B, Tang N, Mak WB, Salituro J, Robinson J, et al. Clinical performance of Abbott RealTime High Risk HPV test for detection of high-grade cervical intraepithelial neoplasia in women with abnormal cytology. Journal of Clinical Virology 2009;45(Suppl 1):S19-23.
Kelly 2006 {published data only}
Kiatpongsan 2006 {published data only}
Kulasingam 2002 {published and unpublished data}
  • Kulasingam SL, Hughes JP, Kiviat NB, Mao C, Weiss NS, Kuypers JM, et al. Evaluation of human papillomavirus testing in primary screening cervical abnormalities: comparison of sensitivity, specificity, and frequency of referral. JAMA 2002;288(14):1749-57. [MEDLINE: 12746]
Lee 2001 {published data only}
  • Lee NW, Kim D, Park JT, Kim A. Is the human papillomavirus test in combination with the Papanicolaou test useful for management of patients with diagnosis of atypical squamous cells of undetermined significance/low-grade squamous intraepithelial lesions?. Archives of Pathology and Laboratory Medicine 2001;125(11):1453-7.
Lee 2009 {published data only}
  • Lee JK, Kim MK, Song SH, Hong JH, Min KJ, Kim JH, et al. Comparison of human papillomavirus detection and typing by Hybrid Capture 2, Llnear Array, DNA Chip, and cycle sequencing in cervical swab samples. International journal of Gynecological Cancer 2009;19:266-72. [MEDLINE: 30228]
Lonky 2003 {published data only}
  • Lonky NM, Felix JC, Naidu YM, Wolde-Tsadik G. Triage of atypical squamous cells of undetermined significance with Hybrid Capture II: colposcopy and histologic human papillomavirus correlation. Obstetrics and Gynecology 2003;101(3):481-9. [MEDLINE: 12929]
Lytwyn 2000 {published and unpublished data}
  • Lytwyn A, Sellors JW, Mahony JB. Comparison of human papillomavirus DNA testing and repeat Papanicolaou test in women with low-grade cervical cytologic abnormalities: a randomized trial. Canadian Medical Association Journal 2000;163:701-7. [MEDLINE: 11417]
Manos 1999 {published data only}
  • Manos MM, Kinney WK, Hurley LB, Sherman ME, Shieh-Ngai J, Kurman RJ, et al. Identifying women with cervical neoplasia: using human papillomavirus DNA testing for equivocal Papanicolaou results. JAMA 1999;281:1605-10.
Monsonego 2006 {published data only}
Monsonego 2008 {published and unpublished data}
  • Monsonego J, Pollini G, Evrard MJ, Sednaoui P, Monfort L, Zerat L, et al. Detection of human papillomavirus genotypes among high-risk women: a comparison of Hybrid Capture and Llnear Array tests. Sexually Transmitted Diseases 2008;35:521-7. [MEDLINE: 28257]
Morin 2001 {published data only}
  • Morin C, Bariati C, Bouchard C, Fortier M, Roy M, Moore L, et al. Managing atypical squamous cells of undetermined significance in Papanicolaou smears. Journal of Reproductive Medicine 2001;46:799-805.
Nieh 2005 {published data only}
  • Nieh S, Chen SF, Chu TY, Lai HC, Lin YS, Fu E, et al. Is p16(INK4A) expression more useful than human papillomavirus test to determine the outcome of atypical squamous cells of undetermined significance-categorized Pap smear? A comparative analysis using abnormal cervical smears with follow-up biopsies. Gynecologic Oncology 2005;97:35-40. [MEDLINE: 24387]
Ordi 2003 {published data only}
  • Ordi J, Puig-Tintore LM, Torne A, Sanz S, Esteve R, Romagosa C, et al. Contribution of high risk human papillomavirus testing to the management of premalignant and malignant lesions of the uterine cervix. Medicina Clínica 2003;121(12):441-5. [MEDLINE: 19409]
Pretorius 2002 {published and unpublished data}
  • Pretorius RG, Peterson P, Novak S, Azizi F, Sadeghi M, Lorincz AT. Comparison of two signal-amplification DNA tests for high-risk HPV as an aid to colposcopy. Journal of Reproductive Medicine 2002;47(4):290-6. [MEDLINE: 12142]
Rebello 2001 {published data only}
  • Rebello G, Hallam N, Smart G, Farquharson D, McCafferty J. Human papillomavirus testing and the management of women with mildly abnormal cervical smears: an observational study. BMJ 2000;322:894-5.
Ronco 2007 {published data only}
  • Ronco G, Cuzick J, Segnan N, Brezzi S, Carozzi F, Folicaldi S, et al. HPV triage for low grade (L-SIL) cytology is appropriate for women over 35 in mass cervical cancer screening using liquid based cytology. European Journal of Cancer 2007;43:476-80. [MEDLINE: 26454]
Sherman 2002 {published and unpublished data}
  • Sherman ME, Schiffman M, Cox JT. Effects of age and human papilloma viral load on colposcopy triage: data from the randomised atypical squamous cells of undetermined significance/low-grade intraepithelial lesion triage study (ALTS). Journal of the National Cancer Institute 2002;94:102-7.
Shlay 2000 {published data only}
  • Shlay JC, Dunn T, Byers T, Baron AE, Douglas JM Jr. Prediction of cervical intraepithelial neoplasia grade 2-3 using risk assessment and human papillomavirus testing in women with atypia on Papanicolaou smears. Obstetrics and Gynecology 2000;96:410-6.
Siddiqui 2008 {published data only}
  • Siddiqui MT, Hornaman K, Cohen C, Nassar A. ProEx C immunocytochemistry and high-risk human papillomavirus DNA testing in Papanicolaou tests with atypical squamous cell (ASC-US) cytology: correlation study with histologic biopsy. Archives of Pathology & Laboratory Medicine 2008;132:1648-52. [MEDLINE: 29056]
Silverloo 2009 {published data only}
Solomon 2001 {published data only}
  • Solomon D, Schiffman M, Tarone B. Comparison of three management strategies for patients with atypical squamous cells of undetermined significance (ASCUS): baseline results from a randomized trial. Journal of the National Cancer Institute 2001;93:293-9.
Szarewski 2008 {published and unpublished data}
  • Szarewski A, Ambroisine L, Cadman L, Austin J, Ho L, Terry G, et al. Comparison of predictors for high-grade cervical intraepithelial neoplasia in women with abnormal smears. Cancer Epidemiology, Biomarkers & Prevention 2008;17:3033-43. [MEDLINE: 29031]
Voss 2010 {published data only}
  • Voss JS, Kipp BR, Campion MB, Sokolova IA, Henry MR, Halling KC, et al. Assessment of fluorescence in situ hybridization and hybrid capture 2 analyses of cervical cytology specimens diagnosed as low grade squamous intraepithelial lesion for the detection of high grade cervical intraepithelial neoplasia. Analytical and Quantitative Cytology and Histology 2010;32:121-30. [MEDLINE: 30454]
Wensveen 2003 {published data only}
  • Wensveen C, Kagie M, Veldhuizen R, De Groot C, Denny L, Zwinderman K, et al. Detection of cervical intraepithelial neoplasia in women with atypical squamous or glandular cells of undetermined significance cytology: a prospective study. Acta Obstetricia et Gynecologica Scandinavica 2003;82(9):883-9. [MEDLINE: 19843]
You 2007 {published data only}
Zielinski 2001 {published data only}

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
Adam 1998 {published data only}
  • Adam E, Kaufman RH, Berkova Z. Is human papillomavirus testing an effective triage method for detection of high-grade (grade 2 or 3) cervical intraepithelial neoplasia?. Obstetrics and Gynecology 1998;92:601-7.
Aerssens 2009 {published data only}
Ahmed 2008 {published data only}
Alameda 2010 {published data only}
Allen 2009 {published data only}
  • Allen GL, Klobocista MM, Sugarman S, Gravel K, Feldman D, Schnatz PF. Prevalence of high-risk human papillomavirus in an inner-city population with atypical squamous cells of undetermined significance. Journal of Lower Genital Tract Disease 2009;13:63-5. [MEDLINE: 29855]
Antonishyn 2009 {published data only}
  • Antonishyn NA, Horsman GB, Kelln RA, Severini A. Human papillomavirus typing and viral gene expression analysis for the triage of women with abnormal results from Papanicolaou test smears to colposcopy. Archives of Pathology & Laboratory Medicine 2009;133:1577-86. [MEDLINE: 30292]
Arbyn 2010 {published data only}
Armah 2009 {published data only}
  • Armah H, Austin RM, Dabbs D, Zhao C. Follow-up findings for women with human papillomavirus-positive and atypical squamous cells of undetermined significance screening test results in a large women's hospital practice. Archives of Pathology & Laboratory Medicine 2009;133:1426-30. [MEDLINE: 30340]
Atkins 2006 {published data only}
Bais 2005 {published data only}
Baseman 2008 {published data only}
  • Baseman JG, Kulasingam SL, Harris TG, Hughes JP, Kiviat NB, Mao C, et al. Evaluation of primary cervical cancer screening with an oncogenic human papillomavirus DNA test and cervical cytologic findings among women who attended family planning clinics in the United States. American Journal of Obstetrics and Gynecology 2008;199:26-8. [MEDLINE: 28478]
Bavin 1993 {published data only}
  • Bavin PJ, Giles JA, Deery A. Use of semi-quantitative PCR for human papillomavirus DNA type 16 to identify women with high grade cervical disease in a population presenting with a mildly dyskaryotic smear report. British Journal of Cancer 1993;67(3):602-5. [MEDLINE: 11822]
Beccati 2008 {published data only}
Bellinson 2009 {published data only}
  • Belinson JL, Pretorius RG, Enerson C, Garcia F, Cruz EP, Belinson SE, et al. The Mexican Cervical Cancer Screening Trial: self-sampling for human papillomavirus with unaided visual inspection as a secondary screen. International Journal of Gynecological Cancer 2009;19:27-32. [MEDLINE: 29851]
Bello 2009 {published data only}
  • Bello BD, Spinillo A, Alberizzi P, Cesari S, Gardella B, D'Ambrosio G, et al. Cervical infections by multiple human papillomavirus (HPV) genotypes: Prevalence and impact on the risk of precancerous epithelial lesions. Journal of Medical Virology 2009;81:703-12. [MEDLINE: 29826]
Bentley 2006 {published data only}
  • Bentley E, Cotton SC, Cruickshank ME, Duncan I, Gray NM, Jenkins D, et al. Refining the management of low-grade cervical abnormalities in the UK National Health Service and defining the potential for human papillomavirus testing: a commentary on emerging evidence. Journal of Lower Genital Tract Diseases 2006;10(1):26-38. [MEDLINE: 25397]
Berkhof 2006a {published data only}
  • Berkhof J, Bulkmans NW, Bleeker MC, Bulk S, Snijders PJ, Voorhorst FJ, et al. Human papillomavirus type-specific 18-month risk of high-grade cervical intraepithelial neoplasia in women with a normal or borderline/mildly dyskaryotic smear. Cancer Epidemiology, Biomarkers & Prevention 2006;15:1268-73. [MEDLINE: 25664]
Berkhof 2006b {published data only}
Bewtra 2005 {published data only}
  • Bewtra C, Xie Q, Soundararajan S, Gatalica Z, Hatcher L. Genital human papillomavirus testing by in situ hybridization in liquid atypical cytologic materials and follow-up biopsies. Acta Cytologica 2005;49:127-31. [MEDLINE: 22908]
Biu 2009 {published data only}
  • Biu H, Zhao J, Li KM, Liao QP. [The significance of HPV-DNA genotyping assays in the ASC]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 2009;23:296-8. [MEDLINE: 30333]
Bjerre 2008 {published data only}
  • Bjerre P, Silfverdal L, Dillner L, Hagmar B, Edvardsson H, Dillner J, et al. A randomized trial of basing treatment on human papillomavirus and/or cytology results in low-grade cervical lesion triage. American Journal of Obstetrics and Gynecology 2008;199:24-7. [MEDLINE: 27959]
Boardman 2005 {published data only}
Boardman 2006 {published data only}
  • Boardman LA, Weitzen S, Stanko C. Atypical squamous cells of undetermined significance, human papillomavirus, and cervical intraepithelial neoplasia 2 or 3 in adolescents: ASC-US, age, and high-grade cervical neoplasia. Journal of Lower Genital Tract Disease 2006;10:140-5. [MEDLINE: 25665]
Bohmer 2002 {published data only}
  • Bohmer G, Petry KU, Iftner T, Brummer O, Gunter HH, Flemming P, et al. Detection of human papillomavirus DNA using hybrid capture does not allow sufficient triaging of recurrent atypical pap smear classified as Pap III D. Zentralblatt für Gynäkologie 2002;124(2):111-5. [MEDLINE: 19773]
Bollen 1997 {published data only}
  • Bollen LJ, Tjong-A-Hung SP, Van der Velden J, Brouwer K, Mol BW, ten Kate FJ, et al. Human papillomavirus deoxyribonucleic acid detection in mildly or moderately dysplastic smears: a possible method for selecting patients for colposcopy. American Journal of Obstetrics and Gynecology 1997;177:548-53.
Botezatu 2009 {published data only}
  • Botezatu A, Socolov D, Goia CD, Iancu IV, Ungureanu C, Huica I, et al. The relationship between HPV16 and HPV18 viral load and cervical lesions progression. Roumanian Archives of Microbiology and Immunology 2009;68:175-82. [MEDLINE: 30343]
Boulanger 2006 {published data only}
  • Boulanger JC, Sevestre H. [ASCUS: an update]. Gynécologie, Obstétrique & Fertilité 2006;34:44-8. [MEDLINE: 27050]
Brismar 2009 {published data only}
  • Brismar-Wendel S, Froberg M, Hjerpe A, Andersson S, Johansson B. Age-specific prevalence of HPV genotypes in cervical cytology samples with equivocal or low-grade lesions. British Journal of Cancer 2009;101:511-7. [MEDLINE: 29768]
Brown 2009 {published data only}
  • Brown CR, Leon ML, Munoz K, Fagioni A, Amador LG, Frain B, et al. Human papillomavirus infection and its association with cervical dysplasia in Ecuadorian women attending a private cancer screening clinic. Brazilian Journal of Medical and Biological Research 2009;42:629-36. [MEDLINE: 30336]
Bruner 2004 {published data only}
Burgis 2009 {published data only}
  • Burgis JT, Brown J, Menon S, Bacon JL. Cervical cytology screening and management of abnormal cytology in adolescents. Journal of the South Carolina Medical Association 2009;105:16-9. [MEDLINE: 29891]
Carozzi 2005 {published data only}
Carozzi 2006 {published data only}
Carozzi 2008 {published data only}
  • Carozzi F, Confortini M, Palma PD, Del Mistro A, Gillio-Tos A, De Marco L, et al. Use of p16-INK4A over expression to increase the specificity of human papillomavirus testing: a nested sub study of the NTCC randomised controlled trial. Lancet Oncology 2008;9:937-45. [MEDLINE: 28827]
Carvalho 2010 {published data only}
Castle 2008 {published data only}
  • Castle PE, Gravitt PE, Solomon D, Wheeler CM, Schiffman M. Comparison of Linear Array and Line Blot assay for detection of human papillomavirus and diagnosis of cervical precancer and cancer in the atypical squamous cell of undetermined significance and low-grade squamous intraepithelial lesion triage study. Journal of Clinical Microbiology 2008;46:109-17. [MEDLINE: 27961]
Castle 2009a {published data only}
Castle 2009b {published data only}
  • Castle PE, Fetterman B, Poitras N, Lorey T, Shaber R, Kinney W. Five-year experience of human papillomavirus DNA and Papanicolaou test cotesting. Obstetrics and Gynecology 2009;113:595-600. [MEDLINE: 29549]
Castle 2010b {published data only}
  • Castle PE, Schiffman M, Wheeler CM, Wentzensen N, Gravitt PE. Impact of improved classification on the association of human papillomavirus with cervical precancer. American Journal of Epidemiology 2010;171:155-63. [MEDLINE: 30189]
Castle 2010c {published data only}
  • Castle PE, Schiffman M, Wheeler CM, Wentzensen N, Gravitt PE. Human papillomavirus genotypes in cervical intraepithelial neoplasia grade 3. Cancer Epidemiology, Biomarkers & Prevention  2010;19:1675-81. [MEDLINE: 30744]
Chaiwongkot 2007 {published data only}
  • Chaiwongkot A, Pientong C, Ekalaksananan T, Kongyingyoes B, Thinkhamrop J, Yuenyao P, et al. Evaluation of primers and PCR performance on HPV DNA screening in normal and low grade abnormal cervical cells. Asian Pacific Journal of Cancer Prevention 2007;8:279-82. [MEDLINE: 30751]
Chen 2005a {published data only}
  • Chen SF, Yang SF, Chu TY, Lai HC, Lin YW, Bai CY, et al. Which test is a better strategy to determine the outcome of atypical glandular cell-categorized Pap smears? Immunocytochemical p16INK4A expression or human papillomavirus test--a retrospective cohort study. Gynecologic Oncology 2005;99(3):578-84. [MEDLINE: 25500]
Chesebro 1997 {published data only}
  • Chesebro MJ, Everett WD, Lorincz AT. High-risk human papilloma virus testing of women with cytological low-grade squamous intraepithelial lesions. Journal of Lower Genital Tract Disease 1997;1:234-9. [MEDLINE: 10832]
Cheung 2010 {published data only}
  • Cheung AN, Tsun KL, Ng KM, Szeto E, Siu MK, Wong ES, et al. P634A4 and TAp73 immunocytochemistry in liquid-based cervical cytology--potential biomarkers for diagnosis and progress prediction of cervical neoplasia. Modern Pathology 2010;23:559-66. [MEDLINE: 30304]
Chivukula 2006 {published data only}
  • Chivukula M, Shidham V. ASC-H in Pap test- definitive categorization of cytomorphological spectrum. CytoJournal [electronic resource] 2006;3(1):1-14. [MEDLINE: 25641]
Conesa-Zamora 2010 {published data only}
  • Conesa-Zamora P, Santaclara V, Gadea-Ninoles E, Ortiz-Reina S, Perez-Guillermo M. Association of polymorphism in FcGR3A gene and progression of low-grade precursor lesions of cervical carcinoma. Human Immunology 2010;71:314-7. [MEDLINE: 30851]
Constandinou-Williams2010 {published data only}
  • Constandinou-Williams C, Collins SI, Roberts S, Young LS, Woodman CB, Murray PG. Is human papillomavirus viral load a clinically useful predictive marker? A longitudinal study. Cancer Epidemiology, Biomarkers & Prevention 2010;19:832-7. [MEDLINE: 30338]
Coste 2003 {published data only}
  • Coste J, Cochand-Priollet B, de Cremoux P, Le Gales C, Cartier I, Molinie V, et al. Cross sectional study of conventional cervical smear, monolayer cytology, and human papillomavirus DNA testing for cervical cancer screening. BMJ 2003;326:733-6. [MEDLINE: 12915]
Cotton 2006 {published data only}
  • Cotton SC, Sharp L, Little J, Duncan I, Alexander L, Cruickshank ME, et al. Trial of management of borderline and other low-grade abnormal smears (TOMBOLA): Trial design. Contemporary Clinical Trials 2006;27:449-71. [MEDLINE: 25624]
Cotton 2010 {published data only}
Cox 1992 {published data only}
  • Cox JT, Schiffman MH, Winzelberg AJ, Patterson JM. An evaluation of human papillomavirus testing as part of referral to colposcopy clinics. Obstetrics and Gynecology 1992;80:389-95.
Cox 1995 {published data only}
  • Cox JT, Lorincz AT, Schiffman MH, Sherman ME, Cullen A, Kurman RJ. Human papillomavirus testing by hybrid capture appears to be useful in triaging women with a cytologic diagnosis of atypical squamous cells of undetermined significance. American Journal of Obstetrics and Gynecology 1995;172:946-54.
Crabtree 2002 {published data only}
Cricca 2009 {published data only}
  • Cricca M, Venturoli S, Leo E, Costa S, Musiani M, Zerbini M. Molecular analysis of HPV 16 E6I/E6II spliced mRNAs and correlation with the viral physical state and the grade of the cervical lesion. Journal of Medical Virology 2009;81:1276-82. [MEDLINE: 29821]
Del Mistro 2007 {published data only}
Del Pino 2009 {published data only}
  • del Pino M, Garcia S, Fuste V, Alonso I, Fuste P, Torne A, et al. Value of p16(INK4a) as a marker of progression/regression in cervical intraepithelial neoplasia grade 1. American Journal of Obstetrics and Gynecology 2009;201:488. [MEDLINE: 30293]
Derchain 2004 {published data only}
  • Derchain SF, Rabelo-Santos SH, Sarian LO, Zeferino LC, Oliveira Zambeli ER, do Amaral Westin MC, et al. Human papillomavirus DNA detection and histological findings in women referred for atypical glandular cells or adenocarcinoma in situ in their Pap smears. Gynecologic Oncology 2004;95(3):618-23. [MEDLINE: 24464]
Diaz-Montes 2007 {published data only}
  • Diaz-Montes TP, Farinola MA, Zahurak ML, Bristow RE, Rosenthal DL. Clinical utility of atypical glandular cells (AGC) classification: cytohistologic comparison and relationship to HPV results. Gynecologic Oncology 2007;104:366-71. [MEDLINE: 26763]
Difurio 2010 {published data only}
  • Difurio MJ, Mailhiot T, Sundborg MJ, Nauschuetz KK. Comparison of the clinical significance of the Papanicolaou test interpretations LSIL cannot rule out HSIL and ASC-H. Diagnostic Cytopathology 2010;38:313-7. [MEDLINE: 30696]
Dockter 2009 {published data only}
  • Dockter J, Schroder A, Hill C, Guzenski L, Monsonego J, Giachetti C. Clinical performance of the APTIMA HPV Assay for the detection of high-risk HPV and high-grade cervical lesions. Journal of Clinical Virology 2009;45:S55-S61. [MEDLINE: 29669]
Duerr 2006 {published data only}
  • Duerr A, Paramsothy P, Jamieson DJ, Heilig CM, Klein RS, Cu-Uvin S, et al. Effect of HIV infection on atypical squamous cells of undetermined significance. Clinical Infectious Diseases 2006;42:855-61. [MEDLINE: 25210]
Duncan 2005 {published data only}
  • Duncan LD, Jacob SV. Atypical squamous cells, cannot exclude a high-grade squamous intraepithelial lesion: the practice experience of a hospital-based reference laboratory with this new Bethesda system diagnostic category. Diagnostic Cytopathology 2005;32:243-6. [MEDLINE: 24686]
Einstein 2010 {published data only}
  • Einstein MH, Martens MG, Garcia FAR, Ferris DG, Mitchell AL, Day SP, et al. Clinical validation of the Cervista HPV HR and 16/18 genotyping tests for use in women with ASC-US cytology. Gynecologic Oncology 2010;118:116-22. [MEDLINE: 30411]
Ekalaksananan 2006 {published data only}
  • Ekalaksananan T, Pientong C, Sriamporn S, Kongyingyoes B, Pengsa P, Kleebkaow P, et al. Usefulness of combining testing for p16 protein and human papillomavirus (HPV) in cervical carcinoma screening. Gynecologic Oncology 2006;103:62-6. [MEDLINE: 25290]
Eleuterio 2007 {published data only}
Eltoum 2005 {published data only}
Evans 2006 {published data only}
Fadare 2009 {published data only}
Fait 1998 {published data only}
  • Fait G, Daniel Y, Kupferminc MJ, Geva E, Ron IG, Lessing JB, et al. Does typing of human papillomavirus assist in the triage of women with repeated low-grade, cervical cytologic abnormalities?. Gynecologic Oncology 1998;70:319-22.
Fait 2000 {published data only}
  • Fait G, Kupferminc MJ, Daniel Y, Lessing JB, Niv J, Bar-Am A. Contribution of human papillomavirus testing by hybrid capture in the triage of women with repeated abnormal pap smears before colposcopy referral.. Gynecologic Oncology 2000;79:177-80.
Farag 2008 {published data only}
  • Farag R, Redline R, Abdul-Karim FW. Value of combining HPV-DNA testing with follow-up Papanicolaou smear in patients with prior atypical squamous cells of undetermined significance. Acta Cytologica 2008;52:294-6. [MEDLINE: 28954]
Feng 2005 {published data only}
Feng 2007a {published data only}
  • Feng J, Husain M. Outcomes of women with atypical squamous cells of undetermined significance and high-risk human papillomavirus DNA. Acta Cytologica 2007;51(5):730-4.
Feng 2007b {published data only}
  • Feng SY, Zhang YN, Liu JH, Liu JG, Yan M. [Expression of epidermal growth factor receptor and the correlation with HPV16/18 infection in cervical intraepithelial neoplasia and cervical carcinoma]. Zhonghua Zhong Liu Za Zhi 2007;29(10):759-63.
Feng 2008 {published data only}
  • Feng J, Al Abbadi MA, Bandyopadhyay S, Salimnia H, Husain M. Significance of high-risk human papillomavirus DNA-positive atypical squamous cells of undetermined significance pap smears in perimenopausal and postmenopausal women. Acta Cytologica 2008;52(4):434-8.
Ferenczy 1996 {published data only}
  • Ferenczy A, Franco E, Arseneau J, Wright TC, Richart RM. Diagnostic performance of Hybrid Capture human papillomavirus deoxyribonucleic acid assay combined with liquid-based cytologic study. American Journal of Obstetrics and Gynecology 1996;175:651-6.
Ferris 1998a {published data only}
  • Ferris DG, Wright TC, Litaker MS, Richart RM, Lorincz AT, Sun XW, et al. Triage of women with ASCUS and LSIL on Pap smear reports: management by repeat Pap smear, HPV DNA testing, or colposcopy?. The Journal of Family Practice 1998;46:125-34.
Ferris 1998b {published data only}
  • Ferris DG, Wright TC, Litaker MS, Richart RM, Lorincz AT, Sun XW, et al. Comparison of two tests for detecting carcinogenic HPV in women with Papanicolaou smear reports of ASCUS and LSIL. The Journal of Family Practice 1998;46:136-41.
Fletcher 2009 {published data only}
  • Fletcher AH, Wilkinson EJ, Knapik JA. Oncogenic human papillomavirus testing in an adolescent population with atypical squamous cells of undetermined significance. Journal of Lower Genital Tract Disease 2009;13(1):28-32.
Fröberg 2008 {published data only}
  • Fröberg M, Johansson B, Hjerpe A, Andersson S. Human papillomavirus "reflex" testing as a screening method in cases of minor cytological abnormalities. British Journal of Cancer 2008;99(4):563-8.
Ge 2009 {published data only}
Getman 2009 {published data only}
  • Getman D, Aiyer A, Dockter J, Giachetti C, Zhang F, Ginocchio CC. Efficiency of the APTIMA HPV Assay for detection of HPV RNA and DNA targets. Journal of Clinical Virology 2009;45 Suppl 1:S49-54.
Goff 1993 {published data only}
Griesser 2009 {published data only}
  • Griesser H, Sander H, Walczak C, Hilfrich RA. HPV vaccine protein L1 predicts disease outcome of high-risk HPV+ early squamous dysplastic lesions. American Journal of Clinical Pathology 2009;132(6):840-5.
Guarisi 2009 {published data only}
Guimaraes 2005 {published data only}
  • Guimaraes MC, Goncalves MA, Soares CP, Bettini JS, Duarte RA, Soares EG. Immunohistochemical expression of p16INK4a and bcl-2 according to HPV type and to the progression of cervical squamous intraepithelial lesions. The Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society 2005;53:509-16. [MEDLINE: 22466]
Guo 2004 {published data only}
  • Guo M, Hu L, Baliga M, He Z, Hughson MD. The predictive value of p16(INK4a) and hybrid capture 2 human papillomavirus testing for high-grade cervical intraepithelial neoplasia. American Journal of Clinical Pathology 2004;122(6):894-901.
Guo 2007 {published data only}
  • Guo M, Patel SJ, Chovanec M, Jan YJ, Tarco E, Bevers TB, et al. A human papillomavirus testing system in women with abnormal Pap results: a comparison study with follow-up biopsies. Acta Cytologica 2007;51(5):749-54.
Guo 2008 {published data only}
  • Guo M, Lin CY, Gong Y, Cogdell DE, Zhang W, Lin E, et al. Human papillomavirus genotyping for the eight oncogenic types can improve specificity of HPV testing in women with mildly abnormal Pap results. Modern Pathology 2008;21:1037-43.
Gupta 2007 {published data only}
  • Gupta S, Sodhani P, Chachra KL, Singh V, Sehgal A. Outcome of "Atypical squamous cells" in a cervical cytology screening program: implications for follow up in resource limited settings. Diagnostic Cytopathology 2007;35(11):677-80.
Gupta 2010 {published data only}
Gustavsson 2009 {published data only}
  • Gustavsson I, Juko-Pecirep I, Backlund I, Wilander E, Gyllensten U. Comparison between the Hybrid Capture 2 and the hpVIR real-time PCR for detection of human papillomavirus in women with ASCUS or low grade dysplasia. Journal of Clinical Virology 2009;45(2):85-9.
Halfon 2007 {published data only}
  • Halfon P, Trepo E, Antoniotti G, Bernot C, Cart-Lamy P, Khiri H, et al. Prospective evaluation of the Hybrid Capture 2 and AMPLICOR human papillomavirus (HPV) tests for detection of 13 high-risk HPV genotypes in atypical squamous cells of uncertain significance. Journal of Clinical Microbiology 2007;45(2):313-6.
Halfon 2010a {published data only}
  • Halfon P, Benmoura D, Agostini A, Khiri H, Martineau A, Penaranda G, et al. Relevance of HPV mRNA detection in a population of ASCUS plus women using the NucliSENS EasyQ HPV assay. Journal of Clinical Virology 2010;47(2):177-81.
Halfon 2010b {published data only}
  • Halfon P, Benmoura D, Khiri H, Penaranda G, Blanc B, Riggio D, et al. Comparison of the clinical performance of carcinogenic HPV typing of the Linear Array and Papillocheck HPV-screening assay. Journal of Clinicla Virology 2010;47(1):38-42.
Hall 1996 {published data only}
  • Hall S, Lorincz A, Shah F, Sherman ME, Abbas F, Paull G, et al. Human papillomavirus DNA detection in cervical specimens by hybrid capture: correlation with cytologic and histologic diagnoses of squamous intraepithelial lesions of the cervix. Gynecologic Oncology 1996;62:353-9.
Harvey 2009 {published data only}
  • Harvey M, Stout S, Starkey CR, Hendren R, Holt S, Miller GC. The clinical performance of Invader technology and SurePath when detecting the presence of high-risk HPV cervical infection. Journal of Clinical Virology 2009;45 Suppl 1:S79-83.
Hatch 1995 {published data only}
  • Hatch KD, Schneider A, Abdel-Nour MW. An evaluation of human papillomavirus testing for intermediate- and high-risk types as triage before colposcopy. American Journal of Obstetrics and Gynecology 1995; Vol. 172:1150-7.
Herrington 1995 {published data only}
  • Herrington CS, Evans MF, Hallam NF, Charnock FM, Gray W, McGee ODJ. Human papillomavirus status in the prediction of high-grade cervical intraepithelial neoplasia with persistent low-grade cervical cytological abnormalities. British Journal of Cancer 1995;71:206-9.
Ho 2003 {published data only}
Howard 2008 {published data only}
  • Howard K, Salkeld G, McCaffery K, Irwig L. HPV triage testing or repeat Pap smear for the management of atypical squamous cells (ASCUS) on Pap smear: is there evidence of process utility?. Health Economics 2008;17(5):593-605.
Howell 2010 {published data only}
  • Howell LP, Wilton M, Bishop J, Afify A. Living with uncertainty: equivocal Pap test results and the evolution of ASC terminology. Diagnostic Cytopathology 2010;38(3):221-32.
Hughes 2002 {published data only}
  • Hughes SA, Sun D, Gibson C, Bellerose B, Rushing L, Chen H, et al. Managing atypical squamous cells of undetermined significance (ASCUS): human papillomavirus testing, ASCUS subtyping, or follow-up cytology?. American Journal of Obstetrics and Gynecology 2002;83:396-403.
Irvin 2005 {published data only}
  • Irvin W, Evans SR, Andersen W, Jazaeri A, Taylor P, Stoler M. The utility of HPV DNA triage in the management of cytological AGC. American Journal of Obstetrics and Gynecology 2005;193(2):559-65. [MEDLINE: 24468]
Jamison 2009 {published data only}
Jarboe 2010 {published data only}
  • Jarboe EA, Venkat P, Hirsch MS, Cibas ES, Crum CP, Garner EI. A weakly positive human papillomavirus Hybrid Capture II result correlates with a significantly lower risk of cervical intraepithelial neoplasia 2,3 after atypical squamous cells of undetermined significance cytology. Journal of Lower Genital Tract Disease 2010;14(3):174-8.
Jeantet 2009 {published data only}
  • Jeantet D, Schwarzmann F, Tromp J, Melchers WJ, van der Wurff AA, Oosterlaken T, et al. NucliSENS EasyQ HPV v1 test - testing for oncogenic activity of human papillomaviruses. Journal of Clinical Virology 2009;45(Suppl 1):S29-37.
Jeronimo 2007 {published data only}
  • Jeronimo J, Massad LS, Schiffman M. Visual appearance of the uterine cervix: correlation with human papillomavirus detection and type. American Journal of Obstetrics and Gynecology 2007;197(1):47-8.
Julian 2006 {published data only}
  • Julian TM, Dexeus S, Kitchener HC, Shier RM. Clinical question: ask the experts. A 45-year-old woman seeks treatment at your clinic with atypical squamous cells from Pap smear results. Journal of Lower Genital Tract Disease 2006;10(1):64-5.
Kapeu 2009 {published data only}
  • Kapeu AS, Luostarinen T, Jellum E, Dillner J, Hakama M, Koskela P, et al. Is smoking an independent risk factor for invasive cervical cancer? A nested case-control study within Nordic biobanks. American Journal of Epidemiology 2009;169(4):480-8.
Kaufman 1997a {published data only}
  • Kaufman RH, Adam E. Does typing of human papillomavirus assist in the triage of women with repeated low-grate, cervical cytologic abnormalities?. Gynecologic Oncology 1997;70:317-8.
Kaufman 1997b {published data only}
  • Kaufman RH, Adam E, Icenogle J, Reeves WC. Human papillomavirus testing as triage for atypical squamous cells of undetermined significance and low-grade squamous intraepithelial lesions: Sensitivity, specificity, and cost-effectiveness. American Journal of Obstetrics and Gynecology 1997;177:930-6.
Kavoussi 2009 {published data only}
  • Kavoussi SK, Smith YR, Ernst SD, Quint EH. Cervical cancer screening with liquid cytology in women with developmental disabilities. Journal of Women's Health  2009;18(1):115-8.
Keegan 2009 {published data only}
  • Keegan H, Mc Inerney J, Pilkington L, Gronn P, Silva I, Karlsen F, et al. Comparison of HPV detection technologies: Hybrid capture 2, PreTect HPV-Proofer and analysis of HPV DNA viral load in HPV16, HPV18 and HPV33 E6/E7 mRNA positive specimens. Journal of Virological Methods 2009;155(1):61-6.
Kendall 2005 {published data only}
  • Kendall BS, Bush AC, Olsen CH, Zahn CM. Reflex high-risk human papillomavirus testing for women with atypical squamous cells of undetermined significance in cytologic smears: effects since implementation in a large clinical practice. American Journal of Clinical Pathology 2005;123:524-8. [MEDLINE: 22511]
Kitchener 2008 {published data only}
Knoepp 2007 {published data only}
  • Knoepp SM, Kuebler DL, Wilbur DC. Resolution of equivocal results with the Hybrid Capture II high-risk HPV DNA test: a cytologic/histologic review of 191 cases. Diagnostic Molecular Pathology  2007;16(3):125-9.
Knoepp 2010 {published data only}
Kong 2007 {published data only}
  • Kong CS, Balzer BL, Troxell ML, Patterson BK, Longacre TA. p16INK4A immunohistochemistry is superior to HPV in situ hybridization for the detection of high-risk HPV in atypical squamous metaplasia. The American Journal of Surgical Pathology 2007;31(1):33-43.
Kovacs 2009 {published data only}
  • Kovacs K, Varnai AD, Bollmann M, Bankfalvi A, Szendy M, Speich N, et al. A 7.5-year prospective study of longer than 18 months type-specific human papillomavirus persistence in a routine cytology-based cervical screening population of about 31,000 women in West Germany. European Journal of Cancer Prevention  2009;18(4):307-15.
Krambeck 2008 {published data only}
  • Krambeck WM, Cadide RM, Dalmarco EM, de Cordova CM. HPV detection and genotyping as an earlier approach in cervical cancer screening of the female genital tract. Clinical and Experimental Obstetrics & Gynecology 2008;35(3):175-8.
Krane 2004 {published data only}
  • Krane JF, Lee KR, Sun D, Yuan L, Crum CP. Atypical glandular cells of undetermined significance. Outcome predictions based on human papillomavirus testing. American Journal of Clinical Pathology 2004;121(1):87-92. [MEDLINE: 18921]
Kulasingam 2006 {published data only}
  • Kulasingam SL, Kim JJ, Lawrence WF, Mandelblatt JS, Myers ER, Schiffman M, et al. Cost-effectiveness analysis based on the atypical squamous cells of undetermined significance/low-grade squamous intraepithelial lesion Triage Study (ALTS). Journal of the National Cancer Institute 2006;98(2):92-100.
Kumar 2007 {published data only}
  • Kumar K, Iyer VK, Bhatla N, Kriplani A, Verma K. Comparative evaluation of smear cytology & hybrid capture II for the diagnosis of cervical cancer. The Indian Journal of Medical Research 2007;126(1):39-44.
Kuperman 2000 {published data only}
  • Kuperman L, Krumholz BA. The triage of women with ASCUS cytology using human papillomavirus DNA testing. Journal of Lower Genital Tract Disease 2000;4(1):1-6. [MEDLINE: 19323]
Layfield 2005 {published data only}
Lee 2006 {published data only}
Lee 2007 {published data only}
  • Lee CY, Ng WK. A follow-up study of atypical squamous cells in gynecologic cytology using conventional Papanicolaou smears and liquid-based preparations: the impact of the Bethesda System 2001. American Journal of Clinical Ppathology 2007;127(4):548-55.
Legood 2006 {published data only}
  • Legood R, Gray A, Wolstenholme J, Moss S. Lifetime effects, costs, and cost effectiveness of testing for human papillomavirus to manage low grade cytological abnormalities: modelling study. BMJ 2006;332(7533):79-85.
Leo 2009 {published data only}
  • Leo E, Venturoli S, Cricca M, Musiani M, Zerbini M. High-throughput two-step LNA real time PCR assay for the quantitative detection and genotyping of HPV prognostic-risk groups. Journal of Clinical Virology 2009;45(4):304-10.
Liang 2010 {published data only}
  • Liang CW, Lin MC, Hsiao CH, Lin YT, Kuo KT. Papillary squamous intraepithelial lesions of the uterine cervix: human papillomavirus-dependent changes in cell cycle expression and cytologic features. Human Pathology 2010;41(3):326-35.
Lim 2010 {published data only}
  • Lim EH, Ng SL, Li JL, Chang AR, Ng J, Ilancheran A, et al. Cervical dysplasia: assessing methylation status (Methylight) of CCNA1, DAPK1, HS3ST2, PAX1 and TFPI2 to improve diagnostic accuracy. Gynecologic Oncology 2010;119(2):225-31.
Liman 2005 {published data only}
Lin 2000 {published data only}
  • Lin CT, Tseng CJ, Lai CH, Hsueh S, Huang HJ, Law KS. High-risk HPV DNA detection by Hybrid Capture II. An adjunctive test for mildly abnormal cytologic smears in women > or = 50 years of age. Journal of Reproductive Medicine 2000;45:345-50.
Lin 2010 {published data only}
  • Lin CJ, Lai HC, Wang KH, Hsiung CA, Liu HW, Ding DC, et al. Testing for methylated PCDH10 or WT1 is superior to the HPV test in detecting severe neoplasms (CIN3 or greater) in the triage of ASC-US smear results. American Journal of Obstetrics and Gynecology 2011;204(1):e1-7.
Longatto-Filho 2005 {published data only}
  • Longatto-Filho A, Utagawa ML, Shirata NK, Pereira SM, Namiyama GM, Kanamura CT, et al. Immunocytochemical expression of p16INK4A and Ki-67 in cytologically negative and equivocal pap smears positive for oncogenic human papillomavirus. International Journal of Gynecological Pathology 2005;24(2):118-24.
Martin 2009 {published data only}
  • Martin CM, Astbury K, McEvoy L, O'Toole S, Sheils O, O'Leary JJ. Gene expression profiling in cervical cancer: identification of novel markers for disease diagnosis and therapy. Methods in Molecular Biology 2009;511:333-59.
Massad 2004 {published data only}
  • Massad LS, Schneider MF, Watts DH, Strickler HD, Melnick S, Palefsky J, et al. HPV testing for triage of HIV-infected women with Papanicolaou smears read as atypical squamous cells of uncertain significance. Journal of Women's Health 2004;13(2):147-53. [MEDLINE: 19756]
Massad 2009 {published data only}
  • Massad LS, Jeronimo J, Katki HA, Schiffman M. The accuracy of colposcopic grading for detection of high-grade cervical intraepithelial neoplasia. Journal of Lower Genital Tract Disease 2009;13(3):137-44.
Maucort-Boulch 2010 {published data only}
McHale 2007 {published data only}
  • McHale MT, Souther J, Elkas JC, Monk BJ, Harrison TA. Is atypical squamous cells that cannot exclude high-grade squamous intraepithelial lesion clinically significant?. Journal of Lower Genital Tract Disease 2007;11(2):86-9.
Melnikow 2006 {published data only}
  • Melnikow J, Birch S. Human papillomavirus triage of atypical squamous cells of undetermined significance: cost-effective, but at what cost?. Journal of the National Cancer Institute 2006;98(2):82-3.
Mesher 2010 {published data only}
  • Mesher D, Szarewski A, Cadman L, Cubie H, Kitchener H, Luesley D, et al. Long-term follow-up of cervical disease in women screened by cytology and HPV testing: results from the HART study. British Journal of Cancer 2010;102:1405-10.
Mirasoli 2009 {published data only}
  • Mirasoli M, Guardigli M, Simoni P, Venturoli S, Ambretti S, Musiani M, et al. Multiplex chemiluminescence microscope imaging of P16(INK4A) and HPV DNA as biomarker of cervical neoplasia. Analytical and Bioanalytical Chemistry 2009;394(4):981-7.
Mo 2008 {published data only}
  • Mo LZ, Monnier-Benoit S, Kantelip B, Petitjean A, Riethmuller D, Pretet JL, et al. Comparison of AMPLICOR and Hybrid Capture II assays for high risk HPV detection in normal and abnormal liquid-based cytology: use of INNO-LiPA Genotyping assay to screen the discordant results. Journal of Clinical Virology 2008;41(2):104-10.
Mokhtar 2008 {published data only}
  • Mokhtar GA, Delatour NL, Assiri AH, Gilliatt MA, Senterman M, Islam S. Atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion: cytohistologic correlation study with diagnostic pitfalls. Acta Cytologica 2008;52(2):169-77.
Molden 2005 {published data only}
Monsonego 2005 {published data only}
  • Monsonego J, Bohbot JM, Pollini G, Krawec C, Vincent C, Merignargues I, et al. Performance of the Roche AMPLICOR(R) Human papillomavirus (HPV) test in prediction of cervical intraepithelial neoplasia (CIN) in women with abnormal PAP smear. Gynecologic Oncology 2005;99:160-8.
Monsonego 2008a {published data only}
  • Monsonego J, Pollini G, Evrard MJ, Sednaoui P, Monfort L, Quinzat D, et al. Linear array genotyping and hybrid capture II assay in detecting human papillomavirus genotypes in women referred for colposcopy due to abnormal Papanicolaou smear. International Journal of STD & AIDS 2008;19(6):385-92.
Moore 2010 {published data only}
  • Moore G, Fetterman B, Cox JT, Poitras N, Lorey T, Kinney W, et al. Lessons from practice: risk of CIN 3 or cancer associated with an LSIL or HPV-positive ASC-US screening result in women aged 21 to 24. Journal of Lower Genital Tract Diseases 2010;14(2):97-102.
Moscicki 2008 {published data only}
  • Moscicki AB. Conservative management of adolescents with abnormal cytology and histology. Journal of the National Comprehensive Cancer Network 2008;6(1):101-6.
Mould 2000 {published data only}
  • Mould TAJ, Singer A, Gallivan S. Quantitative detection of oncogenic HPV DNA using hybrid capture to triage borderline and mildly dyskaryostic Papanicolaou smears. European Journal of Gynaelogical Oncology 2000;21:245-8.
Nassar 2008 {published data only}
  • Nassar A, O'Reilly K, Cohen C, Siddiqui MT. Comparison of p16(INK4A) and Hybrid Capture(R) 2 human papillomavirus testing as adjunctive tests in liquid-based gynecologic SurePathtrade mark preparations. Diagnostic Cytopathology 2008;36(3):142-8.
Noel 2006 {published data only}
  • Noel JC, Bucella D, Fayt I, Romero-Munoz MR, Simon P. Contribution of HPV sequences detection in cervical carcinoma screening. Annales de Pathologie 2006;26(5):389-96.
Nomelini 2007 {published data only}
  • Nomelini RS, Barcelos AC, Michelin MA, Adad SJ, Murta EF. Utilization of human papillomavirus testing for cervical cancer prevention in a university hospital. Cadernos de Saúde Pública 2007;23(6):1309-18.
Nuovo 2008 {published data only}
  • Nuovo GJ, Bartholomew D, Jung WW, Han IK, Um T, Grabarz DF, et al. Correlation of Pap smear, cervical biopsy, and clinical follow-up with an HPV typing microarray system. Diagnostic Molecular Pathology 2008;17(2):107-11.
Nyirjesy 1998 {published data only}
Ogilvie 2010 {published data only}
  • Ogilvie GS, Van Niekerk DJ, Krajden M, Martin RE, Ehlen TG, Ceballos K, et al. A randomized controlled trial of Human Papillomavirus (HPV) testing for cervical cancer screening: trial design and preliminary results (HPV FOCAL Trial). BMC Cancer 2010;10(1):111.
Oliveira 2004 {published data only}
  • Oliveira ER, Derchain SF, Rabelo-Santos SH, Westin MC, Zeferino LC, Campos EA, et al. Detection of high-risk human papillomavirus (HPV) DNA by Hybrid Capture II in women referred due to atypical glandular cells in the primary screening. Diagnostic Cytopathology 2004;31:19-22. [MEDLINE: 19841]
Oliveira 2010 {published data only}
  • Oliveira LH, Ferreira MD, Augusto EF, Melgaco FG, Santos LS, Cavalcanti SM, et al. Human papillomavirus genotypes in asymptomatic young women from public schools in Rio de Janeiro, Brazil. Revista da Sociedade Brasileira de Medicina Tropical 2010;43(1):4-8.
Onuma 2006 {published data only}
Ou 2007 {published data only}
  • Ou H, Bian ML, Zhang XY, Chen QY, Li M, Chen Y, et al. [Application of high-risk human papillomavirus testing in women with abnormal cytology]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 2007;29(5):608-11.
Ozsaran 2003 {published data only}
  • Ozsaran AA, Dikmen Y, Akercan F, Zekioglu O, Terek MC, Mgoyi L, et al. The triage of squamous cell abnormalities of cervical cytology by human papilloma virus screening. European Journal of Gynaelogical Oncology 2003;24(6):535-8. [MEDLINE: 18700]
Pajtler 2010 {published data only}
  • Pajtler M, Milicic-Juhas V, Milojkovic M, Topolovec Z, Curzik D, Mihaljevic I. Assessment of HPV DNA test value in management women with cytological findings of ASC-US, CIN1 and CIN2. Collegium Antropologicum 2010;34(1):81-6.
Pambuccian 2002 {published data only}
  • Pambuccian SE, Lundeen SJ, Woronzoff K, Rohlader J, Kjeldahl K, Curran C, et al. Reflex HPV testing of ASCUS patients: initial experience with PCR-based HPV identification and typing. 50th Annual Scientific Meeting of American Society of Clinical Cytology. Salt Lake City, 2002. [MEDLINE: 18576]
Paternoster 2008 {published data only}
  • Paternoster DM, Cester M, Resente C, Pascoli I, Nanhorngue K, Marchini F, et al. Human papilloma virus infection and cervical intraepithelial neoplasia in transplanted patients. Transplantation Proceedings 2008;40(6):1877-80.
Patton 2008 {published data only}
Peng 2006 {published data only}
Perrons 2005 {published data only}
Philips 2006 {published data only}
Pisal 2003 {published data only}
Poljak 2009 {published data only}
  • Poljak M, Kovanda A, Kocjan BJ, Seme K, Jancar N, Vrtacnik-Bokal E. The Abbott RealTime High Risk HPV test: comparative evaluation of analytical specificity and clinical sensitivity for cervical carcinoma and CIN 3 lesions with the Hybrid Capture 2 HPV DNA test. Acta Dermatovenerologica Alpina, Panonica, et Adriatica 2009;18(3):94-103.
Pretet 2008 {published data only}
  • Pretet JL, Jacquard AC, Saunier M, Clavel C, Dachez R, Gondry J, et al. Human papillomavirus genotype distribution in low-grade squamous intraepithelial lesions in France and comparison with CIN2/3 and invasive cervical cancer: the EDiTH III study. Gynecologic Oncology 2008;110(2):179-84.
Quddus 2002 {published data only}
  • Quddus MR, Zhang S, Sung CJ, Liu F, Neves T, Struminsky J, et al. Utility of HPV DNA detection in thin-layer, liquid-based tests with atypical squamous metaplasia. Acta Cytologica 2002;46(5):808-12.
Quddus 2009 {published data only}
  • Quddus MR, Neves T, Reilly ME, Steinhoff MM, Sung CJ. Does the ThinPrep Imaging System increase the detection of high-risk HPV-positive ASC-US and AGUS? The Women and Infants Hospital experience with over 200,000 cervical cytology cases. CytoJournal 2009;6:15.
Qureshi 2003 {published data only}
Rabelo-Santos 2009 {published data only}
  • Rabelo-Santos SH, Derchain SF, Villa LL, Costa MC, Sarian LO, do Amaral Westin MC, et al. Human papillomavirus-specific genotypes in cervical lesions of women referred for smears with atypical glandular cells or adenocarcinoma in situ. International Journal of Gynecological Pathology 2009;28(3):272-8.
Rana 2004 {published data only}
Raskin 2009 {published data only}
  • Raskin GA, Petrov SV, Orlova RV, Mal'tseva LI, Akhmetzianova AV, Farrakhova LN, et al. [Comparison of efficacy of combined use of liquid cytology and immunohistochemical assay of p16ink4 and standard procedure and high risk evaluation by polymerase chain reaction of human papillomavirus infection in diagnosing cervical dysplasia and carcinoma]. Voprosy Onkologii 2009;55(2):192-5.
Rauber 2008 {published data only}
  • Rauber D, Mehlhorn G, Fasching PA, Beckmann MW, Ackermann S. Prognostic significance of the detection of human papilloma virus L1 protein in smears of mild to moderate cervical intraepithelial lesions. European Journal of Obstetrics, Gynecology, and Reproductive Biology 2008;140(2):258-62.
Recio 1998 {published data only}
  • Recio FO, Sahai Srivastava BJ, Wong C, Hempling RE, Eltabbakh GH, Piver MS. The clinical value of digene hybrid capture HPV DNA testing in a referral-based population with abnormal pap smears. European Journal of Gynaelogical Oncology 1998;19:203-8.
Reesink-Peters 2003 {published data only}
  • Reesink-Peters N, Helder MN, Wisman GB, Knol AJ, Koopmans S, Boezen HM. Detection of telomerase, its components, and human papillomavirus in cervical scrapings as a tool for triage in women with cervical dysplasia. Journal of Clinical Pathology 2003;56:31-5. [MEDLINE: 21797]
Riethmuller 2008 {published data only}
  • Riethmuller D, Gabelle C, Ramanah R, Sautiere JL, Pretet JL, Schaal JP, et al. [Importance of human papillomavirus (HPV) screening in the follow-up after CIN2-3 treatment]. Journal de Gynécologie, Obstétrique et Biologie de la Reproduction 2008;37(4):329-37.
Rijkaart 2009 {published data only}
  • Rijkaart DC, Berkhof J, van Kemenade FJ, Rozendaal L, Verheijen RH, Bulk S, et al. Comparison of HPV and cytology triage algorithms for women with borderline or mild dyskaryosis in population-based cervical screening (VUSA-screen study). International Journal of Cancer 2009;126(9):2175-81.
Robova 2007 {published data only}
  • Robova H, Rob L, Pluta M, Kacirek J, Slavik V, Skapa P, et al. [Progression and regression low grade intraepithelial squamous lesions in context of positivity of high risk human papillomavirus]. Ceská Gynekologie 2007;72(5):347-50.
Rodriguez 2008 {published data only}
  • Rodriguez R, Fadare O. Longitudinal cytological follow-up of patients with a Papanicolaou test interpretation of "atypical squamous cells of undetermined significance" that was followed by a negative reflex test for high-risk human papillomavirus types. International Journal of Gynecological Pathology 2008;27(1):108-12.
Ronnett 1999 {published data only}
  • Ronnett BM, Manos M, Ransley JE, Fetterman B, Kinney W, Hurley A. Atypical glandular cells of undetermined significance (AGUS): cytopathologic features, histopathologic results, and human papillomavirus DNA detection. Human Pathology 1999;30:816-25. [MEDLINE: 10286]
Rosini 2007 {published data only}
  • Rosini S, Zappacosta R, Di Bonaventura G, Caraceni D, Pilla D, Di Girolamo G, et al. Management and triage of women with human papillomavirus infection in follow-up for low-grade cervical disease: association of HPV-DNA and RNA-based methods. International Journal of Immunopathology and Pharmacology 2007;20(2):341-7.
Rowe 2004 {published data only}
Saad 2006 {published data only}
  • Saad RS, Dabbs DJ, Kordunsky L, Kanbour-Shakir A, Silverman JF, Liu Y, et al. Clinical significance of cytologic diagnosis of atypical squamous cells, cannot exclude high grade, in perimenopausal and postmenopausal women. American Journal of Clinical Pathology 2006;126(3):381-8.
Safaeian 2007 {published data only}
  • Safaeian M, Solomon D, Wacholder S, Schiffman M, Castle P. Risk of precancer and follow-up management strategies for women with human papillomavirus-negative atypical squamous cells of undetermined significance. Obstetrics and Gynecology 2007;109(6):1325-31.
Samarawardana 2010 {published data only}
Santos 2003 {published data only}
  • Santos AL, Derchain SF, Martins MR, Sarian LO, Martinez EZ, Syrjanen KJ. Human papillomavirus viral load in predicting high-grade CIN in women with cervical smears showing only atypical squamous cells or low-grade squamous intraepithelial lesion. Sao Paulo Medical Journal 2003;121(6):238-43. [MEDLINE: 25246]
Santos 2006 {published data only}
  • Santos AL, Derchain SF, Sarian LO, Martins MR, Morais SS, Syrjanen KJ. Performance of Pap smear and human papilloma virus testing in the follow-up of women with cervical intraepithelial neoplasia grade 1 managed conservatively. Acta Obstetricia et Gynecologica Scandinavica 2006;85(4):444-50.
Saqi 2006 {published data only}
Sargent 2010 {published data only}
  • Sargent A, Bailey A, Turner A, Almonte M, Gilham C, Baysson H, et al. Optimal threshold for a positive hybrid capture 2 test for detection of human papillomavirus: data from the ARTISTIC trial. Journal of Clinical Microbiology 2010;48(2):554-8.
Sarian 2009 {published data only}
  • Sarian LO, Hammes LS, Longatto-Filho A, Guarisi R, Derchain SF, Roteli-Martins C, et al. Increased risk of oncogenic human papillomavirus infections and incident high-grade cervical intraepithelial neoplasia among smokers: experience from the Latin American screening study. Sexually Transmitted Diseases 2009;36(4):241-8.
Sarode 2003 {published data only}
Schiffman 2006 {published data only}
Schledermann 2008 {published data only}
  • Schledermann D, Andersen BT, Bisgaard K, Dohse M, Ejersbo D, Hoelund B, et al. Are adjunctive markers useful in routine cervical cancer screening? Application of p16(INK4a) and HPV-PCR on ThinPrep samples with histological follow-up. Diagnostic Cytopathology 2008;36(7):453-9.
Schmitz 2009 {published data only}
  • Schmitz M, Scheungraber C, Herrmann J, Teller K, Gajda M, Runnebaum IB, et al. Quantitative multiplex PCR assay for the detection of the seven clinically most relevant high-risk HPV types. Journal of Clinical Virology 2009;44(4):302-7.
Schnatz 2006 {published data only}
Seme 2006 {published data only}
  • Seme K, Fujs K, Kocjan BJ, Poljak M. Resolving repeatedly borderline results of Hybrid Capture 2 HPV DNA Test using polymerase chain reaction and genotyping. Journal of Virological Methods 2006;134(1-2):252-6.
Sharpless 2005a {published data only}
  • Sharpless KE, Schnatz PF, Mandavilli S, Greene JF, Sorosky JI. Dysplasia associated with atypical glandular cells on cervical cytology. Obstetrics and Gynecology 2005;105(3):494-500.
Sharpless 2005b {published data only}
  • Sharpless KE, Schnatz PF, Mandavilli S, Greene JF, Sorosky JI. Lack of adherence to practice guidelines for women with atypical glandular cells on cervical cytology. Obstetrics and Gynecology 2005;105(3):501-6.
Sharpless 2009 {published data only}
  • Sharpless KE, O'sullivan DM, Schnatz PF. The utility of human papillomavirus testing in the management of atypical glandular cells on cytology. Journal of Lower Genital Tract Disease 2009;13(2):72-8.
Sheriff 2007 {published data only}
  • Sheriff SK, Petry KU, Ikenberg H, Crouse G, Mazonson PD, Santas CC. An economic analysis of human papillomavirus triage for the management of women with atypical and abnormal Pap smear results in Germany. European Journal of Health Economics 2007;8(2):153-60.
Shi 2009 {published data only}
  • Shi JF, Belinson JL, Zhao FH, Pretorius RG, Li J, Ma JF, et al. Human papillomavirus testing for cervical cancer screening: results from a 6-year prospective study in rural China. American Journal of Epidemiology 2009;170(6):708-16.
Shidham 2007 {published data only}
  • Shidham VB, Kumar N, Narayan R, Brotzman GL. Should LSIL with ASC-H (LSIL-H) in cervical smears be an independent category? A study on SurePathtrade mark specimens with review of literature. CytoJournal 2007;4(7):1-10.
Shin 2008 {published data only}
Siddiqi 2009 {published data only}
Siddiqui 2008a {published data only}
  • Siddiqui MT, Cohen C, Nassar A. Detecting high-grade cervical disease on ASC-H cytology: role of BD ProEx C and Digene Hybrid Capture II HPV DNA testing. American Journal of Clinical Pathology 2008;130(5):765-70.
Sideri 1998 {published data only}
  • Sideri M, Spinaci L, Schettino F, Mezzetti M, Robertson C, Spolti N, et al. Risk factors for high-grade cervical intraepithelial neoplasia in patients with mild cytological dyskarosis: human papillomavirus testing versus multivariate tree analysis of demographic data. Cancer Epidemiology, Biomarkers and Prevention 1998;7:237-41. [MEDLINE: 10810]
Singh 2009 {published data only}
  • Singh M, Srivastava S, Singh U, Mathur N, Shukla Y. Co-expression of p53 and Bcl-2 proteins in human papillomavirus-induced premalignant lesions of the uterine cervix: correlation with progression to malignancy. Tumour Biology 2009;30(5-6):276-85.
Six 2008 {published data only}
  • Six L, Leodolter S, Sings HL, Barr E, Haupt R, Joura EA. Prevalence of human papillomavirus types 6, 11, 16 and 18 in young Austrian women - baseline data of a phase III vaccine trial. Wiener Klinische Wochenschrift 2008;120(21-22):666-71.
Slawson 1994 {published data only}
  • Slawson DC, Bennett JH, Simon LJ, Herman JM. Should all women with cervical atypia be referred for colposcopy: a HARNET study. Harrisburgh Area Research Network. Journal of Family Practice 1994;38:387-92.
Sorbye 2010 {published data only}
Srodon 2005 {published data only}
Steinman 2008 {published data only}
  • Steinman S, Smith D, Chandler N, Dhurandhar B, Di Filippo L, Scheiber-Pact M, et al. Morphologic, patient and interpreter profiles of high-risk human papillomavirus-positive vs.-negative cases of atypical squamous cells of undetermined significance. Acta Cytologica 2008;52(3):279-85.
Stemberger-Papic 2010 {published data only}
  • Stemberger-Papic S, Vrdoljak-Mozetic D, Ostojic DV, Rubesa-Mihaljevic R, Manestar M. Evaluation of the HPV L1 capsid protein in prognosis of mild and moderate dysplasia of the cervix uteri. Collegium Antropologicum 2010;34(2):419-23.
Stevens 2007 {published data only}
  • Stevens MP, Garland SM, Rudland E, Tan J, Quinn MA, Tabrizi SN. Comparison of the Digene Hybrid Capture 2 assay and Roche AMPLICOR and LINEAR ARRAY human papillomavirus (HPV) tests in detecting high-risk HPV genotypes in specimens from women with previous abnormal Pap smear results. Journal of Clinical Microbiology 2007;45(7):2130-7.
Stoler 2001 {published data only}
Stoler 2007 {published data only}
  • Stoler M, Castle P, Solomon D, Schiffman M. The authors' reply: The expanded use of HPV testing in gynecologic practice per ASCCP-guided management requires the use of well-validated assays. American Journal of Clinical Pathology 2007;128:884-6.
Suba 2009 {published data only}
Sun 2006 {published data only}
  • Sun XR, Che DY, Tu HZ, Li D, Wang J. [Assessment of cervical intraepithelial neoplasia (CIN) lesions by DNA image cytometry]. Zhonghua zhong liu za zhi [Chinese Journal of Oncology] 2006;28(11):831-5.
Sung 2010 {published data only}
  • Sung CO, Kim SR, Oh YL, Song SY. The use of p16(INK4A) immunocytochemistry in "Atypical squamous cells which cannot exclude HSIL" compared with "Atypical squamous cells of undetermined significance" in liquid-based cervical smears. Diagnostic Cytopathology 2010;38(3):168-71.
Tambouret 2008 {published data only}
  • Tambouret RH, Misdraji J, Wilbur DC. Longitudinal clinical evaluation of a novel antibody cocktail for detection of high-grade squamous intraepithelial lesions on cervical cytology specimens. Archives of Pathology & Laboratory Medicine 2008;132(6):918-25.
Tang 2009 {published data only}
  • Tang N, Huang S, Erickson B, Mak WB, Salituro J, Robinson J, et al. High-risk HPV detection and concurrent HPV 16 and 18 typing with Abbott RealTime High Risk HPV test. Journal of Clinical Virology 2009;45(Suppl 1):S25-8.
Tarkkanen 2007 {published data only}
Thrall 2008 {published data only}
  • Thrall MJ, Russell DK, Bonfiglio TA, Hoda RS. Use of the ThinPrep(R) Imaging System does not alter the frequency of interpreting Papanicolaou tests as atypical squamous cells of undetermined significance. CytoJournal 2008;5:10-5.
Thrall 2010 {published data only}
  • Thrall MJ, Smith DA, Mody DR. Women >or=30 years of age with low grade squamous intraepithelial lesion (LSIL) have low positivity rates when co-tested for high-risk human papillomavirus: should we reconsider HPV triage for LSIL in older women?. Diagnostic Cytopathology 2010;38:407-10. [MEDLINE: 30709]
TOMBOLA 2009a {published data only}
  • TOMBOLA Group. Cytological surveillance compared with immediate referral for colposcopy in management of women with low grade cervical abnormalities: multicentre randomised controlled trial. BMJ 2009;339:b2546-57.
TOMBOLA 2009b {published data only}
  • TOMBOLA Group. Biopsy and selective recall compared with immediate large loop excision in management of women with low grade abnormal cervical cytology referred for colposcopy: multicentre randomised controlled trial. BMJ 2009;339:b2548-60.
TOMBOLA 2009c {published data only}
  • TOMBOLA Group. Options for managing low grade cervical abnormalities detected at screening: cost effectiveness study. BMJ 2009;339:b2549-56.
Torres 2009 {published data only}
  • Torres LM, Paez M, Insaurralde A, Rodriguez MI, Castro A, Kasamatsu E. Detection of high risk human papillomavirus cervical infections by the Hybrid Capture in Asunci¢n, Paraguay. The Brazilian Journal of Infectious Disease 2009;13:203-6.
Tu 2009 {published data only}
  • Tu Z, Zhang A, Wu R, Jiang J, Li Y, Wulan N, et al. Genomic amplification of the human telomerase RNA gene for differential diagnosis of cervical disorders. Cancer Genetics and Cytogenetics 2009;191(1):10-6.
Vijayaraghavan 2010 {published data only}
  • Vijayaraghavan A, Efrusy MB, Goodman KA, Santas CC, Huh WK. Cost-effectiveness of using human papillomavirus 16/18 genotype triage in cervical cancer screening. Gynecologic Oncology 2010;119:237-42.
Vince 2001 {published data only}
  • Vince A, Ivanisevic M, Harni V, Skalko D, Jeren T. Molecular detection of human papillomavirus in women with minor-grade cervical cytology abnormalities. Journal of Clinical Virology 2001;20(1-2):91-4. [MEDLINE: 19772]
Walker 2006 {published data only}
  • Walker JL, Wang SS, Schiffman M, Solomon D. Predicting absolute risk of CIN3 during post-colposcopic follow-up: results from the ASCUS-LSIL Triage Study (ALTS). American Journal of Obstetrics and Gynecology 2006;195:341-8.
Wang 2007 {published data only}
  • Wang XL, Zhang R, Wu LY, Li SM, Huang MN, Li N. [The clinical significance and management of cervico-cytologically diagnosed ASCUS/LSIL.]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 2007;21(3):267-9.
Wensveen 2006 {published data only}
Wheeler 2006 {published data only}
  • Wheeler CM, Hunt WC, Schiffman M, Castle PE. Human papillomavirus genotypes and the cumulative 2-year risk of cervical precancer. The Journal of Infectious Diseases 2006;194(9):1291-9.
Wong 2008 {published data only}
  • Wong AK, Chan RC, Nichols WS, Bose S. Human papillomavirus (HPV) in atypical squamous cervical cytology: the Invader HPV test as a new screening assay. Journal of Clinical Microbiology 2008;46(3):869-75.
Wong 2008a {published data only}
  • Wong NK, Ng FY, Leung G. Cytological distinction between high-risk and low-risk human papillomavirus infections in SurePath liquid-based cell preparations. Journal of Clinical Pathology 2008;61(12):1317-22.
Wright 1995 {published data only}
Wright 1998 {published data only}
  • Wright TC, Lorincz AT, Ferris DG, Richart RM, Ferenczy A, Mielzynska I, et al. Reflex papillomavirus deoxyribonucleic acid testing in women with abnormal Papanicolaou smears. American Journal of Obstetrics and Gynecology 1998;178:962-6.
Wright 2006 {published data only}
  • Wright JD, Rader JS, Davila R, Powell MA, Mutch DG, Gao F, et al. Human papillomavirus triage for young women with atypical squamous cells of undetermined significance. Obstetrics and Gynecology 2006;107(4):822-9. [MEDLINE: 25448]
Wu 2006 {published data only}
  • Wu HH, Allen SL, Kirkpatrick JL, Elsheikh TM. Reflex high-risk human papilloma virus DNA test is useful in the triage of women with atypical squamous cells cannot exclude high-grade squamous intraepithelial lesion. Diagnostic Cytopathology 2006;34(10):707-10.
Xi 2009 {published data only}
  • Xi LF, Koutsky LA, Castle PE, Wheeler CM, Galloway DA, Mao C, et al. Human papillomavirus type 18 DNA load and 2-year cumulative diagnoses of cervical intraepithelial neoplasia grades 2-3. Journal of the National Cancer Institute 2009;101(3):153-61.
Yarandi 2009 {published data only}
  • Yarandi F, Shojaei H, Eftekhar Z, Izadi-Mood N. Comparison of three management strategies for patients with atypical squamous cells of undetermined significance, after six months delay: a three-year experience in an Iranian university hospital. The Australian & New Zealand Journal of Obstetrics & Gynaecology 2009;49(2):207-10.
Yu 2010 {published data only}
Zhao 2009a {published data only}
  • Zhao C, Austin RM. High-risk human papillomavirus DNA test results are useful for disease risk stratification in women with unsatisfactory liquid-based cytology pap test results. Journal of Lower Genital Tract Disease 2009;13(2):79-84.
Zhao 2009b {published data only}
  • Zhao C, Florea A, Onisko A, Austin RM. Histologic follow-up results in 662 patients with Pap test findings of atypical glandular cells: results from a large academic women's hospital laboratory employing sensitive screening methods. Gynecologic Oncology 2009;114(3):383-9.
Zivadinovic 2009 {published data only}
  • Zivadinovic R, Lilic V, Dordevic B, Stanojevic Z, Petric A, Lilic G. [The role of colposcopy and typization of human papillomavirus in further diagnostic proceedings in patients with ASC-US cytological finding of the uterine cervix]. Vojnosanitetski Pregled 2009;66(8):651-5.

References to studies awaiting assessment

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
Alameda 2011 {published data only}
Barcelos 2011 {published data only}
  • Barcelos AC, Michelin MA, Adad SJ, Murta EF. Atypical squamous cells of undetermined significance: Bethesda classification and association with human papillomavirus. Infectious Diseases in Obstetrics and Gynecology 2011;2011(904674):1-9.
Belinson 2011 {published data only}
  • Belinson JL, Wu R, Belinson SE, Qu X, Yang B, Du H, et al. A population-based clinical trial comparing endocervical high-risk HPV testing using hybrid capture 2 and Cervista from the SHENCCAST II Study. American Journal of Clinical Pathology 2011;135(5):790-5.
Chao 2013 {published data only}
Clad 2011 {published data only}
  • Clad A, Reuschenbach M, Weinschenk J, Grote R, Rahmsdorf J, Freudenberg N. Performance of the APTIMA high-risk HPV mRNA assay in a referral population in comparison with Hybrid Capture 2 and cytology. Journal of Clinical Microbiology 2011;49(3):1071-6.
Cuzick 2013 {published data only}
Dona 2012 {published data only}
  • Dona MG, Vocaturo A, Giuliani M, Ronchetti L, Rollo F, Pescarmona E, et al. p16/Ki-67 dual staining in cervico-vaginal cytology: Correlation with histology, Human Papillomavirus detection and genotyping in women undergoing colposcopy. Gynecologic Oncology 2012;126(2):198-202.
Dufresne 2011 {published data only}
  • Dufresne S, Sauthier P, Mayrand MH, Petignat P, Provencher D, Drouin P, et al. Human papillomavirus (HPV) DNA triage of women with atypical squamous cells of undetermined significance with Amplicor HPV and Hybrid Capture 2 assays for detection of high-grade lesions of the uterine cervix. Journal of Clinical Microbiology 2011;49(1):48-53.
Edgerton 2011 {published data only}
Gustinucci 2012 {published data only}
  • Gustinucci D, Passamonti B, Cesarini E, Butera D, Palmieri EA, Bulletti S, et al. Role of p16 cytology testing as an adjunct to enhance the diagnostic specificity and accuracy in human papillomavirus-positive women within an organized cervical cancer screening program. Acta Cytologica 2012;56(5):506-14.
Heider 2011 {published data only}
  • Heider A, Austin RM, Zhao C. HPV Test Results Stratify Risk for Histopathologic Follow-Up Findings of High-Grade Cervical Intra-Epithelial Neoplasia in Women with Low-Grade Squamous Intra-Epithelial Lesion Pap Results. Acta Cytologica 2011;55(1):48-53.
Huang 2012 {published data only}
Ibanez 2012 {published data only}
  • Ibanez R, Moreno-Crespi J, Sarda M, Autonell J, Fibla M, Gutierrez C, et al. Prediction of cervical intraepithelial neoplasia grade 2+ (CIN2+) using HPV DNA testing after a diagnosis of atypical squamous cells of undetermined significance (ASC-US) in Catalonia, Spain. BMC Infectious Diseases 2012;12(1):25.
Jakobsson 2012 {published data only}
  • Jakobsson M, Tarkkanen J, Auvinen E, Hakkinen R, Laurila P, Tapper AM. Colposcopy referral rate can be reduced by high-risk human papillomavirus triage in the management of recurrent atypical squamous cells of undetermined significance or low-grade squamous intraepithelial lesion cytology in Finland. International Journal of STD & AIDS 2012;23(7):485-9.
Jiang 2011 {published data only}
  • Jiang L, Zeng Y, Li J, Wang H, Xia Y, Fang X, et al. Performance of high-risk human papillomavirus testing in the triage of abnormal cervical cytology among Chinese younger women in Shanghai, China. Asian Pacific Journal of Cancer Prevention 2011;12(11):2963-7.
Koliopoulos 2012 {published data only}
Lapierre 2012 {published data only}
  • Lapierre SG, Sauthier P, Mayrand MH, Dufresne S, Petignat P, Provencher D, et al. Human papillomavirus (HPV) DNA triage of women with atypical squamous cells of undetermined significance with cobas 4800 HPV and Hybrid Capture 2 tests for detection of high-grade lesions of the uterine cervix. Journal of Clinical Microbiology 2012;50(4):1240-4.
Levi 2011 {published data only}
Loghavi 2012 {published data only}
  • Loghavi S, Walts AE, Bose S. CINtec(R) plus dual immunostain: a triage tool for cervical pap smears with atypical squamous cells of undetermined significance and low grade squamous intraepithelial lesion. Diagnostic Cytopathology 2012;Epub ahead of print:10.1002/dc.22900. [DOI: 10.1002/dc.22900]
Ma 2011 {published data only}
  • Ma YY, Cheng XD, Zhou CY, Qiu LQ, Chen XD, Lu WG, et al. Value of P16 expression in the triage of liquid-based cervical cytology with atypical squamous cells of undetermined significance and low-grade squamous intraepithelial lesions. Chinese Medical Journal 2011;124(16):2443-7.
Monsonego 2011 {published data only}
Nasioutziki 2011 {published data only}
  • Nasioutziki M, Daniilidis A, Dinas K, Kyrgiou M, Valasoulis G, Loufopoulos PD, et al. The evaluation of p16INK4a immunoexpression/immunostaining and human papillomavirus DNA test in cervical liquid-based cytological samples. International Journal of Gynecological Cancer 2011;21(1):79-85.
Origoni 2012 {published data only}
  • Origoni M, Carminati G, Rolla S, Clementi M, Sideri M, Sandri MT, et al. Human papillomavirus viral load expressed as relative light units (RLU) correlates with the presence and grade of preneoplastic lesions of the uterine cervix in atypical squamous cells of undetermined significance (ASCUS) cytology. European Journal of Clinical Microbiology & Infectious Diseases 2012;31(9):2401-6.
Ovestad 2011 {published data only}
  • Ovestad IT, Vennestrom U, Andersen L, Gudlaugsson E, Munk AC, Malpica A, et al. Comparison of different commercial methods for HPV detection in follow-up cytology after ASCUS/LSIL, prediction of CIN2-3 in follow up biopsies and spontaneous regression of CIN2-3. Gynecological Oncology 2011;123(2):278-83.
Pista 2011 {published data only}
Ratnam 2011 {published data only}
  • Ratnam S, Coutlee F, Fontaine D, Bentley J, Escott N, Ghatage P, et al. Aptima HPV E6/E7 mRNA test is as sensitive as Hybrid Capture 2 Assay but more specific at detecting cervical precancer and cancer. Journal of Clinical Microbiology 2011;49(2):557-64.
Rodriguez 2012 {published data only}
  • Rodriguez EF, Reynolds JP, Jenkins SM, Winter SM, Henry MR, Nassar A. Atypical squamous cells of undetermined significance in patients with HPV positive DNA testing and correlation with disease progression by age group: an institutional experience. International Journal of Clinical and Experimental Pathology 2012;5(5):428-35.
Schmidt 2011 {published data only}
Soderlund-Strand 2011 {published data only}
  • Soderlund-Strand A, Eklund C, Kemetli L, Grillner L, Tornberg S, Dillner J, et al. Genotyping of human papillomavirus in triaging of low-grade cervical cytology. American Journal of Obstetrics and Gynecology 2011;205(2):145-6.
Stoler 2011 {published data only}
  • Stoler MH, Wright TC, Sharma A, Apple R, Gutekunst K, Wright TL. High-risk human papillomavirus testing in women with ASC-US cytology: results from the ATHENA HPV study. American Journal of Clinical Pathology 2011;135(3):468-75.
Stoler 2013 {published data only}
  • Stoler MH, Wright TC Jr, Cuzick J, Dockter J, Reid JL, Getman D, et al. APTIMA HPV assay performance in women with atypical squamous cells of undetermined significance cytology results. American Journal of Obstetrics and Gynecology 2013;208(2):144.e1-8. [DOI: 10.1016/j.ajog.2012.12.003]
Szarewski 2012 {published data only}
  • Szarewski A, Mesher D, Cadman L, Austin J, Ashdown-Barr L, Ho L, et al. A comparison of seven tests for high grade cervical intraepithelial neoplasia in women with abnormal smears: the Predictors 2 study. Journal of Clinical Microbiology 2012;50(6):1867-73.
Tsoumpou 2010 {published data only}
  • Tsoumpou I, Valasoulis G, Founta C, Kyrgiou M, Nasioutziki M, Daponte A, et al. High-risk human papillomavirus DNA test and p16(INK4a) in the triage of LSIL: a prospective diagnostic study. Gynecologic Oncology 2010 Dec 29;121:49-53.
Valasoulis 2011 {published data only}
  • Valasoulis G, Tsoumpou I, Founta C, Kyrgiou M, Dalkalitsis N, Nasioutziki M, et al. The role of p16INK4a immunostaining in the risk assessment of women with LSIL cytology: a prospective pragmatic study. European Journal of Gynaecological Oncology 2011;32(2):150-2.
Waldstrom 2011 {published data only}
  • Waldstrom M, Ornskov D. Clinical performance of a human papillomavirus messenger RNA test (Aptima HPV assay) on residual material from archived 3-year-old PreservCyt samples with low-grade squamous intraepithelial lesion. Archives of Pathology & Laboratory Medicine 2011;135(8):1052-6.
Wentzensen 2012 {published data only}
  • Wentzensen N, Schwartz L, Zuna RE, Smith KM, Mathews C, Gold M, et al. Performance of p16/Ki-67 immunostaining to detect cervical cancer precursors in a colposcopy referral population. Clinical Cancer Research 2012;18(15):4154-62.
Wong 2011 {published data only}
  • Wong OG, Lo CK, Szeto E, Cheung AN. Efficacy of Abbott RealTime High Risk HPV test in evaluation of atypical squamous cells of undetermined significance from an Asian screening population. Journal of Clinical Virology 2011;51(2):136-8.
Wong 2012 {published data only}
  • Wong OG, Lo CK, Chow JN, Tsun OK, Szeto E, Liu SS, et al. Comparison of the GenoFlow human papillomavirus (HPV) test and the Linear Array assay for HPV screening in an Asian population. Journal of Clinical Microbiology 2012;50(5):1691-7.
Wu 2010 {published data only}
  • Wu R, Belinson SE, Du H, Na W, Qu X, Wu R, et al. Human papillomavirus messenger RNA assay for cervical cancer screening: the Shenzhen Cervical Cancer Screening Trial I. International Journal of Gynecological Cancer 2010;20(8):1411-4.
Ziemke 2012 {published data only}
  • Ziemke P, Marquardt K. Immunocytochemistry of p16(INK4a) and Ki-67 as adjunctive method for routine gynecological cytology of mild and moderate dysplasia. Pathologe 2012;Epub ahead of print:Jul 4.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
ACOG 2009
  • American College of Obstetricians and Gynecologists. ACOG Practice Bulletin No. 109: Cervical cytology screening. Obstetrics and Gynecology 2009;114(6):1409-20.
ALTS Group 2003a
  • ALTS Group. Results of a randomised trial on the management of cytology interpretations of atypical squamous cells of undetermined significance. American Journal of Obstetrics and Gynecology 2003;188:1383-92.
ALTS Group 2000
  • ALTS Group. Human papillomavirus testing for triage of women with cytologic evidence of low-grade squamous intraepithelial lesions: baseline data from a randomized trial. Journal of the National Cancer Institute 2000;92:397-402.
ANAES 2002
  • Agence nationale d'accréditation et d'évaluation en santé (ANAES). Conduite à tenir devant une patiente ayant un frottis cervico-utérin anormal. Service Recommandations et Références Professionnelles et Service Evaluation Economique. ANAES 2002.
Arbyn 2002
  • Arbyn M, Buntinx F, Van Ranst M, Cortiñas Abrahantes J. Triage of women with atypical or low-grade cytological abnormalities of the cervix by HPV testing: systematic review and meta-analysis. IPH/EPI-REPORTS Nr. 2001-019, 1-101. 2002.
Arbyn 2004a
  • Arbyn M, Buntinx F, Van Ranst M, Paraskevaidis E, Martin-Hirsch P, Dillner J. Virologic versus cytologic triage of women with equivocal Pap smears: a meta-analysis of the accuracy to detect high-grade intraepithelial neoplasia. Journal of the National Cancer Institute 2004;96:280-93. [MEDLINE: 18809]
Arbyn 2004b
  • Arbyn M, Dillner J, Van Ranst M, Buntinx F, Martin-Hirsch P, Paraskevaidis E. Have we resolved how to triage equivocal cervical cytology?. Journal of the National Cancer Institute 2004;96(18):1401-2. [MEDLINE: 19421]
Arbyn 2005
  • Arbyn M, Paraskevaidis E, Martin-Hirsch P, Prendiville W, Dillner J. Clinical utility of HPV DNA detection: triage of minor cervical lesions, follow-up of women treated for high-grade CIN. An update of pooled evidence. Gynecologic Oncology 2005;99(Suppl 3):7-11. [MEDLINE: 22712]
Arbyn 2006
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