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Cyanoacrylate microbial sealants for skin preparation prior to surgery

  1. Allyson Lipp1,*,
  2. Cheryl Phillips2,
  3. Paul Harris3,
  4. Iwan Dowie2

Editorial Group: Cochrane Wounds Group

Published Online: 21 AUG 2013

Assessed as up-to-date: 3 JUL 2013

DOI: 10.1002/14651858.CD008062.pub3


How to Cite

Lipp A, Phillips C, Harris P, Dowie I. Cyanoacrylate microbial sealants for skin preparation prior to surgery. Cochrane Database of Systematic Reviews 2013, Issue 8. Art. No.: CD008062. DOI: 10.1002/14651858.CD008062.pub3.

Author Information

  1. 1

    Department of Care Sciences, University of South Wales, Faculty of Health, Sport and Science, Pontypridd, Rhondda Cynon Taff, UK

  2. 2

    Department of Care Sciences, University of Glamorgan, Faculty of Health, Sport and Science, Pontypridd, Rhondda Cynon Taff, UK

  3. 3

    Princess of Wales Hospital, Abertawe Bro Morgannwg University NHS Trust, Main Theatres, Bridgend, UK

*Allyson Lipp, Faculty of Health, Sport and Science, Department of Care Sciences, University of South Wales, Glyn Taff Campus, Pontypridd, Rhondda Cynon Taff, CF37 1DL, UK. allyson.lipp@southwales.ac.uk.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 21 AUG 2013

SEARCH

This is not the most recent version of the article. View current version (18 MAY 2016)

References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
  5. References to other published versions of this review
Iyer 2011 {published data only}
  • A Iyer, I Gilfillan, S Thakur, S Sharma. Reduction of surgical site infection using a microbial sealant: A randomized trial. Perioperative Management 2011;142(2):438-42.
Towfigh 2008 {published and unpublished data}
von Eckardstein 2011 {published data only}
  • von Eckardstein AS, Lim CH, Dohmen PM, Pêgo-Fernandes PM, Cooper WA, Oslund SG, et al. A randomized trial of a skin sealant to reduce the risk of incision contamination in cardiac surgery. Annals of Thoracic Surgery 2011;92(2):632-7.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
  5. References to other published versions of this review
Dohmen 2007 {published data only}
  • Dohmen PM, Konertz W. A review of current strategies to reduce intraoperative bacterial contamination of surgical wounds. GMS Krankenhaushyg Interdiszio 2007;2(22):Doc27.
Dohmen 2008b {published data only}
  • Dohmen PM, Gabbieri D, Linneweber J, Weymann A, Konertz WF. Can we prevent surgical site infections during cardiac surgery by additional use of a microbial sealant?. 13th ICID International Conference for Infectious Disease; June 19-22, 2008; Kuala Lumpur, Malaysia. 2008.
Dohmen 2008c {published data only}
  • Dohmen PM, Gabbieri D, Dorgham O, Linneweber J, Konertz W. Clinical investigation of InteguSeal in coronary artery bypass procedures: a matched case-control study. Cardiovascular Science Forum 2008;3(1):9-16.
Dohmen 2008d {published data only}
  • Dohmen PM, Gabbieri D, Weymann A, Linneweber J, Konertz W. A preliminary study of InteguSeal use in patients undergoing cardiac surgery to prevent surgical site infections. Interactive Cardiovascular and Thoracic Surgery 2008;7:S65.
Dohmen 2009 {published data only}
  • Dohmen PM, Gabbieri D, Weymann A, Linneweber J, Konertz W. Reduction in surgical site infection in patients treated with microbial sealant prior to coronary artery bypass graft surgery: a case-control study. Journal of Hospital Infection 2009;72:119-26.
Dohmen 2011 {published data only}
  • PM Dohmen, D Gabbieri, A Weymann, J Linneweber, T Geyer, W Konertz. A retrospective non-randomized study on the impact of INTEGUSEAL, a preoperative microbial skin sealant, on the rate of surgical site infections after cardiac surgery. International journal of Infectious Diseases 2011;15:e395-e400.
Pekar 2009 {unpublished data only}
  • Pekar F. Can the use of InteguSeal improve clinical outcome and reduce prevalence of surgical site infection?. 58th ESCVS International Congress April 30-May 2, 2009; Warsaw, Poland. 2009.

References to studies awaiting assessment

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
  5. References to other published versions of this review
Dohmen 2012 {published data only}
Doorly 2013 {published data only}
  • Doorly M, Choi J, Floyd A, Senagore A. Microbial sealants do not decrease surgical site infection for clean contaminated colorectal procedures. Diseases of the Colon and Rectum 2013;56(4):e309-e310.
Dromzee 2012 {published data only}
  • Dromzee E, Tribot-Laspiere Q, Bachy M, Zakine S, Mary P, Vialle R. Efficacy of Integuseal for surgical skin preparation in children and adolescents undergoing scoliosis correction. Spine 2012;37(21):E1331-5.
Waldow 2012 {published data only}
  • Waldow T, Szlapka M, Hensel J, Plötze K, Matschke K, Jatzwauk L. Skin sealant InteguSeal® has no impact on prevention of postoperative mediastinitis after cardiac surgery. Journal of Hospital Infection 2012;81(4):278-82.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
  5. References to other published versions of this review
Bailey 1992
  • IS Bailey, SE Karran, K Toyn, P Brough, C Ranaboldo, SJ Karran. Community surveillance of complications after hernia surgery. British Medical Journal 1992;304(6825):469-471.
Dohmen 2008a
Edwards 2004
  • Edwards P, Lipp A, Holmes A. Preoperative skin antiseptics for preventing surgical wound infections after clean surgery. Cochrane Database of Systematic Reviews 2004, Issue 3. [DOI: 10.1002/14651858.CD003949.pub2]
Fleischmann 1996
Higgins 2003
Higgins 2011
  • Higgins JPT, Altman DG, Sterne JAC on behalf of the Cochrane Statistical Methods Group and the Cochrane Bias Methods Group (Editors). Chapter 8: Assessing risk of bias in included studies. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
Kimberly-Clark 2008
  • Kimberly-Clark. InteguSeal Microbial Sealant Brochure. Brochure 2008.
Lefebvre 2009
  • Lefebvre C, Manheimer E, Glanville J, on behalf of the Cochrane Information Retrieval Methods Group. Chapter 6: Searching for studies. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.2 [updated September 2009]. The Cochrane Collaboration, 2009. Available from www.cochrane-handbook.org.
Mangram 1999
  • Mangram AJ, Horan TC, Pearson ML, Silver LC, Jarvis WR. Guideline for prevention of surgical site infection: CDC US department of Health and Human Services. Infection Control and Hospital Epidemiology 1999;20(4):247-78.
McLaws 2000
National Audit Office 2004
  • National Audit Office. Improving patient care by reducing the risk of hospital acquired infection: a progress report. http://www.nao.org.uk/publications/0304/improving_patient_care.aspx. London: Comptroller and Auditor general, 2004.
Neumayer 2007
  • Neumayer L, Hosokawa P, Itani K, El-Tamer M, Henderson WG, Khuri SF. Multivariable predictors of postoperative surgical site infection after general and vascular surgery: results from the patient safety in surgery study. Journal of the American College of Surgeons 2007;204(6):1178-87.
Nichols 1996
Owens (accessed 17 June 2010)
  • Owens CD. Study of a combination of a cyanoacrylate and surgical solutions in reducing flora contamination. ClinicalTrials.gov (accessed 17 June 2010).
RevMan 2008 [Computer program]
  • The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). Version 5.0. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2008.
SIGN 2009
  • Scottish Intercollegiate Guidelines Network (SIGN). Search filters. http://www.sign.ac.uk/methodology/filters.html#random (accessed 30 April 2009).
Singer 2008
Smyth 2000
SSHAIP 2004
  • Scottish Surveillance of Healthcare Associated Infection Programme. Surveillance of surgical site infection for procedures carried out from 01/04/02-30/06/03. Report. Scotland: Centre for Infection and Environmental Health, 2004.
Tanner 2006
Webster 2007

References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
  5. References to other published versions of this review
Lipp 2010
  • A Lipp, C Phillips, P Harris, I Dowie. Cyanoacrylate microbial sealants for skin preparation prior to surgery. Cochrane Database of Systematic Reviews 2010, Issue 10. [DOI: 10.1002/14651858]