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Thymectomy for non-thymomatous myasthenia gravis

  1. Gabriel Cea1,*,
  2. Michael Benatar2,
  3. Renato J Verdugo3,
  4. Rodrigo A Salinas1

Editorial Group: Cochrane Neuromuscular Group

Published Online: 14 OCT 2013

Assessed as up-to-date: 31 MAR 2013

DOI: 10.1002/14651858.CD008111.pub2


How to Cite

Cea G, Benatar M, Verdugo RJ, Salinas RA. Thymectomy for non-thymomatous myasthenia gravis. Cochrane Database of Systematic Reviews 2013, Issue 10. Art. No.: CD008111. DOI: 10.1002/14651858.CD008111.pub2.

Author Information

  1. 1

    Hospital del Salvador, Universidad de Chile, Departamento de Neurosciencias, Santiago, Chile

  2. 2

    University of Miami, Department of Neurology, Miami, Florida, USA

  3. 3

    Universidad del Desarrollo - Clínica Alemana, Servicio de Neurología, Facultad de Medicina, Santiago, Region Metropolitana of Santiago, Chile

*Gabriel Cea, Departamento de Neurosciencias, Hospital del Salvador, Universidad de Chile, Avda Salvador 364, Providencia, Santiago, 6640517, Chile. jcea@med.uchile.cl.

Publication History

  1. Publication Status: New
  2. Published Online: 14 OCT 2013

SEARCH

References

References to studies excluded from this review

  1. References to studies excluded from this review
  2. References to ongoing studies
  3. Additional references
  4. References to other published versions of this review
Beekman 1997 {published data only}
Beghi 1991 {published data only}
  • Beghi E, Antozzi C, Batocchi AP, Cornelio F, Cosi V, Evoli A, et al. Prognosis of myasthenia gravis: a multicenter follow-up study of 844 patients. Journal of the Neurological Sciences 1991;106(2):213-20.
Buckingham 1976 {published data only}
  • Buckingham JM, Howard FM Jr, Bernatz PE, Payne WS, Harrison EG Jr, O'Brien PC, et al. The value of thymectomy in myasthenia gravis: a computer-assisted matched study. Annals of Surgery 1976;184(4):453-8.
Donaldson 1990 {published data only}
Durelli 1991 {published data only}
  • Durelli L, Maggi G, Casadio C, Ferri R, Rendine S, Bergamini L. Actuarial analysis of the occurrence of remissions following thymectomy for myasthenia gravis in 400 patients. Journal of Neurology, Neurosurgery, and Psychiatry 1991;54(5):406-11.
Eaton 1955 {published data only}
Edwards 1972 {published data only}
Emeryk 1976 {published data only}
Grob 1987 {published data only}
Henson 1965 {published data only}
Kawaguchi 2007 {published data only}
  • Kawaguchi N, Kuwabara S, Nemoto Y, Fukutake T, Arimura K, Osame M, et al. Effects of thymectomy on late-onset myasthenia gravis without thymoma. Clinical Neurology and Neurosurgery 2007;109(10):858-61.
Mack 1996 {published data only}
  • Mack MJ, Landreneau RJ, Yim AP, Hazelrigg SR, Scruggs GR. Results of video-assisted thymectomy in patients with myasthenia gravis. Journal of Thoracic and Cardiovascular Surgery 1996;112(5):1352-9.
Manlulu 2005 {published data only}
Mantegazza 1990 {published data only}
  • Mantegazza R, Beghi E, Pareyson D, Antozzi C, Peluchetti D, Sghirlanzoni A. A multicentre follow-up study of 1152 patients with myasthenia gravis in Italy. Journal of Neurology 1990;237(6):339-44.
McQuillen 1977 {published data only}
Molly 2009 {published data only}
Olanow 1987 {published data only}
Oosterhuis 1981 {published data only}
Papatestas 1987 {published data only}
Perlo 1971 {published data only}
Roberts 2001 {published data only}
  • Roberts PF, Venuta F, Rendina E, De Giacomo T, Coloni GF, Follette DM, et al. Thymectomy in the treatment of ocular myasthenia gravis. Journal of Thoracic and Cardiovascular Surgery 2001;122(3):562-8.
Rodriguez 1983 {published data only}
Romi 2003 {published data only}
  • Romi F, Gilhus NE, Varhaug JE, Myking A, Aarli JA. Thymectomy in nonthymoma early-onset myasthenia gravis in correlation with disease severity and muscle autoantibodies. European Neurology 2003;49(4):210-7.
Savcenko 2002 {published data only}
  • Savcenko M, Wendt GK, Prince SL, Mack MJ. Video-assisted thymectomy for myasthenia gravis: an update of a single institution experience. European Journal of Cardiothoracic Surgery 2002;22(6):978-83.
Scadding 1985 {published data only}
Simpson 1958 {published data only}
Soleimani 2004 {published data only}
  • Soleimani A, Moayyeri A, Akhondzadeh S, Sadatsafavi M, Tavakoli Shalmani H, Soltanzadeh A. Frequency of myasthenic crisis in relation to thymectomy in generalized myasthenia gravis: a 17-year experience. BMC Neurology 2004;4:12.
Tellez-Zenteno 2001 {published data only}
  • Téllez-Zenteno JF, Remes-Troche JM, García-Ramos G, Estañol B, Garduño-Espinoza J. Prognostic factors of thymectomy in patients with myasthenia gravis: a cohort of 132 patients. European Neurology 2001;46(4):171-7.
Werneck 1991 {published data only}
  • Werneck LC, Moreira PR. Myasthenia gravis: clinical and surgical treatment [Miatenia Grave: tratamiento clinico y cirurgico]. Arquivos de Neuro-psiquiatria 1991;49(4):409-17.
Yim 1995 {published data only}
Zeldowicz 1969 {published data only}
  • Zeldowicz LR, Saxton GD. Myasthenia gravis: comparative evaluation of medical and surgical treatment. Canadian Medical Association Journal 1969;101(10):88-93.

References to ongoing studies

  1. References to studies excluded from this review
  2. References to ongoing studies
  3. Additional references
  4. References to other published versions of this review
NCT00294658 {published data only}
  • NCT00294658. A multi-center, single-blind, randomized study comparing thymectomy to no thymectomy in non-thymomatous myasthenia gravis (MG) patients receiving prednisone. http://clinicaltrials.gov/ct2/show/NCT00294658 (accessed April 7 2009).

Additional references

  1. References to studies excluded from this review
  2. References to ongoing studies
  3. Additional references
  4. References to other published versions of this review
Aarli 1999
Bedlack 2002
  • Bedlack RS, Sanders DB. On the concept of myasthenic crisis. Journal of Clinical Neuromuscular Disease 2002;4(1):40-2.
Bever 1983
Burns 2008
Buzzard 1905
  • Buzzard EF. The clinical history and postmortem examination of five cases of myasthenia gravis. Brain 1905;28:438-83.
Casetta 2010
  • Casetta I, Groppo E, De Gennaro R, Cesnik E, Piccolo L, Volpato S, Granieri E. Myasthenia gravis: a changing pattern of incidence. Journal of Neurology 2010;257(12):2015-9.
Christensen 1998
  • Christensen PB, Jensen TS, Tsiropoulos I, Sørensen T, Kjaer M, Højer-Pedersen E, et al. Mortality and survival in myasthenia gravis: a Danish population based study. Journal of Neurology, Neurosurgery, and Psychiatry 1998;64(1):78-83.
Evoli 2003
  • Evoli A, Tonali PA, Padua L, Monaco ML, Scuderi F, Batocchi AP, et al. Clinical correlates with anti-MuSK antibodies in generalized seronegative myasthenia gravis. Brain 2003;126(Pt 10):2304-11.
French 2008
Gajdos 2002
  • Gajdos P, Chevret S, Toyka K. Plasma exchange for myasthenia gravis. Cochrane Database of Systematic Reviews 2002, Issue 4. [DOI: 10.1002/14651858.CD002275]
Gajdos 2008
Grimes 2002
Gronseth 2000
  • Gronseth GS, Barohn RJ. Practice parameter: thymectomy for autoimmune myasthenia gravis (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2000;55(1):7-15.
Hart 2007
Higgins 2011a
  • Higgins JPT, Altman DG, Sterne JAC (editors). Chapter 8: Assessing risk of bias in included studies. Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
Higgins 2011b
  • Higgins JPT, Deeks JJ (editors). Chapter 7: Selecting studies and collecting data. In: Higgins JPT, Green S (editors), Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
Higuchi 2011
Hughes 2005
Jaretzki 2000
  • Jaretzki A 3rd, Barohn RJ, Ernstoff RM, Kaminski HJ, Keesey JC, Penn AS, et al. Myasthenia gravis: recommendations for clinical research standards. Task Force of the Medical Scientific Advisory Board of the Myasthenia Gravis Foundation of America. Neurology 2000;55(1):16-23.
Kaminski 2003
  • Kaminski HJ. Myasthenia Gravis and Related Disorders. Totowa, NJ: Humana Press, 2003.
Kuks 1991
  • Kuks JB, Oosterhuis HJ, Limburg PC, The TH. Anti-acetylcholine receptor antibodies decrease after thymectomy in patients with myasthenia gravis. Clinical correlations. Journal of Autoimmunity 1991;4(2):197-211.
Lanska 1990
Matsuda 2005
  • Matsuda M, Dohi-Iijima N, Nakamura A, Sekijima Y, Morita H, Matsuzawa S, et al. Increase in incidence of elderly-onset patients with myasthenia gravis in Nagano Prefecture, Japan. Internal Medicine 2005;44(6):572-7. [PUBMED: 16020882]
Mehndiratta 2011
Melms 1988
  • Melms A, Schalke BC, Kirchner T, Müller-Hermelink HK, Albert E, Wekerle H. Thymus in myasthenia gravis. Isolation of T-lymphocyte lines specific for the nicotinic acetylcholine receptor from thymuses of myasthenic patients. Journal of Clinical Investigation 1988;81(3):902-8.
Meriggioli 2009
Monden 1984
  • Monden Y, Nakahara K, Kagotani K, Fujii Y, Masaoka A, Kawashima Y. Myasthenia gravis with thymoma: analysis of and postoperative prognosis for 65 patients with thymomatous myasthenia gravis. Annals of Thoracic Surgery 1984;38(1):46-52.
NCT00619671
  • NCT00619671. Phase 1-2 pilot study of rituximab (Rituxan) in refractory myasthenia gravis. http://clinicaltrials.gov/ct2/show/NCT00619671 (accessed 18 March 2013).
NCT00774462
  • NCT00774462. Rituximab for the treatment of refractory inflammatory myopathies and refractory myasthenia gravis. http://clinicaltrials.gov/ct2/show/NCT00774462 (accessed 18 March 2013).
Newsom-Davis 2001
  • Newsom-Davis J, Beeson D. Myasthenia gravis and myasthenic syndromes: autoimmune and genetic disorders. In: Karpati G, Hilton-Jones D, Griggs RC editor(s). Disorders of Voluntary Muscle. Cambridge: Cambridge University Press, 2001:660-75.
Oosterhuis 1989
Oostertihuis 1982
Palace 1998
Pascuzzi 1984
Penn 1994
  • Penn AS. Thymectomy for myasthenia gravis. In: Lisak RP editor(s). Handbook of Myasthenia Gravis and Myasthenic syndrome. New York: Marcel Dekker, 1994:321-39.
Pevzner 2012
  • Pevzner A, Schoser B, Peters K, Cosma NC, Karakatsani A, Schalke B, et al. Anti-LRP4 autoantibodies in AChR- and MuSK-antibody-negative myasthenia gravis. Journal of Neurology 2012;259(3):427-35.
Phillips 2003
Reeves 2011
  • Reeves BC, Deeks JJ, Higgins JPT, Wells GA. Chapter 13: Including non-randomized studies. Higgins JPT, Green S (editors), Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org. Chichester (UK): John Wiley & Sons.
Riegelman 2005
  • Riegelman RK. Database research: retrospective cohort studies. Studying a Study and Testing a Test: How to Read the Medical Evidence. 5th Edition. Philadelphia, PA: Wolters Kluwer, 2005:89-98.
Salomon 1998
  • Salomon AM, Bruand C, Cardona A, Changeux JP, Berrih-Aknin S. An acetylcholine receptor α-subunit promoter confers intrathymic expression in transgenic mice. Implications for tolerance of a transgenic self-antigen and for autoreactivity in myasthenia gravis. Journal of Clinical Investigation 1998;101(11):2340-50.
Schluep 1987
Schneider-Gold 2005
Schünemann 2011
  • Schünemann HJ, Oxman AD, Higgins JPT, Vist GE, Glasziou P, Guyatt GH. Chapter 11: Presenting results and ‘Summary of findings' tables. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
Sonett 2008
Tindall 1993
  • Tindall RS, Phillips JT, Rollins JA, Wells L, Hall K. A clinical therapeutic trial of cyclosporine in myasthenia gravis. Annals of the New York Academy of Sciences 1993;681:539-51.
Vincent 2001
Vincent 2002
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Vincent 2007
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References to other published versions of this review

  1. References to studies excluded from this review
  2. References to ongoing studies
  3. Additional references
  4. References to other published versions of this review
Cea 2009
  • Cea G, Benatar M, Verdugo RJ, Salinas RA. Thymectomy for non-thymomatous myasthenia gravis. Cochrane Database of Systematic Reviews 2009, Issue 4. [DOI: 10.1002/14651858.CD008111]