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Autologous hematopoietic stem cell transplantation following high dose chemotherapy for non-rhabdomyosarcoma soft tissue sarcomas

  1. Frank Peinemann1,*,
  2. Lesley A Smith2,
  3. Carmen Bartel3

Editorial Group: Cochrane Gynaecological Cancer Group

Published Online: 7 AUG 2013

Assessed as up-to-date: 5 DEC 2012

DOI: 10.1002/14651858.CD008216.pub4


How to Cite

Peinemann F, Smith LA, Bartel C. Autologous hematopoietic stem cell transplantation following high dose chemotherapy for non-rhabdomyosarcoma soft tissue sarcomas. Cochrane Database of Systematic Reviews 2013, Issue 8. Art. No.: CD008216. DOI: 10.1002/14651858.CD008216.pub4.

Author Information

  1. 1

    Children's Hospital, University of Cologne, Pediatric Oncology and Hematology, Cologne, NW, Germany

  2. 2

    Oxford Brookes University, Department of Social Work & Public Health, Faculty of Health & Life Sciences, Oxford, UK

  3. 3

    Institute for Quality and Efficiency in Health Care (IQWiG), Dep. Quality of Health Care, Cologne, Germany

*Frank Peinemann, Pediatric Oncology and Hematology, Children's Hospital, University of Cologne, Kerpener Str. 62, Cologne, NW, 50937, Germany. pubmedprjournal@gmail.com.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 7 AUG 2013

SEARCH

[Figure 1]
Figure 1. Literature search and study flow.
[Figure 2]
Figure 2. Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
[Figure 3]
Figure 3. Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
[Figure 4]
Figure 4. Kaplan-Meyer analysis of overall survival of individual cases data from patient with various NRSTS

  • X-axis below line: years


  • X-axis above line: number of patients at risk


  • Y-axis: probability of overall survival


The Kaplan-Meyer analysis of overall survival was conducted using individual data of patients with NRSTS with available follow-up information (total 80, failed 46, censored 34) from 41 case series and case reports. Information about outcome (dead or alive) and follow-up (time of survival after diagnosis or begin of treatment) was required for each individual. Number of subjects at risk after each additional year of follow up.

Abbreviations: NRSTS: non-rhabdomyosarcoma soft tissue sarcoma
[Figure 5]
Figure 5. Kaplan-Meyer analysis of overall survival of individual cases data from patient with DSRCT only

  • X-axis below line: years


  • X-axis above line: number of patients at risk


  • Y-axis: probability of overall survival


The Kaplan-Meyer analysis of overall survival was conducted using individual data of patients with NRSTS with available follow-up information (total 27, failed 13, censored 14) from case series and case reports. Information about outcome (dead or alive) and follow-up (time of survival after diagnosis or begin of treatment) was required for each individual. Number of subjects at risk after each additional year of follow up.

Abbreviations: DSRCT: desmoplastic small round cell tumor