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Intervention Protocol

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Booster dose vaccination for preventing hepatitis B

  1. Jalal Poorolajal1,*,
  2. Mahmood Mahmoodi2,
  3. AliAkbar Haghdoost3,
  4. Reza Majdzadeh2,
  5. Siavosh Nasseri-Moghaddam4,
  6. Leila Ghalichi2,
  7. Akbar Fotouhi2

Editorial Group: Cochrane Hepato-Biliary Group

Published Online: 20 JAN 2010

Assessed as up-to-date: 4 NOV 2009

DOI: 10.1002/14651858.CD008256

How to Cite

Poorolajal J, Mahmoodi M, Haghdoost A, Majdzadeh R, Nasseri-Moghaddam S, Ghalichi L, Fotouhi A. Booster dose vaccination for preventing hepatitis B (Protocol). Cochrane Database of Systematic Reviews 2010, Issue 1. Art. No.: CD008256. DOI: 10.1002/14651858.CD008256.

Author Information

  1. 1

    Hamedan University of Medical Sciences (UMSHA), Department of Epidemiology and Biostatistics, Hamedan, Hamedan, Iran

  2. 2

    Tehran University of Medical Science (TUMS), Department of Epidemiology and Biostatistics, Tehran, Iran

  3. 3

    Kerman University of Medical Sciences, Community Medicine Department and Physiology Research Center, Kerman, Kerman, Iran

  4. 4

    Shariati Hospital, Tehran University of Medical Sciences, Digestive Disease Research Center, Tehran, Tehran, Iran

*Jalal Poorolajal, Department of Epidemiology and Biostatistics, Hamedan University of Medical Sciences (UMSHA), Shahid Fahmideh Ave., Hamedan, Hamedan, 6517838695, Iran.

Publication History

  1. Publication Status: New
  2. Published Online: 20 JAN 2010


This is not the most recent version of the article. View current version (07 JUN 2016)


Additional references

Banatvala 2003
But 2008
  • But DYK, Lai CL, Lim WL, Fung J, Wong DKH, Yuen MF. Twenty-two years follow-up of a prospective randomized trial of hepatitis B vaccines without booster dose in children: Final report. Vaccine 2008;26:6587-91.
Chadha 2000
  • Chadha MS, Arankalle VA. Ten-year serological follow up of hepatitis B vaccine recipients. Indian Journal of Gastroenterology. 2000;19(4):168-71.
Chen 2005
DeMets 1987
Dentinger 2005
  • Dentinger CM, McMahon BJ, Butler JC, Dunaway CE, Zanis CL, Bulkow LR, et al. Persistence of antibody to hepatitis B and protection from disease among Alaska Natives immunized at birth. Pediatric Infectious Disease Journal 2005;24(9):786-92.
DerSimonian 1986
Durlach 2003
  • Durlach R, Laugas S, Freuler CB, Rodriguez VE, Costa M. Ten-year persistence of antibody to hepatitis B surface antigen in healthcare workers vaccinated against hepatitis B virus, and response to booster vaccination. Infection Control and Hospital Epidemiology 2003;24(10):773-6.
European Consensus Group 2000
  • European Consensus Group on Hepatitis B Immunity. Are booster immunizations needed for lifelong hepatitis B immunity?. Lancet 2000;355:561–5.
FitzSimons 2005
  • FitzSimons D, Francois G, Hall A, McMahon B, Meheus A, Zanetti A, et al. Long-term efficacy of hepatitis B vaccine, booster policy and impact of hepatitis B virus mutants. Vaccine 2005;23:4158-66.
Gamble 2005
Gilca 2008
  • Gilca V, De Serres G, Boulianne N, De Wals P, Trudeau G, Massé R, et al. Antibody kinetics after vaccination with Engerix-B at the age of 8-10 years and the effect of a booster dose given five or ten years later. 8th Canadian Immunization Conference. Toronto, 2008.
Gluud 2009
  • Gluud C, Nikolova D, Klingenberg SL, Whitfield K, Alexakis N, Als-Nielsen B, et al. Cochrane Hepato-Biliary Group. About The Cochrane Collaboration (Cochrane Review Groups (CRGs)). 2009, Issue 2. Art. No.: LIVER.
Goh 1995
  • Goh KT, Oon CJ, Heng BH, Lim GK. Long-term immunogenicity and efficacy of a reduced dose of plasma-based hepatitis B vaccine in young adults. Bulletin of the World Health Organization 1995;73(4):523-7.
Hadler 1986
  • Hadler SC, Francis DP, Sc D, Maynard JE, Thompson SE, Judson FN, et al. Long-term immunogenicity and efficacy of hepatitis B vaccine in homosexual men. New England Journal of Medicine 1986;315(4):209-14.
Higgins 2003
Higgins 2008
  • Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.0 [updated February 2008]. The Cochrane Collaboration, 2008. Available from
John 2005
Joshi 1995
  • Joshi N, Kumar YRN, Srinivas DV, Kumar A, Rao PN. Recombinant hepatitis-B vaccine long-term efficacy in hospital personnel. Gastroenterology 1995;108(4):A1093.
Lai 1993
Lee 2006
Liao 1999
Mast 2006
  • Mast EE, Weinbaum CM, Fiore AE, Alter MJ, Bell BP, Finelli L, et al. A comprehensive immunization strategy to eliminate transmission of hepatitis B virus infection in the United States: recommendations of the Advisory Committee on Immunization Practices (ACIP) Part II: immunization of adults. MMWR. Morbidity and Mortality Weekly Report 2006;55(RR-16):1-33.
McMahon 2005
  • McMahon BJ, Bruden DL, Petersen KM, Bulkow LR, Parkinson AJ, Nainan O, et al. Antibody levels and protection after hepatitis B vaccination: Results of a 15-year follow-up. Annals of Internal Medicine 2005;142(5):333-41.
Mintai 1993
  • Mintai Z, Kezhou L, Lieming D, Raymond S. Duration and efficacy of immune response to hepatitis-B vaccine in high-risk Chinese adolescents. Clinical Infectious Diseases 1993;16(1):165-7.
Puro 2005
  • Puro V, Carli GD, Cicalini S, Soldani F, Balslev U, Begovac J, et al. European recommendations for the management of healthcare workers occupationally exposed to hepatitis B virus and hepatitis C virus. Euro Surveillance 2005;10(10):260-4.
RevMan 2008
  • The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). 5.0. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2008.
Royle 2003
  • Royle P, Milne R. Literature searching for randomized controlled trials used in Cochrane reviews: rapid versus exhaustive searches. International Journal of Technology Assessment in Health Care 2003;19(4):591-603.
Samandari 2007
  • Samandari T, Fiore AE, Negus S, Williams JL, Kuhnert W, McMahon BJ, et al. Differences in response to a hepatitis B vaccine booster dose among Alaskan children and adolescents vaccinated during infancy. Pediatrics 2007;120(2):e373-e381.
Stata 9
  • Stata. Intercooled Stata 9.1. 9.1 for Windows. StataCorp LP, 2005.
van der Sande 2007
  • van der Sande MAB, Waight PA, Mendy M, Zaman S, Kaye S, Sam O, et al. Long-term protection against HBV chronic carriage of Gambian adolescents vaccinated in infancy and immune response in HBV booster trial in adolescence. PLoS ONE 2007;2(8):e753.
Wainwright 1989
  • Wainwright RB, McMahon BJ, Bulkow LR, Hall DB, Fitzgerald MA, Harpster AP, et al. Duration of immunogenicity and efficacy of hepatitis B vaccine in a Yupik Eskimo population. JAMA 1989;261(16):2362-6.
Wainwright 1997
  • Wainwright RB, Bulkow LR, Parkinson AJ, Zanis C, McMahon BJ. Protection provided by hepatitis B vaccine in a Yupik Eskimo population - Results of a 10-year study. Journal of Infectious Diseases 1997;175:674-7.
Watson 2001
Whittle 2002
  • Whittle H, Jaffar S, Wansbrough M, Mendy M, Dumpis U, Collinson A, et al. Observational study of vaccine efficacy 14 years after trial of hepatitis B vaccination in Gambian children. BMJ (Clinical Research Ed.) 2002;325:569-75.
WHO 2001
  • World Health Organization. Introduction of hepatitis B vaccine into childhood immunization services. 2001 (accessed 14 September 2009).
WHO 2002
  • World Health Organization. Hepatitis B. 2002 (accessed 14 September 2009).
WHO 2003
  • World Health Organization. Expanded program on immunization: Measles and Hepatitis B. 2003 (accessed 14 September 2009).
Williams 2003
  • Williams IT, Goldstein ST, Tufa J, Tauillii S, Margolis HS, Mahoney FJ. Long term antibody response to hepatitis B vaccination beginning at birth and to subsequent booster vaccination. Pediatric Infectious Disease Journal 2003;22(2):157-63.
Yuen 1999
Yuen 2004
  • Yuen MF, Lim WL, Chan AOO, Wong DKH, Sum SSM, Lai CL. 18-year follow-up study of a prospective randomized trial of hepatitis B vaccinations without booster doses in children. Clinical Gastroenterology and Hepatology 2004;2:941-5.
Zhang 1993
  • Zhang M, Liu K, Jin J, Ding L, Zhou S, Yu Q, et al. Five-year follow-up of immune response to hepatitis B vaccine in juveniles. Chinese Medical Journal 1993;106(2):97-9.