Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
---|
| 1 Failure (overall) | 8 | 1606 | Risk Ratio (M-H, Random, 95% CI) | 0.88 [0.74, 1.04] |
| | 6 | 908 | Risk Ratio (M-H, Random, 95% CI) | 0.80 [0.62, 1.03] |
| | 3 | 698 | Risk Ratio (M-H, Random, 95% CI) | 0.99 [0.79, 1.24] |
| 2 Discontinuation for adverse events | 8 | 1597 | Risk Ratio (M-H, Random, 95% CI) | 0.68 [0.44, 1.07] |
| | 6 | 899 | Risk Ratio (M-H, Random, 95% CI) | 0.77 [0.39, 1.53] |
| | 3 | 698 | Risk Ratio (M-H, Random, 95% CI) | 0.63 [0.34, 1.18] |
| 3 Virologic failure | 8 | 1587 | Risk Ratio (M-H, Random, 95% CI) | 1.39 [0.95, 2.02] |
| | 6 | 899 | Risk Ratio (M-H, Random, 95% CI) | 1.49 [0.72, 3.08] |
| | 3 | 688 | Risk Ratio (M-H, Random, 95% CI) | 1.32 [0.89, 1.97] |
| 4 Death | 4 | 1044 | Risk Ratio (M-H, Fixed, 95% CI) | 1.80 [0.43, 7.61] |
| | 3 | 579 | Risk Ratio (M-H, Fixed, 95% CI) | 3.87 [0.44, 34.22] |
| | 1 | 465 | Risk Ratio (M-H, Fixed, 95% CI) | 0.71 [0.07, 6.74] |
| 5 Death & AIDS related events | 4 | 1044 | Risk Ratio (M-H, Fixed, 95% CI) | 1.66 [0.62, 4.42] |
| | 3 | 579 | Risk Ratio (M-H, Fixed, 95% CI) | 1.44 [0.41, 5.04] |
| | 1 | 465 | Risk Ratio (M-H, Fixed, 95% CI) | 2.12 [0.43, 10.38] |
| 6 Any Adverse Events | 3 | 837 | Risk Ratio (M-H, Random, 95% CI) | 0.92 [0.73, 1.15] |
| | 2 | 372 | Risk Ratio (M-H, Random, 95% CI) | 1.01 [0.80, 1.27] |
| | 1 | 465 | Risk Ratio (M-H, Random, 95% CI) | 0.75 [0.61, 0.94] |
| 7 Rate of patients with Viral Load < 50 cp/ml | 5 | 774 | Risk Ratio (M-H, Random, 95% CI) | 1.04 [0.92, 1.18] |
| | 4 | 640 | Risk Ratio (M-H, Random, 95% CI) | 1.05 [0.91, 1.21] |
| | 1 | 134 | Risk Ratio (M-H, Random, 95% CI) | 0.98 [0.76, 1.27] | |