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Intervention Review

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Combined pharmacotherapy and behavioural interventions for smoking cessation

  1. Lindsay F Stead*,
  2. Tim Lancaster

Editorial Group: Cochrane Tobacco Addiction Group

Published Online: 17 OCT 2012

Assessed as up-to-date: 4 SEP 2012

DOI: 10.1002/14651858.CD008286.pub2


How to Cite

Stead LF, Lancaster T. Combined pharmacotherapy and behavioural interventions for smoking cessation. Cochrane Database of Systematic Reviews 2012, Issue 10. Art. No.: CD008286. DOI: 10.1002/14651858.CD008286.pub2.

Author Information

  1. University of Oxford, Department of Primary Care Health Sciences, Oxford, UK

*Lindsay F Stead, Department of Primary Care Health Sciences, University of Oxford, Radcliffe Observatory Quarter, Woodstock Road, Oxford, OX2 6GG, UK. lindsay.stead@phc.ox.ac.uk.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 17 OCT 2012

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This is not the most recent version of the article. View current version (24 MAR 2016)

References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
An 2006 {published data only}
  • An LC, Partin M, Zhu SH, Arikian NJ, Nelson DB, Nugent SM, et al. Delivery of bupropion SR as part of a telephone counseling intervention for veteran smokers (POS1-040). Society for Research on Nicotine and Tobacco 10th Annual Meeting February 18-21, Phoenix, Arizona. 2004.
  • An LC, Zhu SH, Arikian NJ, Nelson DB, Nugent SM, Partin M, et al. Telestop: a randomized trial of increased access to behavioral and pharmacological therapy for smoking cessation (abstract). Nicotine & Tobacco Research 2005;7(4):689.
  • An LC, Zhu S-H, Nelson DB, Arikian NJ, Nugent S, Partin MR, et al. Benefits of telephone care over primary care for smoking cessation. Archives of Internal Medicine 2006;166:536-42.
  • Smith M, Fu S, Nugent S, Nelson D, Joseph A, An L. A cost-effective telehealth intervention for smoking cessation. Journal of General Internal Medicine 2010;25(Suppl 3):208.
Baker 2006 {published data only}
  • Baker A, Richmond R, Haile M, Lewin TJ, Carr VJ, Taylor RL, et al. A randomized controlled trial of a smoking cessation intervention among people with a psychotic disorder. American Journal of Psychiatry 2006;163(11):1934-42.
  • Baker A, Richmond R, Haile M, Lewin TJ, Carr VJ, Taylor RL, et al. Characteristics of smokers with a psychotic disorder and implications for smoking interventions. Psychiatry Research 2007;150(2):141-52.
  • Baker A, Richmond R, Kay-Lambkin F, Lewin TJ, Carr VJ. Randomized controlled trial of a smoking cessation intervention among people with a psychotic disorder: 3-year follow-up (PA2-2). Society for Research on Nicotine and Tobacco 13th Annual Meeting February 21-24, Austin, Texas. 2007.
  • Richmond R, Baker A, Haile MJ, Carr V, Lewin T, Wilhelm K, et al. Randomized control trial of nicotine patch and cognitive behavioral therapy among smokers with psychotic illness (PA5-4). Society for Research on Nicotine and Tobacco 10th Annual Meeting February 18-21, Phoenix, Arizona. 2004.
  • Richmond RL, Baker A, Haile M, Carr V, Lewin T, Wilhelm K, et al. Intervention for tobacco dependence among people with a psychotic illness: RCT with one year outcome. Nicotine & Tobacco Research 2005;7(4):681.
Binnie 2007 {published data only}
  • Binnie VI, McHugh S, Jenkins W, Borland W, MacPherson LM. A randomised controlled trial of a smoking cessation intervention delivered by dental hygienists: A feasibility study. BMC Oral Health 2007;7:5.
Brandstein 2011 {published and unpublished data}
  • Brandstein K. A proactive smoking cessation intervention with hospitalized smokers: A randomized controlled trial. Dissertation Abstracts International 2012;72(8-B):4600.
  • Brandstein K. A proactive smoking cessation intervention with hospitalized smokers: A randomized controlled trial. PhD Dissertation, University of California San Diego & San Diego State University 2011.
Chan 2010 {published data only}
  • Chan SS, Leung DY, Abdullah AS, Lo SS, Yip AW, Kok WM, et al. Smoking-cessation and adherence intervention among Chinese patients with erectile dysfunction. American Journal of Preventive Medicine 2010;39(3):251-8.
Chouinard 2005 {published data only}
  • Chouinard MC, Robichaud-Ekstrand S. The effectiveness of a nursing inpatient smoking cessation program in individuals with cardiovascular disease. Nursing Research 2005;54(4):243-54.
Cooney 2007 {published data only}
  • Cooney N, Pilkey D, Steinberg H, Cooney J, Litt M, Oncken C. Ecological momentary assessment of alcohol-tobacco interactions after concurrent alcohol-tobacco treatment. Society for Research on Nicotine and Tobacco 11th Annual Meeting, 20-23 March 2005; Prague, Czech Republic. 2005.
  • Cooney N, Pilkey D, Steinberg H, Cooney J, Litt M, Oncken C. Efficacy of intensive versus brief smoking cessation treatment concurrent with intensive outpatient alcohol treatment (POS4-62). Society for Research on Nicotine and Tobacco 9th Annual Meeting February 19-22 New Orleans, Louisiana. 2003.
  • Cooney NL, Litt MD, Cooney JL, Pilkey DT, Steinberg HR, Oncken CA. Concurrent brief versus intensive smoking intervention during alcohol dependence treatment. Psychology of Addictive Behaviors 2007;21:570-5.
  • Cooney NL, Litt MD, Cooney JL, Pilkey DT, Steinburg HR, Oncken CA. Alcohol and tobacco cessation in alcohol-dependent smokers: analysis of real-time reports. Psychology of Addictive Behaviors 2007;21:277-86.
Duffy 2006 {published data only}
  • Duffy SA, Ronis DL, Valenstein M, Lambert MT, Fowler KE, Gregory L, et al. A tailored smoking, alcohol, and depression intervention for head and neck cancer patients. Cancer Epidemiology, Biomarkers & Prevention 2006;15(11):2203-8.
  • Duffy SA, Scheumann AL, Fowler KE, Darling-Fisher C, Terrell JE. Perceived difficulty quitting predicts enrollment in a smoking-cessation program for patients with head and neck cancer. Oncology Nursing Forum 2010;37(3):349-56.
Emmons 2005 {published data only}
  • Emmons KM, Puleo E, Mertens A, Gritz ER, Diller L, Li FP. Long-term smoking cessation outcomes among childhood cancer survivors in the Partnership for Health Study. Journal of Clinical Oncology 2009;27:52-60.
  • Emmons KM, Puleo E, Park E, Gritz ER, Butterfield RM, Weeks JC, et al. Peer-delivered smoking counseling for childhood cancer survivors increases rate of cessation: the Partnership for Health Study. Journal of Clinical Oncology 2005;23:6516-23.
  • Park ER, Puleo E, Butterfield RM, Zorn M, Mertens AC, Gritz ER, et al. A process evaluation of a telephone-based peer-delivered smoking cessation intervention for adult survivors of childhood cancer: the Partnership for Health Study. Preventive Medicine 2006;42:435-42.
Hall 2002 {published data only}
  • Hall SM, Humfleet GL, Reus VI, Munoz RF, Hartz DT, Maude-Griffin R. Psychological intervention and antidepressant treatment in smoking cessation. Archives of General Psychiatry 2002;59:930-6.
  • Hall SM, Lightwood JM, Humfleet GL, Bostrom A, Reus VI, Munoz R. Cost-effectiveness of bupropion, nortriptyline, and psychological intervention in smoking cessation. Journal of Behavioral Health Services & Research 2005;32:381-92.
Hall 2006 {published data only}
  • Barnett PG, Wong W, Hall S. The cost-effectiveness of a smoking cessation program for out-patients in treatment for depression. Addiction 2008;103(5):834-40.
  • Hall SM, Tsoh JY, Prochaska JJ, Eisendrath S, Rossi JS, Redding CA, et al. Treatment for cigarette smoking among depressed mental health outpatients: A randomized clinical trial. American Journal of Public Health 2006;96(10):1808-14.
  • Haug NA, Hall SM, Prochaska JJ, Rosen AB, Tsoh JY, Humfleet G, et al. Acceptance of nicotine dependence treatment among currently depressed smokers. Nicotine & Tobacco Research 2005;7:217-224.
  • Prochaska JJ, Hall SM, Tsoh JY, Eisendrath S, Rossi JS, Redding CA, et al. Treating tobacco dependence in clinically depressed smokers: effect of smoking cessation on mental health functioning. American Journal of Public Health 2008;98(3):446-8.
  • Prochaska JJ, Rossi JS, Redding CA, Rosen AB, Tsoh JY, Humfleet GL, et al. Depressed smokers and stage of change: implications for treatment interventions. Drug and Alcohol Dependence 2004;76:143-51.
Hanioka 2010 {published data only}
Hollis 2007 {published data only}
  • Hollis JF, McAfee TA, Fellows JL, Zbikowski SM, Stark M, Riedlinger K. The effectiveness and cost effectiveness of telephone counselling and the nicotine patch in a state tobacco quitline. Tobacco Control 2007;16(Suppl 1):i53-9.
Juarranz Sanz 1998 {published data only}
  • Juarranz Sanz M, Soriano Llora T, Reyes Martin G, Sanchez Sachez MI. Efficacy of the treatment with substitute of nicotine in the smoking cessation from the Primary Health Care. Revista de Medicina Familiar y Comunitaria 1998;8(6):376-83.
Katz 2004 {published data only}
  • Katz DA, Muehlenbruch DR, Brown RL, Fiore MC, Baker TB. Effectiveness of implementing the Agency for Healthcare Research and Quality smoking cessation clinical practice guideline: a randomized, controlled trial. Journal of the National Cancer Institute 2004;96(8):594-603.
Kotz 2009 {published data only}
  • Kotz D, Wesseling G, Huibers MJ, van Schayck OC. Efficacy of confrontational counselling for smoking cessation in smokers with previously undiagnosed mild to moderate airflow limitation: study protocol of a randomized controlled trial. BMC Public Health 2007;7:332.
  • Kotz D, Wesseling G, Huibers MJH, van Schayck OCP. Efficacy of confronting smokers with airflow limitation for smoking cessation. European Respiratory Journal 2009;33:754-62.
Lewis 1998 {published data only}
Lung Health Study {published data only}
  • Anthonisen NR, Skeans MA, Wise RA, Manfreda J, Kanner RE, Connett JE, et al. The effects of a smoking cessation intervention on 14.5-year mortality: a randomized clinical trial. Annals of Internal Medicine 2005;142:233-39.
  • Bjornson W, Rand C, Connett JE, Lindgren P, Nides M, Pope F, et al. Gender differences in smoking cessation after 3 years in the Lung Health Study. American Journal of Public Health 1995;85:223-30.
  • Connett JE, Kusek JW, Bailey WC, O'Hara P, Wu M. Design of the Lung Health Study: a randomized clinical trial of early intervention for chronic obstructive pulmonary disease. Controlled Clinical Trials 1993;14(2 Suppl):3S-19S.
  • Nides MA, Rakos RF, Gonzales D, Murray RP, Tashkin DP, Bjornson-Benson WM, et al. Predictors of initial smoking cessation and relapse through the first 2 years of the Lung Health Study. Journal of Consulting & Clinical Psychology 1995;63:60-9.
  • O'Hara P, Grill J, Rigdon MA, Connett JE, Lauger GA Johnston JJ. Design and results of the initial intervention program for the Lung Health Study. Preventive Medicine 1993;22:304-15.
  • Wise RA, Kanner RE, Lindgren P, Connett JE, Altose MD, Enright PL, et al. The effect of smoking intervention and an inhaled bronchodilator on airways reactivity in COPD: the Lung Health Study. Chest 2003;124(2):449-58.
McCarthy 2008 {published data only}
  • McCarthy DE. Mechanisms of tobacco cessation treatment: Self-report mediators of counseling and bupropion sustained release treatment. Dissertation Abstracts International: Section B: The Sciences and Engineering 2007;67(9-B):5414.
  • McCarthy DE, Piasecki TM, Lawrence DL, Jorenby DE, Shiffman S, Baker TB. Psychological mediators of bupropion sustained-release treatment for smoking cessation. Addiction 2008;103:1521-33.
  • McCarthy DE, Piasecki TM, Lawrence DL, Jorenby DE, Shiffman S, Fiore MC, et al. A randomized controlled clinical trial of bupropion SR and individual smoking cessation counseling. Nicotine & Tobacco Research 2008;10:717-29.
  • Minami H, McCarthy DE, Jorenby DE, Baker TB. An Ecological Momentary Assessment analysis of relations among coping, affect and smoking during a quit attempt. Addiction 2011;106:641-50.
Mohiuddin 2007 {published data only}
  • Mohiuddin SM, Mooss AN, Hunter CB, Grollmes TL, Cloutier DA, Hilleman DE. Intensive smoking cessation intervention reduces mortality in high-risk smokers with cardiovascular disease. Chest 2007;131:446-52.
Molyneux 2003 {published data only}
  • Molyneux A, Lewis S, Leivers U, Anderton A, Antoniak M, Brackenridge A, et al. Clinical trial comparing nicotine replacement therapy (NRT) plus brief counselling, brief counselling alone, and minimal intervention on smoking cessation in hospital inpatients. Thorax 2003;58:484-8.
Ockene 1991 {published data only}
  • Hebert JR, Kristeller J, Ockene JK, Landon J, Luippold R, Goldberg RJ, et al. Patient characteristics and the effect of three physician- delivered smoking interventions. Preventive Medicine 1992;21:557-73.
  • Ockene JK, Kristeller J, Goldberg R, Amick TL, Pekow PS, Hosmer D, et al. Increasing the efficacy of physician-delivered smoking interventions: a randomized clinical trial. Journal of General Internal Medicine 1991;6:1-8.
  • Ockene JK, Kristeller J, Pbert L, Hebert JR, Luippold R, Goldberg RJ, et al. The physician-delivered smoking intervention project: can short-term interventions produce long-term effects for a general outpatient population?. Health Psychology 1994;13:278-81.
  • Rosal MC, Ockene JK, Hurley TG, Kalan K, Hebert JR. Effectiveness of nicotine-containing gum in the physician- delivered smoking intervention study. Preventive Medicine 1998;27(2):262-7.
Okuyemi 2007 {published data only}
  • Ahluwalia JS, Nollen N, Kaur H, James AS, Mayo MS, Resnicow K. Pathway to health: cluster-randomized trial to increase fruit and vegetable consumption among smokers in public housing. Health Psychology 2007;26(2):214-21.
  • Boardman T, Catley D, Grobe JE, Little TD, Ahluwalia JS. Using motivational interviewing with smokers: do therapist behaviors relate to engagement and therapeutic alliance?. Journal of Substance Abuse Treatment 2006;31(4):329-39.
  • Okuyemi KS, James AS, Mayo MS, Nollen N, Catley D, Choi WS, et al. Pathways to health: a cluster randomized trial of nicotine gum and motivational interviewing for smoking cessation in low-income housing. Health Education & Behavior 2007;34(1):43-54.
Otero 2006 {published data only}
  • Otero UB, Perez CA, Szklo M, Esteves GA, dePinho MM, Szklo AS, et al. Randomized clinical trial: effectiveness of the cognitive-behavioral approach and the use of nicotine replacement transdermal patches for smoking cessation among adults in Rio de Janeiro, Brazil [Portuguese] [Ensaio clinico randomizado: efetividade da abordagem cognitivo-comportamental e uso de adesivos transdermicos de reposicao de nicotina, na cessacao de fumar, em adultos residentes no Municipio do Rio de Janeiro, Brasil]. Cadernos de Saude Publica 2006;22:439-49.
Ratner 2004 {published data only}
Reid 2003 {published data only}
  • Reid R, Pipe A, Higginson L, Johnson K, D'Angelo MS, Cooke D, et al. Stepped care approach to smoking cessation in patients hospitalized for coronary artery disease. Journal of Cardiopulmonary Rehabilitation 2003;23(3):176-82.
Reid 2008 {published data only}
  • Reid MS, Fallon B, Sonne S, Flammino F, Nunes EV, Jiang H, et al. Smoking cessation treatment in community-based substance abuse rehabilitation programs. Journal of Substance Abuse Treatment 2008;35(1):68-77.
  • Reid MS, Jiang H, Fallon B, Sonne S, Rinaldi P, Turrigiano E, et al. Smoking cessation treatment among patients in community-based substance abuse rehabilitation programs: Exploring predictors of outcome as clues toward treatment improvement. American Journal of Drug and Alcohol Abuse 2011;37(5):472-8.
  • Reid MS, Jiang H, Fallon B, Sonne S, Rinaldi P, Turrigiano E, et al. Smoking cessation treatment among patients in community-based substance abuse rehabilitation programs: Exploring predictors of outcome as clues toward treatment improvement. American Journal of Drug and Alcohol Abuse 2011;37(5):472-8.
  • Sonne SC, Nunes EV, Jiang H, Tyson C, Rotrosen J, Reid MS. The relationship between depression and smoking cessation outcomes in treatment-seeking substance abusers. American Journal on Addictions 2010;19:111-18.
Rodriguez 2003 {published data only (unpublished sought but not used)}
  • Guallar-Castillon P, Lafuente Urdinguio P, Garteizaurrekoa Dublang P, Sainz Martinez O, Diez Azcarate JI, Foj Aleman M, et al. Probability of success in tobacco quitting during the course of two simple medical interventions [Probabilidad de exito en el abandono del tabaco en el curso de dos intervenciones sencillas para dejar de fumar]. Revista Espanol de Salud Publica 2003;77(1):117-24.
  • Rodriguez-Artalejo F, Lafuente Urdinguio P, Guallar-Castillon P, Garteizaurrekoa Dublang P, Sainz Martinez O, Diez Azcarate JI, et al. One year effectiveness of an individualised smoking cessation intervention at the workplace: a randomised controlled trial. Occupational Environmental Medicine 2003;60(3):358-63.
Sadr Azodi 2009 {published data only}
Schauffler 2001 {published data only}
  • Schauffler HH, McMenamin S, Olson K, Boyce-Smith G, Rideout JA, Kamil J. Variations in treatment benefits influence smoking cessation: results of a randomised controlled trial. Tobacco Control 2001;10(2):175-80.
Segnan 1991 {published data only}
  • Segnan N, Ponti A, Battista RN, Senore C, Rosso S, Shapiro SH, et al. A randomized trial of smoking cessation interventions in general practice in Italy. Cancer Causes and Control 1991;2:239-46. [MEDLINE: 1991338418]
  • Senore C, Battista RN, Ponti A, Segnan N, Shapiro SH, Rosso S, et al. Comparing participants and nonparticipants in a smoking cessation trial: Selection factors associated with general practitioner recruitment activity. Journal of Clinical Epidemiology 1999;52:83-9.
  • Senore C, Battista RN, Shapiro SH, Segnan N, Ponti A, Rosso S, et al. Predictors of smoking cessation following physicians' counseling. Preventive Medicine 1998;27(3):412-21.
Simon 1997 {published data only}
Thomsen 2010 {published data only}
  • Thomsen T, Tonnesen H, Okholm M, Kroman N, Maibom A, Sauerberg ML, et al. Brief smoking cessation intervention in relation to breast cancer surgery: a randomized controlled trial. Nicotine & Tobacco Research 2010;12(11):1118-24.
Tonnesen 2006 {published data only}
Velicer 2006 {published data only}
  • Velicer WF, Friedman RH, Fava JL, Gulliver SB, Keller S, Sun X, et al. Evaluating nicotine replacement therapy and stage-based therapies in a population-based effectiveness trial. Journal of Consulting and Clinical Psychology 2006;74(6):1162-72.
Vial 2002 {published data only}
  • Vial RJ, Jones TE, Ruffin RE, Gilbert AL. Smoking cessation program using nicotine patches linking hospital to the community. Journal of Pharmacy Practice and Research 2002;32(1):57-62.
Villebro 2008 {published data only}
Wakefield 2004 {published data only}
  • Wakefield M, Olver I, Whitford H, Rosenfeld E. Motivational interviewing as a smoking cessation intervention for patients with cancer: randomized controlled trial. Nursing Research 2004;53(6):396-405.
Wewers 2000 {published data only}
  • Wewers ME, Neidig JL, Kihm KE. The feasibility of a nurse-managed, peer-led tobacco cessation intervention among HIV-positive smokers. Journal of the Association of Nurses In Aids Care 2000;11(6):37-44.
Wewers 2009 {published data only}
  • Troyer MB, Ferketich AK, Murray DM, Paskett ED, Wewers ME. Characteristics of rural Appalachian women who enroll in a tobacco dependence treatment clinical trial. Nicotine & Tobacco Research 2011;13(9):880-5.
  • Wewers ME, Ferketich AK, Harness J, Paskett ED. Effectiveness of a nurse-managed, lay-led tobacco cessation intervention among Ohio Appalachian women. Cancer Epidemiology, Biomarkers & Prevention 2009;18:3451-8.
Wilson 1988 {published data only}
  • Wilson DM, Taylor DW, Gilbert JR, Best JA, Lindsay EA, Willms DG, et al. A randomized trial of a family physician intervention for smoking cessation. Journal of the American Medical Association 1988;260(11):1570-4.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
Ahluwalia 2006 {published data only}
Alterman 2001 {published data only}
Andrews 2007 {published data only}
Aveyard 2007 {published data only}
Bernstein 2011 {published data only}
Bock 2008 {published data only}
  • Bock BC, Becker BM, Niaura RS, Partridge R, Fava JL, Trask P. Smoking cessation among patients in an emergency chest pain observation unit: outcomes of the Chest Pain Smoking Study (CPSS). Nicotine & Tobacco Research 2008;10(10):1523-31.
Boyle 2007 {published data only}
  • Boyle RG, Solberg LI, Asche SE, Boucher JL, Pronk NP, Jensen CJ. Offering telephone counseling to smokers using pharmacotherapy. Nicotine & Tobacco Research 2005;7(Suppl 1):S19-27.
  • Boyle RG, Solberg LI, Asche SE, Maciosek MV, Boucher JL, Pronk NP. Proactive recruitment of health plan smokers into telephone counseling. Nicotine & Tobacco Research 2007;9:581-9.
Brown 2007 {published data only}
  • Brown RA, Niaura R, Lloyd-Richardson EE, Strong DR, Kahler CW, Abrantes AM, et al. Bupropion and cognitive-behavioral treatment for depression in smoking cessation. Nicotine & Tobacco Research 2007;9(7):721-30.
  • Strong DR, Kahler CW, Leventhal AM, Abrantes AM, Lloyd-Richardson E, Niaura R, et al. Impact of bupropion and cognitive-behavioral treatment for depression on positive affect, negative affect, and urges to smoke during cessation treatment. Nicotine & Tobacco Research 2009;11:1142-53.
BTS 1983 {published data only}
  • British Thoracic Society. Comparison of four methods of smoking withdrawal in patients with smoking related diseases. Report by a subcommittee of the Research Committee of the British Thoracic Society. BMJ 1983;286:595-7.
Buchanan 2004 {published data only}
Bushnell 1997 {published data only}
Campbell 1995 {published data only}
Carmody 2012 {published data only}
  • Carmody TP, Delucchi K, Duncan CL, Banys P, Simon JA, Solkowitz SN, et al. Intensive intervention for alcohol-dependent smokers in early recovery: a randomized trial. Drug and Alcohol Dependence 2012;122(3):186-94.
Chan 2011 {published data only}
Christenhusz 2007 {published data only}
  • Christenhusz L, Pieterse M, Seydel E, van der PJ. Prospective determinants of smoking cessation in COPD patients within a high intensity or a brief counseling intervention. Patient Education & Counseling 2007;66(2):162-6.
Costello 2011 {published data only}
  • Costello MJ, Sproule B, Victor JC, Leatherdale ST, Zawertailo L, Selby P. Effectiveness of pharmacist counseling combined with nicotine replacement therapy: a pragmatic randomized trial with 6,987 smokers. Cancer Causes & Control 2011;22(2):167-80.
Cropsey 2008 {published data only}
  • Cropsey K, Eldridge G, Weaver M, Villalobos G, Stitzer M, Best A. Smoking cessation intervention for female prisoners: addressing an urgent public health need. American Journal of Public Health 2008;98(10):1894-901.
  • Cropsey KL, Weaver MF, Eldridge GD, Villalobos GC, Best AM, Stitzer ML. Differential success rates in racial groups: results of a clinical trial of smoking cessation among female prisoners. Nicotine & Tobacco Research 2009;11(6):690-7.
Ellerbeck 2009 {published data only}
  • Cox LS, Cupertino AP, Mussulman LM, Nazir N, Greiner KA, Mahnken JD, et al. Design and baseline characteristics from the KAN-QUIT disease management intervention for rural smokers in primary care. Preventive Medicine 2008;47(2):200-5.
  • Ellerbeck EF, Mahnken JD, Cupertino AP, Cox LS, Greiner KA, Mussulman LM, et al. Effect of varying levels of disease management on smoking cessation: a randomized trial. Annals of Internal Medicine 2009;150(7):437-46.
Ferguson 2012 {published data only}
  • Coleman T, McEwen A, Bauld L, Ferguson J, Lorgelly P, Lewis S. Protocol for the Proactive Or Reactive Telephone Smoking CeSsation Support (PORTSSS) trial. Trials [Electronic Resource] 2009;10:26.
  • Ferguson J, Docherty G, Bauld L, Lewis S, Lorgelly P, Boyd KA, et al. Effect of offering different levels of support and free nicotine replacement therapy via an English national telephone quitline: randomised controlled trial. BMJ March 2012;344:e1696. [DOI: 10.1136/bmj.e1696]
Fiore 2004 {published data only}
  • Fiore MC, McCarthy DE, Jackson TC, Zehner ME, Jorenby DE, Mielke M, et al. Integrating smoking cessation treatment into primary care: An effectiveness study. Preventive Medicine 2004;38:412-20.
Gariti 2009 {published data only}
  • Gariti P, Levin S, Whittingham T, Barou D, Kampman KM, Lynch K, et al. Why do those who request smoking treatment fail to attend the first appointment?. Journal of Substance Abuse Treatment 2008;35:62-7.
  • Gariti P, Lynch K, Alterman A, Kampman K, Xie H, Varillo K. Comparing smoking treatment programs for lighter smokers with and without a history of heavier smoking. Journal of Substance Abuse Treatment 2009;37(3):247-55.
Ginsberg 1992 {published data only}
  • Ginsberg D, Hall SM, Rosinski M. Partner support, psychological treatment, and nicotine gum in smoking treatment: an incremental study. International Journal of the Addictions 1992;27:503-14.
Gordon 2010 {published data only}
  • Gordon JS, Andrews JA, Albert DA, Crews KM, Payne TJ, Severson HH. Tobacco cessation via public dental clinics: results of a randomized trial. American Journal of Public Health 2010;100(7):1307-12.
Hall 1987 {published data only}
Hall 1994 {published data only}
Hall 1996 {published data only}
  • Hall SM, Munoz RF, Reus VI, Sees KL, Duncan C, Humfleet GL, et al. Mood management and nicotine gum in smoking treatment - a therapeutic contact and placebo-controlled study. Journal of Consulting and Clinical Psychology 1996;64:1003-09.
Hall 1998 {published data only}
  • Hall SM, Reus VI, Munoz RF, Sees KL, Humfleet G, Hartz DT, et al. Nortriptyline and cognitive-behavioral therapy in the treatment of cigarette smoking. Archives of General Psychiatry 1998;55:683-90.
  • Hall SM, Reus VI, Munoz RF, Sees KL, Humfleet GL, Frederick S. Nortriptyline and cognitive-behavioral treatment of cigarette smoking. CPDD Annual Meeting. San Juan, Puerto Rico, 1996:52.
Hall 2004 {published data only}
Hall 2009 {published data only}
Hall 2011 {published data only}
  • Hall SM, Humfleet GL, Muñoz RF, Reus VI, Prochaska JJ, Robbins JA. Using extended cognitive behavioral treatment and medication to treat dependent smokers. American Journal of Public Health 2011;101(12):2349-56.
Hegaard 2003 {published data only}
Hokanson 2006 {published data only}
  • Hokanson JM, Anderson RL, Hennrikus DJ, Lando HA, Kendall DM. Integrated tobacco cessation counseling in a diabetes self-management training program: a randomized trial of diabetes and reduction of tobacco. The Diabetes Educator 2006;32(4):562-70.
Huber 1988 {published data only}
Huber 2003 {published data only}
  • Huber D, Gastner J. Smoking cessation: A comparison of behavior therapy, nicotine replacement therapy and their combination. Verhaltenstherapie und Verhaltenshmedizin 2003;24:167-85.
Ingersoll 2009 {published data only}
Japuntich 2006 {published data only}
  • Japuntich SJ, Zehner ME, Smith SS, Jorenby DE, Valdez JA, Fiore MC, et al. Smoking cessation via the internet: a randomized clinical trial of an internet intervention as adjuvant treatment in a smoking cessation intervention. Nicotine & Tobacco Research 2006;8(Suppl 1):S59-67.
Jorenby 1995 {published data only}
Joseph 2004 {published data only}
  • Joseph AM, Nelson DB, Nugent SM, Willenbring ML. Timing of alcohol and smoking cessation (TASC): smoking among substance use patients screened and enrolled in a clinical trial. Journal of Addictive Disease 2003;22:87-107.
  • Joseph AM, Willenbring ML, Nugent SM, Nelson DB. A randomized trial of concurrent versus delayed smoking intervention for patients in alcohol dependence treatment. Journal of Studies on Alcohol 2004;65(6):681-91.
Joyce 2008 {published data only}
Katz 2002 {published data only}
  • Katz DA, Muehlenbruch DR, Brown RB, Fiore MC, Baker TB. Effectiveness of a clinic-based strategy for implementing the AHRQ Smoking Cessation Guideline in primary care. Preventive Medicine 2002;35:293-301.
Kinnunen 2008 {published data only}
  • Kinnunen T, Leeman RF, Korhonen T, Quiles ZN, Terwal DM, Garvey AJ, et al. Exercise as an adjunct to nicotine gum in treating tobacco dependence among women. Nicotine & Tobacco Research 2008;10(4):689-703.
  • Korhonen T, Goodwin A, Miesmaa P, Dupuis EA, Kinnunen T. Smoking cessation program with exercise improves cardiovascular disease biomarkers in sedentary women. Journal of Women's Health 2011;20(7):1051-64.
Lacasse 2008 {published data only}
  • Lacasse Y, Lamontagne R, Martin S, Simard S, Arsenault M. Randomized trial of a smoking cessation intervention in hospitalized patients. Nicotine & Tobacco Research 2008;10(7):1215-21.
Lando 1997 {published data only}
  • Lando HA, Rolnick S, Klevan D, Roski J, Cherney L, Lauger G. Telephone support as an adjunct to transdermal nicotine in smoking cessation. American Journal of Public Health 1997;87:1670-4.
  • Rolnick SJ, Klevan D, Cherney L, Lando HA. Nicotine replacement therapy in a group model HMO. HMO Practice 1997;11:34-7.
Levine 2010 {published data only}
  • Levine MD, Perkins KA, Kalarchian MA, Cheng Y, Houck PR, Slane JD, et al. Bupropion and cognitive behavioral therapy for weight-concerned women smokers. Archives of Internal Medicine 2010;170:543-50.
Lifrak 1997 {published data only}
MacLeod 2003 {published data only}
  • Macleod ZR, Charles MA, Arnaldi VC, Adams IM. Telephone counselling as an adjunct to nicotine patches in smoking cessation: a randomised controlled trial. Medical Journal of Australia 2003;179:349-52.
Marshall 1985 {published data only}
Martin 1997 {published data only}
  • Martin JE, Calfas KJ, Patten CA, Polarek M, Hofstetter CR, Noto J, et al. Prospective evaluation of three smoking interventions in 205 recovering alcoholics: one-year results of project SCRAP-tobacco. Journal of Consulting and Clinical Psychology 1997;65:190-4.
  • Patten CA, Martin JE, Calfas KJ, Brown SA, Schroeder DR. Effect of three smoking cessation treatments on nicotine withdrawal in 141 abstinent alcoholic smokers. Addictive Behaviors 2000;25:301-6.
Mochizuki 2004 {published data only}
  • Mochizuki M, Hatsugaya M, Rokujoh E, Arita E, Hashiguchi M, Shimizu N, et al. [Randomized controlled study on the effectiveness of community pharmacists' advice for smoking cessation by Nicorette--evaluation at three months after initiation]. Yakugaku Zasshi 2004;124(12):989-95.
Nilsson 1996 {published data only}
Okuyemi 2006 {published data only}
  • Okuyemi KS, Thomas JL, Hall S, Nollen NL, Richter KP, Jeffries SK, et al. Smoking cessation in homeless populations: A pilot clinical trial. Nicotine & Tobacco Research 2006;8(5):689-99.
Park 2011 {published data only}
  • Park ER, Japuntich S, Temel J, Lanuti M, Pandiscio J, Hilgenberg J, et al. A smoking cessation intervention for thoracic surgery and oncology clinics: A pilot trial. Journal of Thoracic Oncology 2011;6(6):1059-65.
Rovina 2009 {published data only}
  • Rovina N, Nikoloutsou I, Katsani G, Dima E, Fransis K, Roussos C, et al. Effectiveness of pharmacotherapy and behavioral interventions for smoking cessation in actual clinical practice. Therapeutic Advances in Respiratory Disease 2009;3:279-87.
Schmitz 2007 {published data only}
Schnoll 2005 {published data only}
  • Schnoll RA, Rothman RL, Wielt DB, Lerman C, Pedri H, Wang H, et al. A randomized pilot study of cognitive-behavioral therapy versus basic health education for smoking cessation among cancer patients. Annals of Behavioral Medicine 2005;30(1):1-11.
Shiffman 2000 {published data only}
  • Hollis JF, McAfee TA, Fellows JL, Zbikowski SM, Stark M, Riedlinger K. The effectiveness and cost effectiveness of telephone counselling and the nicotine patch in a state tobacco quitline. Tobacco Control 2007;16(Suppl 1):i53-9.
Shiffman 2001 {published data only}
  • Shiffman S, Paty JA, Rohay JM, Di Marino ME, Gitchell JG. The efficacy of computer-tailored smoking cessation material as a supplement to nicotine patch therapy. Drug & Alcohol Dependence 2001;64(1):35-46.
Simon 2003 {published data only}
  • Simon JA, Carmody TP, Hudes ES, Snyder E, Murray J. Intensive smoking cessation counseling versus minimal counseling among hospitalized smokers treated with transdermal nicotine replacement: a randomized trial. American Journal of Medicine 2003;114(7):555-62.
Smith 2001 {published data only}
  • Smith SS, Jorenby DE, Fiore MC, Anderson JE, Mielke MM, Beach KE, et al. Strike while the iron is hot: can stepped-care treatments resurrect relapsing smokers?. Journal of Consulting and Clinical Psychology 2001;69:429-39.
Sorensen 2003 {published data only}
  • Sorensen LT, Jorgensen T. Short-term preoperative smoking cessation intervention does not affect postoperative complications in colorectal surgery: A randomised clinical trial. Colorectal Disease 2003;5:347-52.
Stein 2006 {published data only}
Strecher 2005 {published data only}
Swan 2003 {published data only}
  • Jack LM, Swan GE, Thompson E, Curry SJ, McAfee T, Dacey S, et al. Bupropion SR and smoking cessation in actual practice: methods for recruitment, screening, and exclusion for a field trial in a managed-care setting. Preventive Medicine 2003;36:585-93.
  • Javitz HS, Swan GE, Zbikowski SM, Curry SJ, McAfee TA, Decker DL, et al. Cost-effectiveness of different combinations of bupropion SR dose and behavioral treatment for smoking cessation: a societal perspective. American Journal of Managed Care 2004;10:217-26.
  • Swan GE, Jack LM, Curry S, Chorost M, Javitz H, McAfee T, et al. Bupropion SR and counseling for smoking cessation in actual practice: Predictors of outcome. Nicotine & Tobacco Research 2003;5:911-21.
  • Swan GE, Jack LM, Javitz HS, McAfee T, McClure JB. Predictors of 12-month outcome in smokers who received bupropion sustained-release for smoking cessation. Central Nervous System Drugs 2008;22(3):239-56.
  • Swan GE, Javitz HS, Jack LM, Curry SJ, McAfee T. Heterogeneity in 12-month outcome among female and male smokers. Addiction 2004;99:237-50.
  • Swan GE, McAfee T, Curry SJ, Jack LM, Javitz H, Dacey S, et al. Effectiveness of bupropion sustained release for smoking cessation in a health care setting: a randomized trial. Archives of Internal Medicine 2003;163:2337-44.
  • Swan GE, Valdes AM, Ring HZ, Khroyan TV, Jack LM, Ton CC, et al. Dopamine receptor DRD2 genotype and smoking cessation outcome following treatment with bupropion SR. Pharmacogenomics Journal 2005;5:21-9.
Ward 2001 {published data only}
Wiggers 2006 {published data only}
  • Wiggers LC, Oort FJ, Dijkstra A, de Haes JC, Legemate DA, Smets EM. Cognitive changes in cardiovascular patients following a tailored behavioral smoking cessation intervention. Preventive Medicine 2005;40:812-21.
  • Wiggers LC, Smets EM, Oort FJ, Peters RJ, Storm-Versloot MN, Vermeulen H, et al. The effect of a minimal intervention strategy in addition to nicotine replacement therapy to support smoking cessation in cardiovascular outpatients: a randomized clinical trial. European Journal of Cardiovascular Prevention & Rehabilitation 2006;13:931-7.
  • Wiggers LC, Smets EM, Oort FJ, Storm-Versloot MN, Vermeulen H, van Loenen LB, et al. Adherence to nicotine replacement patch therapy in cardiovascular patients. International Journal of Behavioral Medicine 2006;13:79-88.
  • Wiggers LCW, Oort FJ, Peters RJG, Legemate DA, de Haes HCJM, Smets EMA. Smoking cessation may not improve quality of life in atherosclerotic patients. Nicotine & Tobacco Research 2006;8(4):581-9.
Wolfenden 2005 {published data only}
Wolfenden 2008 {published data only}
  • Wolfenden L, Wiggers J, Campbell E, Knight J. Pilot of a preoperative smoking cessation intervention incorporating post-discharge support from a Quitline. Health Promotion Journal of Australia 2008;19(2):158-60.
Wu 2009 {published data only}
  • Wu D, Ma GX, Zhou K, Zhou D, Liu A, Poon AN. The effect of a culturally tailored smoking cessation for Chinese American smokers. Nicotine & Tobacco Research 2009;11:1448-57.
Yu 2006 {published data only}
  • Yu H, Zang Y, Lin J. The effect of the abstinence from smoking with nicotine replacement therapy combining with psychological and behavior intervention. Zhongguo Kangfu Yixue Zazhi 2006;21(12):1104-6.

References to ongoing studies

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
Cummins 2012 {published data only}
  • Cummins S, Zhu SH, Gamst A, Kirby C, Brandstein K, Klonhoff-Cohen H, et al. Nicotine patches and quitline counseling to help hospitalized smokers stay quit: Study protocol for a randomized controlled trial. Trials 2012;13(1):128 [epub ahead of print]. [: http://clinicaltrials.gov/show/NCT01289275]
Wong 2008 {published data only}
  • Wong CC, Tsoh JY, Tong EK, Hom FB, Cooper B, Chow EA. The Chinese community smoking cessation project: A community sensitive intervention trial. Journal of Community Health 2008;33(6):363-73.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
Cahill 2012
Fiore 2008
  • Fiore MC, Jaén CR, Baker TB, et al. Treating Tobacco Use and Dependence: 2008 Update. Clinical Practice Guideline. AHRQ publication No. 00-0032. Rockville, MD: US Dept of Health and Human Services. Public Health Services, May 2008.
Higgins 2003
Higgins 2011
  • Higgins JPT, Green S (eds). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
Hughes 1995
  • Hughes JR. Combining behavioral therapy and pharmacotherapy for smoking cessation: an update. NIDA Research Monograph 1995;150:92-109.
Hughes 2007
Kotz 2009b
Lancaster 2005a
Lancaster 2005b
Reus 2008
Rigotti 2012
Schulz 2002a
Schulz 2002b
Shiffman 2008
Stead 2005
Stead 2006
  • Stead LF, Perera R, Lancaster T. Telephone counselling for smoking cessation. Cochrane Database of Systematic Reviews 2006, Issue 3. [DOI: 10.1002/14651858.CD002850.pub2]
Stead 2008
Stead 2012